Study to Assess the Effects of PTC857 Treatment in Participants With Amyotrophic Lateral Sclerosis ALS
Public ClinicalTrials.gov record NCT05349721. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel Study to Assess the Efficacy, Safety, Tolerability, PK, and Biomarker Effects of PTC857 in Adult Subjects With Amyotrophic Lateral Sclerosis (CARDINALS)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will assess the efficacy and safety of PTC857 treatment in participants diagnosed with ALS.
Study identification
- NCT ID
- NCT05349721
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 336 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 15, 2022 (Actual)
- Primary completion
- Sep 26, 2024 (Actual)
- Completion
- Jan 30, 2025 (Actual)
- Last update posted
- Aug 1, 2025
2022 – 2025
United States locations
- U.S. sites
- 14
- U.S. states
- 10
- U.S. cities
- 14
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UC Irvine Health ALS and Neuromuscular Center | Orange | California | 92868 | — |
| Forbes Norris MDA/ALS Research Center at California Pacific Medical Center | San Francisco | California | 94109 | — |
| Holy Cross Hospital, Phil Smith Neuroscience Institute | Fort Lauderdale | Florida | 33308 | — |
| University of South Florida - Carol and Frank Morsani Center for Advanced Healthcare | Tampa | Florida | 33612 | — |
| Augusta University | Augusta | Georgia | 30912 | — |
| University of Kansas Medical Center (KUMC) - Landon Center on Aging | Kansas City | Kansas | 66205 | — |
| Henry Ford Health System Department of Neurology | Detroit | Michigan | 48202 | — |
| Neurology Associates, P.C. / Somnos Clinical Research | Lincoln | Nebraska | 68506 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198-8440 | — |
| Providence Brain and Spine Institute | Portland | Oregon | 97213 | — |
| Lewis Katz School of Medicine at Temple Universtiy | Philadelphia | Pennsylvania | 19140 | — |
| National Neuromuscular Research Institute | Austin | Texas | 78759 | — |
| Nerve and Muscle Center of Texas | Houston | Texas | 77030 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 41 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05349721, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 1, 2025 · Synced Oct 27, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05349721 live on ClinicalTrials.gov.