Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events
Public ClinicalTrials.gov record NCT05360446. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multi-center, Randomized, Double-blind, Placebo-controlled, Parallel-group Phase IIIb Study Evaluating the Effect of Inclisiran on Atherosclerotic Plaque Progression Assessed by Coronary Computed Tomography Angiography (CCTA) in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events (VICTORION-PLAQUE)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
CKJX839D12303 is a research study to determine if the study treatment, called inclisiran, in comparison to placebo taken in addition to statin medication can effectively reduce the total amount of plaque formed in the heart's vessels as measured by coronary computed tomography angiography (CCTA) from baseline to month 24. This study is being conducted in eligible participants with a diagnosis of non-obstructive coronary artery disease (NOCAD), where the coronary arteries are blocked less than 50%, and with no previous cardiovascular events.
Study identification
- NCT ID
- NCT05360446
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 610 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 8, 2022 (Actual)
- Primary completion
- Oct 26, 2026 (Estimated)
- Completion
- Oct 26, 2026 (Estimated)
- Last update posted
- Oct 5, 2026
2022 – 2026
United States locations
- U.S. sites
- 27
- U.S. states
- 19
- U.S. cities
- 25
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Heart Center Research Llc | Huntsville | Alabama | 35801 | — |
| Alaska Heart and Vascular | Anchorage | Alaska | 99508 | — |
| Cardiovascular Res Found | Beverly Hills | California | 90210 | — |
| UC San Diego Health | La Jolla | California | 92037 | — |
| Stanford Health Care | Stanford | California | 94305 | — |
| Lundquist Inst BioMed at Harbor | Torrance | California | 90509-2910 | — |
| Bridgeport Hospital | Bridgeport | Connecticut | 06610 | — |
| George Washington Univ Medical Ctr | Washington D.C. | District of Columbia | 20037 | — |
| Inpatient Research Clinical LLC | Miami Lakes | Florida | 33014 | — |
| NorthShore University Health System | Evanston | Illinois | 60201 | — |
| Reid Physician Associates | Richmond | Indiana | 47374 | — |
| Midwest Heart and Vascular Spec | Overland Park | Kansas | 66211 | — |
| Anderson Medical Research | Ft. Washington | Maryland | 20744 | — |
| Minneapolis Heart Institute | Minneapolis | Minnesota | 55407 | — |
| R Ins For Heart And Vascular Health | Reno | Nevada | 89502 | — |
| Cardio Metabolic Institute | Somerset | New Jersey | 08873 | — |
| Icahn School of Med at Mt Sinai | New York | New York | 10029 | — |
| State Uni of NY at Stony Brook | Stony Brook | New York | 11794-3362 | — |
| Westchester Medical Center | Valhalla | New York | 10595 | — |
| Aultman Hospital | Canton | Ohio | 44710 | — |
| Oregon Health Sciences University | Portland | Oregon | 97239 | — |
| Soltero Cardiovascular Research Center | Dallas | Texas | 75226 | — |
| Orion Medical | Houston | Texas | 77034 | — |
| Inova Fairfax Hospital | Falls Church | Virginia | 22042 | — |
| Virginia Heart | Falls Church | Virginia | 22042 | — |
| Swedish Medical Center-Cardiovascular Research | Seattle | Washington | 98122 | — |
| Univ of Washington Medical Center | Seattle | Washington | 98195 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 62 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05360446, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 5, 2026 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05360446 live on ClinicalTrials.gov.