Independent directory Public ClinicalTrials.gov records United States
ClinicalTrials.gov record
Withdrawn Phase 2 Interventional

Testing the Use of Targeted Treatment for RET Positive Advanced Non-small Cell Lung Cancer

ClinicalTrials.gov ID: NCT05364645

Public ClinicalTrials.gov record NCT05364645. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 21, 2026, 4:28 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized Phase II Study of Carboplatin and Pemetrexed w/ or w/o Selpercatinib in Participants With Non-Squamous RET Fusion-Positive Stage IV Non-Small Cell Lung Cancer and Progression of Disease on Prior RET Directed Therapy (Lung-MAP Sub-Study)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This phase II Lung-MAP treatment trial tests whether carboplatin and pemetrexed with or without selpercatinib works to shrink tumors in patients with RET fusion-positive non-small cell lung cancer that is stage IV or has not responded to previous RET directed therapy. Chemotherapy drugs, such as carboplatin and pemetrexed, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Selpercatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving selpercatinib in combination with carboplatin and pemetrexed may help lower the chance of the cancer growing and spreading.

Study identification

NCT ID
NCT05364645
Recruitment status
Withdrawn
Study type
Interventional
Phase
Phase 2
Lead sponsor
SWOG Cancer Research Network
Network
Enrollment
Not listed

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jul 25, 2022 (Estimated)
Primary completion
Jun 27, 2023 (Estimated)
Completion
May 1, 2029 (Estimated)
Last update posted
Jul 9, 2024

2022 – 2029

United States locations

U.S. sites
265
U.S. states
28
U.S. cities
222
Facility City State ZIP Site status
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro Jonesboro Arkansas 72401 —
University of Arkansas for Medical Sciences Little Rock Arkansas 72205 —
Kaiser Permanente-Anaheim Anaheim California 92806 —
Sutter Auburn Faith Hospital Auburn California 95602 —
Kaiser Permanente-Baldwin Park Baldwin Park California 91706 —
Kaiser Permanente-Bellflower Bellflower California 90706 —
Alta Bates Summit Medical Center-Herrick Campus Berkeley California 94704 —
Kaiser Permanente-Fontana Fontana California 92335 —
Palo Alto Medical Foundation-Fremont Fremont California 94538 —
Kaiser Permanente - Harbor City Harbor City California 90710 —
Kaiser Permanente-Irvine Irvine California 92618 —
Loma Linda University Medical Center Loma Linda California 92354 —
Kaiser Permanente Los Angeles Medical Center Los Angeles California 90027 —
Kaiser Permanente West Los Angeles Los Angeles California 90034 —
Kaiser Permanente-Ontario Ontario California 91761 —
Palo Alto Medical Foundation Health Care Palo Alto California 94301 —
Kaiser Permanente - Panorama City Panorama City California 91402 —
Kaiser Permanente-Riverside Riverside California 92505 —
Sutter Roseville Medical Center Roseville California 95661 —
Sutter Medical Center Sacramento Sacramento California 95816 —
University of California Davis Comprehensive Cancer Center Sacramento California 95817 —
Kaiser Permanente-San Diego Zion San Diego California 92120 —
California Pacific Medical Center-Pacific Campus San Francisco California 94115 —
Veterans Affairs Medical Center - San Francisco San Francisco California 94121 —
Kaiser Permanente-San Marcos San Marcos California 92078 —
Saint Helena Hospital St. Helena California 94574 —
Palo Alto Medical Foundation-Sunnyvale Sunnyvale California 94086 —
Sutter Solano Medical Center/Cancer Center Vallejo California 94589 —
Presbyterian Intercommunity Hospital Whittier California 90602 —
Kaiser Permanente-Woodland Hills Woodland Hills California 91367 —
Mount Sinai Medical Center Miami Beach Florida 33140 —
Moffitt Cancer Center Tampa Florida 33612 —
Saint Alphonsus Cancer Care Center-Boise Boise Idaho 83706 —
Saint Luke's Cancer Institute - Boise Boise Idaho 83712 —
Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho 83605 —
Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho 83814 —
Saint Luke's Cancer Institute - Fruitland Fruitland Idaho 83619 —
Saint Luke's Cancer Institute - Meridian Meridian Idaho 83642 —
Saint Luke's Cancer Institute - Nampa Nampa Idaho 83686 —
Saint Alphonsus Cancer Care Center-Nampa Nampa Idaho 83687 —
Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho 83854 —
Kootenai Cancer Clinic Sandpoint Idaho 83864 —
Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho 83301 —
Advocate Good Shepherd Hospital Barrington Illinois 60010 —
Illinois CancerCare-Bloomington Bloomington Illinois 61704 —
Illinois CancerCare-Canton Canton Illinois 61520 —
Illinois CancerCare-Carthage Carthage Illinois 62321 —
Centralia Oncology Clinic Centralia Illinois 62801 —
Northwestern University Chicago Illinois 60611 —
Advocate Illinois Masonic Medical Center Chicago Illinois 60657 —
AMG Crystal Lake - Oncology Crystal Lake Illinois 60014 —
Carle on Vermilion Danville Illinois 61832 —
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526 —
Decatur Memorial Hospital Decatur Illinois 62526 —
Northwestern Medicine Cancer Center Kishwaukee DeKalb Illinois 60115 —
Illinois CancerCare-Dixon Dixon Illinois 61021 —
Advocate Good Samaritan Hospital Downers Grove Illinois 60515 —
Carle Physician Group-Effingham Effingham Illinois 62401 —
Crossroads Cancer Center Effingham Illinois 62401 —
Advocate Sherman Hospital Elgin Illinois 60123 —
Illinois CancerCare-Eureka Eureka Illinois 61530 —
Illinois CancerCare-Galesburg Galesburg Illinois 61401 —
Northwestern Medicine Cancer Center Delnor Geneva Illinois 60134 —
Advocate South Suburban Hospital Hazel Crest Illinois 60429 —
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443 —
Northwestern Medicine Lake Forest Hospital Lake Forest Illinois 60045 —
AMG Libertyville - Oncology Libertyville Illinois 60048 —
Condell Memorial Hospital Libertyville Illinois 60048 —
Illinois CancerCare-Macomb Macomb Illinois 61455 —
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938 —
Cancer Care Center of O'Fallon O'Fallon Illinois 62269 —
Advocate Christ Medical Center Oak Lawn Illinois 60453-2699 —
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350 —
Advocate Lutheran General Hospital Park Ridge Illinois 60068 —
Illinois CancerCare-Pekin Pekin Illinois 61554 —
Illinois CancerCare-Peoria Peoria Illinois 61615 —
Illinois CancerCare-Peru Peru Illinois 61354 —
Illinois CancerCare-Princeton Princeton Illinois 61356 —
Southern Illinois University School of Medicine Springfield Illinois 62702 —
Springfield Clinic Springfield Illinois 62702 —
Memorial Medical Center Springfield Illinois 62781 —
Carle Cancer Center Urbana Illinois 61801 —
Northwestern Medicine Cancer Center Warrenville Warrenville Illinois 60555 —
Mercy Medical Center - Des Moines Des Moines Iowa 50314 —
HaysMed University of Kansas Health System Hays Kansas 67601 —
University of Kansas Cancer Center Kansas City Kansas 66160 —
Lawrence Memorial Hospital Lawrence Kansas 66044 —
Olathe Health Cancer Center Olathe Kansas 66061 —
University of Kansas Cancer Center-Overland Park Overland Park Kansas 66210 —
Salina Regional Health Center Salina Kansas 67401 —
University of Kansas Health System Saint Francis Campus Topeka Kansas 66606 —
University of Kansas Hospital-Westwood Cancer Center Westwood Kansas 66205 —
University of Kentucky/Markey Cancer Center Lexington Kentucky 40536 —
UPMC Western Maryland Cumberland Maryland 21502 —
Saint Joseph Mercy Hospital Ann Arbor Michigan 48106 —
Bronson Battle Creek Battle Creek Michigan 49017 —
Saint Joseph Mercy Brighton Brighton Michigan 48114 —
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan 48114 —
Saint Joseph Mercy Canton Canton Michigan 48188 —
Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan 48188 —
Saint Joseph Mercy Chelsea Chelsea Michigan 48118 —
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan 48118 —
Ascension Saint John Hospital Detroit Michigan 48236 —
Great Lakes Cancer Management Specialists-Doctors Park East China Township Michigan 48054 —
Genesee Cancer and Blood Disease Treatment Center Flint Michigan 48503 —
Genesee Hematology Oncology PC Flint Michigan 48503 —
Genesys Hurley Cancer Institute Flint Michigan 48503 —
Hurley Medical Center Flint Michigan 48503 —
Spectrum Health at Butterworth Campus Grand Rapids Michigan 49503 —
Academic Hematology Oncology Specialists Grosse Pointe Woods Michigan 48236 —
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center Grosse Pointe Woods Michigan 48236 —
Bronson Methodist Hospital Kalamazoo Michigan 49007 —
West Michigan Cancer Center Kalamazoo Michigan 49007 —
Sparrow Hospital Lansing Michigan 48912 —
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154 —
Great Lakes Cancer Management Specialists-Macomb Medical Campus Macomb Michigan 48044 —
Trinity Health Muskegon Hospital Muskegon Michigan 49444 —
Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores Michigan 49444 —
Spectrum Health Reed City Hospital Reed City Michigan 49677 —
Marie Yeager Cancer Center Saint Joseph Michigan 49085 —
Bhadresh Nayak MD PC-Sterling Heights Sterling Heights Michigan 48312 —
Munson Medical Center Traverse City Michigan 49684 —
Great Lakes Cancer Management Specialists-Macomb Professional Building Warren Michigan 48093 —
Saint John Macomb-Oakland Hospital Warren Michigan 48093 —
Metro Health Hospital Wyoming Michigan 49519 —
Huron Gastroenterology PC Ypsilanti Michigan 48106 —
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan 48197 —
Sanford Joe Lueken Cancer Center Bemidji Minnesota 56601 —
Essentia Health Saint Joseph's Medical Center Brainerd Minnesota 56401 —
Mercy Hospital Coon Rapids Minnesota 55433 —
Essentia Health - Deer River Clinic Deer River Minnesota 56636 —
Essentia Health Cancer Center Duluth Minnesota 55805 —
Fairview Southdale Hospital Edina Minnesota 55435 —
Essentia Health Hibbing Clinic Hibbing Minnesota 55746 —
Minneapolis VA Medical Center Minneapolis Minnesota 55417 —
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416 —
Regions Hospital Saint Paul Minnesota 55101 —
United Hospital Saint Paul Minnesota 55102 —
Essentia Health Sandstone Sandstone Minnesota 55072 —
Essentia Health Virginia Clinic Virginia Minnesota 55792 —
Baptist Memorial Hospital and Cancer Center-Golden Triangle Columbus Mississippi 39705 —
Baptist Cancer Center-Grenada Grenada Mississippi 38901 —
Baptist Memorial Hospital and Cancer Center-Union County New Albany Mississippi 38652 —
Baptist Memorial Hospital and Cancer Center-Oxford Oxford Mississippi 38655 —
Baptist Memorial Hospital and Cancer Center-Desoto Southhaven Mississippi 38671 —
Saint Francis Medical Center Cape Girardeau Missouri 63703 —
Parkland Health Center - Farmington Farmington Missouri 63640 —
Truman Medical Centers Kansas City Missouri 64108 —
University of Kansas Cancer Center - North Kansas City Missouri 64154 —
University of Kansas Cancer Center - Lee's Summit Lee's Summit Missouri 64064 —
University of Kansas Cancer Center at North Kansas City Hospital North Kansas City Missouri 64116 —
Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri 63670 —
Missouri Baptist Medical Center St Louis Missouri 63131 —
Missouri Baptist Sullivan Hospital Sullivan Missouri 63080 —
Missouri Baptist Outpatient Center-Sunset Hills Sunset Hills Missouri 63127 —
Community Hospital of Anaconda Anaconda Montana 59711 —
Billings Clinic Cancer Center Billings Montana 59101 —
Bozeman Deaconess Hospital Bozeman Montana 59715 —
Benefis Healthcare- Sletten Cancer Institute Great Falls Montana 59405 —
Kalispell Regional Medical Center Kalispell Montana 59901 —
Community Medical Hospital Missoula Montana 59804 —
OptumCare Cancer Care at Charleston Las Vegas Nevada 89102 —
OptumCare Cancer Care at Fort Apache Las Vegas Nevada 89148 —
New Hampshire Oncology Hematology PA-Concord Concord New Hampshire 03301 —
Solinsky Center for Cancer Care Manchester New Hampshire 03103 —
Virtua Samson Cancer Center Moorestown New Jersey 08057 —
Virtua Voorhees Voorhees Township New Jersey 08043 —
University of New Mexico Cancer Center Albuquerque New Mexico 87102 —
University of Rochester Rochester New York 14642 —
AdventHealth Infusion Center Asheville Asheville North Carolina 28803 —
AdventHealth Infusion Center Haywood Clyde North Carolina 28721 —
AdventHealth Hendersonville Hendersonville North Carolina 28792 —
AdventHealth Infusion Center Weaverville Weaverville North Carolina 28787 —
Sanford Bismarck Medical Center Bismarck North Dakota 58501 —
Essentia Health Cancer Center-South University Clinic Fargo North Dakota 58103 —
Sanford Broadway Medical Center Fargo North Dakota 58122 —
Sanford Roger Maris Cancer Center Fargo North Dakota 58122 —
Aultman Health Foundation Canton Ohio 44710 —
Miami Valley Hospital South Centerville Ohio 45459 —
Cleveland Clinic Cancer Center/Fairview Hospital Cleveland Ohio 44111 —
Cleveland Clinic Foundation Cleveland Ohio 44195 —
Miami Valley Hospital Dayton Ohio 45409 —
Miami Valley Hospital North Dayton Ohio 45415 —
Atrium Medical Center-Middletown Regional Hospital Franklin Ohio 45005-1066 —
Cleveland Clinic Cancer Center Mansfield Mansfield Ohio 44906 —
Hillcrest Hospital Cancer Center Mayfield Heights Ohio 44124 —
North Coast Cancer Care Sandusky Ohio 44870 —
Trinity's Tony Teramana Cancer Center Steubenville Ohio 43952 —
Cleveland Clinic Cancer Center Strongsville Strongsville Ohio 44136 —
ProMedica Flower Hospital Sylvania Ohio 43560 —
Upper Valley Medical Center Troy Ohio 45373 —
South Pointe Hospital Warrensville Heights Ohio 44122 —
Cleveland Clinic Wooster Family Health and Surgery Center Wooster Ohio 44691 —
Saint Alphonsus Medical Center-Ontario Ontario Oregon 97914 —
Kaiser Permanente Northwest Portland Oregon 97227 —
UPMC Altoona Altoona Pennsylvania 16601 —
UPMC-Heritage Valley Health System Beaver Beaver Pennsylvania 15009 —
UPMC Hillman Cancer Center at Butler Health System Butler Pennsylvania 16001 —
UPMC Camp Hill Camp Hill Pennsylvania 17011 —
Carlisle Regional Cancer Center Carlisle Pennsylvania 17015 —
WellSpan Medical Oncology and Hematology Chambersburg Pennsylvania 17201 —
UPMC Hillman Cancer Center - Passavant - Cranberry Cranberry Township Pennsylvania 16066 —
Ephrata Cancer Center Ephrata Pennsylvania 17522 —
UPMC Hillman Cancer Center Erie Erie Pennsylvania 16505 —
UPMC Cancer Center at UPMC Horizon Farrell Pennsylvania 16121 —
Adams Cancer Center Gettysburg Pennsylvania 17325 —
UPMC Cancer Centers - Arnold Palmer Pavilion Greensburg Pennsylvania 15601 —
Oncology Hematology Associates Greenville Pennsylvania 16125 —
UPMC Pinnacle Cancer Center/Community Osteopathic Campus Harrisburg Pennsylvania 17109 —
IRMC Cancer Center Indiana Pennsylvania 15701 —
UPMC-Johnstown/John P. Murtha Regional Cancer Center Johnstown Pennsylvania 15901 —
Sechler Family Cancer Center Lebanon Pennsylvania 17042 —
UPMC Cancer Center at UPMC McKeesport McKeesport Pennsylvania 15132 —
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion Mechanicsburg Pennsylvania 17050 —
UPMC Cancer Center - Monroeville Monroeville Pennsylvania 15146 —
UPMC Hillman Cancer Center - Monroeville Monroeville Pennsylvania 15146 —
UPMC Hillman Cancer Center in Coraopolis Moon Township Pennsylvania 15108 —
Arnold Palmer Cancer Center Medical Oncology Norwin N. Huntingdon Pennsylvania 15642 —
UPMC Cancer Center-Natrona Heights Natrona Heights Pennsylvania 15065 —
UPMC Hillman Cancer Center - New Castle New Castle Pennsylvania 16105 —
UPMC-Saint Margaret Pittsburgh Pennsylvania 15215 —
UPMC-Mercy Hospital Pittsburgh Pennsylvania 15219 —
University of Pittsburgh Cancer Institute (UPCI) Pittsburgh Pennsylvania 15232 —
UPMC-Passavant Hospital Pittsburgh Pennsylvania 15237 —
UPMC-Saint Clair Hospital Cancer Center Pittsburgh Pennsylvania 15243 —
UPMC Cancer Center at UPMC Northwest Seneca Pennsylvania 16346 —
UPMC Cancer Center-Uniontown Uniontown Pennsylvania 15401 —
UPMC Uniontown Hospital Radiation Oncology Uniontown Pennsylvania 15401 —
UPMC Washington Hospital Radiation Oncology Washington Pennsylvania 15301 —
UPMC West Mifflin-Cancer Center Jefferson West Mifflin Pennsylvania 15122 —
WellSpan Health-York Cancer Center York Pennsylvania 17403 —
WellSpan Health-York Hospital York Pennsylvania 17403 —
UPMC Memorial York Pennsylvania 17408 —
Prisma Health Cancer Institute - Spartanburg Boiling Springs South Carolina 29316 —
Ralph H Johnson VA Medical Center Charleston South Carolina 29401 —
Medical University of South Carolina Charleston South Carolina 29425 —
Prisma Health Cancer Institute - Easley Easley South Carolina 29640 —
Prisma Health Cancer Institute - Butternut Greenville South Carolina 29605 —
Prisma Health Cancer Institute - Faris Greenville South Carolina 29605 —
Prisma Health Greenville Memorial Hospital Greenville South Carolina 29605 —
Prisma Health Cancer Institute - Eastside Greenville South Carolina 29615 —
Prisma Health Cancer Institute - Greer Greer South Carolina 29650 —
Prisma Health Cancer Institute - Seneca Seneca South Carolina 29672 —
Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota 57104 —
Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota 57117-5134 —
Baptist Memorial Hospital and Cancer Center-Collierville Collierville Tennessee 38017 —
Baptist Memorial Hospital and Cancer Center-Memphis Memphis Tennessee 38120 —
Duluth Clinic Ashland Ashland Wisconsin 54806 —
Aurora Cancer Care-Southern Lakes VLCC Burlington Wisconsin 53105 —
Aurora Health Care Germantown Health Center Germantown Wisconsin 53022 —
Aurora Cancer Care-Grafton Grafton Wisconsin 53024 —
Aurora BayCare Medical Center Green Bay Wisconsin 54311 —
Aurora Cancer Care-Kenosha South Kenosha Wisconsin 53142 —
Gundersen Lutheran Medical Center La Crosse Wisconsin 54601 —
Aurora Bay Area Medical Group-Marinette Marinette Wisconsin 54143 —
Aurora Cancer Care-Milwaukee Milwaukee Wisconsin 53209 —
Aurora Saint Luke's Medical Center Milwaukee Wisconsin 53215 —
Aurora Sinai Medical Center Milwaukee Wisconsin 53233 —
Vince Lombardi Cancer Clinic - Oshkosh Oshkosh Wisconsin 54904 —
Aurora Cancer Care-Racine Racine Wisconsin 53406 —
Vince Lombardi Cancer Clinic-Sheboygan Sheboygan Wisconsin 53081 —
Aurora Medical Center in Summit Summit Wisconsin 53066 —
Vince Lombardi Cancer Clinic-Two Rivers Two Rivers Wisconsin 54241 —
Aurora Cancer Care-Milwaukee West Wauwatosa Wisconsin 53226 —
Aurora West Allis Medical Center West Allis Wisconsin 53227 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05364645, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jul 9, 2024 · Synced Oct 21, 2026

Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT05364645 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →