ClinicalTrials.gov record
Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician's Choice in Patients With Previously Untreated Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer
ClinicalTrials.gov ID: NCT05382299
Public ClinicalTrials.gov record NCT05382299. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Open-label, Phase 3 Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients With Previously Untreated, Locally Advanced, Inoperable or Metastatic Triple-Negative Breast Cancer Whose Tumors Do Not Express PD-L1 or in Patients Previously Treated With Anti-PD-(L)1 Agents in the Early Setting Whose Tumors Do Express PD-L1
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of this study is to compare the progression-free survival (PFS) between sacituzumab govitecan-hziy (SG) versus treatment of physician's choice (TPC) in participants with previously untreated, locally advanced, inoperable or metastatic triple-negative breast cancer whose tumors do not express programmed cell death ligand 1 (PD-L1) or in participants previously treated with anti-programmed cell death (ligand or protein) 1 (Anti-PD-(L)1) Agents in the early setting whose tumors do express PD-L1.
Study identification
- NCT ID
- NCT05382299
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 623 participants
Conditions and interventions
Conditions
Interventions
- Sacituzumab Govitecan-hziy Drug
- Paclitaxel Drug
- nab-Paclitaxel Drug
- Gemcitabine Drug
- Carboplatin Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 20, 2022 (Actual)
- Primary completion
- Jul 2028 (Estimated)
- Completion
- Jul 2028 (Estimated)
- Last update posted
- Apr 6, 2026
2022 – 2028
United States locations
- U.S. sites
- 130
- U.S. states
- 17
- U.S. cities
- 95
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Oncology Associates, PC-Hope,1845 W Orange Grove Rd | Tucson | Arizona | 85704 | — |
| Arizona Oncology Associates, PC-Hope,2070 W. Rudasill Rd. | Tucson | Arizona | 85704 | — |
| Arizona Oncology Associates, PC-Hope | Tucson | Arizona | 85711 | — |
| Arizona Oncology Associates, PC-Hope,1620 West St. Mary's Road | Tucson | Arizona | 85745 | — |
| University of California Los Angeles - Jonsson Comprehensive Cancer Center,201 S. Buena Vista Street, Suite 200 | Burbank | California | 91505 | — |
| University of California San Diego Moores Cancer | La Jolla | California | 92093 | — |
| University of California Los Angeles - Jonsson Comprehensive Cancer Center,24302 Paseo de Valencia, Suite 200 | Laguna Hills | California | 91505 | — |
| University of California Los Angeles - Jonsson Comprehensive Cancer Center,892 Aerovista Place, Suite 240 | San Luis Obispo | California | 93401 | — |
| University of California Los Angeles - Jonsson Comprehensive Cancer Center,2020 Santa Monica Blvd, Suite 600 | Santa Monica | California | 90404 | — |
| University of California Los Angeles - Jonsson Comprehensive Cancer Center,2336 Santa Monica, Suites 302 and 304 | Santa Monica | California | 90404 | — |
| University of California Los Angeles - Jonsson Comprehensive Cancer Center | Santa Monica | California | 90404 | — |
| Torrance Memorial Physician Network - Cancer Care | Torrance | California | 90505 | — |
| University of California Los Angeles - Jonsson Comprehensive Cancer Center,1250 La Venta Dr, Suite 100 | Westlake Village | California | 91361 | — |
| Rocky Mountain Cancer Centers,1700 South Potomac Street | Aurora | Colorado | 80012 | — |
| Rocky Mountain Cancer Centers | Boulder | Colorado | 80303 | — |
| Rocky Mountain Cancer Centers,2312 N. Nevada Avenue | Colorado Springs | Colorado | 80907 | — |
| Rocky Mountain Cancer Centers,6031 E. Woodman Rd. | Colorado Springs | Colorado | 80923 | — |
| Rocky Mountain Cancer Centers,4700 E. Hale Parkway | Denver | Colorado | 80220 | — |
| Rocky Mountain Cancer Centers,11750 West 2nd Place | Lakewood | Colorado | 80228 | — |
| Rocky Mountain Cancer Centers,22 West Dry Creek Circle | Littleton | Colorado | 80120 | — |
| Rocky Mountain Cancer Centers,10107 Ridge Gate Parkway | Lone Tree | Colorado | 80124 | — |
| Rocky Mountain Cancer Centers,2030 Mountain View Ave Ste 210 | Longmont | Colorado | 80124 | — |
| Rocky Mountain Cancer Centers,3676 Parker Blvd | Pueblo | Colorado | 81008 | — |
| Rocky Mountain Cancer Centers,525 W. 15th Street | Pueblo | Colorado | 81008 | — |
| Rocky Mountain Cancer Centers,8820 Huron Street | Thornton | Colorado | 80260 | — |
| AdventHealth Medical Group | Altamonte Springs | Florida | 32701 | — |
| Florida Cancer Specialists - North Region Research Office,750 Orienta Ave | Altamonte Springs | Florida | 32701 | — |
| Florida Cancer Specialists,9776 Bonita Beach Road Southeast Suite 201 A | Bonita Springs | Florida | 34135 | — |
| Florida Cancer Specialists,3630 Manatee Avenue West | Bradenton | Florida | 34205 | — |
| Florida Cancer Specialists,5985 Silver Falls Run | Bradenton | Florida | 34211 | — |
| Florida Cancer Specialists - North Region Research Office,403 S. Kings Ave. | Brandon | Florida | 33511 | — |
| Florida Cancer Specialists,1030 Commerce Creek Blvd | Cape Coral | Florida | 33909 | — |
| Florida Cancer Specialists - North Region Research Office,3280 McMullen Booth Road | Clearwater | Florida | 33761 | — |
| Florida Cancer Specialists | Fort Myers | Florida | 33901 | — |
| Florida Cancer Specialists,8981 Colonial Center Drive | Fort Myers | Florida | 33905 | — |
| Florida Cancer Specialists,8260 Gladiolus Dr | Fort Myers | Florida | 33908 | — |
| Florida Cancer Specialists - North Region Research Office,6420 W. Newberry Road | Gainesville | Florida | 32605 | — |
| Florida Cancer Specialists - North Region Research Office,100 Highland Avenue | Largo | Florida | 33770 | — |
| Florida Cancer Specialists - North Region Research Office,521 North Lecanto Highway | Lecanto | Florida | 34461 | — |
| Florida Cancer Specialists,1100 Goodlette Road | Naples | Florida | 34102 | — |
| Florida Cancer Specialists,681 4th Avenue North | Naples | Florida | 34102 | — |
| Florida Cancer Specialists - North Region Research Office,4945 SW 49th Place | Ocala | Florida | 34474 | — |
| Florida Cancer Specialists - North Region Research Office,2824 Enterprise Rd | Orange City | Florida | 32763 | — |
| AdventHealth Medical Group,2501 North Orange Ave | Orlando | Florida | 32804 | — |
| Florida Cancer Specialists - North Region Research Office,70 W. Gore Street | Orlando | Florida | 32806 | — |
| Florida Cancer Specialists,22395 Edgewater Drive | Port Charlotte | Florida | 33980 | — |
| Florida Cancer Specialists,600 North Cattlemen Road | Sarasota | Florida | 34232 | — |
| Florida Cancer Specialists,1970 Golf Street | Sarasota | Florida | 34236 | — |
| Florida Cancer Specialists - North Region Research Office,7154 Medical Center Drive | Spring Hill | Florida | 34608 | — |
| Florida Cancer Specialists - North Region Research Office,1201 Fifth Avenue North | St. Petersburg | Florida | 33705 | — |
| Florida Cancer Specialists - North Region Research Office | St. Petersburg | Florida | 33705 | — |
| Florida Cancer Specialists - North Region Research Office,3402 West Dr. Martin Luther King Jr. Boulevard | Tampa | Florida | 33607 | — |
| Florida Cancer Specialists - North Region Research Office,4100 Waterman Way | Tavares | Florida | 32778 | — |
| Florida Cancer Specialists - North Region Research Office,1400 US Highway 441 N | The Villages | Florida | 32159 | — |
| Florida Cancer Specialists - North Region Research Office,9320 State Road 54 | Trinity | Florida | 34655 | — |
| Florida Cancer Specialists,901 South Tamiami Trail | Venice | Florida | 34285 | — |
| Florida Cancer Specialists,836 Sunset Lake Blvd | Venice | Florida | 34292 | — |
| Florida Cancer Specialists - North Region Research Office,460 N Orlando Ave | Winter Park | Florida | 32789 | — |
| Northside Hospital,125 King Avenue | Athens | Georgia | 30606 | — |
| Northside Hospital,5670 Peachtree Dunwoody Rd. | Atlanta | Georgia | 30342 | — |
| Northside Hospital | Atlanta | Georgia | 30342 | — |
| Northside Hospital,308 Deep South Farm Rd, Suite 200 | Blairsville | Georgia | 30512 | — |
| Northside Hospital,228 Riverstone Dr. | Canton | Georgia | 30114 | — |
| Northwest Georgia Oncology Northwest Georgia Oncology Centers, PCCenters, PC,157 Clinic Avenue | Carrollton | Georgia | 30117 | — |
| Northwest Georgia Oncology Northwest Georgia Oncology Centers, PCCenters, PC,100 Market Place Blvd | Cartersville | Georgia | 30121 | — |
| Northside Hospital,1505 Northside Blvd, Suite 4600 | Cumming | Georgia | 30041 | — |
| Northside Hospital,3855 Pleasant Hill Rd., Suite 480 | Duluth | Georgia | 30096 | — |
| Northside Hospital,308 Coliseum Dr. | Macon | Georgia | 31217 | — |
| Northwest Georgia Oncology Northwest Georgia Oncology Centers, PCCenters, PC | Marietta | Georgia | 30060 | — |
| Robert H. Lurie Comprehensive Cancer Center of Northwestern University | Chicago | Illinois | 60611 | — |
| Robert H. Lurie Comprehensive Cancer Center of Northwestern University,1 Kish Hospital Drive | DeKalb | Illinois | 60115 | — |
| Robert H. Lurie Comprehensive Cancer Center of Northwestern University,10 Health Services Drive | DeKalb | Illinois | 60115 | — |
| Robert H. Lurie Comprehensive Cancer Center of Northwestern University,300 Randall Road | Geneva | Illinois | 60134 | — |
| Robert H. Lurie Comprehensive Cancer Center of Northwestern University,304 Randall Road | Geneva | Illinois | 60134 | — |
| Robert H. Lurie Comprehensive Cancer Center of Northwestern University,1000 N. Westmoreland Road | Lake Forest | Illinois | 60045 | — |
| Robert H. Lurie Comprehensive Cancer Center of Northwestern University,4405 Weaver Parkway | Warrenville | Illinois | 25731 | — |
| Robert H. Lurie Comprehensive Cancer Center of Northwestern University,4455 Weaver Parkway | Warrenville | Illinois | 60555 | — |
| Robert H. Lurie Comprehensive Cancer Center of Northwestern University,25 N Winfield Road | Winfield | Illinois | 60190 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| Norton Cancer Institute - Saint Matthews,234 E. Gray Strret | Louisville | Kentucky | 40202 | — |
| Norton Cancer Institute - Saint Matthews,676 S. Floyd Street | Louisville | Kentucky | 40202 | — |
| Norton Cancer Institute - Saint Matthews | Louisville | Kentucky | 40207 | — |
| Norton Cancer Institute - Saint Matthews,4955 Norton Healthcare Blvd | Louisville | Kentucky | 40241 | — |
| Cancer Institute Ascension Saint Agnes | Baltimore | Maryland | 21229 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| The West Clinic, PLLC dba West Cancer Center,7668 Airways Blvd | Southaven | Mississippi | 38671 | — |
| New York Cancer & Blood Specialists - Port Jeffers,72 East Main St. | Babylon | New York | 11702 | — |
| New York Cancer & Blood Specialists - Port Jeffers,1 Delaware Dr. | New Hyde Park | New York | 11042 | — |
| New York Cancer & Blood Specialists - Port Jeffers,365 East Main St. | Patchogue | New York | 11772 | — |
| New York Cancer & Blood Specialists - Port Jeffers,1500 Rte, 112, Building 4 | Port Jefferson | New York | 11776 | — |
| New York Cancer & Blood Specialists - Port Jeffers,49 Rte. 347, Newconset Hwy | Port Jefferson Station | New York | 11776 | — |
| New York Cancer & Blood Specialists - Port Jeffers | Port Jefferson Station | New York | 11776 | — |
| New York Cancer & Blood Specialists - Port Jeffers,750 Old County Rd. Suite 4 | Riverhead | New York | 11901 | — |
| New York Cancer & Blood Specialists - Port Jeffers,12 East 86th St, Suite 4 | The Bronx | New York | 10028 | — |
| New York Cancer & Blood Specialists - Port Jeffers,2330 Eastchester Road, Suite 360 | The Bronx | New York | 10469 | — |
| Novant Health Cancer Institute - Forsyth,125 Queens Road, Suite 650 | Charlotte | North Carolina | 28204 | — |
| Novant Health Cancer Institute - Forsyth,2131 S. 17th Street | Wilmington | North Carolina | 28401 | — |
| Novant Health Cancer Institute - Forsyth | Winston-Salem | North Carolina | 27103 | — |
| Magee-Womens Hospital of UPMC,2500 West 12th Street | Erie | Pennsylvania | 16505 | — |
| Magee-Womens Hospital of UPMC,201 State Street, 6 Main | Erie | Pennsylvania | 16550 | — |
| Magee-Womens Hospital of UPMC,4300 Londonberry Road | Harrisburg | Pennsylvania | 17109 | — |
| Magee-Womens Hospital of UPMC,2035 Technology Parkway | Mechanicsburg | Pennsylvania | 17050 | — |
| University of Pennsylvania Abramson Cancer Center | Philadelphia | Pennsylvania | 19104 | — |
| Magee-Womens Hospital of UPMC | Pittsburgh | Pennsylvania | 15213 | — |
| Magee-Womens Hospital of UPMC,5115 Centre Avenue | Pittsburgh | Pennsylvania | 15232 | — |
| Magee-Womens Hospital of UPMC,1703 Innovation Drive | York | Pennsylvania | 17408 | — |
| Tennessee Oncology, PLLC,103 Natchez Park Drive | Dickson | Tennessee | 37055 | — |
| Tennessee Oncology, PLLC,4488 Carothers Parkway | Franklin | Tennessee | 37067 | — |
| Tennessee Oncology, PLLC,225 Big Station Camp Blvd | Gallatin | Tennessee | 37066 | — |
| The West Clinic, PLLC dba West Cancer Center | Germantown | Tennessee | 38138 | — |
| Tennessee Oncology, PLLC,353 New Shackle Island Road | Hendersonville | Tennessee | 37075 | — |
| Tennessee Oncology, PLLC,5653 First Blvd. | Hermitage | Tennessee | 37076 | — |
| Tennessee Oncology, PLLC,103 Physicians Way | Lebanon | Tennessee | 37090 | — |
| Tennessee Oncology, PLLC,1840 Medical Center Parkway | Murfreesboro | Tennessee | 37129 | — |
| Tennessee Oncology, PLLC,2004 Hayes Street | Nashville | Tennessee | 37203 | — |
| Tennessee Oncology, PLLC,SCRI Oncology Partners | Nashville | Tennessee | 37203 | — |
| Tennessee Oncology, PLLC | Nashville | Tennessee | 37203 | — |
| Tennessee Oncology, PLLC,4220 Harding Rd | Nashville | Tennessee | 37205 | — |
| Tennessee Oncology, PLLC,3443 Dickerson Road | Nashville | Tennessee | 37207 | — |
| Tennessee Oncology, PLLC,397 Wallace Road | Nashville | Tennessee | 37211 | — |
| Tennessee Oncology, PLLC,120 Frank Martin Road | Shelbyville | Tennessee | 37160 | — |
| Tennessee Oncology, PLLC,300 Stonecrest Blvd | Smyrna | Tennessee | 37167 | — |
| Texas Oncology PA,901 West 38th Street | Austin | Texas | 78705 | — |
| Texas Oncology PA | Austin | Texas | 78731 | — |
| Texas Oncology PA,4101 James Casey, Suite 100 | Austin | Texas | 78745 | — |
| Virginia Oncology Associates,744 N. Battlefield Blvd | Chesapeake | Virginia | 23320 | — |
| Virginia Oncology Associates,1051 Loftis Blvd Suite 100 | Newport News | Virginia | 23606 | — |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | — |
| Virginia Oncology Associates,1950 Glenn Mitchell Drive | Virginia Beach | Virginia | 23456 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 233 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05382299, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 6, 2026 · Synced Nov 6, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05382299 live on ClinicalTrials.gov.