A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

ClinicalTrials.gov ID: NCT05382338

Public ClinicalTrials.gov record NCT05382338. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 5:05 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3 Study of Sodium Thiosulfate for Reduction of Cisplatin-Induced Ototoxicity in Children With Average-Risk Medulloblastoma and Reduced Therapy in Children With Medulloblastoma With Low-Risk Features

Study identification

NCT ID: NCT05382338
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Children's Oncology Group; Network
Enrollment: 225 participants

Conditions and interventions

Conditions

Childhood Medulloblastoma

Interventions

Audiometric Test Procedure
Auditory Brainstem Response Procedure
Biospecimen Collection Procedure
Cisplatin Drug
Cyclophosphamide Drug
Lomustine Drug
Magnetic Resonance Imaging Procedure
Quality-of-Life Assessment Other
Radiation Therapy Radiation
Sodium Thiosulfate Drug
Survey Administration Other
Vincristine Drug

Procedure · Drug · Other + 1 more

Eligibility (public fields only)

Age range: 4 Years to 21 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Feb 19, 2023
Primary completion: Dec 30, 2029
Completion: Dec 30, 2029
Last update posted: May 4, 2026

2023 – 2029

United States locations

U.S. sites: 101
U.S. states: 39
U.S. cities: 91

Facility	City	State	ZIP	Site status
Children's Hospital of Alabama	Birmingham	Alabama	35233	Active, not recruiting
USA Health Strada Patient Care Center	Mobile	Alabama	36604	Recruiting
Phoenix Childrens Hospital	Phoenix	Arizona	85016	Recruiting
Arkansas Children's Hospital	Little Rock	Arkansas	72202-3591	Recruiting
Loma Linda University Medical Center	Loma Linda	California	92354	Recruiting
Miller Children's and Women's Hospital Long Beach	Long Beach	California	90806	Recruiting
Children's Hospital Los Angeles	Los Angeles	California	90027	Recruiting
Valley Children's Hospital	Madera	California	93636	Recruiting
Kaiser Permanente-Oakland	Oakland	California	94611	Recruiting
Children's Hospital of Orange County	Orange	California	92868	Recruiting
University of California Davis Comprehensive Cancer Center	Sacramento	California	95817	Recruiting
Rady Children's Hospital - San Diego	San Diego	California	92123	Recruiting
UCSF Medical Center-Mission Bay	San Francisco	California	94158	Recruiting
Children's Hospital Colorado	Aurora	Colorado	80045	Recruiting
Connecticut Children's Medical Center	Hartford	Connecticut	06106	Recruiting
Yale University	New Haven	Connecticut	06520	Recruiting
Alfred I duPont Hospital for Children	Wilmington	Delaware	19803	Recruiting
Children's National Medical Center	Washington D.C.	District of Columbia	20010	Recruiting
Golisano Children's Hospital of Southwest Florida	Fort Myers	Florida	33908	Recruiting
Memorial Regional Hospital/Joe DiMaggio Children's Hospital	Hollywood	Florida	33021	Recruiting
Nemours Children's Clinic-Jacksonville	Jacksonville	Florida	32207	Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center	Miami	Florida	33136	Recruiting
Nicklaus Children's Hospital	Miami	Florida	33155	Recruiting
Arnold Palmer Hospital for Children	Orlando	Florida	32806	Recruiting
Nemours Children's Hospital	Orlando	Florida	32827	Recruiting
Nemours Children's Clinic - Pensacola	Pensacola	Florida	32504	Recruiting
Saint Joseph's Hospital/Children's Hospital-Tampa	Tampa	Florida	33607	Recruiting
Children's Healthcare of Atlanta - Arthur M Blank Hospital	Atlanta	Georgia	30329	Recruiting
Kapiolani Medical Center for Women and Children	Honolulu	Hawaii	96826	Recruiting
University of Illinois	Chicago	Illinois	60612	Recruiting
Saint Jude Midwest Affiliate	Peoria	Illinois	61637	Recruiting
Southern Illinois University School of Medicine	Springfield	Illinois	62702	Recruiting
Riley Hospital for Children	Indianapolis	Indiana	46202	Recruiting
Blank Children's Hospital	Des Moines	Iowa	50309	Recruiting
University of Iowa/Holden Comprehensive Cancer Center	Iowa City	Iowa	52242	Recruiting
Norton Children's Hospital	Louisville	Kentucky	40202	Recruiting
Children's Hospital New Orleans	New Orleans	Louisiana	70118	Recruiting
Sinai Hospital of Baltimore	Baltimore	Maryland	21215	Recruiting
Johns Hopkins University/Sidney Kimmel Cancer Center	Baltimore	Maryland	21287	Recruiting
Massachusetts General Hospital Cancer Center	Boston	Massachusetts	02114	Recruiting
C S Mott Children's Hospital	Ann Arbor	Michigan	48109	Recruiting
Children's Hospital of Michigan	Detroit	Michigan	48201	Recruiting
Corewell Health Children's	Royal Oak	Michigan	48073	Recruiting
Children's Hospitals and Clinics of Minnesota - Minneapolis	Minneapolis	Minnesota	55404	Recruiting
Mayo Clinic in Rochester	Rochester	Minnesota	55905	Recruiting
University of Mississippi Medical Center	Jackson	Mississippi	39216	Suspended
Children's Mercy Hospitals and Clinics	Kansas City	Missouri	64108	Recruiting
Cardinal Glennon Children's Medical Center	St Louis	Missouri	63104	Recruiting
Washington University School of Medicine	St Louis	Missouri	63110	Recruiting
Children's Hospital and Medical Center of Omaha	Omaha	Nebraska	68114	Recruiting
University of Nebraska Medical Center	Omaha	Nebraska	68198	Recruiting
Saint Peter's University Hospital	New Brunswick	New Jersey	08901	Recruiting
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital	New Brunswick	New Jersey	08903	Recruiting
Newark Beth Israel Medical Center	Newark	New Jersey	07112	Recruiting
Saint Joseph's Regional Medical Center	Paterson	New Jersey	07503	Recruiting
Albany Medical Center	Albany	New York	12208	Recruiting
Roswell Park Cancer Institute	Buffalo	New York	14263	Recruiting
The Steven and Alexandra Cohen Children's Medical Center of New York	New Hyde Park	New York	11040	Recruiting
Laura and Isaac Perlmutter Cancer Center at NYU Langone	New York	New York	10016	Recruiting
Mount Sinai Hospital	New York	New York	10029	Recruiting
Stony Brook University Medical Center	Stony Brook	New York	11794	Recruiting
State University of New York Upstate Medical University	Syracuse	New York	13210	Recruiting
Montefiore Medical Center - Moses Campus	The Bronx	New York	10467	Recruiting
New York Medical College	Valhalla	New York	10595	Recruiting
UNC Lineberger Comprehensive Cancer Center	Chapel Hill	North Carolina	27599	Recruiting
Carolinas Medical Center/Levine Cancer Institute	Charlotte	North Carolina	28203	Recruiting
East Carolina University	Greenville	North Carolina	27834	Recruiting
Wake Forest University Health Sciences	Winston-Salem	North Carolina	27157	Recruiting
Sanford Broadway Medical Center	Fargo	North Dakota	58122	Recruiting
Children's Hospital Medical Center of Akron	Akron	Ohio	44308	Recruiting
Cincinnati Children's Hospital Medical Center	Cincinnati	Ohio	45229	Recruiting
Rainbow Babies and Childrens Hospital	Cleveland	Ohio	44106	Recruiting
Nationwide Children's Hospital	Columbus	Ohio	43205	Recruiting
Dayton Children's Hospital	Dayton	Ohio	45404	Recruiting
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital	Toledo	Ohio	43606	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
Legacy Emanuel Children's Hospital	Portland	Oregon	97227	Recruiting
Oregon Health and Science University	Portland	Oregon	97239	Recruiting
Geisinger Medical Center	Danville	Pennsylvania	17822	Recruiting
Children's Hospital of Philadelphia	Philadelphia	Pennsylvania	19104	Recruiting
Children's Hospital of Pittsburgh of UPMC	Pittsburgh	Pennsylvania	15224	Recruiting
Rhode Island Hospital	Providence	Rhode Island	02903	Recruiting
Prisma Health Richland Hospital	Columbia	South Carolina	29203	Recruiting
BI-LO Charities Children's Cancer Center	Greenville	South Carolina	29605	Recruiting
Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	57117-5134	Recruiting
Vanderbilt University/Ingram Cancer Center	Nashville	Tennessee	37232	Suspended
Dell Children's Medical Center of Central Texas	Austin	Texas	78723	Recruiting
Driscoll Children's Hospital	Corpus Christi	Texas	78411	Recruiting
Medical City Dallas Hospital	Dallas	Texas	75230	Recruiting
UT Southwestern/Simmons Cancer Center-Dallas	Dallas	Texas	75390	Recruiting
El Paso Children's Hospital	El Paso	Texas	79905	Recruiting
Children's Hospital of San Antonio	San Antonio	Texas	78207	Recruiting
University of Texas Health Science Center at San Antonio	San Antonio	Texas	78229	Recruiting
University of Virginia Cancer Center	Charlottesville	Virginia	22908	Recruiting
VCU Massey Comprehensive Cancer Center	Richmond	Virginia	23298	Recruiting
Seattle Children's Hospital	Seattle	Washington	98105	Recruiting
Providence Sacred Heart Medical Center and Children's Hospital	Spokane	Washington	99204	Recruiting
Mary Bridge Children's Hospital and Health Center	Tacoma	Washington	98405	Recruiting
University of Wisconsin Carbone Cancer Center - University Hospital	Madison	Wisconsin	53792	Recruiting
Marshfield Medical Center-Marshfield	Marshfield	Wisconsin	54449	Recruiting
Children's Hospital of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05382338, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 4, 2026 · Synced May 8, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05382338 live on ClinicalTrials.gov.

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