Asciminib Monotherapy, With Dose Escalation, for 2nd and 1st Line Chronic Myelogenous Leukemia
Public ClinicalTrials.gov record NCT05384587. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase II Multicenter, Open-label, Single-arm Dose Escalation Study of Asciminib Monotherapy in 2nd and 1st Line Chronic Phase - Chronic Myelogenous Leukemia (ASC2ESCALATE)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This will be a multicenter Phase II open-label study of asciminib in CML-CP patients who have been previously treated with one prior ATP- binding site TKI with discontinuation due to treatment failure, warning or intolerance. (2L patient cohort). In addition, newly diagnosed CML-CP patients who may have received up to 4 weeks of prior TKI are included in a separate 1L patient cohort.
Study identification
- NCT ID
- NCT05384587
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 34 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 100 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 11, 2022 (Actual)
- Primary completion
- Aug 13, 2025 (Actual)
- Completion
- Oct 17, 2027 (Estimated)
- Last update posted
- Oct 14, 2025
2022 – 2027
United States locations
- U.S. sites
- 80
- U.S. states
- 35
- U.S. cities
- 74
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35233-0271 | — |
| Alaska Oncology and Hematology | Anchorage | Alaska | 99508 | — |
| City of Hope Phoenix | Scottsdale | Arizona | 85258 | — |
| USO Arizona Oncology | Tucson | Arizona | 85711 | — |
| Onco Inst of Hope and Innovation | Cerritos | California | 90703 | — |
| City of Hope National Medical | Duarte | California | 91010 | — |
| UCSF Fresno Internal Medicine | Fresno | California | 93701 | — |
| Virginia K Crosson Cancer Center | Fullerton | California | 92835 | — |
| UCLA | Los Angeles | California | 90095 | — |
| Alta Bates Summit Medical Center | Oakland | California | 94609 | — |
| Lundquist Inst BioMed at Harbor | Torrance | California | 90509-2910 | — |
| Rocky Mountain Cancer Centers | Boulder | Colorado | 80304 | — |
| Yale University School Of Medicine | New Haven | Connecticut | 06520 | — |
| The Stamford Hospital | Stamford | Connecticut | 06904 | — |
| Florida Cancer Specialists | Fort Myers | Florida | 33901 | — |
| Baptist MD Anderson Cancer Center | Jacksonville | Florida | 32207 | — |
| Florida Cancer Specialists-North | St. Petersburg | Florida | 33705 | — |
| Florida Cancer Specialists East | Stuart | Florida | 34994 | — |
| City Of Hope Atlanta | Atlanta | Georgia | 30033 | — |
| Emory University School of Medicine Winship Cancer Institute | Atlanta | Georgia | 30308 | — |
| Augusta University Georgia | Augusta | Georgia | 30912 | — |
| Northwest Georgia Oncology Center | Marietta | Georgia | 30060 | — |
| Franciscan Health Indianapolis | Indianapolis | Indiana | 42637 | — |
| Investigative Clinicl Rsrch of Indi | Indianapolis | Indiana | 46260 | — |
| Holden Comp Can Cent Quad Cities U | Iowa City | Iowa | 52242 | — |
| Wichita Community Clcl Onco Program | Wichita | Kansas | 67214 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Louisiana State University | Shreveport | Louisiana | 71130 | — |
| Dana Farber Cancer Center | Boston | Massachusetts | 02215 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202-2689 | — |
| Jackson Onc Associates | Jackson | Mississippi | 39216 | — |
| University Missouri Ellis Fischel Cancer Center | Columbia | Missouri | 65203 | — |
| Siteman Cancer Center | St Louis | Missouri | 63110 | — |
| St Vincent Frontier Cancer Center | Billings | Montana | 59102 | — |
| Nebraska Hematology Oncology P C | Lincoln | Nebraska | 68506 | — |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Care Access Research Clifton | Clifton | New Jersey | 07013 | — |
| Hackensack Meridian Health | Edison | New Jersey | 88837 | — |
| Hackensack University Medical Ctr | Hackensack | New Jersey | 07601 | — |
| Rutgers Cancer Institute of NJ | New Brunswick | New Jersey | 08901 | — |
| UNM | Albuquerque | New Mexico | 87102 | — |
| Clinical Research Alliance | Lake Success | New York | 11042 | — |
| NYU Langone Long Island | Mineola | New York | 11501 | — |
| Manhattan Hematol Oncol Associates | New York | New York | 10016 | — |
| Mt Sinai Medical Center | New York | New York | 10029-6574 | — |
| New York Bld And Cancer Specialists | Port Jefferson | New York | 11776 | — |
| SUNY Stony Brook Medical Oncology | Stony Brook | New York | 11794-8174 | — |
| SUNY Upstate Medical Center | Syracuse | New York | 13210 | — |
| University of North Carolina | Chapel Hill | North Carolina | 27514 | — |
| Novant Health Heart Vas Inst | Charlotte | North Carolina | 28204 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Wake Forest Uni Health Sci | Winston-Salem | North Carolina | 27157 | — |
| Gabrail Cancer Center | Canton | Ohio | 44718 | — |
| Hematology Oncology Care | Cincinnati | Ohio | 45236 | — |
| James Cancer Hospital and Solove Research Institute Ohio State | Columbus | Ohio | 43210 | — |
| Oregon Health Sciences University | Portland | Oregon | 97239 | — |
| Care Access Research | Easton | Pennsylvania | 18045 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| UPMC | Pittsburgh | Pennsylvania | 15213 | — |
| Bon Secours Cancer Center | Greenville | South Carolina | 29607 | — |
| Avera Cancer | Sioux Falls | South Dakota | 57105 | — |
| Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | — |
| Texas Oncology P A | Austin | Texas | 78121 | — |
| Texas Oncology | Dallas | Texas | 75251 | — |
| Ctr For Cancer And Blood Disorders | Fort Worth | Texas | 76104 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| Univ of TX MD Anderson Cancer Cntr | Houston | Texas | 77030 | — |
| Mays Cancer Center | San Antonio | Texas | 78229 | — |
| Texas Oncology San Antonio | San Antonio | Texas | 78258 | — |
| Texas Oncology Northeast Texas | Tyler | Texas | 75702 | — |
| Community Cancer Trials of Utah | Ogden | Utah | 84405 | — |
| Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | — |
| Virginia Cancer Specialists | Gainesville | Virginia | 20155 | — |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | — |
| Virginia Cancer Institute | Richmond | Virginia | 23230 | — |
| VA Puget Sound Health Care System | Seattle | Washington | 98108 | — |
| Fred Hutch Cancer Research | Seattle | Washington | 98109 | — |
| Northwest Medical Specialties | Tacoma | Washington | 98405 | — |
| Dean Health System | Madison | Wisconsin | 53717 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05384587, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 14, 2025 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05384587 live on ClinicalTrials.gov.