A Study to Assess the Long-Term Safety and Efficacy of Donidalorsen in the Prophylactic Treatment of Hereditary Angioedema (HAE)
Public ClinicalTrials.gov record NCT05392114. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-Label, Long Term Safety and Efficacy Study of Donidalorsen in the Prophylactic Treatment of Hereditary Angioedema (HAE)
Study identification
- NCT ID
- NCT05392114
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Ionis Pharmaceuticals, Inc.
- Industry
- Enrollment
- 154 participants
Conditions and interventions
Conditions
Interventions
- Donidalorsen Drug
Drug
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 12, 2022
- Primary completion
- Nov 30, 2026
- Completion
- Feb 28, 2027
- Last update posted
- Dec 11, 2025
2022 – 2027
United States locations
- U.S. sites
- 16
- U.S. states
- 12
- U.S. cities
- 16
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ionis Investigative Site | Paradise Valley | Arizona | 85253 | — |
| Ionis Investigative Site | La Jolla | California | 92037 | — |
| Ionis Investigative Site | Santa Monica | California | 90404 | — |
| Ionis Investigative Site | Walnut Creek | California | 94598 | — |
| Ionis Investigative Site | Tampa | Florida | 33613 | — |
| Ionis Investigative Site | Kansas City | Kansas | 66103 | — |
| Ionis Investigative Site | Boston | Massachusetts | 02114 | — |
| Ionis Investigative Site | Ann Arbor | Michigan | 48109 | — |
| Ionis Investigative Site | Detroit | Michigan | 48202 | — |
| Ionis Investigative Site | St Louis | Missouri | 63141 | — |
| Ionis Investigative Site | Mooresville | North Carolina | 28117 | — |
| Ionis Investigative Site | Cincinnati | Ohio | 45236 | — |
| Ionis Investigative Site | Columbus | Ohio | 43235 | — |
| Ionis Investigative Site | Hershey | Pennsylvania | 17033 | — |
| Ionis Investigative Site | Dallas | Texas | 75231 | — |
| Ionis Investigative Site | Murray | Utah | 84107 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 34 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05392114, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 11, 2025 · Synced Jul 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05392114 live on ClinicalTrials.gov.