The BEST Trial: Biomarkers for Evaluating Spine Treatments
Public ClinicalTrials.gov record NCT05396014. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The BEST Trial (Biomarkers for Evaluating Spine Treatments) is a National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)-sponsored clinical trial being conducted through the NIH Helping to End Addiction Long-term (HEAL) Initiative's Back Pain Consortium (BACPAC) Research Program. The primary objective of this trial is to inform a precision medicine approach to the treatment of Chronic Low-Back Pain by estimating the optimal treatment or combination of treatments based on patient features and response to the initial treatment. Interventions being evaluated in this trial are: (1) enhanced self-care (ESC), (2) acceptance and commitment therapy (ACT), (3) evidence-based exercise and manual therapy (EBEM), and (4) duloxetine.
Study identification
- NCT ID
- NCT05396014
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 1,014 participants
Conditions and interventions
Conditions
Interventions
- Enhanced Self-Care (ESC) Behavioral
- Acceptance and Commitment Therapy (ACT) Behavioral
- Evidence-Based Exercise and Manual Therapy (EBEM) Behavioral
- Duloxetine Drug
Behavioral · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 11, 2022
- Primary completion
- Jul 29, 2024
- Completion
- Oct 21, 2024
- Last update posted
- Jul 22, 2025
2022 – 2024
United States locations
- U.S. sites
- 12
- U.S. states
- 9
- U.S. cities
- 12
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Stanford University | Redwood City | California | 94063 | — |
| University of California, San Diego | San Diego | California | 92037 | — |
| University of California, San Francisco | San Francisco | California | 94158 | — |
| University of Kansas Health System | Kansas City | Kansas | 66160 | — |
| Massachusetts General Hospital/Brigham Women's Hospital, Harvard Medical School | Boston | Massachusetts | 02114 | — |
| University of Michigan | Ann Arbor | Michigan | 48189 | — |
| University of North Carolina Hospital Pain Management Clinic | Chapel Hill | North Carolina | 27599 | — |
| Atrium Health Wake Forest Baptist | Winston-Salem | North Carolina | 27517 | — |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43203 | — |
| University of Pittsburgh | Pittsburgh | Pennsylvania | 15219 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| University of Washington | Seattle | Washington | 98104 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05396014, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 22, 2025 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05396014 live on ClinicalTrials.gov.