Research Study Investigating How Well NDec Works in People With Sickle Cell Disease
Public ClinicalTrials.gov record NCT05405114. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicentre Trial Evaluating the Efficacy and Safety of Oral Decitabine Tetrahydrouridine (NDec) in Patients With Sickle Cell Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study examines how well a new, potential medicine called NDec works and is tolerated in people with sickle cell disease. NDec is a combination of two medicines (decitabine-tetrahydrouridine). Both medicines are new for the treatment of sickle cell disease. Participants who are not taking Hydroxyurea (HU) will get NDec, NDec and placebo, or placebo. Participants who are on HU treatment before joining the study will get NDec, NDec and placebo, or continue on HU. Which treatment participants get is decided by chance. Participants getting NDec and/or Placebo will get capsules to take twice weekly. The study will last for about a year.
Study identification
- NCT ID
- NCT05405114
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 96 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 7, 2022 (Actual)
- Primary completion
- Jul 24, 2025 (Actual)
- Completion
- Jul 24, 2025 (Actual)
- Last update posted
- Jul 22, 2026
2022 – 2025
United States locations
- U.S. sites
- 53
- U.S. states
- 27
- U.S. cities
- 40
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University Of South Alabama | Mobile | Alabama | 36617 | — |
| Keck Medical Center of USC - Outpatient Clinic | Los Angeles | California | 90033 | — |
| UCSF Oakland Benioff ChildHosp | Oakland | California | 94609 | — |
| Center for Inherited Blood Dis | Orange | California | 92868 | — |
| Harbor-UCLA Medical Center | Torrance | California | 90502-2004 | — |
| Clinical and Transl Res Center | Aurora | Colorado | 80045 | — |
| Carole&Ray Neag Comp S.C. Ctr | Farmington | Connecticut | 06030 | — |
| Tova Community Health Inc | Wilmington | Delaware | 19805 | — |
| Howard University Hospital Department Med | Washington D.C. | District of Columbia | 20060 | — |
| Howard University | Washington D.C. | District of Columbia | 20060 | — |
| Foundation for Sickle Cell Disease Research | Hollywood | Florida | 33023 | — |
| University of Florida, College of Medicine Jacksonville | Jacksonville | Florida | 32209 | — |
| University of Miami Hospital & Clinics | Miami | Florida | 33136 | — |
| Emory University School Of Med | Atlanta | Georgia | 30333 | — |
| Aflac Cancer/Blood Dis CCH | Atlanta | Georgia | 30342 | — |
| Emory University School Of Med | Atlanta | Georgia | 30342 | — |
| Augusta University | Augusta | Georgia | 30912 | — |
| Rush University Med. Cntr | Chicago | Illinois | 60612 | — |
| Univer Of Illinois at Chicago | Chicago | Illinois | 60612 | — |
| Tulane Sickle Cell Ctr- So LA | Metairie | Louisiana | 70002 | — |
| Mass General Cancer Center | Boston | Massachusetts | 02114 | — |
| Wayne State University/University Health Center | Detroit | Michigan | 48201 | — |
| Children's Hospitals And Clinics Of Minnesota | Minneapolis | Minnesota | 55404 | — |
| University of Minnesota_Minneapolis_0 | Minneapolis | Minnesota | 55455 | — |
| Mississippi Center Advanced Medicine | Madison | Mississippi | 39110 | — |
| Univ of NE Med Center_Omaha | Omaha | Nebraska | 68198 | — |
| Cure 4 the Kids Foundation | Las Vegas | Nevada | 89135 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Interfaith Medical Center | Brooklyn | New York | 11238 | — |
| Queens Hospital Center | Jamaica | New York | 11432-1121 | — |
| Mount Sinai School of Medicine | New York | New York | 10029 | — |
| Jacobi Medical Center | The Bronx | New York | 10461 | — |
| Montefiore Medical Center | The Bronx | New York | 10467 | — |
| University of North Carlolina-Chapel Hill | Chapel Hill | North Carolina | 27599 | — |
| Atrium Levine Children's/Atrium Health | Charlotte | North Carolina | 28204 | — |
| Duke Comprehen Sickle Cell | Durham | North Carolina | 27710 | — |
| East Carolina Univ-Greenville | Greenville | North Carolina | 27834-4300 | — |
| East Carolina Univ-Greenville | Greenville | North Carolina | 27834 | — |
| Dayton Children's Hosptial | Dayton | Ohio | 45404 | — |
| Univ Oklahoma HSC_Okla City | Oklahoma City | Oklahoma | 73104 | — |
| University of Oklahoma Health Sciences Center_Oklahoma City | Oklahoma City | Oklahoma | 73104 | — |
| Penn Comprehensive Hemophilia & Thrombosis Program | Philadelphia | Pennsylvania | 19104 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| St Christopher Hosp for Child | Philadelphia | Pennsylvania | 19134 | — |
| Hemophilia Center of Western PA | Pittsburgh | Pennsylvania | 15213 | — |
| Medical Univ of SC Charleston | Charleston | South Carolina | 29425 | — |
| University Of Tennessee | Memphis | Tennessee | 38163 | — |
| Baylor College of Medicine Texas Childen's Hospital | Houston | Texas | 77030 | — |
| Baylor College of Medicine_Houston | Houston | Texas | 77030 | — |
| Dan L. Duncan Comprehensive Cancer Center | Houston | Texas | 77030 | — |
| Univ Texas HSC-Houston | Houston | Texas | 77030 | — |
| University Of Virginia Hospital | Charlottesville | Virginia | 22908 | — |
| Medical College of Wisconsin & Zablocki VAMC | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 65 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05405114, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 22, 2026 · Synced Oct 20, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05405114 live on ClinicalTrials.gov.