Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD

ClinicalTrials.gov ID: NCT05407636

Public ClinicalTrials.gov record NCT05407636. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 9, 2026, 6:35 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Partially Masked, Controlled, Phase 3 Clinical Study to Evaluate the Efficacy and Safety of RGX-314 Gene Therapy in Participants With nAMD

Study identification

NCT ID: NCT05407636
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: AbbVie; Industry
Enrollment: 714 participants

Conditions and interventions

Conditions

Interventions

ABBV-RGX-314 Dose 1 Genetic
ABBV-RGX-314 Dose 2 Genetic
Aflibercept (EYLEA®) Biological

Genetic · Biological

Eligibility (public fields only)

Age range: 50 Years to 89 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jan 12, 2022
Primary completion: Sep 30, 2026
Completion: Oct 31, 2027
Last update posted: Apr 19, 2026

2022 – 2027

United States locations

U.S. sites: 107
U.S. states: 33
U.S. cities: 97

Facility	City	State	ZIP	Site status
Barnet Dulaney Eye Center-Phoenix /ID# 256340	Phoenix	Arizona	85016	Recruiting
Retinal Research Institute /ID# 256238	Phoenix	Arizona	85053	Recruiting
Retina Macula Institute of Arizona /ID# 271026	Scottsdale	Arizona	85255-4134	Recruiting
California Retina Consultants - Bakersfield /ID# 256240	Bakersfield	California	93309-1677	Recruiting
Retina Vitreous Assoc Med Grp /ID# 256246	Beverly Hills	California	90211	Recruiting
Retinal Diagnostic Center /ID# 256262	Campbell	California	95008	Recruiting
The Retina Partners - Encino /ID# 259660	Encino	California	91436	Recruiting
Retina Consultants of Orange County /ID# 256267	Fullerton	California	92835	Active, not recruiting
Jacobs Retina Center at UCSD/ID# 256320	La Jolla	California	92093	Active, not recruiting
California Retina Consultants - Oxnard - North Ventura Road /ID# 262883	Oxnard	California	93036	Recruiting
Byers Eye Institute Stanford /ID# 262853	Palo Alto	California	94303	Recruiting
Retina Consultants of San Diego /ID# 256258	Poway	California	92064-2530	Active, not recruiting
Kaiser Permanente - Riverside Medical Center /ID# 262413	Riverside	California	92505	Recruiting
UC Davis Health Eye Center	Sacramento	California	95817	Active, not recruiting
Retinal Consultants Medical Group, Inc. - Greenback /ID# 256353	Sacramento	California	95841	Active, not recruiting
Orange County Retina Medical Group /ID# 256286	Santa Ana	California	92705	Recruiting
Macula Retina Vitreous Center - Torrance /ID# 270247	Torrance	California	90503	Recruiting
Bay Area Retina Associates - Walnut Creek - Lennon Lane /ID# 268513	Walnut Creek	California	94598	Recruiting
Retina Consultants of Southern Colorado /ID# 256285	Colorado Springs	Colorado	80909	Recruiting
Southwest Retina Research Center /ID# 256261	Durango	Colorado	81303	Active, not recruiting
Colorado Retina Associates /ID# 256378	Lakewood	Colorado	80228	Completed
Advanced Vision Research Institute /ID# 256380	Longmont	Colorado	80503	Recruiting
Retina Consultants, P.C. /ID# 273610	Manchester	Connecticut	06042-3556	Recruiting
Rand Eye Institute /ID# 256337	Deerfield Beach	Florida	33064	Completed
National Ophthalmic Research Institute /ID# 256344	Fort Myers	Florida	33912-7125	Active, not recruiting
Vitreoretinal Associates, P.A. /ID# 256266	Gainesville	Florida	32607	Active, not recruiting
Florida Retina Consultants /ID# 256321	Lakeland	Florida	33805	Recruiting
Florida Retina Institute - Orlando /ID# 256373	Orlando	Florida	32806-1101	Recruiting
Retina Specialty Institute /ID# 256268	Pensacola	Florida	32503	Recruiting
Fort Lauderdale Eye Institute /ID# 266011	Plantation	Florida	33324	Completed
Retina Vitreous Associates of Florida - St. Petersburg /ID# 256279	St. Petersburg	Florida	33711-1141	Recruiting
Center for Retina and Macular Disease /ID# 256335	Winter Haven	Florida	33880	Recruiting
Georgia Retina - Marietta /ID# 256264	Marietta	Georgia	30060	Recruiting
Retina Consultants of Hawaii /ID# 256278	‘Aiea	Hawaii	96701	Recruiting
Northwestern Memorial Hospital - Department of Ophthalmology /ID# 256379	Chicago	Illinois	60611-2987	Recruiting
University Retina and Macula Associates /ID# 256288	Lemont	Illinois	60439	Active, not recruiting
University Retina and Macula Associates /ID# 256287	Oak Forest	Illinois	60452	Completed
Illinois Retina Associates - Oak Park /ID# 256375	Oak Park	Illinois	60304	Active, not recruiting
Springfield Clinic - First /ID# 256371	Springfield	Illinois	62702	Recruiting
Retina Partners Midwest, PC /ID# 256277	Indianapolis	Indiana	46290	Recruiting
John-Kenyon American Eye Institute -New Albany /ID# 256283	New Albany	Indiana	47150	Active, not recruiting
Wolfe Eye Clinic - West Des Moines /ID# 256314	West Des Moines	Iowa	50266	Active, not recruiting
Retina Associates - Lenexa /ID# 258296	Lenexa	Kansas	66215	Recruiting
Maine Eye Center - Marginal Way Campus /ID# 256391	Portland	Maine	04101	Recruiting
Retina Specialists /ID# 256392	Baltimore	Maryland	21204	Active, not recruiting
Johns Hopkins Hospital /ID# 256236	Baltimore	Maryland	21287	Completed
Mid Atlantic Retina Specialists - Hagerstown /ID# 256310	Hagerstown	Maryland	21740-5965	Active, not recruiting
MA Eye & Ear Infirmary /ID# 262430	Boston	Massachusetts	02114	Active, not recruiting
Ophthalmic Consultants of Boston /ID# 256233	Boston	Massachusetts	02114	Recruiting
Vitreo Retinal Associates - Worcester /ID# 266008	Worcester	Massachusetts	01605	Recruiting
Retina Associates of Michigan /ID# 256393	Grand Blanc	Michigan	48439	Recruiting
Associated Retinal Consultants /ID# 256269	Royal Oak	Michigan	48073	Recruiting
VitreoRetinal Surgery PLLC DBA Retina Consultants of Minnesota /ID# 256272	Edina	Minnesota	55435	Recruiting
Mayo Clinic - Rochester /ID# 258295	Rochester	Minnesota	55905-0001	Recruiting
Mississippi Retina Associates /ID# 270934	Madison	Mississippi	39110-2028	Recruiting
Mid America Surgery Center /ID# 258993	Chesterfield	Missouri	63017	Completed
University of Missouri Hospital /ID# 262474	Columbia	Missouri	65212	Recruiting
Washington University School of Medicine - St. Louis /ID# 256383	St Louis	Missouri	63108	Recruiting
Sierra Eye Associates /ID# 256239	Reno	Nevada	89502	Completed
Envision Ocular, LLC /ID# 256367	Bloomfield	New Jersey	07003	Recruiting
Monmouth Retina Consultants /ID# 275895	Little Silver	New Jersey	07739	Recruiting
Columbia University of New York - Edward S. Harkness Eye Institute /ID# 256342	New York	New York	10032	Active, not recruiting
Retina Associates of Western New York /ID# 256374	Rochester	New York	14620	Completed
Asheville Eye Associates- Retina Division /ID# 256355	Asheville	North Carolina	28803	Recruiting
Duke University Medical Center /ID# 256245	Durham	North Carolina	27710	Recruiting
Graystone Eye /ID# 256424	Hickory	North Carolina	28602	Recruiting
Cincinnati Eye Institute /ID# 256247	Cincinnati	Ohio	45242-5664	Recruiting
Retina Associates of Cleveland-Middleburg Heights /ID# 256280	Cleveland	Ohio	44130	Active, not recruiting
Cleveland Clinic - Cleveland /ID# 256282	Cleveland	Ohio	44195	Active, not recruiting
Ohio State University /ID# 256275	Columbus	Ohio	43210	Recruiting
Midwest Retina /ID# 276644	Dublin	Ohio	43016	Completed
Retina Vitreous Center, Research /ID# 256284	Edmond	Oklahoma	73013	Recruiting
University of Pennsylvania /ID# 258995	Philadelphia	Pennsylvania	19104-5502	Active, not recruiting
Mid Atlantic Retina /ID# 256232	Philadelphia	Pennsylvania	19107	Active, not recruiting
University of Pittsburgh Medical Center /ID# 258994	Pittsburgh	Pennsylvania	15213	Active, not recruiting
Charleston Neuroscience Institute - Beaufort /ID# 256385	Beaufort	South Carolina	29902-6216	Recruiting
Charleston Neurosciences Institute /ID# 256351	Charleston	South Carolina	29414-5896	Recruiting
Palmetto Retina Center-Florence /ID# 256244	Florence	South Carolina	29501	Completed
Charleston Neurosciences Institute /ID# 256336	Ladson	South Carolina	29414-5896	Recruiting
Black Hills Regional Eye Institute /ID# 262872	Rapid City	South Dakota	57701	Recruiting
Southeastern Retina Associates - Chattanooga /ID# 258992	Chattanooga	Tennessee	37421	Completed
Charles Retina Institute /ID# 256237	Germantown	Tennessee	38138	Completed
Southeastern Retina Associates - Johnson City /ID# 256396	Johnson City	Tennessee	37604	Recruiting
Tennessee Retina - Nashville /ID# 256388	Nashville	Tennessee	37203-1513	Recruiting
Vanderbilt University Medical Center /ID# 256372	Nashville	Tennessee	37232-0011	Recruiting
Retina Research Institute of Texas /ID# 256263	Abilene	Texas	79606-1224	Completed
Austin Research Center for Retina /ID# 256265	Austin	Texas	78705	Recruiting
Austin Clinical Research, LLC /ID# 256274	Austin	Texas	78750-2298	Completed
Retina Consultants of Texas - Bellaire /ID# 256377	Bellaire	Texas	77401	Recruiting
Star Retina - Burleson /ID# 256376	Burleson	Texas	76028	Active, not recruiting
Texas Retina Associates /ID# 256259	Dallas	Texas	75231	Recruiting
Texas Retina Associates - Fort Worth /ID# 256326	Fort Worth	Texas	76104	Recruiting
Austin Retina Associates - Round Rock /ID# 256387	Round Rock	Texas	78681	Recruiting
Retina Consultants of Texas/ID# 259661	San Antonio	Texas	78240-1655	Recruiting
Retina Associates of South Texas	San Antonio	Texas	78240	Recruiting
Retina Consultants of Texas /ID# 256382	San Antonio	Texas	78251	Recruiting
Retina Center Of Texas (Rct) - Southlake /ID# 256281	Southlake	Texas	76092	Recruiting
Rocky Mountain Retina Consultants /ID# 256369	Murray	Utah	84107	Active, not recruiting
Retina Associates of Utah /ID# 256276	Salt Lake City	Utah	84107	Recruiting
Piedmont Eye Center /ID# 256386	Lynchburg	Virginia	24502	Completed
Wagner Kapoor Research Institute - Norfolk /ID# 256260	Norfolk	Virginia	23502	Completed
Retina Institute of Virginia /ID# 256394	Richmond	Virginia	23235	Completed
Vistar Eye Center /ID# 271024	Roanoke	Virginia	24019	Recruiting
Pacific Northwest Retina /ID# 258999	Bellevue	Washington	98004	Completed
Retina Center NW, PLLC /ID# 256395	Silverdale	Washington	98383	Recruiting
Spokane Eye Clinic /ID# 256338	Spokane	Washington	99204	Active, not recruiting
Gundersen Health System - La Crosse Medical Center /ID# 276012	La Crosse	Wisconsin	54601	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 74 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05407636, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 19, 2026 · Synced May 9, 2026

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The complete protocol, eligibility criteria, and contact information for NCT05407636 live on ClinicalTrials.gov.

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