Testing the Use of Ado-Trastuzumab Emtansine Compared to the Usual Treatment (Chemotherapy With Docetaxel Plus Trastuzumab) or Trastuzumab Deruxtecan for Recurrent, Metastatic, or Unresectable HER2-Expressing Salivary Gland Cancers

ClinicalTrials.gov ID: NCT05408845

Public ClinicalTrials.gov record NCT05408845. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 2:55 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase II Trial of HER2-Targeted Therapies for Recurrent, Metastatic, or Unresectable HER2-Expressing Salivary Gland Cancers

Study identification

NCT ID: NCT05408845
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: NRG Oncology; Other
Enrollment: 146 participants

Conditions and interventions

Conditions

Interventions

Biopsy Procedure Procedure
Biospecimen Collection Procedure
Computed Tomography Procedure
Docetaxel Drug
Echocardiography Test Procedure
Magnetic Resonance Imaging Procedure
Multigated Acquisition Scan Procedure
Questionnaire Administration Other
Trastuzumab Biological
Trastuzumab Deruxtecan Biological
Trastuzumab Emtansine Biological

Procedure · Drug · Other + 1 more

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 2, 2023
Primary completion: Jul 30, 2028
Completion: Jul 30, 2028
Last update posted: May 3, 2026

2023 – 2028

United States locations

U.S. sites: 150
U.S. states: 30
U.S. cities: 128

Facility	City	State	ZIP	Site status
University of Alabama at Birmingham Cancer Center	Birmingham	Alabama	35233	Active, not recruiting
City of Hope Comprehensive Cancer Center	Duarte	California	91010	Active, not recruiting
Kaiser Permanente Dublin	Dublin	California	94568	Recruiting
Kaiser Permanente-Fremont	Fremont	California	94538	Recruiting
Kaiser Permanente Fresno Orchard Plaza	Fresno	California	93720	Recruiting
Kaiser Permanente-Fresno	Fresno	California	93720	Recruiting
City of Hope at Irvine Lennar	Irvine	California	92618	Active, not recruiting
Kaiser Permanente- Modesto MOB II	Modesto	California	95356	Recruiting
Kaiser Permanente-Modesto	Modesto	California	95356	Recruiting
Kaiser Permanente-Oakland	Oakland	California	94611	Recruiting
Stanford Cancer Institute Palo Alto	Palo Alto	California	94304	Recruiting
Kaiser Permanente-Roseville	Roseville	California	95661	Recruiting
Kaiser Permanente Downtown Commons	Sacramento	California	95814	Recruiting
Kaiser Permanente-South Sacramento	Sacramento	California	95823	Recruiting
Kaiser Permanente-San Francisco	San Francisco	California	94115	Recruiting
UCSF Medical Center-Mission Bay	San Francisco	California	94158	Suspended
Kaiser Permanente-Santa Teresa-San Jose	San Jose	California	95119	Recruiting
Kaiser Permanente San Leandro	San Leandro	California	94577	Recruiting
Kaiser San Rafael-Gallinas	San Rafael	California	94903	Recruiting
Kaiser Permanente Medical Center - Santa Clara	Santa Clara	California	95051	Recruiting
Kaiser Permanente-Santa Rosa	Santa Rosa	California	95403	Recruiting
Kaiser Permanente-South San Francisco	South San Francisco	California	94080	Recruiting
Kaiser Permanente-Vallejo	Vallejo	California	94589	Recruiting
Kaiser Permanente-Walnut Creek	Walnut Creek	California	94596	Recruiting
UCHealth University of Colorado Hospital	Aurora	Colorado	80045	Recruiting
UCHealth Highlands Ranch Hospital	Highlands Ranch	Colorado	80129	Recruiting
Emory University Hospital Midtown	Atlanta	Georgia	30308	Recruiting
Kaiser Permanente Moanalua Medical Center	Honolulu	Hawaii	96819	Recruiting
Saint Luke's Cancer Institute - Boise	Boise	Idaho	83712	Recruiting
Saint Luke's Cancer Institute - Fruitland	Fruitland	Idaho	83619	Recruiting
Saint Luke's Cancer Institute - Meridian	Meridian	Idaho	83642	Recruiting
Saint Luke's Cancer Institute - Nampa	Nampa	Idaho	83687	Recruiting
Saint Luke's Cancer Institute - Twin Falls	Twin Falls	Idaho	83301	Recruiting
Carle at The Riverfront	Danville	Illinois	61832	Recruiting
Carle Physician Group-Effingham	Effingham	Illinois	62401	Recruiting
Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	61938	Recruiting
Memorial Hospital East	Shiloh	Illinois	62269	Recruiting
Carle Cancer Center	Urbana	Illinois	61801	Recruiting
McFarland Clinic - Ames	Ames	Iowa	50010	Active, not recruiting
UI Health Care Mission Cancer and Blood - Ankeny Clinic	Ankeny	Iowa	50023	Recruiting
Saint Anthony Regional Hospital	Carroll	Iowa	51401	Recruiting
UI Health Care Mission Cancer and Blood - West Des Moines Clinic	Clive	Iowa	50325	Recruiting
Iowa Methodist Medical Center	Des Moines	Iowa	50309	Recruiting
UI Health Care Mission Cancer and Blood - Des Moines Clinic	Des Moines	Iowa	50309	Recruiting
Broadlawns Medical Center	Des Moines	Iowa	50314	Recruiting
Mercy Medical Center - Des Moines	Des Moines	Iowa	50314	Recruiting
UI Health Care Mission Cancer and Blood - Laurel Clinic	Des Moines	Iowa	50314	Recruiting
UI Healthcare Mission Cancer and Blood - Fort Dodge	Fort Dodge	Iowa	50501	Recruiting
UI Health Care Mission Cancer and Blood - Waukee Clinic	Waukee	Iowa	50263	Recruiting
The Iowa Clinic PC	West Des Moines	Iowa	50266	Recruiting
HaysMed	Hays	Kansas	67601	Recruiting
University of Kansas Cancer Center	Kansas City	Kansas	66160	Recruiting
Lawrence Memorial Hospital	Lawrence	Kansas	66044	Recruiting
The University of Kansas Cancer Center - Olathe	Olathe	Kansas	66061	Recruiting
University of Kansas Cancer Center-Overland Park	Overland Park	Kansas	66210	Recruiting
University of Kansas Hospital-Indian Creek Campus	Overland Park	Kansas	66211	Recruiting
Salina Regional Health Center	Salina	Kansas	67401	Recruiting
University of Kansas Health System Saint Francis Campus	Topeka	Kansas	66606	Recruiting
University of Kansas Hospital-Westwood Cancer Center	Westwood	Kansas	66205	Recruiting
University of Kentucky/Markey Cancer Center	Lexington	Kentucky	40536	Recruiting
UPMC Western Maryland	Cumberland	Maryland	21502	Recruiting
University of Michigan Rogel Cancer Center	Ann Arbor	Michigan	48109	Recruiting
Wayne State University/Karmanos Cancer Institute	Detroit	Michigan	48201	Active, not recruiting
Weisberg Cancer Treatment Center	Farmington Hills	Michigan	48334	Active, not recruiting
Sanford Joe Lueken Cancer Center	Bemidji	Minnesota	56601	Recruiting
Mercy Hospital	Coon Rapids	Minnesota	55433	Recruiting
Fairview Southdale Hospital	Edina	Minnesota	55435	Recruiting
Abbott-Northwestern Hospital	Minneapolis	Minnesota	55407	Recruiting
Hennepin County Medical Center	Minneapolis	Minnesota	55415	Recruiting
Mayo Clinic in Rochester	Rochester	Minnesota	55905	Recruiting
Park Nicollet Clinic - Saint Louis Park	Saint Louis Park	Minnesota	55416	Recruiting
Regions Hospital	Saint Paul	Minnesota	55101	Recruiting
United Hospital	Saint Paul	Minnesota	55102	Recruiting
Siteman Cancer Center at Saint Peters Hospital	City of Saint Peters	Missouri	63376	Recruiting
Siteman Cancer Center at West County Hospital	Creve Coeur	Missouri	63141	Recruiting
University Health Truman Medical Center	Kansas City	Missouri	64108	Recruiting
University of Kansas Cancer Center - North	Kansas City	Missouri	64154	Recruiting
University of Kansas Cancer Center - Lee's Summit	Lee's Summit	Missouri	64064	Recruiting
Washington University School of Medicine	St Louis	Missouri	63110	Recruiting
Siteman Cancer Center-South County	St Louis	Missouri	63129	Recruiting
Siteman Cancer Center at Christian Hospital	St Louis	Missouri	63136	Recruiting
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center	Lebanon	New Hampshire	03756	Recruiting
Memorial Sloan Kettering Basking Ridge	Basking Ridge	New Jersey	07920	Recruiting
Memorial Sloan Kettering Monmouth	Middletown	New Jersey	07748	Recruiting
Memorial Sloan Kettering Bergen	Montvale	New Jersey	07645	Recruiting
University of New Mexico Cancer Center	Albuquerque	New Mexico	87106	Recruiting
Memorial Sloan Kettering Commack	Commack	New York	11725	Recruiting
Memorial Sloan Kettering Westchester	East White Plains	New York	10604	Recruiting
Mount Sinai Chelsea	New York	New York	10011	Active, not recruiting
Mount Sinai Hospital	New York	New York	10029	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
Memorial Sloan Kettering Nassau	Uniondale	New York	11553	Recruiting
Sanford Bismarck Medical Center	Bismarck	North Dakota	58501	Recruiting
Sanford Broadway Medical Center	Fargo	North Dakota	58122	Recruiting
Sanford Roger Maris Cancer Center	Fargo	North Dakota	58122	Recruiting
University of Cincinnati Cancer Center-UC Medical Center	Cincinnati	Ohio	45219	Recruiting
Ohio State University Comprehensive Cancer Center	Columbus	Ohio	43210	Active, not recruiting
Trinity's Tony Teramana Cancer Center	Steubenville	Ohio	43952	Recruiting
University of Cincinnati Cancer Center-West Chester	West Chester	Ohio	45069	Recruiting
Cancer Centers of Southwest Oklahoma Research	Lawton	Oklahoma	73505	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
UPMC Altoona	Altoona	Pennsylvania	16601	Recruiting
UPMC-Heritage Valley Health System Beaver	Beaver	Pennsylvania	15009	Recruiting
UPMC Hillman Cancer Center at Butler Health System	Butler	Pennsylvania	16001	Recruiting
UPMC Camp Hill	Camp Hill	Pennsylvania	17011	Active, not recruiting
Carlisle Regional Cancer Center	Carlisle	Pennsylvania	17015	Recruiting
UPMC Hillman Cancer Center - Passavant - Cranberry	Cranberry Township	Pennsylvania	16066	Recruiting
UPMC Hillman Cancer Center Erie	Erie	Pennsylvania	16505	Recruiting
UPMC Cancer Center at UPMC Horizon	Farrell	Pennsylvania	16121	Recruiting
UPMC Cancer Centers - Arnold Palmer Pavilion	Greensburg	Pennsylvania	15601	Recruiting
UPMC Pinnacle Cancer Center/Community Osteopathic Campus	Harrisburg	Pennsylvania	17109	Recruiting
IRMC Cancer Center	Indiana	Pennsylvania	15701	Recruiting
UPMC-Johnstown/John P. Murtha Regional Cancer Center	Johnstown	Pennsylvania	15901	Recruiting
UPMC Cancer Center at UPMC McKeesport	McKeesport	Pennsylvania	15132	Recruiting
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion	Mechanicsburg	Pennsylvania	17050	Recruiting
UPMC Hillman Cancer Center - Monroeville	Monroeville	Pennsylvania	15146	Recruiting
UPMC Hillman Cancer Center in Coraopolis	Moon Township	Pennsylvania	15108	Recruiting
UPMC Hillman Cancer Center - Part of Frick Hospital	Mount Pleasant	Pennsylvania	15666	Recruiting
UPMC Cancer Center-Natrona Heights	Natrona Heights	Pennsylvania	15065	Recruiting
UPMC Hillman Cancer Center - New Castle	New Castle	Pennsylvania	16105	Recruiting
Arnold Palmer Cancer Center Medical Oncology Norwin	North Huntingdon	Pennsylvania	15642	Recruiting
UPMC-Saint Margaret	Pittsburgh	Pennsylvania	15215	Recruiting
UPMC-Mercy Hospital	Pittsburgh	Pennsylvania	15219	Recruiting
University of Pittsburgh Cancer Institute (UPCI)	Pittsburgh	Pennsylvania	15232	Recruiting
UPMC-Passavant Hospital	Pittsburgh	Pennsylvania	15237	Recruiting
UPMC-Saint Clair Hospital Cancer Center	Pittsburgh	Pennsylvania	15243	Recruiting
UPMC Cancer Center at UPMC Northwest	Seneca	Pennsylvania	16346	Recruiting
UPMC Cancer Center-Uniontown	Uniontown	Pennsylvania	15401	Recruiting
UPMC Cancer Center-Washington	Washington	Pennsylvania	15301	Recruiting
Divine Providence Hospital	Williamsport	Pennsylvania	17754	Recruiting
UPMC Memorial	York	Pennsylvania	17408	Recruiting
Medical University of South Carolina	Charleston	South Carolina	29425	Recruiting
Sanford Cancer Center Oncology Clinic	Sioux Falls	South Dakota	57104	Recruiting
Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	57117-5134	Recruiting
Vanderbilt University/Ingram Cancer Center	Nashville	Tennessee	37232	Recruiting
Huntsman Cancer Institute/University of Utah	Salt Lake City	Utah	84112	Recruiting
Dartmouth Cancer Center - North	Saint Johnsbury	Vermont	05819	Suspended
VCU Massey Comprehensive Cancer Center	Richmond	Virginia	23298	Recruiting
Swedish Cancer Institute-Issaquah	Issaquah	Washington	98029	Recruiting
Fred Hutchinson Cancer Center	Seattle	Washington	98109	Recruiting
Marshfield Medical Center-EC Cancer Center	Eau Claire	Wisconsin	54701	Recruiting
Marshfield Medical Center-Marshfield	Marshfield	Wisconsin	54449	Recruiting
Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting
Marshfield Medical Center - Minocqua	Minocqua	Wisconsin	54548	Recruiting
ProHealth D N Greenwald Center	Mukwonago	Wisconsin	53149	Recruiting
ProHealth Oconomowoc Memorial Hospital	Oconomowoc	Wisconsin	53066	Recruiting
Marshfield Medical Center-Rice Lake	Rice Lake	Wisconsin	54868	Recruiting
Marshfield Medical Center-River Region at Stevens Point	Stevens Point	Wisconsin	54482	Recruiting
UW Cancer Center at ProHealth Care	Waukesha	Wisconsin	53188	Recruiting
Marshfield Medical Center - Weston	Weston	Wisconsin	54476	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05408845, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 3, 2026 · Synced May 8, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05408845 live on ClinicalTrials.gov.

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