ClinicalTrials.gov record
Testing Cabozantinib With or Without Atezolizumab in Patients With Advanced Papillary Kidney Cancer, PAPMET2 Trial
ClinicalTrials.gov ID: NCT05411081
Public ClinicalTrials.gov record NCT05411081. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 5, 2026, 12:33 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase II Randomized Trial of Cabozantinib (NSC #761968) With or Without Atezolizumab (NSC #783608) in Patients With Advanced Papillary Renal Cell Carcinoma (PAPMET2)
Study identification
- NCT ID
- NCT05411081
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- National Cancer Institute (NCI)
- NIH
- Enrollment
- 200 participants
Conditions and interventions
Interventions
- Atezolizumab Biological
- Biospecimen Collection Procedure
- Bone Scan Procedure
- Cabozantinib S-malate Drug
- Computed Tomography Procedure
- Magnetic Resonance Imaging Procedure
Biological · Procedure · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 23, 2023
- Primary completion
- Jun 30, 2027
- Completion
- Jun 30, 2027
- Last update posted
- Apr 30, 2026
2023 – 2027
United States locations
- U.S. sites
- 199
- U.S. states
- 26
- U.S. cities
- 161
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | — |
| Cancer Center at Saint Joseph's | Phoenix | Arizona | 85004 | — |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Kaiser Permanente-Anaheim | Anaheim | California | 92806 | — |
| Kaiser Permanente-Baldwin Park | Baldwin Park | California | 91706 | — |
| Kaiser Permanente-Bellflower | Bellflower | California | 90706 | — |
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010 | — |
| Epic Care-Dublin | Dublin | California | 94568 | — |
| Epic Care Partners in Cancer Care | Emeryville | California | 94608 | — |
| Kaiser Permanente-Fontana | Fontana | California | 92335 | — |
| Kaiser Permanente South Bay | Harbor City | California | 90710 | — |
| Kaiser Permanente-Irvine | Irvine | California | 92618 | — |
| Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | 90027 | — |
| Kaiser Permanente West Los Angeles | Los Angeles | California | 90034 | — |
| Contra Costa Regional Medical Center | Martinez | California | 94553-3156 | — |
| Kaiser Permanente-Ontario | Ontario | California | 91761 | — |
| Kaiser Permanente - Panorama City | Panorama City | California | 91402 | — |
| Kaiser Permanente-Riverside | Riverside | California | 92505 | — |
| University of California Davis Comprehensive Cancer Center | Sacramento | California | 95817 | — |
| Kaiser Permanente-San Diego Zion | San Diego | California | 92120 | — |
| Kaiser Permanente-San Marcos | San Marcos | California | 92078 | — |
| Epic Care Cyberknife Center | Walnut Creek | California | 94597 | — |
| Kaiser Permanente-Woodland Hills | Woodland Hills | California | 91367 | — |
| MedStar Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | — |
| Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | 83706 | — |
| Saint Luke's Cancer Institute - Boise | Boise | Idaho | 83712 | — |
| Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho | 83605 | — |
| Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho | 83814 | — |
| Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho | 83619 | — |
| Saint Luke's Cancer Institute - Meridian | Meridian | Idaho | 83642 | — |
| Saint Alphonsus Cancer Care Center-Nampa | Nampa | Idaho | 83687 | — |
| Saint Luke's Cancer Institute - Nampa | Nampa | Idaho | 83687 | — |
| Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho | 83854 | — |
| Kootenai Clinic Cancer Services - Sandpoint | Sandpoint | Idaho | 83864 | — |
| Saint Luke's Cancer Institute - Twin Falls | Twin Falls | Idaho | 83301 | — |
| Illinois CancerCare-Bloomington | Bloomington | Illinois | 61704 | — |
| Illinois CancerCare-Canton | Canton | Illinois | 61520 | — |
| Illinois CancerCare-Carthage | Carthage | Illinois | 62321 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Carle at The Riverfront | Danville | Illinois | 61832 | — |
| Northwestern Medicine Cancer Center Kishwaukee | DeKalb | Illinois | 60115 | — |
| Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | 62526 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Illinois CancerCare-Dixon | Dixon | Illinois | 61021 | — |
| Carle Physician Group-Effingham | Effingham | Illinois | 62401 | — |
| Crossroads Cancer Center | Effingham | Illinois | 62401 | — |
| Illinois CancerCare-Eureka | Eureka | Illinois | 61530 | — |
| Illinois CancerCare-Galesburg | Galesburg | Illinois | 61401 | — |
| Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | 60134 | — |
| Northwestern Medicine Glenview Outpatient Center | Glenview | Illinois | 60026 | — |
| Northwestern Medicine Grayslake Outpatient Center | Grayslake | Illinois | 60030 | — |
| Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois | 61443 | — |
| Northwestern Medicine Lake Forest Hospital | Lake Forest | Illinois | 60045 | — |
| Illinois CancerCare-Macomb | Macomb | Illinois | 61455 | — |
| Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | 61938 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Cancer Care Center of O'Fallon | O'Fallon | Illinois | 62269 | — |
| Northwestern Medicine Orland Park | Orland Park | Illinois | 60462 | — |
| Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | 61350 | — |
| Illinois CancerCare-Pekin | Pekin | Illinois | 61554 | — |
| Illinois CancerCare-Peoria | Peoria | Illinois | 61615 | — |
| Illinois CancerCare-Peru | Peru | Illinois | 61354 | — |
| Illinois CancerCare-Princeton | Princeton | Illinois | 61356 | — |
| UW Health Carbone Cancer Center Rockford | Rockford | Illinois | 61114 | — |
| Memorial Hospital East | Shiloh | Illinois | 62269 | — |
| Southern Illinois University School of Medicine | Springfield | Illinois | 62702 | — |
| Springfield Clinic | Springfield | Illinois | 62702 | — |
| Springfield Memorial Hospital | Springfield | Illinois | 62781 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | 60555 | — |
| Illinois CancerCare - Washington | Washington | Illinois | 61571 | — |
| Mary Greeley Medical Center | Ames | Iowa | 50010 | — |
| McFarland Clinic - Ames | Ames | Iowa | 50010 | — |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic | Ankeny | Iowa | 50023 | — |
| McFarland Clinic - Boone | Boone | Iowa | 50036 | — |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic | Clive | Iowa | 50325 | — |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic | Des Moines | Iowa | 50309 | — |
| Mercy Medical Center - Des Moines | Des Moines | Iowa | 50314 | — |
| UI Health Care Mission Cancer and Blood - Laurel Clinic | Des Moines | Iowa | 50314 | — |
| McFarland Clinic - Trinity Cancer Center | Fort Dodge | Iowa | 50501 | — |
| McFarland Clinic - Jefferson | Jefferson | Iowa | 50129 | — |
| McFarland Clinic - Marshalltown | Marshalltown | Iowa | 50158 | — |
| UI Health Care Mission Cancer and Blood - Waukee Clinic | Waukee | Iowa | 50263 | — |
| Cotton O'Neil Cancer Center / Stormont Vail Health | Topeka | Kansas | 66606 | — |
| Mary Bird Perkins Cancer Center - Metairie | Metairie | Louisiana | 70002 | — |
| East Jefferson General Hospital | Metairie | Louisiana | 70006 | — |
| LSU Healthcare Network / Metairie Multi-Specialty Clinic | Metairie | Louisiana | 70006 | — |
| University Medical Center New Orleans | New Orleans | Louisiana | 70112 | — |
| Touro Infirmary | New Orleans | Louisiana | 70115 | — |
| Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Maryland | 21287 | — |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor | Ann Arbor | Michigan | 48106 | — |
| Bronson Battle Creek | Battle Creek | Michigan | 49017 | — |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton | Brighton | Michigan | 48114 | — |
| Trinity Health Medical Center - Brighton | Brighton | Michigan | 48114 | — |
| Trinity Health IHA Medical Group Hematology Oncology - Canton | Canton | Michigan | 48188 | — |
| Trinity Health Medical Center - Canton | Canton | Michigan | 48188 | — |
| Caro Cancer Center | Caro | Michigan | 48723 | — |
| Chelsea Hospital | Chelsea | Michigan | 48118 | — |
| Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital | Chelsea | Michigan | 48118 | — |
| Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Weisberg Cancer Treatment Center | Farmington Hills | Michigan | 48334 | — |
| Cancer Hematology Centers - Flint | Flint | Michigan | 48503 | — |
| Genesee Hematology Oncology PC | Flint | Michigan | 48503 | — |
| Genesys Hurley Cancer Institute | Flint | Michigan | 48503 | — |
| Hurley Medical Center | Flint | Michigan | 48503 | — |
| Corewell Health Grand Rapids Hospitals - Butterworth Hospital | Grand Rapids | Michigan | 49503 | — |
| Bronson Methodist Hospital | Kalamazoo | Michigan | 49007 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| Beacon Kalamazoo Cancer Center | Kalamazoo | Michigan | 49009 | — |
| University of Michigan Health - Sparrow Lansing | Lansing | Michigan | 48912 | — |
| Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | 48154 | — |
| Saint Mary's Oncology/Hematology Associates of Marlette | Marlette | Michigan | 48453 | — |
| Trinity Health Muskegon Hospital | Muskegon | Michigan | 49444 | — |
| Corewell Health Lakeland Hospitals - Niles Hospital | Niles | Michigan | 49120 | — |
| Cancer and Hematology Centers of Western Michigan - Norton Shores | Norton Shores | Michigan | 49444 | — |
| Trinity Health Saint Joseph Mercy Oakland Hospital | Pontiac | Michigan | 48341 | — |
| MyMichigan Medical Center Saginaw | Saginaw | Michigan | 48601 | — |
| Oncology Hematology Associates of Saginaw Valley PC | Saginaw | Michigan | 48604 | — |
| Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center | Saint Joseph | Michigan | 49085 | — |
| MyMichigan Medical Center Tawas | Tawas City | Michigan | 48764 | — |
| Munson Medical Center | Traverse City | Michigan | 49684 | — |
| Saint Mary's Oncology/Hematology Associates of West Branch | West Branch | Michigan | 48661 | — |
| University of Michigan Health - West | Wyoming | Michigan | 49519 | — |
| Huron Gastroenterology PC | Ypsilanti | Michigan | 48106 | — |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus | Ypsilanti | Michigan | 48197 | — |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Fairview Southdale Hospital | Edina | Minnesota | 55435 | — |
| Saint John's Hospital - Healtheast | Maplewood | Minnesota | 55109 | — |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | 55416 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| United Hospital | Saint Paul | Minnesota | 55102 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Saint Francis Medical Center | Cape Girardeau | Missouri | 63703 | — |
| Siteman Cancer Center at Saint Peters Hospital | City of Saint Peters | Missouri | 63376 | — |
| Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri | 63141 | — |
| Parkland Health Center - Farmington | Farmington | Missouri | 63640 | — |
| Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri | 63670 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Mercy Hospital South | St Louis | Missouri | 63128 | — |
| Siteman Cancer Center-South County | St Louis | Missouri | 63129 | — |
| Missouri Baptist Medical Center | St Louis | Missouri | 63131 | — |
| Siteman Cancer Center at Christian Hospital | St Louis | Missouri | 63136 | — |
| Mercy Hospital Saint Louis | St Louis | Missouri | 63141 | — |
| Missouri Baptist Sullivan Hospital | Sullivan | Missouri | 63080 | — |
| BJC Outpatient Center at Sunset Hills | Sunset Hills | Missouri | 63127 | — |
| Community Hospital of Anaconda | Anaconda | Montana | 59711 | — |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | — |
| Saint Vincent Frontier Cancer Center | Billings | Montana | 59102 | — |
| Bozeman Health Deaconess Hospital | Bozeman | Montana | 59715 | — |
| Benefis Sletten Cancer Institute | Great Falls | Montana | 59405 | — |
| Logan Health Medical Center | Kalispell | Montana | 59901 | — |
| Community Medical Center | Missoula | Montana | 59804 | — |
| OptumCare Cancer Care at Charleston | Las Vegas | Nevada | 89102 | — |
| OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada | 89183 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Duke Cancer Center Cary | Cary | North Carolina | 27518 | — |
| Southeastern Medical Oncology Center-Clinton | Clinton | North Carolina | 28328 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Southeastern Medical Oncology Center-Goldsboro | Goldsboro | North Carolina | 27534 | — |
| Southeastern Medical Oncology Center-Jacksonville | Jacksonville | North Carolina | 28546 | — |
| FirstHealth of the Carolinas-Moore Regional Hospital | Pinehurst | North Carolina | 28374 | — |
| Duke Cancer Center Raleigh | Raleigh | North Carolina | 27609 | — |
| UH Seidman Cancer Center at UH Avon Health Center | Avon | Ohio | 44011 | — |
| UHHS-Chagrin Highlands Medical Center | Beachwood | Ohio | 44122 | — |
| Miami Valley Hospital South | Centerville | Ohio | 45459 | — |
| Case Western Reserve University | Cleveland | Ohio | 44106 | — |
| Miami Valley Hospital | Dayton | Ohio | 45409 | — |
| Premier Blood and Cancer Center | Dayton | Ohio | 45409 | — |
| Dayton Physician LLC - Englewood | Dayton | Ohio | 45415 | — |
| Miami Valley Hospital North | Dayton | Ohio | 45415 | — |
| Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | 45005-1066 | — |
| Miami Valley Cancer Care and Infusion | Greenville | Ohio | 45331 | — |
| Kettering Medical Center | Kettering | Ohio | 45429 | — |
| Upper Valley Medical Center | Troy | Ohio | 45373 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Oklahoma Cancer Specialists and Research Institute-Tulsa | Tulsa | Oklahoma | 74146 | — |
| Providence Newberg Medical Center | Newberg | Oregon | 97132 | — |
| Saint Alphonsus Cancer Care Center-Ontario | Ontario | Oregon | 97914 | — |
| Providence Willamette Falls Medical Center | Oregon City | Oregon | 97045 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Providence Saint Vincent Medical Center | Portland | Oregon | 97225 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| UT Southwestern Simmons Cancer Center - RedBird | Dallas | Texas | 75237 | — |
| UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | 75390 | — |
| UT Southwestern/Simmons Cancer Center-Fort Worth | Fort Worth | Texas | 76104 | — |
| UT Southwestern Clinical Center at Richardson/Plano | Richardson | Texas | 75080 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229 | — |
| Farmington Health Center | Farmington | Utah | 84025 | — |
| Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | 84112 | — |
| VCU Massey Cancer Center at Stony Point | Richmond | Virginia | 23235 | — |
| VCU Massey Comprehensive Cancer Center | Richmond | Virginia | 23298 | — |
| West Virginia University Charleston Division | Charleston | West Virginia | 25304 | — |
| Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin | 54701 | — |
| Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | 54449 | — |
| Marshfield Medical Center - Minocqua | Minocqua | Wisconsin | 54548 | — |
| Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin | 54868 | — |
| Marshfield Medical Center-River Region at Stevens Point | Stevens Point | Wisconsin | 54482 | — |
| Marshfield Medical Center - Weston | Weston | Wisconsin | 54476 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05411081, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 30, 2026 · Synced May 5, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05411081 live on ClinicalTrials.gov.