INSPIRE Trial for Skin and Soft Tissue Infections
Public ClinicalTrials.gov record NCT05423756. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
The INSPIRE-ASP Trial (INtelligent Stewardship Prompts to Improve Real-Time Empiric Antibiotic Selection for Patients) for Skin and Soft Tissue (SST) Infections
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The INSPIRE Skin and Soft Tissue Infection trial is a cluster-randomized controlled trial of HCA Healthcare hospitals comparing routine empiric antibiotic stewardship practices with real-time, precision medicine computerized physician order entry (CPOE) smart prompts providing the probability that a non-critically ill adult admitted with skin and soft tissue infection is infected with a resistant pathogen. Note: enrolled "subjects" represent 102 individual HCA Healthcare hospitals that have been randomized into 92 clusters. Hospitals were grouped into the same randomization cluster if they shared campuses or antibiotic stewardship staff.
Study identification
- NCT ID
- NCT05423756
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 118,562 participants
Conditions and interventions
Conditions
Interventions
- Arm 1: Routine Care Other
- Arm 2: INSPIRE Stewardship Bundle for Skin and Soft Tissue Infection Other
Other
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 1, 2023 (Actual)
- Primary completion
- May 9, 2024 (Actual)
- Completion
- May 9, 2024 (Actual)
- Last update posted
- Aug 28, 2026
2023 – 2024
United States locations
- U.S. sites
- 102
- U.S. states
- 15
- U.S. cities
- 83
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Riverside Community hospital | Riverside | California | 92501 | — |
| Regional Medical Center of San Jose | San Jose | California | 95116 | — |
| Good Samaritan Hospital | San Jose | California | 95124 | — |
| Los Robles Hospital & Medical Center | Thousand Oaks | California | 91360 | — |
| West Hills Hospital & Medical Center | West Hills | California | 91307 | — |
| The Medical Center of Aurora | Aurora | Colorado | 80012 | — |
| Swedish Medical Center | Englewood | Colorado | 80113 | — |
| Sky Ridge Medical Center | Lone Tree | Colorado | 80124 | — |
| North Suburban Medical Center | Thornton | Colorado | 80229 | — |
| Blake Medical Center | Bradenton | Florida | 34209 | — |
| Brandon Regional Hospital | Brandon | Florida | 33511 | — |
| Oak Hill Hospital | Brooksville | Florida | 34613 | — |
| Englewood Community Hospital | Englewood | Florida | 34223 | — |
| Fort Walton Beach Medical Center | Fort Walton Beach | Florida | 32547 | — |
| Lawnwood Regional Medical Center | Ft. Pierce | Florida | 34950 | — |
| Regional Medical Center Bayonet Point | Hudson | Florida | 34667 | — |
| Memorial Hospital Jacksonville | Jacksonville | Florida | 32216 | — |
| Lake City Medical Center | Lake City | Florida | 32055 | — |
| Largo Medical Center | Largo | Florida | 33770 | — |
| Northwest Medical Center | Margate | Florida | 33060 | — |
| Mercy Hospital | Miami | Florida | 33133 | — |
| Kendall Regional Medical Center | Miami | Florida | 33175 | — |
| Orange Park Medical Center | Orange Park | Florida | 32073 | — |
| Oviedo Medical Center | Oviedo | Florida | 32765 | — |
| Gulf Coast Regional Medical Center | Panama City | Florida | 32405 | — |
| Fawcett Memorial Hospital | Port Charlotte | Florida | 33952 | — |
| St. Lucie Medical Center | Port Saint Lucie | Florida | 34952 | — |
| Doctors Hospital of Sarasota | Sarasota | Florida | 34233 | — |
| Palms of Pasadena | St. Petersburg | Florida | 33707 | — |
| Northside Hospital | St. Petersburg | Florida | 33709 | — |
| St. Petersburg General Hospital | St. Petersburg | Florida | 33710 | — |
| South Bay Hospital | Sun City Center | Florida | 33573 | — |
| Capital Regional Medical Center | Tallahassee | Florida | 32308 | — |
| HCA Florida South Tampa Hospital | Tampa | Florida | 33609 | — |
| HCA Florida West Tampa Hospital | Tampa | Florida | 33615 | — |
| Medical Center of Trinity | Trinity | Florida | 34655 | — |
| JFK Medical Center - North Campus | West Palm Beach | Florida | 33407 | — |
| Fairview Park Hospital | Dublin | Georgia | 31040 | — |
| Eastern Idaho Regional Medical Center | Idaho Falls | Idaho | 83404 | — |
| Menorah Medical Center | Overland Park | Kansas | 66209 | — |
| Overland Park Regional Medical Center | Overland Park | Kansas | 66215 | — |
| Wesley Medical Center | Wichita | Kansas | 67214 | — |
| Wesley Woodlawn Hospital & ER | Wichita | Kansas | 67220 | — |
| TriStar Greenview Regional Hospital | Bowling Green | Kentucky | 42104 | — |
| Lakeview Regional Medical Center | Covington | Louisiana | 70433 | — |
| Tulane Medical Center | New Orleans | Louisiana | 70112 | — |
| Centerpoint Medical Center | Independence | Missouri | 64057 | — |
| Research Medical Center | Kansas City | Missouri | 64132 | — |
| Lee's Summit Medical Center | Lee's Summit | Missouri | 64063 | — |
| Sunrise Hospital and Medical Center | Las Vegas | Nevada | 89109 | — |
| Southern Hills Hospital & Medical Center | Las Vegas | Nevada | 89148 | — |
| Trident Medical Center | Charleston | South Carolina | 29406 | — |
| Grand Strand Medical Center | Myrtle Beach | South Carolina | 29572 | — |
| Parkridge Medical Center | Chattanooga | Tennessee | 37404 | — |
| Parkridge East Hospital | Chattanooga | Tennessee | 37412 | — |
| TriStar Horizon Medical Center | Dickson | Tennessee | 37055 | — |
| TriStar Hendersonville Medical Center | Hendersonville | Tennessee | 37075 | — |
| TriStar Centennial Medical Center | Nashville | Tennessee | 37203 | — |
| TriStar Southern Hills Medical Center | Nashville | Tennessee | 37211 | — |
| TriStar StoneCrest Medical Center | Smyrna | Tennessee | 37167 | — |
| Medical City Arlington | Arlington | Texas | 76015 | — |
| St. David's Medical Center | Austin | Texas | 78705 | — |
| St. David's North Austin Medical Center | Austin | Texas | 78758 | — |
| Valley Regional Medical Center | Brownsville | Texas | 78526 | — |
| HCA Houston Healthcare Conroe | Conroe | Texas | 77304 | — |
| Corpus Christi Medical Center - Doctors Regional | Corpus Christi | Texas | 78411 | — |
| Corpus Christi Medical Center - Bay Area | Corpus Christi | Texas | 78412 | — |
| Corpus Christi Medical Center - Heart Hospital | Corpus Christi | Texas | 78412 | — |
| Medical City Dallas | Dallas | Texas | 75230 | — |
| Medical City Denton | Denton | Texas | 76210 | — |
| Las Palmas Medical Center | El Paso | Texas | 79902 | — |
| Del Sol Medical Center | El Paso | Texas | 79925 | — |
| Medical City Fortworth | Fort Worth | Texas | 76104 | — |
| Medical City Alliance | Fort Worth | Texas | 76177 | — |
| Medical City Frisco | Frisco | Texas | 75034 | — |
| HCA Houston Healthcare West | Houston | Texas | 77082 | — |
| Medical City Las Colinas | Irving | Texas | 75039 | — |
| HCA Houston Healthcare Kingwood | Kingwood | Texas | 77339 | — |
| Medical City Lewisville | Lewisville | Texas | 75057 | — |
| Methodist Hospital | Metropolitan | Live Oak | Texas | 78212 | — |
| Methodist Hospital | Northeast | Live Oak | Texas | 78233 | — |
| Rio Grande Regional Hospital Main Campus | McAllen | Texas | 78503 | — |
| Medical City McKinney | McKinney | Texas | 75069 | — |
| Medical City North Hills | North Richland Hills | Texas | 76180 | — |
| HCA Houston Healthcare Southeast | Pasadena | Texas | 77504 | — |
| HCA Houston Healthcare Pearland | Pearland | Texas | 77584 | — |
| Medical City Plano | Plano | Texas | 75075 | — |
| St. David's Round Rock Medical Center | Round Rock | Texas | 78681 | — |
| Methodist Hospital | Texsan | San Antonio | Texas | 78201 | — |
| Methodist Hospital | Specialty and Trasnplant | San Antonio | Texas | 78229 | — |
| Methodist Hospital | San Antonio | Texas | 78229 | — |
| HCA Houston Healthcare Mainland | Texas City | Texas | 77591 | — |
| Medical City Weatherford | Weatherford | Texas | 76086 | — |
| HCA Houston Healthcare Clear Lake | Webster | Texas | 77598 | — |
| Ogden Regional Medical Center | Ogden | Utah | 84405 | — |
| LewisGale Hospital Montgomery | Blacksburg | Virginia | 24060 | — |
| John Randolph Medical Center | Hopewell | Virginia | 23860 | — |
| LewisGale Hospital Pulaski | Pulaski | Virginia | 24301 | — |
| Reston Hospital Center | Reston | Virginia | 20190 | — |
| Henrico Doctor's Hospital | Richmond | Virginia | 23220 | — |
| CJW Medical Center (Chippenham & Johnston Willis Campuses) | Richmond | Virginia | 23225 | — |
| LewisGale Medical Center | Salem | Virginia | 24153 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05423756, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 28, 2026 · Synced Oct 20, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05423756 live on ClinicalTrials.gov.