A Phase 2/3 Study in Adult and Adolescent Participants With SCD
Public ClinicalTrials.gov record NCT05431088. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2/3 Randomized, Multicenter Study of Osivelotor Administered Orally to Adult and Adolescent Participants With Sickle Cell Disease
Study identification
- NCT ID
- NCT05431088
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Lead sponsor
- Pfizer
- Industry
- Enrollment
- 389 participants
Conditions and interventions
Conditions
Interventions
- Osivelotor Drug
Drug
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 21, 2022
- Primary completion
- Dec 29, 2030
- Completion
- Dec 30, 2032
- Last update posted
- Mar 19, 2026
2022 – 2032
United States locations
- U.S. sites
- 24
- U.S. states
- 10
- U.S. cities
- 14
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Smilow Cancer Hospital | New Haven | Connecticut | 06511 | Not yet recruiting |
| Edward Jenner Research Group Center LLC | Plantation | Florida | 33317 | Recruiting |
| Pediatric Hematology / Oncology a division of Kidz Medical services | West Palm Beach | Florida | 33407 | Not yet recruiting |
| St. Mary's Medical Center | West Palm Beach | Florida | 33407 | Not yet recruiting |
| Alpha Clinical Research Georgia | Dunwoody | Georgia | 30350 | Active, not recruiting |
| Sonar Clinical Research | Riverdale | Georgia | 30274 | Active, not recruiting |
| University of Illinois at Chicago Clinical Research Center | Chicago | Illinois | 60612 | Not yet recruiting |
| University of Illinois Hospital and Health Sciences System - Investigational Drug Services (IDS) | Chicago | Illinois | 60612 | Not yet recruiting |
| University of Illinois Hospital and Health Sciences System | Chicago | Illinois | 60612 | Not yet recruiting |
| LSU Health Baton Rouge-North Clinic | Baton Rouge | Louisiana | 70805 | Active, not recruiting |
| Our Lady of the Lake Hospital, Inc. | Baton Rouge | Louisiana | 70808 | Active, not recruiting |
| Our lady of the Lake Hospital | Baton Rouge | Louisiana | 70808 | Active, not recruiting |
| University Medical Center New Orleans | New Orleans | Louisiana | 70112 | Active, not recruiting |
| Mississippi Center for Advanced Medicine | Madison | Mississippi | 39110 | Active, not recruiting |
| University Health | Kansas City | Missouri | 64108 | Not yet recruiting |
| Clinical & Translational Research Center (CTRC) | Chapel Hill | North Carolina | 27514 | Not yet recruiting |
| UNC Health | Chapel Hill | North Carolina | 27514 | Not yet recruiting |
| UNC Eastowne Medical Office Building - Consent Only | Chapel Hill | North Carolina | 27517 | Not yet recruiting |
| UNC IDS | Morrisville | North Carolina | 27560 | Not yet recruiting |
| McGovern Medical School at UTHealth | Houston | Texas | 77030 | Active, not recruiting |
| Memorial Hermann Hospital, Texas Medical Center - Clinical Research Unit (CRU) | Houston | Texas | 77030 | Active, not recruiting |
| The University of Texas Health Science Center at Houston | Houston | Texas | 77030 | Active, not recruiting |
| UT Physicians Comprehensive Sickle Cell Clinic | Houston | Texas | 77030 | Active, not recruiting |
| Inova Schar Cancer Institute | Fairfax | Virginia | 22031 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 25 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05431088, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 19, 2026 · Synced Jul 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05431088 live on ClinicalTrials.gov.