A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD
Public ClinicalTrials.gov record NCT05431088. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 2/3 RANDOMIZED, MULTICENTER STUDY OF OSIVELOTOR ADMINISTERED ORALLY TO ADULT AND ADOLESCENT PARTICIPANTS WITH SICKLE CELL DISEASE
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the safety, tolerability, efficacy, pharmacokinetics and pharmacodynamics of osivelotor.
Study identification
- NCT ID
- NCT05431088
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 389 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 21, 2022
- Primary completion
- Dec 29, 2030
- Completion
- Dec 30, 2032
- Last update posted
- Aug 17, 2026
2022 – 2032
United States locations
- U.S. sites
- 46
- U.S. states
- 15
- U.S. cities
- 30
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| AMR Clinical | Mobile | Alabama | 36608 | Recruiting |
| Connecticut Children's Medical Center | Hartford | Connecticut | 06106 | Not yet recruiting |
| Smilow Cancer Hospital | New Haven | Connecticut | 06511 | Not yet recruiting |
| Edward Jenner Research Group LLC. | Plantation | Florida | 33317 | Recruiting |
| Pediatric Hematology / Oncology a division of Kidz Medical services | West Palm Beach | Florida | 33407 | Recruiting |
| St. Mary's Medical Center | West Palm Beach | Florida | 33407 | Recruiting |
| Children's Center for Advanced Pediatrics | Atlanta | Georgia | 30329 | Recruiting |
| Alpha Clinical Research Georgia | Dunwoody | Georgia | 30350 | Active, not recruiting |
| Sonar Clinical Research | Riverdale | Georgia | 30274 | Active, not recruiting |
| University of Illinois at Chicago Clinical Research Center | Chicago | Illinois | 60612 | Recruiting |
| University of Illinois Hospital and Health Sciences System - Investigational Drug Services (IDS) | Chicago | Illinois | 60612 | Recruiting |
| University of Illinois Hospital and Health Sciences System | Chicago | Illinois | 60612 | Recruiting |
| LSU Health Baton Rouge-North Clinic | Baton Rouge | Louisiana | 70805 | Active, not recruiting |
| Our Lady of the Lake Hospital, Inc. | Baton Rouge | Louisiana | 70808 | Active, not recruiting |
| Our lady of the Lake Hospital | Baton Rouge | Louisiana | 70808 | Active, not recruiting |
| University Medical Center New Orleans | New Orleans | Louisiana | 70112 | Active, not recruiting |
| Children's Hospital of Michigan | Detroit | Michigan | 48201 | Not yet recruiting |
| Great Lakes Research Institute, Flourish Detroit | Southfield | Michigan | 48075 | Not yet recruiting |
| Southern Specialty Research | Flowood | Mississippi | 39232 | Recruiting |
| Mississippi Center for Advanced Medicine | Madison | Mississippi | 39110 | Active, not recruiting |
| University Health | Kansas City | Missouri | 64108 | Recruiting |
| Jack & Sheryl Morris Cancer Center | New Brunswick | New Jersey | 08901 | Recruiting |
| Robert Wood Johnson University Hospital | New Brunswick | New Jersey | 08901 | Recruiting |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08901 | Recruiting |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | Recruiting |
| Jacobi Medical Center | The Bronx | New York | 10461 | Recruiting |
| Clinical & Translational Research Center (CTRC) | Chapel Hill | North Carolina | 27514 | Not yet recruiting |
| UNC Health | Chapel Hill | North Carolina | 27514 | Not yet recruiting |
| UNC Eastowne Medical Office Building - Consent Only | Chapel Hill | North Carolina | 27517 | Not yet recruiting |
| Duke University IDS Pharmacy | Durham | North Carolina | 27710 | Recruiting |
| Duke University Medical Center | Durham | North Carolina | 27710 | Recruiting |
| ECU Physicians, Brody Outpatient Clinic | Greenville | North Carolina | 27834 | Recruiting |
| UNC IDS | Morrisville | North Carolina | 27560 | Not yet recruiting |
| Prisma Health Laurens County Hospital | Clinton | South Carolina | 29325 | Recruiting |
| Prisma Health - Upstate | Greenville | South Carolina | 29605 | Recruiting |
| Prisma Health Greenville Memorial Hospital | Greenville | South Carolina | 29605 | Recruiting |
| Prisma Health Outpatient Radiology - Greenville | Greenville | South Carolina | 29605 | Recruiting |
| Prisma Health Patewood Hospital | Greenville | South Carolina | 29615 | Recruiting |
| Prisma Health Greer Memorial Hospital | Greer | South Carolina | 29650 | Recruiting |
| Prisma Health Hillcrest Hospital | Simpsonville | South Carolina | 29681 | Recruiting |
| Prisma Health North Greenville Hospital | Travelers Rest | South Carolina | 29690 | Recruiting |
| McGovern Medical School at UTHealth | Houston | Texas | 77030 | Active, not recruiting |
| Memorial Hermann Hospital, Texas Medical Center - Clinical Research Unit (CRU) | Houston | Texas | 77030 | Active, not recruiting |
| The University of Texas Health Science Center at Houston | Houston | Texas | 77030 | Active, not recruiting |
| UT Physicians Comprehensive Sickle Cell Clinic | Houston | Texas | 77030 | Active, not recruiting |
| Inova Schar Cancer Institute | Fairfax | Virginia | 22031 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 34 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05431088, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 17, 2026 · Synced Sep 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05431088 live on ClinicalTrials.gov.