A Study of YL201 in Patients With Advanced Solid Tumors
Public ClinicalTrials.gov record NCT05434234. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1A/1B, Multicenter, Nonrandomized, Open-Label, First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of YL201 as a Single Agent and in Combination With Other Anti-Cancer Therapies in Patients With Advanced Solid Tumors
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a phase 1, multicenter, nonrandomized, open-label, first-in-human study of YL201 conducted in China and the United States. The study will include 2 parts: a dose escalation part (Part 1) followed by a dose expansion part (Part 2). Part 1 will estimate the MTD/RED(s) in dose escalation cohorts of patients with advanced solid tumors unresponsive to currently available therapies or for whom no standard therapy is available. Part 2 will include patients with selected advanced solid tumor types enrolled at the MTD/RED(s), to better define the safety profile and evaluate the efficacy of YL201.
Study identification
- NCT ID
- NCT05434234
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 312 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 24, 2022
- Primary completion
- Apr 5, 2027
- Completion
- Oct 5, 2027
- Last update posted
- Jun 21, 2026
2022 – 2027
United States locations
- U.S. sites
- 19
- U.S. states
- 13
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| 002 | Fair Oaks | California | 95628 | Recruiting |
| 001 | La Jolla | California | 92093-0698 | Recruiting |
| 003 | Lone Tree | Colorado | 80124 | Recruiting |
| 004 | Washington D.C. | District of Columbia | 20007 | Recruiting |
| 005 | Boston | Massachusetts | 02114 | Recruiting |
| 006 | Ann Arbor | Michigan | 48109 | Recruiting |
| 007 | Detroit | Michigan | 48292 | Recruiting |
| 008 | St Louis | Missouri | 63110 | Recruiting |
| 009 | Santa Fe | New Mexico | 87505-699 | Recruiting |
| 010 | New York | New York | 10029 | Recruiting |
| 011 | Chapel Hill | North Carolina | 27514 | Recruiting |
| 012 | Nashville | Tennessee | 37203 | Recruiting |
| 014 | Houston | Texas | 77030 | Recruiting |
| 015 | Irving | Texas | 75039 | Recruiting |
| 013 | San Antonio | Texas | 78229 | Recruiting |
| 016 | Tyler | Texas | 75701 | Recruiting |
| 017 | Fairfax | Virginia | 22031 | Recruiting |
| 018 | Spokane | Washington | 99208 | Recruiting |
| 019 | Tacoma | Washington | 98405 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 26 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05434234, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 21, 2026 · Synced Sep 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05434234 live on ClinicalTrials.gov.