ClinicalTrials.gov record
Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases
ClinicalTrials.gov ID: NCT05438212
Public ClinicalTrials.gov record NCT05438212. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 8, 2026, 7:55 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Phase III Trial of Pre-Operative Compared to Post-Operative Stereotactic Radiosurgery in Patients With Resectable Brain Metastases
Study identification
- NCT ID
- NCT05438212
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- NRG Oncology
- Other
- Enrollment
- 237 participants
Conditions and interventions
Conditions
Interventions
- Brain Surgery Procedure
- Quality-of-Life Assessment Other
- Questionnaire Administration Other
- Stereotactic Radiosurgery Radiation
Procedure · Other · Radiation
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 23, 2022
- Primary completion
- Mar 15, 2027
- Completion
- Mar 15, 2027
- Last update posted
- May 6, 2026
2022 – 2027
United States locations
- U.S. sites
- 208
- U.S. states
- 31
- U.S. cities
- 157
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Saint Joseph's Hospital and Medical Center | Phoenix | Arizona | 85013 | — |
| Banner University Medical Center - Tucson | Tucson | Arizona | 85719 | — |
| University of Arizona Cancer Center-North Campus | Tucson | Arizona | 85719 | — |
| Kaiser Permanente-Anaheim | Anaheim | California | 92806 | — |
| Sutter Auburn Faith Hospital | Auburn | California | 95602 | — |
| Sutter Cancer Centers Radiation Oncology Services-Auburn | Auburn | California | 95603 | — |
| Kaiser Permanente-Bellflower | Bellflower | California | 90706 | — |
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care | Irvine | California | 92612 | — |
| Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | 90027 | — |
| Memorial Medical Center | Modesto | California | 95355 | — |
| Kaiser Permanente-Ontario | Ontario | California | 91761 | — |
| Saint Joseph Hospital - Orange | Orange | California | 92868 | — |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California | 92868 | — |
| Stanford Cancer Institute Palo Alto | Palo Alto | California | 94304 | — |
| Sutter Cancer Centers Radiation Oncology Services-Roseville | Roseville | California | 95661 | — |
| Sutter Roseville Medical Center | Roseville | California | 95661 | — |
| Sutter Medical Center Sacramento | Sacramento | California | 95816 | — |
| University of California Davis Comprehensive Cancer Center | Sacramento | California | 95817 | — |
| California Pacific Medical Center-Pacific Campus | San Francisco | California | 94115 | — |
| UCSF Medical Center-Parnassus | San Francisco | California | 94143 | — |
| Sutter Pacific Medical Foundation | Santa Rosa | California | 95403 | — |
| Sutter Solano Medical Center/Cancer Center | Vallejo | California | 94589 | — |
| UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables | Florida | 33146 | — |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida | 33442 | — |
| UM Sylvester Comprehensive Cancer Center at Doral | Doral | Florida | 33166 | — |
| Mayo Clinic in Florida | Jacksonville | Florida | 32224-9980 | — |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | 33136 | — |
| Miami Cancer Institute | Miami | Florida | 33176 | — |
| UM Sylvester Comprehensive Cancer Center at Plantation | Plantation | Florida | 33324 | — |
| Moffitt Cancer Center-International Plaza | Tampa | Florida | 33607 | — |
| Moffitt Cancer Center - McKinley Campus | Tampa | Florida | 33612 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Moffitt Cancer Center at Wesley Chapel | Wesley Chapel | Florida | 33544 | — |
| Grady Health System | Atlanta | Georgia | 30303 | — |
| Emory University Hospital Midtown | Atlanta | Georgia | 30308 | — |
| Piedmont Hospital | Atlanta | Georgia | 30309 | — |
| Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Emory Saint Joseph's Hospital | Atlanta | Georgia | 30342 | — |
| Hawaii Cancer Care Inc - Waterfront Plaza | Honolulu | Hawaii | 96813 | — |
| Queen's Cancer Cenrer - POB I | Honolulu | Hawaii | 96813 | — |
| Queen's Medical Center | Honolulu | Hawaii | 96813 | — |
| Straub Clinic and Hospital | Honolulu | Hawaii | 96813 | — |
| University of Hawaii Cancer Center | Honolulu | Hawaii | 96813 | — |
| Queen's Cancer Center - Kuakini | Honolulu | Hawaii | 96817 | — |
| The Cancer Center of Hawaii-Liliha | Honolulu | Hawaii | 96817 | — |
| Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | 96826 | — |
| Castle Medical Center | Kailua | Hawaii | 96734 | — |
| Wilcox Memorial Hospital and Kauai Medical Clinic | Lihue | Hawaii | 96766 | — |
| Hawaii Cancer Care - Westridge | ‘Aiea | Hawaii | 96701 | — |
| Pali Momi Medical Center | ‘Aiea | Hawaii | 96701 | — |
| The Queen's Medical Center - West Oahu | ‘Ewa Beach | Hawaii | 96706 | — |
| Advocate Outpatient Center - Aurora | Aurora | Illinois | 60506 | — |
| Advocate Good Shepherd Hospital | Barrington | Illinois | 60010 | — |
| Centralia Oncology Clinic | Centralia | Illinois | 62801 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| University of Chicago Comprehensive Cancer Center | Chicago | Illinois | 60637 | — |
| AMG Crystal Lake - Oncology | Crystal Lake | Illinois | 60014 | — |
| Carle at The Riverfront | Danville | Illinois | 61832 | — |
| Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | 62526 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Advocate Good Samaritan Hospital | Downers Grove | Illinois | 60515 | — |
| Carle Physician Group-Effingham | Effingham | Illinois | 62401 | — |
| Crossroads Cancer Center | Effingham | Illinois | 62401 | — |
| Elmhurst Memorial Hospital | Elmhurst | Illinois | 60126 | — |
| Advocate South Suburban Hospital | Hazel Crest | Illinois | 60429 | — |
| AMG Libertyville - Oncology | Libertyville | Illinois | 60048 | — |
| Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | 61938 | — |
| Edward Hospital/Cancer Center | Naperville | Illinois | 60540 | — |
| UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois | 60451 | — |
| Cancer Care Center of O'Fallon | O'Fallon | Illinois | 62269 | — |
| Advocate Christ Medical Center | Oak Lawn | Illinois | 60453-2699 | — |
| Advocate Lutheran General Hospital | Park Ridge | Illinois | 60068 | — |
| Southern Illinois University School of Medicine | Springfield | Illinois | 62702 | — |
| Springfield Clinic | Springfield | Illinois | 62702 | — |
| Springfield Memorial Hospital | Springfield | Illinois | 62781 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | 60555 | — |
| Ascension Saint Vincent Indianapolis Hospital | Indianapolis | Indiana | 46260 | — |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic | Ankeny | Iowa | 50023 | — |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic | Clive | Iowa | 50325 | — |
| Iowa Methodist Medical Center | Des Moines | Iowa | 50309 | — |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic | Des Moines | Iowa | 50309 | — |
| UI Health Care Mission Cancer and Blood - Laurel Clinic | Des Moines | Iowa | 50314 | — |
| UI Health Care Mission Cancer and Blood - Waukee Clinic | Waukee | Iowa | 50263 | — |
| Norton Brownsboro Hospital and Medical Campus | Louisville | Kentucky | 40241 | — |
| University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | 21201 | — |
| UM Upper Chesapeake Medical Center | Bel Air | Maryland | 21014 | — |
| UM Baltimore Washington Medical Center/Tate Cancer Center | Glen Burnie | Maryland | 21061 | — |
| UM Capital Region Medical Center | Largo | Maryland | 20774 | — |
| University of Michigan Rogel Cancer Center | Ann Arbor | Michigan | 48109 | — |
| Weisberg Cancer Treatment Center | Farmington Hills | Michigan | 48334 | — |
| Corewell Health William Beaumont University Hospital | Royal Oak | Michigan | 48073 | — |
| Corewell Health Beaumont Troy Hospital | Troy | Michigan | 48085 | — |
| Essentia Health Saint Joseph's Medical Center | Brainerd | Minnesota | 56401 | — |
| Essentia Health - Deer River Clinic | Deer River | Minnesota | 56636 | — |
| Essentia Health Cancer Center | Duluth | Minnesota | 55805 | — |
| Essentia Health Saint Mary's Medical Center | Duluth | Minnesota | 55805 | — |
| Miller-Dwan Hospital | Duluth | Minnesota | 55805 | — |
| Essentia Health Hibbing Clinic | Hibbing | Minnesota | 55746 | — |
| Coborn Cancer Center at Saint Cloud Hospital | Saint Cloud | Minnesota | 56303 | — |
| Essentia Health Sandstone | Sandstone | Minnesota | 55072 | — |
| Essentia Health Virginia Clinic | Virginia | Minnesota | 55792 | — |
| Parkland Health Center - Farmington | Farmington | Missouri | 63640 | — |
| Saint Luke's Hospital of Kansas City | Kansas City | Missouri | 64111 | — |
| Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri | 63670 | — |
| Mercy Hospital Springfield | Springfield | Missouri | 65804 | — |
| Missouri Baptist Medical Center | St Louis | Missouri | 63131 | — |
| Missouri Baptist Sullivan Hospital | Sullivan | Missouri | 63080 | — |
| BJC Outpatient Center at Sunset Hills | Sunset Hills | Missouri | 63127 | — |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | — |
| Benefis Sletten Cancer Institute | Great Falls | Montana | 59405 | — |
| Renown Regional Medical Center | Reno | Nevada | 89502 | — |
| Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center | Lebanon | New Hampshire | 03756 | — |
| Cooper Hospital University Medical Center | Camden | New Jersey | 08103 | — |
| Jersey City Medical Center | Jersey City | New Jersey | 07302 | — |
| Saint Barnabas Medical Center | Livingston | New Jersey | 07039 | — |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08903 | — |
| Newark Beth Israel Medical Center | Newark | New Jersey | 07112 | — |
| The Valley Hospital - Luckow Pavilion | Paramus | New Jersey | 07652 | — |
| Capital Health Medical Center-Hopewell | Pennington | New Jersey | 08534 | — |
| Valley Health System Ridgewood Campus | Ridgewood | New Jersey | 07450 | — |
| Community Medical Center | Toms River | New Jersey | 08755 | — |
| Valley Health System-Hematology/Oncology | Westwood | New Jersey | 07675 | — |
| New York-Presbyterian/Brooklyn Methodist Hospital | Brooklyn | New York | 11215 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| The New York Hospital Medical Center of Queens | Flushing | New York | 11355 | — |
| Northern Westchester Hospital | Mount Kisco | New York | 10549 | — |
| Mount Sinai Chelsea | New York | New York | 10011 | — |
| Mount Sinai West | New York | New York | 10019 | — |
| Mount Sinai Hospital | New York | New York | 10029 | — |
| NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center | New York | New York | 10032 | — |
| Manhattan Eye Ear and Throat Hospital | New York | New York | 10065 | — |
| NYP/Weill Cornell Medical Center | New York | New York | 10065 | — |
| Lenox Hill Hospital | New York | New York | 10075 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Stony Brook University Medical Center | Stony Brook | New York | 11794 | — |
| State University of New York Upstate Medical University | Syracuse | New York | 13210 | — |
| Montefiore Medical Center-Einstein Campus | The Bronx | New York | 10461 | — |
| Montefiore Medical Center-Weiler Hospital | The Bronx | New York | 10461 | — |
| Montefiore Medical Center - Moses Campus | The Bronx | New York | 10467 | — |
| Good Samaritan University Hospital | West Islip | New York | 11795 | — |
| Carolinas Medical Center/Levine Cancer Institute | Charlotte | North Carolina | 28203 | — |
| Atrium Health Cabarrus/LCI-Concord | Concord | North Carolina | 28025 | — |
| CaroMont Regional Medical Center | Gastonia | North Carolina | 28054 | — |
| Novant Health Cancer Institute Radiation Oncology - Wilmington | Wilmington | North Carolina | 28401 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| Sanford Broadway Medical Center | Fargo | North Dakota | 58122 | — |
| Sanford Roger Maris Cancer Center | Fargo | North Dakota | 58122 | — |
| Indu and Raj Soin Medical Center | Beavercreek | Ohio | 45431 | — |
| Case Western Reserve University | Cleveland | Ohio | 44106 | — |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | — |
| Riverside Methodist Hospital | Columbus | Ohio | 43214 | — |
| Grant Medical Center | Columbus | Ohio | 43215 | — |
| Delaware Health Center-Grady Cancer Center | Delaware | Ohio | 43015 | — |
| Grady Memorial Hospital | Delaware | Ohio | 43015 | — |
| Kettering Medical Center | Kettering | Ohio | 45429 | — |
| Mercy Health - Perrysburg Hospital | Perrysburg | Ohio | 43551 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Northeast Radiation Oncology Center | Dunmore | Pennsylvania | 18512 | — |
| Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania | 17033-0850 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| UPMC-Presbyterian Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC-Shadyside Hospital | Pittsburgh | Pennsylvania | 15232 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Gibbs Cancer Center-Gaffney | Gaffney | South Carolina | 29341 | — |
| Gibbs Cancer Center-Pelham | Greer | South Carolina | 29651 | — |
| Spartanburg Medical Center | Spartanburg | South Carolina | 29303 | — |
| SMC Center for Hematology Oncology Union | Union | South Carolina | 29379 | — |
| Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | 57104 | — |
| Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | 57117-5134 | — |
| The Children's Hospital at TriStar Centennial | Nashville | Tennessee | 37203 | — |
| Covenant Medical Center-Lakeside | Lubbock | Texas | 79410 | — |
| Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | 84112 | — |
| Inova Schar Cancer Institute | Fairfax | Virginia | 22031 | — |
| Henrico Doctor's Hospital | Richmond | Virginia | 23229 | — |
| CJW Medical Center - Johnston-Willis Campus | Richmond | Virginia | 23235 | — |
| VCU Massey Comprehensive Cancer Center | Richmond | Virginia | 23298 | — |
| Carilion Roanoke Memorial Hospital | Roanoke | Virginia | 24033 | — |
| Swedish Medical Center-Cherry Hill | Seattle | Washington | 98122-5711 | — |
| ThedaCare Regional Cancer Center | Appleton | Wisconsin | 54911 | — |
| Duluth Clinic Ashland | Ashland | Wisconsin | 54806 | — |
| Northwest Wisconsin Cancer Center | Ashland | Wisconsin | 54806 | — |
| Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin | 53105 | — |
| Aurora Health Care Germantown Health Center | Germantown | Wisconsin | 53022 | — |
| Aurora Cancer Care-Grafton | Grafton | Wisconsin | 53024 | — |
| Aurora BayCare Medical Center | Green Bay | Wisconsin | 54311 | — |
| Essentia Health-Hayward Clinic | Hayward | Wisconsin | 54843 | — |
| University of Wisconsin Carbone Cancer Center - Johnson Creek | Johnson Creek | Wisconsin | 53038 | — |
| Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin | 53142 | — |
| University of Wisconsin Carbone Cancer Center - Eastpark Medical Center | Madison | Wisconsin | 53718 | — |
| University of Wisconsin Carbone Cancer Center - University Hospital | Madison | Wisconsin | 53792 | — |
| Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin | 53209 | — |
| Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | 53215 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
| Aurora Sinai Medical Center | Milwaukee | Wisconsin | 53233 | — |
| Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin | 54904 | — |
| Aurora Cancer Care-Racine | Racine | Wisconsin | 53406 | — |
| Aspirus Cancer Care - James Beck Cancer Center | Rhinelander | Wisconsin | 54501 | — |
| Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin | 53081 | — |
| Essentia Health-Spooner Clinic | Spooner | Wisconsin | 54801 | — |
| Aspirus Cancer Care - Stevens Point | Stevens Point | Wisconsin | 54481 | — |
| Aurora Medical Center in Summit | Summit | Wisconsin | 53066 | — |
| Essentia Health Saint Mary's Hospital - Superior | Superior | Wisconsin | 54880 | — |
| UW Cancer Center at ProHealth Care | Waukesha | Wisconsin | 53188 | — |
| Aspirus Regional Cancer Center | Wausau | Wisconsin | 54401 | — |
| Aurora Cancer Care-Milwaukee West | Wauwatosa | Wisconsin | 53226 | — |
| Aurora West Allis Medical Center | West Allis | Wisconsin | 53227 | — |
| Aspirus Cancer Care - Wisconsin Rapids | Wisconsin Rapids | Wisconsin | 54494 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 8 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05438212, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 6, 2026 · Synced May 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05438212 live on ClinicalTrials.gov.