A Study to Learn About How 20-Valent Pneumococcal Conjugate Vaccine Works in a Real-world Setting

ClinicalTrials.gov ID: NCT05452941

Public ClinicalTrials.gov record NCT05452941. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 18, 2026, 6:17 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 4 Study Using a Test-Negative Design to Evaluate the Effectiveness of a 20-valent Pneumococcal Conjugate Vaccine Against Vaccine-type Radiologically-confirmed Community-acquired Pneumonia in Adults >/= 65 Years of Age

Study identification

NCT ID: NCT05452941
Recruitment status: Recruiting
Study type: Observational
Phase: Not listed
Lead sponsor: Pfizer; Industry
Enrollment: 12,500 participants

Conditions and interventions

Conditions

Pneumonia

Interventions

Diagnostic test on urine samples Diagnostic Test

Diagnostic Test

Eligibility (public fields only)

Age range: 65 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 26, 2022
Primary completion: Jun 3, 2027
Completion: Jun 3, 2027
Last update posted: May 10, 2026

2022 – 2027

United States locations

U.S. sites: 40
U.S. states: 12
U.S. cities: 28

Facility	City	State	ZIP	Site status
El Centro Regional Medical Center	El Centro	California	92243	Recruiting
Kaiser Permanente Fontana Medical Center	Fontana	California	92335	Recruiting
Kaiser Permanente West Los Angeles Medical Center	Los Angeles	California	90034	Recruiting
Kaiser Permanente Vaccine Study Center	Oakland	California	94612	Recruiting
Kaiser Permanente Oakland Medical Center	Oakland	California	96411	Recruiting
Kaiser Permanente Ontario Medical Center	Ontario	California	91761	Recruiting
Southern California Permanente Medical Group (SCPMG)	Pasadena	California	91101	Recruiting
Kaiser Permanente Riverside Medical Center	Riverside	California	92505	Recruiting
Kaiser Permanente Roseville Medical Center	Roseville	California	95661	Recruiting
Kaiser Permanente South Sacramento Medical Center	Sacramento	California	95823	Recruiting
Kaiser Permanente Sacramento Medical Center	Sacramento	California	95825	Recruiting
Kaiser Permanente Zion Medical Center	San Diego	California	92120	Recruiting
Kaiser Permanente San Diego Medical Center	San Diego	California	92123	Recruiting
Kaiser Permanente Santa Clara Medical Center	Santa Clara	California	95051	Recruiting
Kaiser Permanente South San Francisco Medical Center	South San Francisco	California	94080	Recruiting
Kaiser Permanente Walnut Creek Medical Center	Walnut Creek	California	94596	Recruiting
Starling Physicians	Hartford	Connecticut	06106	Active, not recruiting
MedStar Washington Hospital Center	Washington D.C.	District of Columbia	20010	Recruiting
Emory Children's Center - Vaccine Research Clinic (ECC-VRC)	Atlanta	Georgia	30322	Recruiting
Emory University Hospital	Atlanta	Georgia	30322	Recruiting
University of Louisville School of Medicine, Division of Infectious Diseases	Louisville	Kentucky	40202	Recruiting
Robley Rex VA Medical Center	Louisville	Kentucky	40206	Recruiting
UofL Health, Mary & Elizabeth Hospital	Louisville	Kentucky	40215	Recruiting
Norton Audubon Hospital	Louisville	Kentucky	40217	Recruiting
Norton Brownsboro Hospital	Louisville	Kentucky	40241	Recruiting
Norton Women's and Children's Hospital	Louisville	Kentucky	40241	Recruiting
Ochsner Medical Center - Kenner	Kenner	Louisiana	70065	Recruiting
Ochsner Baptist Medical Center	New Orleans	Louisiana	70115	Recruiting
Ochsner Clinic Foundation	New Orleans	Louisiana	70121	Recruiting
University of Maryland	Baltimore	Maryland	21201	Recruiting
UMass Memorial Medical Center	Worcester	Massachusetts	01655	Recruiting
ECU Health Medical Center	Greenville	North Carolina	27834	Recruiting
UNC Hospitals Hillsborough Campus	Hillsborough	North Carolina	27278	Recruiting
Summa Health Clinical Research Center - Specialty	Akron	Ohio	44304	Recruiting
Summa Health	Akron	Ohio	44304	Recruiting
Ahuja Medical Center	Beachwood	Ohio	44122	Recruiting
University Hospitals Cleveland Medical Center	Cleveland	Ohio	44106	Recruiting
Kaiser Permanente Sunnyside Medical Center	Clackamas	Oregon	97015	Recruiting
Memorial Hermann Hospital	Houston	Texas	77030	Recruiting
Michael E. DeBakey VA Medical Center	Houston	Texas	77030	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 14 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05452941, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 10, 2026 · Synced May 18, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05452941 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →