A Study to Learn About How 20-Valent Pneumococcal Conjugate Vaccine Works in a Real-world Setting
Public ClinicalTrials.gov record NCT05452941. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 4 Study Using a Test-Negative Design to Evaluate the Effectiveness of a 20-valent Pneumococcal Conjugate Vaccine Against Vaccine-type Radiologically-confirmed Community-acquired Pneumonia in Adults >/= 65 Years of Age
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to learn about how well the 20-valent pneumococcal conjugate vaccine (20vPnC) works against radiologically-confirmed community-acquired pneumonia (RAD+CAP) due to the 7 new serotypes (types of a bacteria called Streptococcus pneumoniae that cause pneumonia) included in 20vPnC vaccine. This study is seeking participants who: * are male or female ≥65 years of age. * are hospitalized with physician suspicion of community acquired pneumonia (CAP). * have pneumonia confirmed with imaging like a chest x-ray Participants will be asked to provide demographic and medical history information, and to provide a urine sample that will be used to test for pneumonia caused by specific strains of a bacteria called Streptococcus pneumoniae. We will compare the proportion of participants who have pneumonia caused by specific strains of the bacteria Streptococcus pneumoniae and were previously vaccinated with 20vPnC with the proportion of participants who have pneumonia caused by something other than vaccine type Streptococcus pneumoniae and have been vaccinated with 20vPnC. Participants will actively take part in the study for about 1-2 days. Information on participant's illness and hospitalization details will be collected through day 30 of their hospitalization through medical chart review.
Study identification
- NCT ID
- NCT05452941
- Recruitment status
- Recruiting
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 12,500 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 65 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 26, 2022
- Primary completion
- Jun 3, 2027
- Completion
- Jun 3, 2027
- Last update posted
- May 10, 2026
2022 – 2027
United States locations
- U.S. sites
- 40
- U.S. states
- 12
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| El Centro Regional Medical Center | El Centro | California | 92243 | Recruiting |
| Kaiser Permanente Fontana Medical Center | Fontana | California | 92335 | Recruiting |
| Kaiser Permanente West Los Angeles Medical Center | Los Angeles | California | 90034 | Recruiting |
| Kaiser Permanente Vaccine Study Center | Oakland | California | 94612 | Recruiting |
| Kaiser Permanente Oakland Medical Center | Oakland | California | 96411 | Recruiting |
| Kaiser Permanente Ontario Medical Center | Ontario | California | 91761 | Recruiting |
| Southern California Permanente Medical Group (SCPMG) | Pasadena | California | 91101 | Recruiting |
| Kaiser Permanente Riverside Medical Center | Riverside | California | 92505 | Recruiting |
| Kaiser Permanente Roseville Medical Center | Roseville | California | 95661 | Recruiting |
| Kaiser Permanente South Sacramento Medical Center | Sacramento | California | 95823 | Recruiting |
| Kaiser Permanente Sacramento Medical Center | Sacramento | California | 95825 | Recruiting |
| Kaiser Permanente Zion Medical Center | San Diego | California | 92120 | Recruiting |
| Kaiser Permanente San Diego Medical Center | San Diego | California | 92123 | Recruiting |
| Kaiser Permanente Santa Clara Medical Center | Santa Clara | California | 95051 | Recruiting |
| Kaiser Permanente South San Francisco Medical Center | South San Francisco | California | 94080 | Recruiting |
| Kaiser Permanente Walnut Creek Medical Center | Walnut Creek | California | 94596 | Recruiting |
| Starling Physicians | Hartford | Connecticut | 06106 | Active, not recruiting |
| MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | Recruiting |
| Emory Children's Center - Vaccine Research Clinic (ECC-VRC) | Atlanta | Georgia | 30322 | Recruiting |
| Emory University Hospital | Atlanta | Georgia | 30322 | Recruiting |
| University of Louisville School of Medicine, Division of Infectious Diseases | Louisville | Kentucky | 40202 | Recruiting |
| Robley Rex VA Medical Center | Louisville | Kentucky | 40206 | Recruiting |
| UofL Health, Mary & Elizabeth Hospital | Louisville | Kentucky | 40215 | Recruiting |
| Norton Audubon Hospital | Louisville | Kentucky | 40217 | Recruiting |
| Norton Brownsboro Hospital | Louisville | Kentucky | 40241 | Recruiting |
| Norton Women's and Children's Hospital | Louisville | Kentucky | 40241 | Recruiting |
| Ochsner Medical Center - Kenner | Kenner | Louisiana | 70065 | Recruiting |
| Ochsner Baptist Medical Center | New Orleans | Louisiana | 70115 | Recruiting |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | Recruiting |
| University of Maryland | Baltimore | Maryland | 21201 | Recruiting |
| UMass Memorial Medical Center | Worcester | Massachusetts | 01655 | Recruiting |
| ECU Health Medical Center | Greenville | North Carolina | 27834 | Recruiting |
| UNC Hospitals Hillsborough Campus | Hillsborough | North Carolina | 27278 | Recruiting |
| Summa Health Clinical Research Center - Specialty | Akron | Ohio | 44304 | Recruiting |
| Summa Health | Akron | Ohio | 44304 | Recruiting |
| Ahuja Medical Center | Beachwood | Ohio | 44122 | Recruiting |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | Recruiting |
| Kaiser Permanente Sunnyside Medical Center | Clackamas | Oregon | 97015 | Recruiting |
| Memorial Hermann Hospital | Houston | Texas | 77030 | Recruiting |
| Michael E. DeBakey VA Medical Center | Houston | Texas | 77030 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 14 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05452941, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 10, 2026 · Synced Sep 5, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05452941 live on ClinicalTrials.gov.