A Study of MK-2214 in Adults With Mild Cognitive Impairment or Mild-to-Moderate Alzheimer's Disease (MK-2214-002)
Public ClinicalTrials.gov record NCT05466422. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multiple Ascending Dose Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MK-2214 in Adults With Mild Cognitive Impairment or Mild-to-Moderate Alzheimer's Disease
Study identification
- NCT ID
- NCT05466422
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1
- Lead sponsor
- Merck Sharp & Dohme LLC
- Industry
- Enrollment
- 34 participants
Conditions and interventions
Conditions
Interventions
- MK-2214 Biological
- Placebo Drug
Biological · Drug
Eligibility (public fields only)
- Age range
- 50 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 19, 2022
- Primary completion
- Jul 2, 2025
- Completion
- Jul 2, 2025
- Last update posted
- Aug 26, 2025
2022 – 2025
United States locations
- U.S. sites
- 12
- U.S. states
- 5
- U.S. cities
- 12
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| California Clinical Trials Medical Group managed by PAREXEL-PAREXEL International ( Site 0007) | Glendale | California | 91206 | — |
| Collaborative Neuroscience Research, LLC ( Site 0009) | Los Alamitos | California | 90720 | — |
| NRC Research Institute ( Site 0015) | Orange | California | 92868 | — |
| Velocity Clinical Research, Hallandale Beach ( Site 0001) | Hallandale | Florida | 33009 | — |
| Research Centers of America ( Hollywood ) ( Site 0004) | Hollywood | Florida | 33024 | — |
| K2 Medical Research ( Site 0005) | Maitland | Florida | 32751 | — |
| Charter Research - Winter Park ( Site 0012) | Orlando | Florida | 32803 | — |
| Progressive Medical Research-Alzheimer's Team ( Site 0013) | Port Orange | Florida | 32127 | — |
| Charter Research - Lady Lake ( Site 0011) | The Villages | Florida | 32162 | — |
| CenExel iResearch, LLC ( Site 0002) | Decatur | Georgia | 30030 | — |
| Global Medical Institutes LLC; Princeton Medical Institute ( Site 0003) | Princeton | New Jersey | 08540 | — |
| Neuro-Behavioral Clinical Research ( Site 0016) | North Canton | Ohio | 44720 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05466422, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 26, 2025 · Synced May 7, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05466422 live on ClinicalTrials.gov.