A Study of TSC-100 and TSC-101 in AML, ALL and MDS in Patients Undergoing Allogeneic Peripheral Blood Stem Transplantation

ClinicalTrials.gov ID: NCT05473910

Public ClinicalTrials.gov record NCT05473910. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 19, 2026, 5:45 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Controlled Multi-Arm Phase 1 Umbrella Study Evaluating the Safety and Feasibility of T-Cell Receptor Engineered Donor T-Cells Targeting HA1 (TSC-100) or HA2 (TSC-101) in HLA-A0201 Positive Patients Undergoing Allogeneic Peripheral Blood Stem Cell Transplantation

Study identification

NCT ID: NCT05473910
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1
Lead sponsor: TScan Therapeutics, Inc.; Industry
Enrollment: 75 participants

Conditions and interventions

Conditions

Interventions

Control Other
SOC + TSC-100 Drug
SOC + TSC-101 Drug

Other · Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 31, 2022
Primary completion: May 31, 2026
Completion: May 31, 2026
Last update posted: Apr 7, 2026

2022 – 2026

United States locations

U.S. sites: 15
U.S. states: 13
U.S. cities: 14

Facility	City	State	ZIP	Site status
City of Hope	Duarte	California	91010	Recruiting
Yale	New Haven	Connecticut	06510	Recruiting
Memorial Healthcare System	Hollywood	Florida	33021	Recruiting
Northside Hospital	Atlanta	Georgia	30342	Recruiting
John Hopkins University	Baltimore	Maryland	21287	Recruiting
Mass General Hospital	Boston	Massachusetts	02114	Recruiting
Karmanos Cancer Institute	Detroit	Michigan	48201	Recruiting
Hackensack University Medical Center	Hackensack	New Jersey	07601	Recruiting
Columbia University	New York	New York	10027	Recruiting
Mount Sinai	New York	New York	10029-6696	Recruiting
University North Carolina	Chapel Hill	North Carolina	27599	Recruiting
UPenn	Philadelphia	Pennsylvania	19104	Recruiting
Baylor University Medical Center	Dallas	Texas	75246	Recruiting
MD Anderson	Houston	Texas	77030	Recruiting
Froedert and Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05473910, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 7, 2026 · Synced May 19, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05473910 live on ClinicalTrials.gov.

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