ClinicalTrials.gov record
Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial
ClinicalTrials.gov ID: NCT05478304
Public ClinicalTrials.gov record NCT05478304. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This trial is a prospective, randomized, multicenter, multinational, blinded, superiority trial. The objective of this trial is to evaluate the effectiveness of left atrial appendage exclusion (LAAE) for the prevention of ischemic stroke or systemic arterial embolism in subjects undergoing cardiac surgery who have risk factors for atrial fibrillation and ischemic stroke.
Study identification
- NCT ID
- NCT05478304
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 6,573 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 25, 2023 (Actual)
- Primary completion
- Dec 2031 (Estimated)
- Completion
- Apr 2032 (Estimated)
- Last update posted
- Mar 24, 2026
2023 – 2032
United States locations
- U.S. sites
- 102
- U.S. states
- 38
- U.S. cities
- 84
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Heart Center Research / Huntsville Hospital | Huntsville | Alabama | 35801 | — |
| HonorHealth Shea Scottsdale Healthcare | Scottsdale | Arizona | 85258 | — |
| St. Bernard's Heart & Vascular | Jonesboro | Arkansas | 72401 | — |
| CHI St. Vincent | Little Rock | Arkansas | 72205 | — |
| Arkansas Heart Hospital | Little Rock | Arkansas | 72211 | — |
| Memorial Care Long Beach Medical Center | Long Beach | California | 90806 | — |
| Keck Medical Center of USC | Los Angeles | California | 90033 | — |
| Hoag Memorial Hospital Presbyterian | Newport Beach | California | 92663 | — |
| Sutter Sacramento Hospital | Sacramento | California | 95816 | — |
| Stanford University | Stanford | California | 94305 | — |
| University of Colorado | Boulder | Colorado | 80309 | — |
| Hartford Hospital | Hartford | Connecticut | 06102 | — |
| Christiana Care Health Services | Newark | Delaware | 19718 | — |
| Medstar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| HCA Florida JFK Hospital | Atlantis | Florida | 33462 | — |
| HealthPark Medical Center | Fort Myers | Florida | 33908 | — |
| University of Florida Hospital | Gainesville | Florida | 32610 | — |
| Memorial Regional Hospital | Hollywood | Florida | 33021 | — |
| Baptist Health Jacksonville | Jacksonville | Florida | 32207 | — |
| Baptist Health South Florida | Miami | Florida | 33176 | — |
| Orlando Regional Medical Center | Orlando | Florida | 32806 | — |
| Sarasota Memorial Hospital | Sarasota | Florida | 34239 | — |
| Tampa General Hospital | Tampa | Florida | 33606 | — |
| Baycare Health System | Tampa | Florida | 33607 | — |
| Emory University Hospital | Atlanta | Georgia | 30308 | — |
| Piedmont Hospital | Atlanta | Georgia | 30309 | — |
| Wellstar - Kennestone | Marietta | Georgia | 30060 | — |
| St. Luke's Regional Medical Center | Boise | Idaho | 83712 | — |
| Portneuf Medical Center | Idaho Falls | Idaho | 83404 | — |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Memorial Hospital (SIU Medicine) | Springfield | Illinois | 62702 | — |
| Ascension St. Vincent | Carmel | Indiana | 46290 | — |
| Franciscan | Indianapolis | Indiana | 46237 | — |
| Mercy Medical Center | Des Moines | Iowa | 50266 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52245 | — |
| St. Luke's Hospital | Kansas City | Kansas | 64111 | — |
| Kansas University Medical Center | Kansas City | Kansas | 66160 | — |
| Baptist Health | Lexington | Kentucky | 40503 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Norton Healthcare | Louisville | Kentucky | 40202 | — |
| University of Louisville Health / Jewish Hospital | Louisville | Kentucky | 40202 | — |
| Novant Presbyterian Hospital | Louisville | Kentucky | 40205 | — |
| Our Lady of the Lake Hospital | Baton Rouge | Louisiana | 70808 | — |
| Johns Hopkins Hospital | Baltimore | Maryland | 21287 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Corewell Health | Grand Rapids | Michigan | 49503 | — |
| Corewell Health East | Royal Oak | Michigan | 48073 | — |
| Munson Medical Center | Traverse City | Michigan | 49684 | — |
| Trinity Health (formerly St. Joseph Mercy) | Ypsilanti | Michigan | 48197 | — |
| Mercy Medical Center | Coon Rapids | Minnesota | 55433 | — |
| Abbott Northwestern / Minneapolis Heart | Minneapolis | Minnesota | 55407 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| North Mississippi Medical Center | Tupelo | Mississippi | 38801 | — |
| Midwest Heart and Vascular (HCA) | Kansas City | Missouri | 64132 | — |
| St. Lukes Hospital | St Louis | Missouri | 63017 | — |
| Washington University | St Louis | Missouri | 63110 | — |
| Mercy Hospital St. Louis | St Louis | Missouri | 63141 | — |
| Nebraska Methodist | Omaha | Nebraska | 68114 | — |
| The Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| North Shore University Hospital (Northwell) | Manhasset | New York | 11030 | — |
| St. Francis Hospital | Roslyn | New York | 11576 | — |
| St. Joseph Hospital | Syracuse | New York | 13203 | — |
| Atrium Health Carolinas Medical Center | Charlotte | North Carolina | 28203 | — |
| Duke University | Durham | North Carolina | 27705 | — |
| WakeMed Health & Hospitals | Raleigh | North Carolina | 27610 | — |
| Wake Forest Baptist | Winston-Salem | North Carolina | 27157 | — |
| TriHealth / Bethesda North Hospital | Cincinnati | Ohio | 45202 | — |
| Christ Hospital / Lindner Research Center | Cincinnati | Ohio | 45219 | — |
| University Hospitals of Cleveland | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Ohio State Medical Center | Columbus | Ohio | 43210 | — |
| Riverside Methodist | Columbus | Ohio | 43214 | — |
| The Toledo Hospital (Promedica) | Toledo | Ohio | 43606 | — |
| Lehigh Valley Health Network | Allentown | Pennsylvania | 18103 | — |
| UPMC Pinnacle | Harrisburg | Pennsylvania | 17050 | — |
| Lancaster General Hospital | Lancaster | Pennsylvania | 17602 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| UPMC Health System | Pittsburgh | Pennsylvania | 15232 | — |
| Lankenau Hospital | Wynnewood | Pennsylvania | 19096 | — |
| Medical University of South Carolina (MUSC) | Charleston | South Carolina | 29425 | — |
| Sanford USD Medical Center | Sioux Falls | South Dakota | 57105 | — |
| Jackson Madison County General | Jackson | Tennessee | 38301 | — |
| Centennial Medical Center (TriStar) | Nashville | Tennessee | 37203 | — |
| Ascension St. Thomas West | Nashville | Tennessee | 37205 | — |
| UT Dell Medical School | Austin | Texas | 78705 | — |
| HCA Medical City Dallas | Dallas | Texas | 75243 | — |
| University of Texas Southwestern | Dallas | Texas | 75390 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| Baylor Heart Hospital - Plano | Plano | Texas | 75093 | — |
| Trinity Mother Frances (CHRISTUS) | Tyler | Texas | 75702 | — |
| University of Utah | Salt Lake City | Utah | 84132 | — |
| Inova Fairfax Medical | Falls Church | Virginia | 22042 | — |
| Sentara Hospitals & Sentara Medical Group | Norfolk | Virginia | 23507 | — |
| Swedish Heart and Vascular Research | Seattle | Washington | 98122 | — |
| Charleston Area Medical Center (CAMC) | Charleston | West Virginia | 25301 | — |
| West Virginia University | Morgantown | West Virginia | 26506 | — |
| Aspirus Hospital | Wausau | Wisconsin | 54401 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 36 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05478304, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 24, 2026 · Synced Oct 25, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05478304 live on ClinicalTrials.gov.