Phase 2 Study of DKN-01 in Colorectal Cancer
Public ClinicalTrials.gov record NCT05480306. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized Phase 2 Study of DKN-01 Plus FOLFIRI/FOLFOX and Bevacizumab Versus FOLFIRI/FOLFOX and Bevacizumab as Second-line Treatment of Advanced Colorectal Cancer (DeFianCe)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 2 randomized, open-label, two-part, multicenter study with a safety run-in to evaluate efficacy and safety of DKN-01 plus FOLFIRI/FOLFOX and bevacizumab versus standard of care (SOC) \[FOLFIRI/FOLFOX and bevacizumab\] as second-line treatment of advanced CRC patients.
Study identification
- NCT ID
- NCT05480306
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 188 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 30, 2022 (Actual)
- Primary completion
- Jul 10, 2025 (Actual)
- Completion
- Jul 10, 2025 (Actual)
- Last update posted
- Aug 3, 2025
2022 – 2025
United States locations
- U.S. sites
- 25
- U.S. states
- 13
- U.S. cities
- 22
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| The University of Arizona Cancer Center | Tucson | Arizona | 85719 | — |
| UCLA | Los Angeles | California | 90404 | — |
| Florida Cancer Specialists & Research Institute (FCS) | Cape Coral | Florida | 33909 | — |
| Florida Cancer Specialists & Research Institute | Fleming Island | Florida | 32003 | — |
| Florida Cancer Specialists & Research Institute | Gainesville | Florida | 32605 | — |
| Miami Cancer Institute | Miami | Florida | 33176 | — |
| Florida Cancer Specialists & Research Institute | Wellington | Florida | 33414 | — |
| Hematology Oncology Clinic | Baton Rouge | Louisiana | 70809 | — |
| Center for Cancer and Blood Disorders | Bethesda | Maryland | 20817 | — |
| Oncology Hematology Associates - Springfield | Springfield | Missouri | 65807 | — |
| Northwell Health | Lake Success | New York | 11020 | — |
| New York University | New York | New York | 10016 | — |
| Cornell University | New York | New York | 10021 | — |
| Mount Sinai Medical Center - New York | New York | New York | 10029 | — |
| White Plains Hospital | White Plains | New York | 10601 | — |
| Messino Cancer Centers | Asheville | North Carolina | 28806 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Wake Forest University | Winston-Salem | North Carolina | 27157 | — |
| Prisma Health Cancer Institute - Faris | Greenville | South Carolina | 29605 | — |
| Sanford Cancer Center | Sioux Falls | South Dakota | 57104 | — |
| Tennessee Oncology | Chattanooga | Tennessee | 37404 | — |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | — |
| Tennessee Oncology | Nashville | Tennessee | 37203 | — |
| MultiCare Tacoma General Hospital | Tacoma | Washington | 98405 | — |
| University of Wisconsin Hospital and Clinics | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 15 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05480306, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 3, 2025 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05480306 live on ClinicalTrials.gov.