Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis

ClinicalTrials.gov ID: NCT05485961

Public ClinicalTrials.gov record NCT05485961. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 3:54 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2b / 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Combined Dose-Finding and Cardiovascular Outcome Study to Investigate the Efficacy and Safety of CSL300 (Clazakizumab) in Subjects With End Stage Kidney Disease Undergoing Dialysis

Study identification

NCT ID: NCT05485961
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2, Phase 3
Lead sponsor: CSL Behring; Industry
Enrollment: 2,310 participants

Conditions and interventions

Conditions

Interventions

CSL300 Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 20, 2022
Primary completion: May 21, 2029
Completion: May 21, 2029
Last update posted: Apr 30, 2026

2022 – 2029

United States locations

U.S. sites: 163
U.S. states: 33
U.S. cities: 121

Facility	City	State	ZIP	Site status
Nephrology of North Alabama	Decatur	Alabama	35601	Recruiting
Nephrology Consultants, LLC	Huntsville	Alabama	35805	Recruiting
DaVita Clinical Research Montgomery	Montgomery	Alabama	36117	Recruiting
AKDHC Medical	Glendale	Arizona	85305	Recruiting
Kidney Disease Medical Group	Glendale	Arizona	91206	Recruiting
AKDHC Medical	Phoenix	Arizona	85018	Recruiting
AKDHC Medical	Tucson	Arizona	85705	Recruiting
Southern Arizona VA Health Care System	Tucson	Arizona	85723	Recruiting
National Institute of Clinical Research	Bakersfield	California	93309	Recruiting
Amicis Research Center	Beverly Hills	California	90211	Recruiting
California Institute of Renal Research	Chula Vista	California	91910	Recruiting
The Medical Research Group, Inc.	Fresno	California	93720	Recruiting
Davita Fullerton Dialysis Center	Fullerton	California	92832	Recruiting
National Institute of Clinical Research, Inc.	Fullerton	California	92835	Recruiting
National Institute of Clinical Research, Inc.	Garden Grove	California	92843	Recruiting
St. Jude Medical Center	Garden Grove	California	92843	Recruiting
National Institute of Clinical Research	Garden Grove	California	92844	Recruiting
Sherman Medical Group, Inc	Glendale	California	91204	Recruiting
Kidney Disease Medical Group	Glendale	California	91206	Recruiting
Renal Consultants Medical Group	Granada Hills	California	91344	Recruiting
Balboa Research	La Jolla	California	92037	Recruiting
California Institute of Renal Research	La Mesa	California	91942	Recruiting
Southern California Medical Research Center	La Palma	California	90623	Recruiting
Academic Medical Research Institute	Los Angeles	California	90022	Recruiting
National Institute of Clinical Research, Inc.	Los Angeles	California	90027	Recruiting
DaVita Carabello Dialysis Center	Los Angeles	California	90033	Suspended
Cedars-Sinai Medical Center	Los Angeles	California	90048	Recruiting
Renal Medical Associates/NARI	Lynwood	California	90262	Recruiting
Amicis Research Center	Northridge	California	91324	Recruiting
FORMAT Medical Research	Oxnard	California	93036	Recruiting
Van Buren Dialysis Center	Riverside	California	92504	Recruiting
National Nephrology Alliance Research - Riverside	Riverside	California	92505	Recruiting
Central Coast Nephrology Medical Corp	Salinas	California	93901	Recruiting
California Institute of Renal Research	San Diego	California	92111	Recruiting
California Institute of Renal Research	San Diego	California	92123	Suspended
North America Research Institute	San Dimas	California	91773	Recruiting
Satellite Healthcare	San Jose	California	95126	Suspended
Nephrology Educational Services	Tarzana	California	91356	Recruiting
Valiance Clinical Research	Tarzana	California	91356	Recruiting
Amicis Research Center	Vacaville	California	95687	Recruiting
National Institute of Clinical Research, Inc	Victorville	California	92392	Recruiting
DaVita Vista Del Sol Dialysis	Victorville	California	92394	Recruiting
Western Nephrology	Arvada	Colorado	80002	Recruiting
Kidney Associates of Colorado, P.C.	Denver	Colorado	80210	Recruiting
Colorado Kidney Care	Denver	Colorado	80230	Recruiting
Greater Hartford Nephrology, LLC	Bloomfield	Connecticut	06002	Recruiting
Nephrology and Hypertension Associates PC	Middlebury	Connecticut	06762	Recruiting
Nephrology Associates (Delaware)	Newark	Delaware	19713	Recruiting
- Boca Raton Regional - Research Physicians Network Alliance	Boca Raton	Florida	33431	Recruiting
Nova Clinical Research, LLC	Bradenton	Florida	34209	Recruiting
Access Research Institute	Brooksville	Florida	34613	Recruiting
Horizon Research Group LLC	Coral Gables	Florida	33134	Recruiting
South Florida Nephrology Group, PA	Coral Springs	Florida	33071	Recruiting
Family First Medical Research Center	Hialeah Gardens	Florida	33016	Recruiting
Advanced Medical Research Group	Hollywood	Florida	33021	Recruiting
Royal Research, Corp	Hollywood	Florida	33021	Recruiting
Elixia Pines	Hollywood	Florida	33024	Recruiting
South Florida Research Institute	Lauderdale Lakes	Florida	33313	Recruiting
South Florida Research Organization LLC	Medley	Florida	33166	Recruiting
Aviva Health Sciences	Miami	Florida	33125	Recruiting
Iconic Clinical Research Center	Miami	Florida	33126	Recruiting
Total Research Group, LLC	Miami	Florida	33126	Recruiting
Kidney and Hypertension Specialists of Miami	Miami	Florida	33150	Recruiting
Nephrology Associates of South Miami	Miami	Florida	33173	Recruiting
Floridian Clinical Research	Miami Lakes	Florida	33016	Recruiting
Elixia Central Florida	Orlando	Florida	32806	Recruiting
Infigo Clinical Research LLC	Sanford	Florida	32771	Recruiting
Genesis Clinical Research	Tampa	Florida	33603	Suspended
Florida Kidney Specialists	Temple Terrace	Florida	33637	Recruiting
Florida Premier Research Institute	Winter Park	Florida	32789	Recruiting
Southwest Georgia Nephrology Clinic	Albany	Georgia	31701	Recruiting
Coastal Medical Research, LLC	Brunswick	Georgia	31520	Recruiting
Renal Associates LLC	Columbus	Georgia	31904	Recruiting
National Clinical Trials	Cordele	Georgia	31015	Recruiting
American Clinical Trials	Douglasville	Georgia	30101	Recruiting
Georgia Nephrology	Lawrenceville	Georgia	30046	Recruiting
Atekha Nephrology Clinic LLC	Statesboro	Georgia	30458	Completed
NANI Research	Fort Wayne	Indiana	46804	Recruiting
Nephrology Physician's LLC	Mishawaka	Indiana	46545	Recruiting
Dunes Clinical Research LLC	Sioux City	Iowa	57049	Recruiting
Kansas Nephrology Physicians, PA	Wichita	Kansas	67214	Recruiting
Nephrology Associates of Kentuckiana, PSC	Louisville	Kentucky	40205	Recruiting
Renal Associates of Baton Rouge	Baton Rouge	Louisiana	70808	Recruiting
Tufts Medical Center	Boston	Massachusetts	02111	Recruiting
Massachusetts General Hospital	Boston	Massachusetts	02114	Recruiting
Paragon Health, Inc	Kalamazoo	Michigan	49007	Recruiting
Michigan Kidney Consultants, PC	Pontiac	Michigan	48341	Recruiting
St. Clair Nephrology Research	Roseville	Michigan	48066	Recruiting
Center for Advanced Kidney Research, PLC	Saint Clair Shores	Michigan	48081	Recruiting
DCR Edina	Minneapolis	Minnesota	55404	Recruiting
Minneapolis VA Health Care System	Minneapolis	Minnesota	55439	Recruiting
Southwest Mississippi Nephrology PLLC	Brookhaven	Mississippi	39601	Completed
Nephrology Associates, PC	Columbus	Mississippi	39705	Recruiting
- Nephrology and Hypertension Associates Ltd	Tupelo	Mississippi	38801	Recruiting
Clinical Research Consultants	Kansas City	Missouri	64111	Recruiting
Kansas City VA Medical Center	Kansas City	Missouri	64128	Recruiting
DCI-Rockhill	Kansas City	Missouri	64131	Recruiting
GSR Enterprises, Inc.	Lincoln	Nebraska	68510	Recruiting
Great Plains Health - Nephrology	North Platte	Nebraska	69101	Recruiting
DaVita Clinical Research - Henderson	Henderson	Nevada	89074	Recruiting
Kidney Specialists of Southern Nevada	Las Vegas	Nevada	89106	Recruiting
Sierra Nevada Specialty Care	Reno	Nevada	89511	Recruiting
Seacoast Kidney and Hypertension Specialists	Portsmouth	New Hampshire	03801	Recruiting
Hypertension & Nephrology Association	Eatontown	New Jersey	07724	Recruiting
New Jersey Kidney Care	Jersey City	New Jersey	07305	Recruiting
U.S. Renal Care - Gallup	Gallup	New Mexico	87301	Recruiting
Albany Medical College Committee of Research Involving Human Subjects	Albany	New York	12208	Recruiting
SUNY Downstate Medical Center Brooklyn	Brooklyn	New York	11203	Recruiting
Mattoo & Bhat Medical Associates, P.C.	College Point	New York	11356	Recruiting
NYU Langone Hospital - Long Island	Mineola	New York	11501	Recruiting
DaVita Clinic Research Bronx	The Bronx	New York	10461	Completed
Albert Einstein College of Medicine - Montefiore Medical Center	The Bronx	New York	10467	Recruiting
James J Peters VA Medical Center	The Bronx	New York	10468	Recruiting
Metrolina Nephrology Associates, PA	Charlotte	North Carolina	28204	Recruiting
Durham Nephrology Associates, PA	Durham	North Carolina	27704	Recruiting
Duke Translational Medicine Institute	Durham	North Carolina	27705	Recruiting
East Carolina University	Greenville	North Carolina	27858	Recruiting
Eastern Nephrology Associates, PLLC	Kinston	North Carolina	28504	Recruiting
North Carolina Nephrology, PA	Raleigh	North Carolina	27610	Recruiting
Nephrology Associates of the Carolinas	Shelby	North Carolina	28150	Recruiting
HNC Dialysis, Ltd.	Columbus	Ohio	43215	Recruiting
Northeast Clinical Research Center, LLC	Bethlehem	Pennsylvania	18017	Recruiting
Clinical Renal Associates, LTD	Exton	Pennsylvania	19341	Recruiting
Lifespan Clinical Research	East Providence	Rhode Island	02915	Recruiting
Columbia Nephrology	Columbia	South Carolina	29203	Recruiting
Dialysis Clinic, Inc.	Spartanburg	South Carolina	29301	Recruiting
DaVita Clinical Research	Spartanburg	South Carolina	29306	Recruiting
Southeast Renal Research Institute	Chattanooga	Tennessee	37404	Recruiting
Dialysis Clinic Inc - University Nephology	Knoxville	Tennessee	37920	Recruiting
Knoxville Kidney Center PLLC	Knoxville	Tennessee	37923	Recruiting
Lt. Col. Luke Weathers, Jr. VA Medical Center	Memphis	Tennessee	38105	Recruiting
Vanderbilt University Medical Center	Nashville	Tennessee	37232	Recruiting
Cussimanio Research Group LLC	Austin	Texas	78751	Recruiting
Research Management, Inc.	Austin	Texas	78758	Recruiting
MW Clinical Research Center	Beaumont	Texas	77701	Recruiting
Dallas V.A. Medical Center	Dallas	Texas	75216	Recruiting
Dallas Nephrology Associates	Dallas	Texas	75234	Recruiting
US Renal Care	Dallas	Texas	75237	Recruiting
Davita Clinical Research	El Paso	Texas	79925	Recruiting
DaVita Clinical Research - Horizon	El Paso	Texas	79935	Recruiting
Fort Worth Renal Group	Fort Worth	Texas	76110	Recruiting
Clinical Research Strategies	Houston	Texas	77030	Recruiting
DaVita Clinical Research	Houston	Texas	77054	Recruiting
Aqua Research Institute	Houston	Texas	77058	Recruiting
Gulf Coast Clinical Research	Houston	Texas	77070	Recruiting
Houston Medical Research Institute, LLC	Houston	Texas	77074	Recruiting
Clinical Research Strategies, Inc.	Houston	Texas	77090	Recruiting
Southwest Houston Research	Houston	Texas	77099	Recruiting
Laguna Clinical Research Associates, LLC	Laredo	Texas	78041	Recruiting
Prime Clinical Research, Inc.	Mansfield	Texas	76063	Recruiting
Gamma Medical Research, Inc.	McAllen	Texas	78503	Recruiting
National Institute of Clinical Research, Inc.	San Antonio	Texas	78204	Recruiting
DaVita Clinical Research	San Antonio	Texas	78229	Recruiting
Davita Clinical Research	San Antonio	Texas	78251	Recruiting
DCR-San Antonio Stone Oak	San Antonio	Texas	78258	Recruiting
DaVita Clinical Research North Houston	Shenandoah	Texas	77384	Recruiting
Medrasa Clinical Research	Sherman	Texas	75092	Recruiting
Renal Research of Montgomery County	The Woodlands	Texas	77384	Recruiting
DCR-Norfolk Great Bridge	Chesapeake	Virginia	23320	Recruiting
Nephrology Associates of Northern Virginia Inc	Fairfax	Virginia	22033	Recruiting
Peninsula Kidney Associates	Hampton	Virginia	23666	Recruiting
Tidewater Kidney Specialists	Norfolk	Virginia	23502	Recruiting
Nephrology and Hypertension Associates	Bluefield	West Virginia	24701	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 378 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05485961, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 30, 2026 · Synced May 8, 2026

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The complete protocol, eligibility criteria, and contact information for NCT05485961 live on ClinicalTrials.gov.

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