A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)
Public ClinicalTrials.gov record NCT05489705. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Deliver Insights in Hypertrophic Cardiomyopathy and Observational Outcomes in Real World: United States and European Prospective Registry Study
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This registry evaluates patient characteristics, real-world treatment patterns, and short- and long-term outcomes in a population of patients in the United States and Europe with symptomatic obstructive hypertrophic cardiomyopathy (HCM) who are receiving mavacamten, receiving other treatment for obstructive HCM, or not receiving treatment for obstructive HCM due to intolerance or failure of prior treatment. United States Sub-Study: The purpose of this study is to evaluate the safety of mavacamten in patients with symptomatic obstructive HCM in the real-world setting. Europe Sub-Study: The purpose of this study is to evaluate the effectiveness and safety of mavacamten in patients with symptomatic obstructive HCM in the real-world setting.
Study identification
- NCT ID
- NCT05489705
- Recruitment status
- Recruiting
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 1,700 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 15, 2022
- Primary completion
- Aug 16, 2029
- Completion
- Aug 16, 2029
- Last update posted
- Aug 18, 2026
2022 – 2029
United States locations
- U.S. sites
- 60
- U.S. states
- 31
- U.S. cities
- 51
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alaska Heart Institute | Anchorage | Alaska | 99508 | Recruiting |
| Pima Heart and Vascular | Tucson | Arizona | 85704 | Recruiting |
| UAMS | Little Rock | Arkansas | 72205-7199 | Recruiting |
| Local Institution - 0037 | La Jolla | California | 92037 | Active, not recruiting |
| Keck School of Medicine of USC-Usc | Los Angeles | California | 90033 | Recruiting |
| Stanford Health Care Hospital & Clinics | Palo Alto | California | 94304 | Recruiting |
| University Of California San Francisco Medical Center | San Francisco | California | 94117 | Recruiting |
| UC Denver, AMC | Aurora | Colorado | 48377 | Recruiting |
| Local Institution - 0067 | Hartford | Connecticut | 06106 | Active, not recruiting |
| MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | Recruiting |
| Local Institution - 0065 | Jacksonville | Florida | 32209 | Active, not recruiting |
| Local Institution - 0046 | Honolulu | Hawaii | 96813 | Active, not recruiting |
| University of Chicago Dept of Medicine | Chicago | Illinois | 60637 | Recruiting |
| Indiana. University | Indianapolis | Indiana | 46202 | Recruiting |
| Franciscan Physician Network-Indiana Heart Physicians | Indianapolis | Indiana | 46237 | Recruiting |
| Local Institution - 0045 | Iowa City | Iowa | 52242 | Active, not recruiting |
| Local Institution - 0059 | Baltimore | Maryland | 21201 | Active, not recruiting |
| MedStar Health Research Institute | Baltimore | Maryland | 21218 | Recruiting |
| Harvard (Massachusetts General Hospital) | Boston | Massachusetts | 02114 | Recruiting |
| Harvard Medical School - Brigham and Women's Hospital (BWH) | Boston | Massachusetts | 02215 | Recruiting |
| Spectrum Health Medical Group | Grand Rapids | Michigan | 49525 | Recruiting |
| Henry Ford Health System | West Bloomfield | Michigan | 48322 | Recruiting |
| Minneapolis Heart Institute Foundation | Minneapolis | Minnesota | 55407 | Recruiting |
| Cardiology Associates Research, Llc | Tupelo | Mississippi | 38801 | Recruiting |
| St. Luke's Mid-America Heart Institute | Kansas City | Missouri | 64111 | Recruiting |
| Local Institution - 0033 | Kansas City | Missouri | 66160 | Active, not recruiting |
| Washington University | St Louis | Missouri | 63110 | Recruiting |
| CHI Health Reseach Center | Omaha | Nebraska | 68124 | Recruiting |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | Recruiting |
| Local Institution - 0026 | Morristown | New Jersey | 07960 | Active, not recruiting |
| Bassett Medical Center | Cooperstown | New York | 13326 | Recruiting |
| Local Institution - 0009 | New York | New York | 10019 | Active, not recruiting |
| Mount Sinai Hospital | New York | New York | 10029 | Recruiting |
| Saint Francis Hospital | Roslyn | New York | 11576 | Recruiting |
| WMCHealth Advanced Physician Services | Valhalla | New York | 10595 | Recruiting |
| Focus Clinical Research | Charlotte | North Carolina | 28207 | Recruiting |
| Duke University Health System | Durham | North Carolina | 27710 | Recruiting |
| Christ Hospital Health Network | Cincinnati | Ohio | 45219 | Recruiting |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | Recruiting |
| Local Institution - 0003 | Cleveland | Ohio | 44195 | Active, not recruiting |
| St. Luke's University Health Network | Bethlehem | Pennsylvania | 18015 | Recruiting |
| Local Institution - 0076 | Lancaster | Pennsylvania | 17603 | Active, not recruiting |
| University Of Pittsburgh | Pittsburgh | Pennsylvania | 15213 | Recruiting |
| Geisinger Health System | Wilkes-Barre | Pennsylvania | 18711 | Recruiting |
| Prisma Health - Upstate | Greenville | South Carolina | 29605 | Recruiting |
| Tristar Centennial Medical Ctr | Nashville | Tennessee | 37203 | Recruiting |
| Saint Thomas Health | Nashville | Tennessee | 37205-2018 | Recruiting |
| North Texas Cardiology Center | Dallas | Texas | 75208 | Recruiting |
| Baylor Scott & White Research Institute | Dallas | Texas | 75246 | Recruiting |
| The Methodist Hospital, Methodist Cancer Cencer | Houston | Texas | 77030 | Recruiting |
| BI Research Center | Houston | Texas | 77084 | Recruiting |
| Baylor Scott & White The Heart Hospital Plano | Plano | Texas | 75093 | Recruiting |
| Baylor Scott & White Medical Centre - Temple | Temple | Texas | 76508 | Recruiting |
| The Rector and Visitors of the Univ of Virginia | Charlottesville | Virginia | 22908 | Recruiting |
| VCU Medical Center | Richmond | Virginia | 23298 | Recruiting |
| Carilion Clinic; Virginia Tech-Carilion School of Medicine | Roanoke | Virginia | 24014 | Recruiting |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | Recruiting |
| WVU Hospitals | Morgantown | West Virginia | 26506 | Recruiting |
| Local Institution - 0004 | Madison | Wisconsin | 53792 | Active, not recruiting |
| Medical College of Wisconsin, Inc (PI Address) | Milwaukee | Wisconsin | 53226 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 41 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05489705, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 18, 2026 · Synced Sep 5, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05489705 live on ClinicalTrials.gov.