A Study of Ponsegromab in People With Heart Failure
Public ClinicalTrials.gov record NCT05492500. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 2, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, 4-ARM STUDY TO INVESTIGATE SYMPTOMS, FUNCTION, HEALTH-RELATED QUALITY OF LIFE AND SAFETY WITH REPEATED SUBCUTANEOUS ADMINISTRATION OF PONSEGROMAB VERSUS PLACEBO IN ADULT PARTICIPANTS WITH HEART FAILURE
Study identification
- NCT ID
- NCT05492500
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Pfizer
- Industry
- Enrollment
- 455 participants
Conditions and interventions
Conditions
Interventions
- Main cohort (Cohort A): Ponsegromab low dose Drug
- Main cohort (Cohort A): Ponsegromab medium dose Drug
- Main cohort (Cohort A): ponsegromab high dose Drug
- Main cohort (Cohort A): Matched placebo Other
- Open-label, PK Cohort (Cohort B): ponsegromab low dose Drug
- Open-label, PK Cohort (Cohort B): ponsegromab medium dose Drug
- Open-label, PK Cohort (Cohort B): ponsegromab high dose Drug
- Optional Cohort C: Ponsegromab low dose Drug
- Optional Cohort C: Matched placebo Other
- Optional Cohort D: Ponsegromab high dose Drug
- Optional Cohort D: Matched placebo Other
Drug · Other
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 25, 2022
- Primary completion
- Mar 4, 2025
- Completion
- Mar 4, 2025
- Last update posted
- Mar 17, 2026
2022 – 2025
United States locations
- U.S. sites
- 22
- U.S. states
- 14
- U.S. cities
- 16
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Eastern shore Research Institute LLC | Fairhope | Alabama | 36532 | — |
| Keck Medical Center of USC | Los Angeles | California | 90033 | — |
| MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| Emory University School of Medicine-Grady Campus | Atlanta | Georgia | 30303 | — |
| Chicago Medical Research | Hazel Crest | Illinois | 60429 | — |
| Reid Physician Associates | Richmond | Indiana | 47374 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Traverse Heart & Vascular | Traverse City | Michigan | 49684 | — |
| M Health Fairview Clinics and Surgery Center | Minneapolis | Minnesota | 55455 | — |
| M Health Fairview University of Minnesota Investigational Drug Services | Minneapolis | Minnesota | 55455 | — |
| M Health Fairview University of Minnesota Medical Center-East Bank | Minneapolis | Minnesota | 55455 | — |
| University of Minnesota/Lillehei Clinical Research Unit | Minneapolis | Minnesota | 55455 | — |
| Saint Luke's Hospital of Kansas City | Kansas City | Missouri | 64111 | — |
| Washington University in St. Louis Center for Outpatient Health (COH) | St Louis | Missouri | 63108 | — |
| Washington University in St. Louis Center for Advanced Medicine (CAM) | St Louis | Missouri | 63110 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Holy Name Medical Center | Teaneck | New Jersey | 07666 | — |
| University of North Carolina Medical Center | Chapel Hill | North Carolina | 27514 | — |
| Clinical and Translational Research Center | Chapel Hill | North Carolina | 27599 | — |
| South Oklahoma Heart Research, LLC | Oklahoma City | Oklahoma | 73135 | — |
| Texas Health Heart & Vascular Specialist (THHVS) #18760 | Dallas | Texas | 75231 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 100 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05492500, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 17, 2026 · Synced Jul 20, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05492500 live on ClinicalTrials.gov.