A Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of SPR720 as Compared With Placebo for the Treatment of Participants With Mycobacterium Avium Complex (MAC) Pulmonary Disease
Public ClinicalTrials.gov record NCT05496374. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Investigator-Blinded, Placebo-Controlled, Multicenter, Phase 2, Dose-Ranging Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of SPR720 as Compared With Placebo for the Treatment of Patients With Mycobacterium Avium Complex (MAC) Pulmonary Disease
Study identification
- NCT ID
- NCT05496374
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Spero Therapeutics
- Industry
- Enrollment
- 25 participants
Conditions and interventions
Interventions
- Placebo Drug
- SPR720 500 mg Drug
- SPR720 1000 mg Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 13, 2022
- Primary completion
- Oct 7, 2024
- Completion
- Dec 1, 2024
- Last update posted
- Oct 8, 2025
2022 – 2024
United States locations
- U.S. sites
- 28
- U.S. states
- 17
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Medical Facility | Birmingham | Alabama | 35233 | — |
| Medical Facility | Fresno | California | 93701 | — |
| Medical Facility | Los Angeles | California | 90033 | — |
| Medical Facility | Newport Beach | California | 92663 | — |
| Medical Facility | Northridge | California | 91324 | — |
| Medical Facility | Santa Clarita | California | 91355 | — |
| Medical Facility | Washington D.C. | District of Columbia | 20007 | — |
| Medical Facility | Kissimmee | Florida | 34746-4654 | — |
| Medical Facility | Loxahatchee Groves | Florida | 33470 | — |
| Medical Facility | Miami | Florida | 33136 | — |
| Medical Facility | Sebring | Florida | 33870 | — |
| Medical Facility | Tampa | Florida | 33606 | — |
| Medical facility | Atlanta | Georgia | 30342 | — |
| Medical Facility | Iowa City | Iowa | 52242 | — |
| Medical Facility | Kansas City | Kansas | 66103 | — |
| Medical Facility | New Bedford | Massachusetts | 02740 | — |
| Medical Facility | Rochester | Minnesota | 55905 | — |
| Medical Facility | Lebanon | New Hampshire | 03756 | — |
| Medical Facility | New Hyde Park | New York | 11042 | — |
| Medical Facility | Chapel Hill | North Carolina | 27599 | — |
| Medical Facility | Winston-Salem | North Carolina | 27103 | — |
| Medical Facility | Cleveland | Ohio | 44106 | — |
| Medical Facility | Portland | Oregon | 97239 | — |
| Medical Facility | Pittsburgh | Pennsylvania | 15213 | — |
| Medical Facility | Charleston | South Carolina | 29425 | — |
| Medical Facility | Denison | Texas | 75020 | — |
| Medical Facility | Sherman | Texas | 75090 | — |
| Medical Facility | Tyler | Texas | 75708 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05496374, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 8, 2025 · Synced Jul 21, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05496374 live on ClinicalTrials.gov.