Add-on Reparixin in Adult Patients With ARDS
Public ClinicalTrials.gov record NCT05496868. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase 2, Randomized, Double-blinded, Placebo-controlled, Multicenter Study to Assess Efficacy and Safety of Reparixin as add-on Therapy to SoC in Acute Respiratory Distress Syndrome (RESPIRATIO)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Study objectives 1. To characterize the efficacy of reparixin in ameliorating lung injury and systemic inflammation and expediting clinical recovery and liberation from mechanical ventilation in adult patients with moderate to severe ARDS (PaO2/FIO2 ratio ≤ 200). 2. to assess the effect of reparixin on systemic biomarkers linked to a hyper-inflammatory ARDS phenotype. 3. To evaluate the safety of reparixin vs. placebo in patients enrolled in the study.
Study identification
- NCT ID
- NCT05496868
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 66 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 6, 2022 (Actual)
- Primary completion
- Mar 18, 2025 (Actual)
- Completion
- Apr 18, 2025 (Actual)
- Last update posted
- May 11, 2026
2022 – 2025
United States locations
- U.S. sites
- 33
- U.S. states
- 21
- U.S. cities
- 32
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| The University of Alabama at Birmingham Hospital | Birmingham | Alabama | 35233 | — |
| Banner - University Medical Center Phoenix | Phoenix | Arizona | 85006 | — |
| University of Southern California | Los Angeles | California | 90033 | — |
| University of California Irvine Health | Orange | California | 92868 | — |
| Unversity of California Davis Medical Center | Sacramento | California | 95817 | — |
| Denver Health | Denver | Colorado | 80204 | — |
| University of South Florida | Tampa | Florida | 33606 | — |
| Emory Saint Joseph's Hospital | Atlanta | Georgia | 30342 | — |
| Methodist Hospitals of Northwest Indiana | Gary | Indiana | 46404 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Newton Wellesley Hospital | Newton | Massachusetts | 02462-1607 | — |
| Baystate Health | Springfield | Massachusetts | 01107 | — |
| Detroit Medical Center | Detroit | Michigan | 48201 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| MyMichigan Medical Center Midland | Midland | Michigan | 48670 | — |
| William Beaumont Hospital | Royal Oak | Michigan | 48073 | — |
| Jackson Pulmonary Associates | Jackson | Mississippi | 39202 | — |
| University of Missouri Health Care | Columbia | Missouri | 65212 | — |
| Hackensack Meridian Health | Hackensack | New Jersey | 07601 | — |
| NYU Langone Brooklyn | Brooklyn | New York | 11220 | — |
| New York University Langone Health | New York | New York | 10016 | — |
| The Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | — |
| University of Oklahoma Medical Center | Oklahoma City | Oklahoma | 73104 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| University of Tennessee Medical Center | Knoxville | Tennessee | 37920 | — |
| Baptist Hospitals of Southeast Texas | Beaumont | Texas | 77701 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390-8894 | — |
| Cardiovoyage | Denison | Texas | 75020 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| University of Utah Hospitals & Clinics | Salt Lake City | Utah | 84108 | — |
| Virginia Commonwealth University Health System | Richmond | Virginia | 23298 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05496868, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 11, 2026 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05496868 live on ClinicalTrials.gov.