ClinicalTrials.gov record
A Phase 3 Study to Evaluate the Effect of Resmetirom on Clinical Outcomes in Patients With Well-compensated NASH Cirrhosis (MAESTRO-NASH-OUTCOMES)
ClinicalTrials.gov ID: NCT05500222
Public ClinicalTrials.gov record NCT05500222. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Double-blind Placebo-controlled Phase 3 Study to Evaluate the Effect of Resmetirom on Liver-related Outcomes in Patients With Well-compensated (Child-Pugh A) Non-alcoholic Steatohepatitis (NASH) Cirrhosis (MAESTRO-NASH-OUTCOMES)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will determine the effect of oral 80 mg resmetirom administered once daily on participants with well-compensated non-alcoholic steatohepatitis (NASH) cirrhosis by measuring the time to experiencing a Composite Clinical Outcome event.
Study identification
- NCT ID
- NCT05500222
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 845 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 25, 2022
- Primary completion
- Nov 30, 2026
- Completion
- Dec 31, 2026
- Last update posted
- Jul 7, 2026
2022 – 2027
United States locations
- U.S. sites
- 96
- U.S. states
- 28
- U.S. cities
- 79
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham (UAB) | Birmingham | Alabama | 35249 | — |
| Arizona Liver Health - Chandler | Chandler | Arizona | 85224 | — |
| Arizona Liver Health - Peoria | Peoria | Arizona | 85381 | — |
| Adobe Clinical Research | Tucson | Arizona | 85712 | — |
| Arizona Liver Health - Tucson | Tucson | Arizona | 85712 | — |
| Arkansas Diagnostic Center/Liver Wellness Center | Little Rock | Arkansas | 72205-6414 | — |
| Arkansas Gastroenterology | North Little Rock | Arkansas | 72117 | — |
| Southern California Research Center | Coronado | California | 92118 | — |
| University of California, San Francisco-Fresno | Fresno | California | 93701 | — |
| Univ. of California San Diego School of Medicine | La Jolla | California | 92037 | — |
| Keck School of Medicine of USC | Los Angeles | California | 90033 | — |
| Knowledge Research Center | Orange | California | 92868 | — |
| California Liver Research Institute | Pasadena | California | 91105 | — |
| University of Colorado | Aurora | Colorado | 80045 | — |
| South Denver Gastroenterology | Engelwood | Colorado | 80113 | — |
| Tampa Bay Medical Research | Clearwater | Florida | 33761 | — |
| Hi Tech and Global Research | Coral Gables | Florida | 33134 | — |
| Top Medical Research Inc | Cutler Bay | Florida | 33189 | — |
| Covenant Research - Fort Myers | Fort Myers | Florida | 33912 | — |
| Nature Coast Clinical Research - Inverness | Inverness | Florida | 34452 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| Ocala GI Research DBA Lake Center for Clinical Research | Lady Lake | Florida | 32159 | — |
| Florida Research Institute | Lakewood Rch | Florida | 34238 | — |
| Schiff Center for Liver Diseases/Univ of Miami | Miami | Florida | 33136 | — |
| Sanchez Clinical Research | Miami | Florida | 33157 | — |
| Ocala GI Research | Ocala | Florida | 34471 | — |
| AdventHealth Orlando th Investigational Drug Services | Orlando | Florida | 32804 | — |
| St Johns Center for Clinical Research | Saint Augustine | Florida | 32086 | — |
| Covenant Research | Sarasota | Florida | 34240 | — |
| International Center for Research | Tampa | Florida | 33614 | — |
| Florida Medical Clinic | Zephyrhills | Florida | 33542 | — |
| Summit Clinical Research | Athens | Georgia | 30607 | — |
| Gastrointestinal Specialists of Georgia | Marietta | Georgia | 30060 | — |
| Northwestern University | Chicago | Illinois | 60208 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Kansas Medical Clinic - Gastroenterology | Topeka | Kansas | 666006 | — |
| Delta Research Partners - Bastrop | Bastrop | Louisiana | 71220 | — |
| Tandem Clinical Research | Marrero | Louisiana | 70072 | — |
| Tulane University School of Medicine | New Orleans | Louisiana | 70112 | — |
| Louisiana Research Center | Shreveport | Louisiana | 71105 | — |
| Mercy Medical Center | Baltimore | Maryland | 21202 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Umass Chan Medical School | Worcester | Massachusetts | 01655 | — |
| Henry Ford Columbus Center | Novi | Michigan | 48377 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Kansas City Research Institute | Kansas City | Missouri | 64131 | — |
| Saint Louis University | St Louis | Missouri | 63104 | — |
| Premier Health Research | Sparta | New Jersey | 07871 | — |
| NYU Langone Health Gastroenterology and Hepatology Associates | New York | New York | 10016 | — |
| Weill Cornell Medical College | New York | New York | 10021 | — |
| Mount Sinai Health System | New York | New York | 10029 | — |
| Atrium Health CMC Liver Disease Research | Charlotte | North Carolina | 28204 | — |
| Duke University Medical Center | Durham | North Carolina | 27705 | — |
| Coastal Research Institute | Fayetteville | North Carolina | 28304 | — |
| Lucas Research | Morehead City | North Carolina | 28557 | — |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | — |
| Clinical Research Institute of Ohio | Westlake | Ohio | 44145 | — |
| Regional Gastroenterology Associates of Lancaster | Flourtown | Pennsylvania | 19031 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| UPMC - Center for Liver Diseases | Pittsburgh | Pennsylvania | 15213 | — |
| Velocity Clinical Research - Providence | East Greenwich | Rhode Island | 02818 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Columbia Digestive Health Research | Columbia | South Carolina | 29204 | — |
| Rapid City Medical Center | Rapid City | South Dakota | 57701 | — |
| Premier Medical Group | Clarksville | Tennessee | 37040 | — |
| Gastro One | Cordova | Tennessee | 38018 | — |
| Quality Medical Reseach, PLLC | Nashville | Tennessee | 37211 | — |
| Texas Clinical Research Institute | Arlington | Texas | 76012-3216 | — |
| Pinnacle Clinical Research - Austin | Austin | Texas | 78757 | — |
| Apex Mobile Clinical Research, LLC | Bellaire | Texas | 77401 | — |
| South Texas Research Institute - Brownsville | Brownsville | Texas | 78520 | — |
| The Liver Institute at Methodist Dallas Medical Center | Dallas | Texas | 75203 | — |
| Dallas VA Medical Center | Dallas | Texas | 75216 | — |
| Liver Center of Texas | Dallas | Texas | 75234 | — |
| GI Alliance, Texas Digestive Disease Consultants | Dallas | Texas | 75246 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| South Texas Research Institute - Edinburg | Edinburg | Texas | 78539 | — |
| GI Alliance | Fort Worth | Texas | 76104 | — |
| Pinnacle Clinical Research - Georgetown | Georgetown | Texas | 78626 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| Houston Research Institute | Houston | Texas | 77079 | — |
| DHR Health Institute for Research & Development | McAllen | Texas | 78504 | — |
| Pinnacle Clinical Research - San Antonio | San Antonio | Texas | 78229 | — |
| Impact Research Institute | Waco | Texas | 76710 | — |
| Digestive Health Research of Central Texas | Waco | Texas | 76712 | — |
| University of Vermont Medical Center | Burlington | Vermont | 05401 | — |
| University of Virginia Health System | Charlottesville | Virginia | 22903 | — |
| Bon Secours Liver Institute of Richmond | Richmond | Virginia | 23226 | — |
| GI Select Health Research | Richmond | Virginia | 23236 | — |
| Hunter Holmes McGuire VA Medical Center | Richmond | Virginia | 23249 | — |
| Virginia Commonwealth University School of Medicine | Richmond | Virginia | 23298 | — |
| Harborview Medical Center | Seattle | Washington | 98104 | — |
| Liver Institute Northwest | Seattle | Washington | 98105 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 45 non-U.S. sites.
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About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05500222, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 7, 2026 · Synced Aug 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05500222 live on ClinicalTrials.gov.