ClinicalTrials.gov record
A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer
ClinicalTrials.gov ID: NCT05514054
Public ClinicalTrials.gov record NCT05514054. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 9, 2026, 12:18 PM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
EMBER-4: A Randomized, Open-Label, Phase 3 Study of Adjuvant Imlunestrant vs Standard Adjuvant Endocrine Therapy in Patients Who Have Previously Received 2 to 5 Years of Adjuvant Endocrine Therapy for ER+, HER2- Early Breast Cancer With an Increased Risk of Recurrence
Study identification
- NCT ID
- NCT05514054
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Eli Lilly and Company
- Industry
- Enrollment
- 8,000 participants
Conditions and interventions
Conditions
Interventions
- Anastrozole Drug
- Exemestane Drug
- Imlunestrant Drug
- Letrozole Drug
- Tamoxifen Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 3, 2022
- Primary completion
- Sep 30, 2027
- Completion
- Feb 29, 2032
- Last update posted
- Apr 1, 2026
2022 – 2032
United States locations
- U.S. sites
- 137
- U.S. states
- 32
- U.S. cities
- 118
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| USO - Southern Cancer Center | Daphne | Alabama | 36526 | — |
| Clearview Cancer Institute | Huntsville | Alabama | 35805 | — |
| Infirmary Cancer Care | Mobile | Alabama | 36607 | — |
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | — |
| USO - Arizona Oncology Associates - HAL | Glendale | Arizona | 85308 | — |
| St. Joseph's Hospital and Medical Center | Phoenix | Arizona | 85004 | — |
| Mayo Clinic in Arizona - Phoenix | Phoenix | Arizona | 85054 | — |
| TMC HealthCare | Tucson | Arizona | 85711 | — |
| The University of Arizona Cancer Center - North Campus | Tucson | Arizona | 85719 | — |
| Highlands Oncology Group | Springdale | Arkansas | 72762 | — |
| UCSF - John Muir Health Cancer Center Berkeley | Berkeley | California | 94702 | — |
| Washington Health | Fremont | California | 94538 | — |
| Chao Family Comprehensive Cancer Center and Ambulatory Care (CIACC) - Irvine | Irvine | California | 92612 | — |
| Loma Linda University Cancer Center | Loma Linda | California | 92350-1700 | — |
| Pacific Cancer Care | Monterey | California | 93940 | — |
| St. Joseph Hospital | Orange | California | 92868 | — |
| University of California, Irvine (UCI) Health - UC Irvine Medical Center | Orange | California | 92868 | — |
| University of California Davis (UC Davis) Comprehensive Cancer Center | Sacramento | California | 95817 | — |
| Kaiser Permanente San Diego Mission Road | San Diego | California | 92108 | — |
| Zuckerberg San Francisco General Hospital and Trauma Center | San Francisco | California | 94110 | — |
| UCSF Medical Center at Mission Bay | San Francisco | California | 94158 | — |
| Saint Joseph's Medical Center | Stockton | California | 95204 | — |
| Anschutz Cancer Pavilion | Aurora | Colorado | 80045 | — |
| UCHealth Memorial Hospital | Colorado Springs | Colorado | 80909 | — |
| UCHealth Harmony | Fort Collins | Colorado | 80528 | — |
| Banner MD Anderson Cancer Center at North Colorado Medical Center | Greeley | Colorado | 80631 | — |
| USO - Rocky Mountain Cancer Centers | Lakewood | Colorado | 80228 | — |
| Banner MD Anderson Cancer Center at McKee Medical Center | Loveland | Colorado | 80538 | — |
| Yale-New Haven Hospital | New Haven | Connecticut | 06510 | — |
| Georgetown University Medical Center | Washington D.C. | District of Columbia | 20007 | — |
| MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| AdventHealth Altamonte Springs | Altamonte Springs | Florida | 32701 | — |
| Memorial Regional Hospital | Hollywood | Florida | 33021 | — |
| Millennium Oncology Research Clinic | Hollywood | Florida | 33024 | — |
| Mayo Clinic in Florida | Jacksonville | Florida | 32224 | — |
| Miami Cancer Institute at Baptist Health, Inc. | Miami | Florida | 33176 | — |
| USO - Cancer Care Centers of Brevard | Palm Bay | Florida | 32901 | — |
| USO - Woodlands Medical Specialists | Pensacola | Florida | 32503 | — |
| Miami Cancer Institute - Plantation | Plantation | Florida | 33324 | — |
| Tampa General Hospital | Tampa | Florida | 33606 | — |
| Winship Cancer Institute, Emory University | Atlanta | Georgia | 30322 | — |
| Northside Hospital | Atlanta | Georgia | 30342 | — |
| Summit Cancer Care, PC | Savannah | Georgia | 31405 | — |
| Kaiser Permanente Moanalua Medical Center | Honolulu | Hawaii | 96819 | — |
| Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | 96826 | — |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | — |
| University of Illinois at Chicago | Chicago | Illinois | 60612 | — |
| Illinois Cancer Care | Peoria | Illinois | 61615 | — |
| Simmons Cancer Institute at SIU | Springfield | Illinois | 62702 | — |
| The University of Kansas Cancer Center - Westwood | Westwood | Kansas | 66205 | — |
| Ochsner Clinic Foundation | Covington | Louisiana | 70433 | — |
| Pontchartrain Cancer Center | Hammond | Louisiana | 70403 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| York Hospital | York Village | Maine | 03909 | — |
| Walter Reed National Military Medical Center | Bethesda | Maryland | 20889 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| Mass General/North Shore Cancer Center | Danvers | Massachusetts | 01923 | — |
| Southcoast Centers for Cancer Care | Fairhaven | Massachusetts | 02719 | — |
| Dana-Farber Cancer Institute - Foxborough | Foxborough | Massachusetts | 02035 | — |
| Dana-Farber Cancer Institute - Merrimack Valley | Methuen | Massachusetts | 01844 | — |
| Dana-Farber/Brigham and Women's Cancer Center at Milford Regional Medical Center | Milford | Massachusetts | 01757 | — |
| Mass General Cancer Center at Newton-Wellesley | Newton | Massachusetts | 02462 | — |
| Dana-Farber/Brigham and Women's Cancer Center - South Shore Hospital | South Weymouth | Massachusetts | 02190 | — |
| University of Massachusetts Medical School | Worcester | Massachusetts | 01655 | — |
| M Health Fairview Cancer Clinic -Edina | Edina | Minnesota | 55435 | — |
| USO - Minnesota Oncology Hematology | Minneapolis | Minnesota | 55404 | — |
| Allina Health Cancer Institute | Minneapolis | Minnesota | 55407 | — |
| Mayo Clinic in Rochester, Minnesota | Rochester | Minnesota | 55905 | — |
| University of Missouri Hospital | Columbia | Missouri | 65212 | — |
| Washington University School of Medicine | St Louis | Missouri | 63108 | — |
| Nebraska Methodist Hospital | Omaha | Nebraska | 68114 | — |
| Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Dana-Farber - New Hampshire Oncology/Hematology | Londonderry | New Hampshire | 03053 | — |
| MD Anderson Cancer Center at Cooper | Camden | New Jersey | 08103 | — |
| Astera Cancer Care | East Brunswick | New Jersey | 08816 | — |
| Regional Cancer Care Associates | Little Silver | New Jersey | 07739 | — |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08901 | — |
| Capital Health Medical Center - Hopewell | Pennington | New Jersey | 08534 | — |
| New Mexico Oncology Hematology Consultants Ltd. | Albuquerque | New Mexico | 87109 | — |
| University of New Mexico Comprehensive Cancer Center | Albuquerque | New Mexico | 87131 | — |
| New York Oncology Hematology Associate | Albany | New York | 12206 | — |
| Maimonides Cancer Center | Brooklyn | New York | 11220 | — |
| NYU Langone Health - Brooklyn | Brooklyn | New York | 11220 | — |
| R.J. Zuckerberg Cancer Center | Lake Success | New York | 11042 | — |
| Perlmutter Cancer Center at NYU Langone Hospital - Long Island | Mineola | New York | 11501 | — |
| Northern Westchester Hospital | Mount Kisco | New York | 10549 | — |
| Laura and Isaac Perlmutter Cancer Center | New York | New York | 10016 | — |
| NYC Health + Hospitals / Bellevue | New York | New York | 10016 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | — |
| Queens Medical Associates | Queens | New York | 11374 | — |
| University of Rochester - Wilmot Cancer Institute | Rochester | New York | 14642 | — |
| Phelps Hospital | Sleepy Hollow | New York | 10591 | — |
| Staten Island University Hospital | Staten Island | New York | 10305 | — |
| Clinical Research Alliance | Westbury | New York | 11590 | — |
| Messino Cancer Center | Asheville | North Carolina | 28806 | — |
| Aultman Hospital | Canton | Ohio | 44710 | — |
| USO - Oncology Hematology Care | Cincinnati | Ohio | 45242 | — |
| Mercy Health - St. Vincent Medical Center | Toledo | Ohio | 43608 | — |
| Good Samaritan Regional Medical Center | Corvallis | Oregon | 97330 | — |
| USO - Oncology Associates of Oregon | Eugene | Oregon | 97401 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| USO - Compass Oncology | Tigard | Oregon | 97223 | — |
| St. Luke's University Health Network | Bethlehem | Pennsylvania | 18015 | — |
| USO - Alliance Cancer Specialists, PC | Horsham | Pennsylvania | 19044 | — |
| Thomas Jefferson University - Clinical Research Institute | Philadelphia | Pennsylvania | 19107 | — |
| Lifespan Cancer Institute | Providence | Rhode Island | 02906 | — |
| St Francis Cancer Center | Greenville | South Carolina | 29607 | — |
| The West Clinic, PLLC dba West Cancer Center | Germantown | Tennessee | 38138 | — |
| University of Tennessee Medical Center | Knoxville | Tennessee | 37920 | — |
| Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | — |
| USO - Texas Oncology | Austin | Texas | 78731 | — |
| USO - Texas Oncology | Dallas | Texas | 75231 | — |
| USO - Texas Oncology | Dallas | Texas | 75246 | — |
| USO - Texas Oncology | Denison | Texas | 75020 | — |
| Texas Oncology - West Texas | El Paso | Texas | 79902 | — |
| William Beaumont Army Medical Center | El Paso | Texas | 79918 | — |
| USO - Texas Oncology | Flower Mound | Texas | 75028 | — |
| Brooke Army Medical Center | Fort Sam Houston | Texas | 78234 | — |
| John Peter Smith Hospital | Fort Worth | Texas | 76104 | — |
| The Center for Cancer and Blood Disorders | Fort Worth | Texas | 76104 | — |
| USO - Texas Oncology | Fort Worth | Texas | 76104 | — |
| USO - Texas Oncology | Fredericksburg | Texas | 78624 | — |
| USO - Texas Oncology | McAllen | Texas | 78503 | — |
| USO - Texas Oncology | Plano | Texas | 75075 | — |
| Scott & White Hospital - Round Rock | Round Rock | Texas | 78665 | — |
| Mays Cancer Center | San Antonio | Texas | 78229 | — |
| Baylor Scott & White Medical Center - Temple | Temple | Texas | 76508 | — |
| US Oncology Research Network | The Woodlands | Texas | 77380 | — |
| USO - Texas Oncology | Webster | Texas | 77598 | — |
| University of Virginia Health System | Charlottesville | Virginia | 22908 | — |
| Inova Schar Cancer Institute | Fairfax | Virginia | 22031 | — |
| Fort Belvoir Community Hospital | Fort Belvoir | Virginia | 22060 | — |
| Bon Secours St. Francis Medical Center | Midlothian | Virginia | 23114 | — |
| USO - Virginia Oncology Associates | Norfolk | Virginia | 23502 | — |
| USO - Virginia Cancer Specialists | Reston | Virginia | 20190 | — |
| USO - Oncology & Hematology Associates of Southwest Virginia | Roanoke | Virginia | 24014 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 535 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05514054, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 1, 2026 · Synced May 9, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05514054 live on ClinicalTrials.gov.