ClinicalTrials.gov record
A Research Study to Look Into How Semaglutide, Together With a Lower Dose of Insulin Glargine, Compares to a Higher Dose of Insulin Glargine Alone in People With Type 2 Diabetes (SUSTAIN OPTIMIZE)
ClinicalTrials.gov ID: NCT05514535
Public ClinicalTrials.gov record NCT05514535. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Efficacy and Safety of Once-weekly Semaglutide S.C. 2.0 mg as Add-on to Dose-reduced Insulin Glargine vs Titrated Insulin Glargine in Participants With Type 2 Diabetes and Overweight
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study compares semaglutide, together with a lower dose of insulin glargine, to a higher dose of insulin glargine in participants with type 2 diabetes. The study looks at how well the study medicines control blood glucose levels. Participants will either get semaglutide together with a lower dose of insulin glargine or a higher dose of insulin glargine. The study will last for about 47 weeks (approximately 11 months). Participants will have 9 clinic visits, 15 phone/video calls and 1 home visit. Participants will be asked to wear a sensor that measures their blood sugar all the time in 2 periods of 10 days during the study.
Study identification
- NCT ID
- NCT05514535
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 573 participants
Conditions and interventions
Conditions
Interventions
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 29, 2022 (Actual)
- Primary completion
- Mar 5, 2025 (Actual)
- Completion
- Apr 9, 2025 (Actual)
- Last update posted
- May 11, 2026
2022 – 2025
United States locations
- U.S. sites
- 145
- U.S. states
- 38
- U.S. cities
- 116
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Shoals Primary Care | Sheffield | Alabama | 35660 | — |
| Lenzmeier Fam Med CCT Research | Glendale | Arizona | 85308 | — |
| Synexus Clinical Research US, Inc./Desert Clinical Research, | Mesa | Arizona | 85213 | — |
| OneLife Direct Care Inc. | Searcy | Arkansas | 72143 | — |
| Unity Health-Searcy Medical Center | Searcy | Arkansas | 72143 | — |
| San Fernando Valley Hlth Inst, LLC | Canoga Park | California | 91304 | — |
| Velocity Clin Res-Chula Vista | Chula Vista | California | 91911 | — |
| John Muir Physicians Network | Concord | California | 94520 | — |
| Valley Research | Fresno | California | 93720 | — |
| Ascada Research | Fullerton | California | 92835 | — |
| Providence Medical Foundation | Fullerton | California | 92835 | — |
| Velocity Clinical Research Huntington Park | Huntington Park | California | 90255 | — |
| Scripps Memorial Hospital La Jolla | La Jolla | California | 92037 | — |
| Velocity Clin Res San Diego | La Mesa | California | 91942 | — |
| First Valley Medical Group | Lancaster | California | 93534 | — |
| Loma Linda Univ Hlth Cr Endo | Loma Linda | California | 92354 | — |
| Torrance Clin Res Inst, Inc. | Lomita | California | 90717 | — |
| NRC Research Institute | Los Angeles | California | 90015 | — |
| Downtown LA Res Ctr. Inc. | Los Angeles | California | 90017 | — |
| Velocity Clin Res Los Angeles | Los Angeles | California | 90017 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| San Diego Family Care_San Diego | San Diego | California | 92111 | — |
| Wetlin Research Associates, Inc. | San Diego | California | 92120 | — |
| University Clin Investigators | Tustin | California | 92780 | — |
| Velocity Clin Res, Denver | Denver | Colorado | 80209 | — |
| Chase Medical Research LLC | Waterbury | Connecticut | 06708 | — |
| Indago Research & Health Center Inc. | Hialeah | Florida | 33012 | — |
| Encore Medical Research LLC | Hollywood | Florida | 33024 | — |
| Northeast Res Inst. Inc. | Jacksonville | Florida | 32204 | — |
| Jacksonville Ctr For Clin Res | Jacksonville | Florida | 32216 | — |
| Care-Partners-Clinical-Research, LLC | Jacksonville | Florida | 32277 | — |
| Suncoast Research Group, LLC | Miami | Florida | 33135 | — |
| New Horizon Research Center | Miami | Florida | 33165 | — |
| Elite Research Center | Miami | Florida | 33169 | — |
| Diverse Clinical Research Miami | Miami | Florida | 33175 | — |
| Reyes Clinical Research, Inc | Miami | Florida | 33175 | — |
| International Research Associates, LLC_Miami | Miami | Florida | 33183 | — |
| South Broward Research LLC | Miramar | Florida | 33027 | — |
| Suncoast Clin Res Port Richey | New Port Richey | Florida | 34652 | — |
| Suncoast Clinical Research, Inc._New Port Richey | New Port Richey | Florida | 34652 | — |
| Renstar Medical Research | Ocala | Florida | 34470 | — |
| Clinical Research Trials of Florida | Tampa | Florida | 33607 | — |
| CVS Store Number: 7689 | Atlanta | Georgia | 30329-4015 | — |
| East Coast Institute for Res | Canton | Georgia | 30114 | — |
| Coastal Heritage Clinical Research | Hinesville | Georgia | 31313 | — |
| East Coast Institute for Res | Macon | Georgia | 31210 | — |
| Endocrine Research Solutions | Roswell | Georgia | 30076 | — |
| CVS Store Number: 05520 | Savannah | Georgia | 31405-6901 | — |
| Solaris Clinical Research | Meridian | Idaho | 83646 | — |
| Cedar-Crosse Research Center | Chicago | Illinois | 60607 | — |
| WellNow Urgent Care | Chicago | Illinois | 60661 | — |
| Brengle Family Medicine | Indianapolis | Indiana | 46260 | — |
| West Broadway Clinic | Council Bluffs | Iowa | 51501 | — |
| Iowa Diab & Endo Res Center | West Des Moines | Iowa | 50265 | — |
| Iowa Diab & Endo Res Center | West Des Moines | Iowa | 50266 | — |
| Cotton O'Neil Diab & Endo Ctr | Topeka | Kansas | 66606 | — |
| The Research Group of Lexington LLC | Lexington | Kentucky | 40503 | — |
| L-MARC Research Center | Louisville | Kentucky | 40213 | — |
| Arthritis And Diabetes Clinic, Inc. | Monroe | Louisiana | 71203 | — |
| AMR New Orleans | New Orleans | Louisiana | 70119 | — |
| Ileana J. Tandron, MD APMC (a private medical office) | Slidell | Louisiana | 70461 | — |
| MedStar Hlth Res Institute | Hyattsville | Maryland | 20782 | — |
| Endo And Metab Cons | Rockville | Maryland | 20852 | — |
| Brigham & Women's Hospital | Boston | Massachusetts | 02115 | — |
| Joslin Diabetes Center | Boston | Massachusetts | 02215 | — |
| Northern Pines Hlth Ctr, PC | Buckley | Michigan | 49620 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| Elite Research Center | Flint | Michigan | 48532 | — |
| Arcturus HC PLC Troy Med Res | Troy | Michigan | 48098 | — |
| StudyMetrix Research LLC | City of Saint Peters | Missouri | 63303 | — |
| Mercury Str Med Grp, PLLC | Butte | Montana | 59701 | — |
| Clinical Research Advantage, Inc./Skyline Medical Center, PC | Elkhorn | Nebraska | 68022 | — |
| Methodist Physicians Clinic | Fremont | Nebraska | 68025 | — |
| Velocity Clin Res, Norfolk | Norfolk | Nebraska | 68701 | — |
| Midwest Regional Health Services | Omaha | Nebraska | 68144 | — |
| Univ of Nebraska Medical CTR | Omaha | Nebraska | 68198-3020 | — |
| Palm Research Center Inc-Vegas | Las Vegas | Nevada | 89128 | — |
| Southern New Hampshire Diabetes and Endocrinology | Nashua | New Hampshire | 03060 | — |
| Premier Research Inc. | Trenton | New Jersey | 08611 | — |
| AMC Community Endocrinology | Albany | New York | 12203 | — |
| Dr. Alexander Perkelvald | Brooklyn | New York | 11229 | — |
| Mid Hudson Med Res-New Windsor | New Windsor | New York | 12553 | — |
| Great Lakes Medical Research | Westfield | New York | 14787 | — |
| University of North Carolina Medical Center | Chapel Hill | North Carolina | 27514 | — |
| Physicians East Endocrinology | Greenville | North Carolina | 27834 | — |
| Carteret Medical Group | Morehead City | North Carolina | 28557 | — |
| Centricity Rsrch MHCity Multi | Morehead City | North Carolina | 28557 | — |
| Lillestol Research LLC | Fargo | North Dakota | 58104 | — |
| Velocity Clin Res Cleveland | Beachwood | Ohio | 44122 | — |
| Diab & Endo Assoc of Stark Co | Canton | Ohio | 44718 | — |
| Velocity Clin Res_Cincinnati | Cincinnati | Ohio | 45219 | — |
| Albert J Weisbrot | Mason | Ohio | 45040 | — |
| Advanced Med Res Maumee | Maumee | Ohio | 43537 | — |
| University of Toledo Medical Center | Toledo | Ohio | 43614 | — |
| University of Toledo_Toledo | Toledo | Ohio | 43614 | — |
| Intend Research | Norman | Oklahoma | 73069 | — |
| Lynn Institute of Norman | Norman | Oklahoma | 73069 | — |
| Velocity Clinical Res Medford | Medford | Oregon | 97504 | — |
| Heritage Valley Multispeciality Group Inc | Beaver | Pennsylvania | 15009 | — |
| Richard M Kastelic MD Assoc | Johnstown | Pennsylvania | 15905 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| Preferred Primary Care Physicians, Inc. | Uniontown | Pennsylvania | 15401 | — |
| Carolina Health Specialists | Myrtle Beach | South Carolina | 29572 | — |
| Palmetto Clinical Research | Summerville | South Carolina | 29485 | — |
| Chattanooga Medical Research, LLC | Chattanooga | Tennessee | 37404 | — |
| Univ Diab & Endo Consultants | Chattanooga | Tennessee | 37411 | — |
| Jackson Clinic | Jackson | Tennessee | 38305 | — |
| Holston Medical Group | Kingsport | Tennessee | 37660 | — |
| Accellacare US Inc., d/b/a Accellacare of Knoxville | Knoxville | Tennessee | 37938 | — |
| Clinical Neuroscience Solutions | Memphis | Tennessee | 38119 | — |
| Amarillo Med Spec LLP | Amarillo | Texas | 79106 | — |
| Arlington Family Res. Ctr Inc | Arlington | Texas | 76012-4637 | — |
| Central Texas Clinical Research | Austin | Texas | 78705 | — |
| Velocity Clin Res Austin | Cedar Park | Texas | 78613 | — |
| Thyroid Endocrinology & Diabetes PA | Dallas | Texas | 75208 | — |
| Velocity Clinical Res-Dallas | Dallas | Texas | 75230 | — |
| Academy of Diabetes, T&E | El Paso | Texas | 79935 | — |
| Diabetes and Thyroid Ctr of FW | Fort Worth | Texas | 76132 | — |
| Gonzalez Family & Occupational Medicine | Houston | Texas | 77029 | — |
| JCCT- Juno NW Houston | Houston | Texas | 77040 | — |
| Houston Institute for Clinical Research | Houston | Texas | 77074 | — |
| Protenium Clinical Research | Hurst | Texas | 76054 | — |
| DCOL Ctr for Clin Res | Longview | Texas | 75605 | — |
| Tekton Research | McKinney | Texas | 75069 | — |
| Clinical Investigations Of Texas | Plano | Texas | 75075 | — |
| San Antonio Prem Int Med | San Antonio | Texas | 78220 | — |
| Briggs Clinical Research, LLC | San Antonio | Texas | 78224 | — |
| Diabetes Glandular Diseases Clinic | San Antonio | Texas | 78229 | — |
| VIP Trials | San Antonio | Texas | 78230 | — |
| Diabetes Glandular Diseases Clinic | San Antonio | Texas | 78240 | — |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | — |
| Med-Olam Clinical Reseach LLC | Sugar Land | Texas | 77479 | — |
| Hillcrest Family Health Center | Waco | Texas | 76708 | — |
| Advanced Research Institute | Ogden | Utah | 84405 | — |
| South Ogden Family Medicine/ CCT Research | Ogden | Utah | 84405 | — |
| Olympus Family Medicine | Salt Lake City | Utah | 84117 | — |
| Chrysalis Clinical Research | St. George | Utah | 84790 | — |
| Velocity Clin Res-Salt Lk City | West Jordan | Utah | 84088 | — |
| Virginia Endo Res, LLC | Chesapeake | Virginia | 23321 | — |
| York Clinical Research LLC | Norfolk | Virginia | 23504 | — |
| CVS Store Number: 01396 | Reston | Virginia | 20191-4327 | — |
| CVS Store Number: 1537 | Richmond | Virginia | 23230-3005 | — |
| Amherst Family Practice P.C. | Winchester | Virginia | 22601 | — |
| WVU Medicine | Morgantown | West Virginia | 26506 | — |
| Prevea Health | Green Bay | Wisconsin | 54303 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 94 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05514535, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 11, 2026 · Synced Oct 25, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05514535 live on ClinicalTrials.gov.