A Study of Aticaprant in Adult and Elderly Participants With Major Depressive Disorder (MDD)
Public ClinicalTrials.gov record NCT05518149. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-label, Long-term, Safety and Efficacy Study of Aticaprant as Adjunctive Therapy in Adult and Elderly Participants With Major Depressive Disorder (MDD)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to assess the long-term safety and tolerability of aticaprant administered as adjunctive therapy to a current antidepressant (selective serotonin reuptake inhibitor \[SSRI\] or serotonin and norepinephrine reuptake inhibitor \[SNRI\]) in all participants with major depressive disorder (MDD).
Study identification
- NCT ID
- NCT05518149
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 871 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 74 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 22, 2022 (Actual)
- Primary completion
- Apr 25, 2025 (Actual)
- Completion
- May 8, 2025 (Actual)
- Last update posted
- Oct 6, 2026
2022 – 2025
United States locations
- U.S. sites
- 87
- U.S. states
- 21
- U.S. cities
- 73
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham - The Kirklin Clinic | Birmingham | Alabama | 35233 | — |
| SW Biomedical Research LLC | Tucson | Arizona | 85712 | — |
| University of Arizona | Tucson | Arizona | 85721 | — |
| Advanced Research Center Inc | Anaheim | California | 92805 | — |
| Proscience Research Group | Culver City | California | 90230 | — |
| Behavioral Research Specialists LLC | Glendale | California | 91206 | — |
| Sunwise Clinical Research | Lafayette | California | 94549 | — |
| Asclepes Research | Long Beach | California | 90807 | — |
| Excell Research Inc | Oceanside | California | 92056 | — |
| Pacific Neuropsychiatric Specialists | Orange | California | 92868 | — |
| Prospective Research Innovations Inc | Rancho Cucamonga | California | 91730 | — |
| University of California San Diego Medical Center | San Diego | California | 92103 | — |
| Syrentis Clinical Research | Santa Ana | California | 92705 | — |
| CMB Clinical Trials | Santee | California | 92071 | — |
| California Neuroscience Research | Sherman Oaks | California | 91403 | — |
| Viking Clinical Research Ltd | Temecula | California | 92591 | — |
| Pacific Clinical Research Medical Group | Upland | California | 91786 | — |
| Next Level Clinical Trials, LLC | West Covina | California | 91790 | — |
| MCB Clinical Research Centers LLC | Colorado Springs | Colorado | 80910 | — |
| University of Connecticut Health Center | Farmington | Connecticut | 06030 | — |
| Innovative Research of West Florida, Incorporated | Clearwater | Florida | 33756 | — |
| CNS Clinical Research Group | Coral Springs | Florida | 33067 | — |
| Gulfcoast Medical Research Center | Fort Myers | Florida | 33912 | — |
| Sarkis Clinical Trials | Gainesville | Florida | 32607 | — |
| New Life Medical Research Center, Inc. | Hialeah | Florida | 33012 | — |
| Amedica Research Institute Inc | Hialeah | Florida | 33013 | — |
| Galiz Research | Hialeah | Florida | 33016 | — |
| Vertex Clinical Research | Maitland | Florida | 32751 | — |
| Vital Care Research | Miami | Florida | 33122 | — |
| Global Medical Institutes 1 | Miami | Florida | 33125 | — |
| LCC Medical Research Institute Inc | Miami | Florida | 33126 | — |
| Pharmax Research Clinic Inc | Miami | Florida | 33126 | — |
| A Plus Research | Miami | Florida | 33144 | — |
| Florida Research Center Inc. | Miami | Florida | 33174 | — |
| Ezy Medical Research | Miami | Florida | 33175 | — |
| Felicidad Medical Research | Miami | Florida | 33185 | — |
| Meridian International Research | Miami Gardens | Florida | 33014 | — |
| University of Miami | Miami Lakes | Florida | 33016 | — |
| Bravo Health Care Center | North Bay Village | Florida | 33141 | — |
| K2 Medical Research | Ocoee | Florida | 34761 | — |
| Medical Research Group of Central Florida | Orange City | Florida | 32763 | — |
| APG Research LLC | Orlando | Florida | 32803 | — |
| Combined Research Orlando | Orlando | Florida | 32803 | — |
| Quantum Laboratories | Pompano Beach | Florida | 33064 | — |
| CDC Research Institute LLC | Port Saint Lucie | Florida | 34952 | — |
| USF, Department of Psychiatry and Behavioral Neurosciences | Tampa | Florida | 33613 | — |
| Research Network America | Berwyn | Illinois | 60402 | — |
| Chicago Research Center | Chicago | Illinois | 60634 | — |
| Revive Research Institute | Elgin | Illinois | 60123 | — |
| Psychiatric Medicine Associates LLC | Skokie | Illinois | 60076 | — |
| Tandem Clinical Research | Marrero | Louisiana | 70072 | — |
| Clinical Trials of America | Monroe | Louisiana | 71203 | — |
| CBH Health | Gaithersburg | Maryland | 20877 | — |
| ActivMed Practices and Research | Methuen | Massachusetts | 01844 | — |
| Michigan Clinical Research Institute | Ann Arbor | Michigan | 48105 | — |
| Psychiatric Care and Research Center (PCRC) | O'Fallon | Missouri | 63368 | — |
| Midwest Research Group | Saint Charles | Missouri | 63304 | — |
| Erie County Medical Center | Buffalo | New York | 14215 | — |
| Bioscience Research LLC | Mount Kisco | New York | 10549 | — |
| Manhattan Behavioral Medicine | New York | New York | 10036 | — |
| Fieve Clinical Research Inc | New York | New York | 10168 | — |
| Finger Lakes Clinical Research | Rochester | New York | 14618 1609 | — |
| Montefiore Medical Center PRIME | The Bronx | New York | 10467 | — |
| New Hope Clinical Research | Charlotte | North Carolina | 28211 | — |
| Monroe Biomedical Research | Monroe | North Carolina | 28112 | — |
| Patient Priority Clinical Sites LLC | Cincinnati | Ohio | 45215 | — |
| University of Cincinnati, Dept of Psychiatry & Behavioral Neuroscience | Cincinnati | Ohio | 45219 | — |
| Wexner Medical Center at the Ohio State University | Columbus | Ohio | 43221 | — |
| Midwest Clinical Research Center | Dayton | Ohio | 45417 | — |
| Charak Center for Health and Wellness | Garfield Heights | Ohio | 44125 | — |
| Conrad Clinical Research | Edmond | Oklahoma | 73013 | — |
| Sooner Clinical Research | Oklahoma City | Oklahoma | 73112 | — |
| Paradigm Research Professionals, LLC | Oklahoma City | Oklahoma | 73118 | — |
| Lehigh Center for Clinical Research LLC | Allentown | Pennsylvania | 18103 | — |
| Suburban Research Associates | Media | Pennsylvania | 19063 | — |
| Global Medical Institutes | Moosic | Pennsylvania | 18507 | — |
| University of Pennsylvania - Perelman School of Medicine | Philadelphia | Pennsylvania | 19104 | — |
| Austin Clinical Trial Partners | Austin | Texas | 78737 | — |
| West Houston Clinical Research Service | Bellaire | Texas | 77401 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75235-9119 | — |
| North Texas Clinical Trials | Fort Worth | Texas | 76104 | — |
| Clinical Trial Network - Houston | Houston | Texas | 77074 | — |
| R and H Clinical Research | Katy | Texas | 77494 | — |
| Alpine Research Organization | Clinton | Utah | 84015 | — |
| Cedar Psychiatry | Murray | Utah | 84107 | — |
| University of Virginia | Charlottesville | Virginia | 22908 | — |
| Northwest Clinical Research Center | Bellevue | Washington | 98007 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 147 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05518149, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 6, 2026 · Synced Oct 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05518149 live on ClinicalTrials.gov.