A Deep Longitudinal Analysis of Next Generation Influenza Vaccines in Older Adults

ClinicalTrials.gov ID: NCT05518500

Public ClinicalTrials.gov record NCT05518500. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 25, 2026, 3:53 AM EDT

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Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This is a prospective, single-arm study designed to understand the mechanisms that lead to a loss of response to influenza vaccine in older adults. The investigators will recruit and longitudinally follow a cohort of 75 older adults (65 years and older) who will receive three different influenza vaccines over three annual influenza seasons. Blood samples will be collected from the participants at sixteen study visits over three years. Nasal swab and stool samples will also be collected from participants at seven time-points across the study period. After completion of study visits other than the End of Study visit around vaccination in Year 3, participants will be offered the opportunity to be vaccinated with a different FDA approved influenza vaccine and participate in study visits for Year 4. The study is not designed to assess safety or tolerability of the influenza vaccines administered as part of this study.

Study identification

NCT ID: NCT05518500
Recruitment status: Active, not recruiting
Study type: Interventional
Phase: Phase 4
Lead sponsor: The Jackson Laboratory; Other
Enrollment: 75 participants

Conditions and interventions

Conditions

Interventions

Biological

Eligibility (public fields only)

Age range: 65 Years and older
Sex: All
Healthy volunteers: Accepts healthy volunteers

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Aug 31, 2022 (Actual)
Primary completion: Dec 31, 2026 (Estimated)
Completion: Dec 31, 2026 (Estimated)
Last update posted: Aug 3, 2026

2022 – 2026

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
UConn Health, Center On Aging	Farmington	Connecticut	06030	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05518500, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Aug 3, 2026 · Synced Oct 25, 2026

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The complete public registry record, listed eligibility criteria, and available contact information for NCT05518500 live on ClinicalTrials.gov.

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