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Recruiting Phase 1 Interventional

Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)

ClinicalTrials.gov ID: NCT05519449

Public ClinicalTrials.gov record NCT05519449. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 22, 2026, 3:42 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 1, Open-Label, Multicenter Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer

Study identification

NCT ID
NCT05519449
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 1
Lead sponsor
Janux Therapeutics
Industry
Enrollment
272 participants

Conditions and interventions

Interventions

  • JANX007 Biological
  • Darolutamide Drug

Biological · Drug

Eligibility (public fields only)

Age range
18 Years to 100 Years
Sex
Male
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Sep 14, 2022
Primary completion
Jun 30, 2027
Completion
Nov 30, 2028
Last update posted
Jan 19, 2026

2022 – 2028

United States locations

U.S. sites
32
U.S. states
19
U.S. cities
29
Facility City State ZIP Site status
University of Alabama at Birmingham Hospital Birmingham Alabama 35249 Recruiting
Mayo Clinic Phoenix Arizona 85054 Recruiting
USC Norris Comprehensive Cancer Center Los Angeles California 90033 Recruiting
UCLA Department of Medicine Los Angeles California 90095 Recruiting
Hoag Memorial Hospital Presbyterian Newport Beach California 92663 Recruiting
University of California Davis Comprehensive Cancer Center Sacramento California 95817 Recruiting
UCSF Helen Diller Family Comprehensive Cancer Center San Francisco California 94158 Recruiting
Yale New Haven Hospital New Haven Connecticut 06510 Recruiting
Mayo Clinic Jacksonville Florida 32224 Recruiting
University of Chicago Medical Center Chicago Illinois 60637 Recruiting
University of Maryland Greenebaum Comprehensive Cancer Center Baltimore Maryland 21201 Recruiting
Massachusetts General Hospital Boston Massachusetts 02114 Active, not recruiting
University of Minnesota Medical Center Minneapolis Minnesota 55455 Recruiting
Mayo Clinic Rochester Minnesota 55905 Recruiting
Washington University School of Medicine St Louis Missouri 63110 Recruiting
Northwell Health R.J. Zuckerberg Cancer Hospital Lake Success New York 11042 Recruiting
Memorial Sloan Kettering Cancer Center New York New York 10065 Recruiting
Weill Cornell Medicine New York New York 10065 Recruiting
Montefiore Medical Center The Bronx New York 10461 Recruiting
University of Cincinnati Medical Center Cincinnati Ohio 45267 Recruiting
Oregon Health and Science University Portland Oregon 97239 Active, not recruiting
Penn State Milton S. Hershey Medical Center Hershey Pennsylvania 17033 Recruiting
Thomas Jefferson University Honickman Center Philadelphia Pennsylvania 19107 Recruiting
UPMC Hillman Cancer Center Pittsburgh Pennsylvania 15232 Recruiting
Rhode Island Hospital Providence Rhode Island 02903 Recruiting
Medical University of South Carolina Charleston South Carolina 29425 Recruiting
Sarah Cannon Research Nashville Tennessee 37203 Recruiting
Mary Crowley Cancer Research Dallas Texas 75230 Recruiting
University of Texas Southwestern Medical Center Dallas Texas 75390 Recruiting
Houston Methodist Hospital Houston Texas 77030 Recruiting
University of Wisconsin Carbone Cancer Center Madison Wisconsin 53792 Recruiting
Froedtert Hospital and the Medical College of Wisconsin Milwaukee Wisconsin 53226 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05519449, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jan 19, 2026 · Synced Jul 22, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05519449 live on ClinicalTrials.gov.

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