A Study of RGLS8429 in Patients With Autosomal Dominant Polycystic Kidney Disease
Public ClinicalTrials.gov record NCT05521191. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1b, Double-Blind, Placebo-Controlled, Multiple Ascending Dose and an Open-Label Fixed-Dose Study in Patients With Autosomal Dominant Polycystic Kidney Disease to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of RGLS8429
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Primary Objectives * To assess the safety and tolerability of RGLS8429 * To assess the impact of RGLS8429 on ADPKD biomarkers Secondary Objectives * To assess the impact of RGLS8429 on height-adjusted total kidney volume (htTKV) * To characterize the pharmacokinetic (PK) properties of RGLS8429 * To assess the impact of RGLS8429 on renal function
Study identification
- NCT ID
- NCT05521191
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1
- Enrollment
- 68 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 6, 2022 (Actual)
- Primary completion
- Jan 27, 2025 (Actual)
- Completion
- Mar 27, 2025 (Actual)
- Last update posted
- Jun 3, 2025
2022 – 2025
United States locations
- U.S. sites
- 21
- U.S. states
- 16
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Centricity Research Phoenix Multispecialty | Mesa | Arizona | 85206 | — |
| Academic Medical Research Institute | Los Angeles | California | 90022 | — |
| Yale Nephrology Outpatient Clinic | New Haven | Connecticut | 06510 | — |
| Mayo Clinic - Florida | Jacksonville | Florida | 32224 | — |
| Elixia | Orlando | Florida | 32806 | — |
| Southeastern Clinical Research Institute, LLC | Augusta | Georgia | 30904 | — |
| CARE Institute | Boise | Idaho | 83706 | — |
| CARE Institute | Chubbuck | Idaho | 83202 | — |
| The Idaho Kidney Institute | Idaho Falls | Idaho | 83404 | — |
| University of Chicago | Chicago | Illinois | 60617 | — |
| Research by Design, LLC | Chicago | Illinois | 60643 | — |
| University of Iowa | Iowa City | Iowa | 52242 | — |
| University of Kansas Medical Center Jared Grantham Kidney Institute | Kansas City | Kansas | 66160 | — |
| Witchita Nephrology Group, PA | Wichita | Kansas | 67214 | — |
| University of Maryland School of Medicine, Nephrology | Baltimore | Maryland | 21201 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| St. Clair Nephrology Research | Roseville | Michigan | 48066 | — |
| Mayo Clinic - Rochester | Rochester | Minnesota | 55905 | — |
| Northeast Clinical Research Center | Bethlehem | Pennsylvania | 18017 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Swedish Center for Comprehensive Care | Seattle | Washington | 98104 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05521191, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 3, 2025 · Synced Oct 24, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05521191 live on ClinicalTrials.gov.