Phase 3, Double-blind, Randomized, Placebo-controlled Trial to Evaluate the Efficacy and Safety of AR1001 in Participants With Early Alzheimer's Disease (Polaris-AD)
Public ClinicalTrials.gov record NCT05531526. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Double-blind, Randomized, Placebo-controlled, Multi-center Trial to Evaluate the Efficacy and Safety of AR1001 Over 52 Weeks in Participants With Early Alzheimer's Disease (Polaris-AD)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This AR1001-ADP3-US01 protocol is a double-blind, randomized, placebo-controlled, multi- center, parallel-group comparison pivotal Phase 3 study to evaluate the efficacy and safety of AR1001 for the treatment of participants with early AD.
Study identification
- NCT ID
- NCT05531526
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,535 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 55 Years to 90 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 23, 2022 (Actual)
- Primary completion
- Jun 29, 2026 (Actual)
- Completion
- Oct 2027 (Estimated)
- Last update posted
- Oct 14, 2026
2022 – 2027
United States locations
- U.S. sites
- 75
- U.S. states
- 24
- U.S. cities
- 65
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| IMA Clinical Research Phoenix | Phoenix | Arizona | 85012 | — |
| Perseverance Research Center, LLC | Scottsdale | Arizona | 85253 | — |
| Clinical Endpoints - N. Scottsdale | Scottsdale | Arizona | 85258 | — |
| Banner Sun Health Research Institute | Sun City | Arizona | 85351 | — |
| Voyage Medical | Tempe | Arizona | 85282 | — |
| Sutter Health's Palo Alto Medical Foundation | Burlingame | California | 94010 | — |
| Neuro-Pain Medical Center | Fresno | California | 93710 | — |
| Fullerton Neurology and Headache Center | Fullerton | California | 92835 | — |
| Esperanza Clinical | Murrieta | California | 92562 | — |
| Valley Clinical Trials, INC | Northridge | California | 91325 | — |
| Havana Research Institute | Pasadena | California | 91105 | — |
| Kaizen Brain Center | San Diego | California | 92037 | — |
| Adaptive Research | San Jose | California | 95124 | — |
| The Neuron Clinic | San Marcos | California | 92069 | — |
| Stanford Neuroscience Health Center | Stanford | California | 94305 | — |
| Denver Neurological Research | Denver | Colorado | 80210 | — |
| Mile High Research Center | Denver | Colorado | 80218 | — |
| CenExel Rocky Mountain Clinical Research | Englewood | Colorado | 80113 | — |
| Topaz Clinical Research | Apopka | Florida | 32803 | — |
| BayCare Health System, Inc | Clearwater | Florida | 33756 | — |
| Vertex Research Group | Clermont | Florida | 34711 | — |
| Arrow Clinical Trial | Daytona Beach | Florida | 32117 | — |
| Brainstorm Research - Loxahatchee | Loxahatchee Groves | Florida | 33470 | — |
| ClinCloud LLC | Maitland | Florida | 32751 | — |
| Verus Clinical Research, Corp | Miami | Florida | 33135 | — |
| Vitae Research Center, LLC | Miami | Florida | 33135 | — |
| Caro Medcenter and Community Research | Miami | Florida | 33145 | — |
| Allied Biomedical Research Institute, Inc | Miami | Florida | 33155 | — |
| Future Life Clinical Trials | Miami | Florida | 33169 | — |
| Brainstorm Research | Miami | Florida | 33176 | — |
| Meridian International Research, Inc | Miami Gardens | Florida | 33014 | — |
| Charter Research - Orlando | Orlando | Florida | 32803 | — |
| K2 Medical Research | Orlando | Florida | 32806 | — |
| JEM Research Institute | Palm Beach | Florida | 33462 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Angels Clinical Research Institute, Inc. - Tampa | Tampa | Florida | 33614 | — |
| Charter Research - The Villages | The Villages | Florida | 32162 | — |
| ClinCloud, LLC Melbourn | Viera | Florida | 32940 | — |
| Conquest Research | Winter Park | Florida | 32789 | — |
| iResearch -Atlanta | Atlanta | Georgia | 30030 | — |
| Atlanta Neuroscience Institute | Atlanta | Georgia | 30327 | — |
| Accel Research Sites | Decatur | Georgia | 30030 | — |
| iResearch | Savannah | Georgia | 31405 | — |
| Re:Cognition Health - Chicago | Chicago | Illinois | 60611 | — |
| Tandem Clinical Research | New Orleans | Louisiana | 70072 | — |
| BTC of New Bedford | New Bedford | Massachusetts | 02740 | — |
| Boston Center for Memory | Newton | Massachusetts | 02459 | — |
| Headlands Research - Eastern MA | Plymouth | Massachusetts | 02360 | — |
| Boston Paincare | Waltham | Massachusetts | 02451 | — |
| Sharlin Health Neuroscience Research Center | Ozark | Missouri | 65721 | — |
| Alivation | Lincoln | Nebraska | 68526 | — |
| Wake Research- Clinical Research Center of Nevada, LLC | Las Vegas | Nevada | 89106 | — |
| Advanced Memory Research Institute of New Jersey | Toms River | New Jersey | 08755 | — |
| Dent Neuroscience Research Center | Amherst | New York | 14226 | — |
| Mid-Hudson Medical Research, PLLC - New Windsor | New Windsor | New York | 12553 | — |
| Triad Clinical Trials | Greensboro | North Carolina | 27410 | — |
| AMC Research, LLC | Matthews | North Carolina | 28105 | — |
| Accellacare of Winston-Salem, Triad Neurological Associates | Winston-Salem | North Carolina | 27103 | — |
| NeuroScience Research Center, LLC | Canton | Ohio | 44718 | — |
| American Clinical Research Institute, LLC | Dayton | Ohio | 45432 | — |
| Rhode Island Mood and Memory REsearch | East Providence | Rhode Island | 02914 | — |
| Health Concepts | Rapid City | South Dakota | 57702 | — |
| Neurology Clinic, P.C. | Cordova | Tennessee | 38018 | — |
| Center for Biomedical Research, LLC - Genesis Neuroscience Clinic | Knoxville | Tennessee | 37909 | — |
| Gadolin Research LLC | Beaumont | Texas | 77702 | — |
| Kerwin Medical Center | Dallas | Texas | 75231 | — |
| Cognition Health Corporation- Texas | Houston | Texas | 77030 | — |
| Clinical Trial Network - Houston | Houston | Texas | 77074 | — |
| Bhupesh Dihenia, MD, PA | Lubbock | Texas | 79410 | — |
| Wasatch Clinical Research, LLC | Salt Lake City | Utah | 84107 | — |
| Cognition Health Corporation | Fairfax | Virginia | 22031 | — |
| Integrated Neurology Services | Falls Church | Virginia | 22043 | — |
| Kingfisher Cooperative | Spokane | Washington | 99201 | — |
| Vaught Neurological Services, PLLC | Crab Orchard | West Virginia | 25827 | — |
| Medical College of Wisconsin | Wauwatosa | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 123 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05531526, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 14, 2026 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05531526 live on ClinicalTrials.gov.