Study of Tecovirimat for Human Mpox Virus
Public ClinicalTrials.gov record NCT05534984. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Placebo-Controlled, Double-Blinded Trial of the Safety and Efficacy of Tecovirimat for the Treatment of Human Mpox Virus Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study was to see if tecovirimat is safe and successful at treating mpox. The main questions were whether tecovirimat reduced time to lesion resolution and pain compared to placebo (no treatment).
Study identification
- NCT ID
- NCT05534984
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 719 participants
Conditions and interventions
Conditions
Interventions
- Tecovirimat Oral Capsule Drug
- Placebo for Tecovirimat Drug
- Tecovirimat Oral Capsule (Open Label) Drug
Drug
Eligibility (public fields only)
- Age range
- Not listed
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 8, 2022 (Actual)
- Primary completion
- Oct 23, 2024 (Actual)
- Completion
- Feb 22, 2025 (Actual)
- Last update posted
- Jun 23, 2026
2022 – 2025
United States locations
- U.S. sites
- 44
- U.S. states
- 18
- U.S. cities
- 33
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alabama CRS | Birmingham | Alabama | 35294 | — |
| Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | 90027 | — |
| Los Angeles LGBT Center CRS | Los Angeles | California | 90028 | — |
| UCLA CARE Center CRS | Los Angeles | California | 90035 | — |
| University of California, Davis CRS | Sacramento | California | 95817 | — |
| UCSD Antiviral Research Center CRS | San Diego | California | 92103 | — |
| University of California, San Francisco HIV/AIDS CRS | San Francisco | California | 94110 | — |
| Harbor University of California Los Angeles Center | Torrance | California | 90502 | — |
| University of Colorado Denver NICHD CRS | Aurora | Colorado | 80045 | — |
| University of Colorado Hospital CRS | Aurora | Colorado | 80045 | — |
| Denver Public Health CRS | Denver | Colorado | 80204 | — |
| University of Florida | Gainesville | Florida | 32610 | — |
| University of Florida Jacksonville NICHD CRS | Jacksonville | Florida | 32209 | — |
| University of Miami / Jackson Memorial Hospital | Miami | Florida | 33136 | — |
| Univ. of South Florida (USF) College of Medicine A | Tampa | Florida | 33606 | — |
| The Ponce de Leon Center CRS | Atlanta | Georgia | 30308 | — |
| Rush University Cook County Hospital Chicago NICHD CRS | Chicago | Illinois | 60612 | — |
| Johns Hopkins University CRS | Baltimore | Maryland | 21205 | — |
| Massachusetts General Hospital CRS (MGH CRS) | Boston | Massachusetts | 02114 | — |
| Brigham and Women's Hospital Therapeutics | Boston | Massachusetts | 02115 | — |
| Henry Ford Hospital CRS | Detroit | Michigan | 48202 | — |
| Washington University Therapeutics (WT) CRS | St Louis | Missouri | 63110 | — |
| New Jersey Medical School Clinical Research Center | Newark | New Jersey | 07103 | — |
| Weill Cornell Chelsea CRS | New York | New York | 10010 | — |
| Mount Sinai West Samuels CRS | New York | New York | 10019 | — |
| Harlem Prevention Center | New York | New York | 10027 | — |
| Columbia Physicians & Surgeons (P&S) CRS | New York | New York | 10032 | — |
| Weill Cornell Uptown CRS | New York | New York | 10065 | — |
| Bronx-Lebanon Hospital Center NICHD CRS | New York | New York | 10457 | — |
| Infectious Disease Clinical and Translational Research | New York | New York | 11029 | — |
| University of Rochester Adult HIV Therapeutic | Rochester | New York | 14642 | — |
| SUNY Stony Brook NICHD CRS | Stony Brook | New York | 11794 | — |
| Duke University Medical Center CRS | Durham | North Carolina | 27710 | — |
| Wake Forest Baptist Medical Center CRS | Winston-Salem | North Carolina | 27157 | — |
| Cincinnati CRS | Cincinnati | Ohio | 45267 | — |
| Case Western Reserve University CTU | Cleveland | Ohio | 44106 | — |
| Ohio State University CRS | Columbus | Ohio | 43210 | — |
| Penn Therapeutics CRS | Philadelphia | Pennsylvania | 19104 | — |
| University of Pittsburgh CRS | Pittsburgh | Pennsylvania | 15213 | — |
| St. Jude Children's Research Hospital ATN CRS | Memphis | Tennessee | 38105 | — |
| North Texas Infectious Disease Consultants | Dallas | Texas | 75246 | — |
| UT Southwestern Infectious Disease Research Unit | Dallas | Texas | 75390 | — |
| Houston AIDS Research Team (HART) CRS | Houston | Texas | 77030 | — |
| University of Washington Positive Research | Seattle | Washington | 98104 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 10 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05534984, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 23, 2026 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05534984 live on ClinicalTrials.gov.