Trial of Centanafadine Efficacy and Safety as Monotherapy or as Adjunct to SSRI in Adults With Major Depressive Disorder
Public ClinicalTrials.gov record NCT05536414. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-arm Trial to Assess the Efficacy, Safety, and Tolerability of Centanafadine Extended-release Capsules as Monotherapy or as Adjunct to SSRI in Adult Subjects With Major Depressive Disorder
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a phase 2, multicenter, randomized, double-blind, placebo-controlled, parallel-arm trial to assess the efficacy, safety, and tolerability of centanafadine once-daily (QD) extended-release (XR) capsules for the treatment of adult subjects diagnosed with Major Depressive Disorder (MDD). The trial will evaluate the efficacy and safety of centanafadine QD XR capsules as monotherapy or as adjunct to the selective serotonin reuptake inhibitor (SSRI), escitalopram.
Study identification
- NCT ID
- NCT05536414
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 337 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 12, 2022 (Actual)
- Primary completion
- May 16, 2025 (Actual)
- Completion
- May 16, 2025 (Actual)
- Last update posted
- May 14, 2026
2022 – 2025
United States locations
- U.S. sites
- 62
- U.S. states
- 24
- U.S. cities
- 56
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Yuma CNS Research | Yuma | Arizona | 85365-4905 | — |
| SanRo Clinical Research Group LLC | Bryant | Arkansas | 72022-9252 | — |
| Behavioral Research Specialists-California-Irvine | Glendale | California | 91206-4282 | — |
| Sunwise Clinical Research, LLC - Lafayette - IVY - PPDS | Lafayette | California | 94549 | — |
| OM Research LLC - Lancaster - ClinEdge - PPDS | Lancaster | California | 93534-5504 | — |
| Synergy Research Centers - SRC - ERG - PPDS | Lemon Grove | California | 91945-2956 | — |
| ATP Clinical Research | Orange | California | 92866 | — |
| NRC Research Institute - Orange - PPDS | Orange | California | 92868-2847 | — |
| Prospective Research Innovations | Rancho Cucamonga | California | 91730-4850 | — |
| Anderson Clinical Research - ClinEdge - PPDS | Redlands | California | 92374-4555 | — |
| Lumos Clinical Research | San Jose | California | 95124-4108 | — |
| Syrentis Clinical Research | Santa Ana | California | 92705-8675 | — |
| Schuster Medical Research Institute | Sherman Oaks | California | 91403-1747 | — |
| Viking Clinical Research Ltd | Temecula | California | 92591-5285 | — |
| CNS Clinical Research Group | Coral Springs | Florida | 33067-4644 | — |
| Gulfcoast Clinical Research Center | Fort Myers | Florida | 33912-4367 | — |
| Clinical Neuroscience Solutions Inc | Jacksonville | Florida | 32256-6040 | — |
| South Florida Research Phase I - IV | Miami Springs | Florida | 33166-7225 | — |
| Behavioral Clinical Research, Inc | North Miami | Florida | 33161-5832 | — |
| Clinical Neuroscience Solutions Inc | Orlando | Florida | 32801-2987 | — |
| University of South Florida | Tampa | Florida | 33613-4706 | — |
| Atlanta Center for Medical Research - CenExel ACMR - PPDS | Atlanta | Georgia | 30331 | — |
| iResearch Atlanta - CenExel - PPDS | Decatur | Georgia | 30030-3438 | — |
| Psych Atlanta | Marietta | Georgia | 30060-2585 | — |
| Accelerated Clinical Trials,LLC | Peachtree Corners | Georgia | 30071-2655 | — |
| Northwest Clinical Trials | Boise | Idaho | 83704-8638 | — |
| Flourish Research - Andersonville - PPDS | Chicago | Illinois | 60640-2831 | — |
| Revive Research Institute | Elgin | Illinois | 60123-9215 | — |
| American Medical Research Inc | Oak Brook | Illinois | 60523-1818 | — |
| Louisiana Clinical Research, LLC | Shreveport | Louisiana | 71101-4603 | — |
| MTP Psychiatry, LLC | Baltimore | Maryland | 21229-1506 | — |
| Precise Research Centers - ClinEdge - PPDS | Flowood | Mississippi | 39232 | — |
| Psychiatric Care and Research Center | O'Fallon | Missouri | 63368-8223 | — |
| Bio Behavioral Health | Toms River | New Jersey | 08755-6434 | — |
| Integrative Clinical Trials - Hunt - PPDS | Brooklyn | New York | 11229-3576 | — |
| SPRI Clinical Trials, LLC - ERG - PPDS | Brooklyn | New York | 11235-5660 | — |
| Fieve Clinical Research | New York | New York | 10017-1945 | — |
| Manhattan Behavioral Medicine | New York | New York | 10036-4543 | — |
| Finger Lakes Clinical Research | Rochester | New York | 14618-1609 | — |
| Richmond Behavioral Associates | Staten Island | New York | 10314 | — |
| Patient Priority Clinical Sites LLC | Cincinnati | Ohio | 45215-2123 | — |
| University of Cincinnati | Cincinnati | Ohio | 45219-2498 | — |
| Charak Clinical Research Center | Garfield Heights | Ohio | 44125-2946 | — |
| Neuro-Behavioral Clinical Research Inc - ClinEdge - PPDS | North Canton | Ohio | 44720-1528 | — |
| Cutting Edge Research | Oklahoma City | Oklahoma | 73116-1423 | — |
| Summit Research Network, Inc. - Portland - Headlands - PPDS | Portland | Oregon | 97210-5354 | — |
| Suburban Research Associates - ATLAS - West Chester - PPDS | West Chester | Pennsylvania | 19380-4370 | — |
| LLM Research - South Carolina | Myrtle Beach | South Carolina | 29577-5898 | — |
| Clinical Neuroscience Solutions Inc | Memphis | Tennessee | 38119-4806 | — |
| FutureSearch Trials of Dallas, LLC - IVY - PPDS | Dallas | Texas | 75251 | — |
| InSite Clinical Research, LLC | DeSoto | Texas | 75115-2066 | — |
| Houston Mind & Brain | Houston | Texas | 77055-6349 | — |
| Innovative Medical Research of Texas | Houston | Texas | 77065-4776 | — |
| Red Oak Psychiatry Associates P A | Houston | Texas | 77090-2607 | — |
| University Hills Clinical Research | Irving | Texas | 75062-2762 | — |
| AIM Trials | Plano | Texas | 75093-8346 | — |
| Grayline Clinical Drug Trials | Wichita Falls | Texas | 76309-1608 | — |
| Alpine Research Organization, Inc | Clinton | Utah | 84015-8563 | — |
| Cedar Clinical Research - IVY - PPDS | Draper | Utah | 84020-9884 | — |
| The Memory Clinic | Bennington | Vermont | 05201-9810 | — |
| University of Virginia | Charlottesville | Virginia | 22903-9353 | — |
| Core Clinical Research | Everett | Washington | 98201-4077 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05536414, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 14, 2026 · Synced Oct 27, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05536414 live on ClinicalTrials.gov.