ClinicalTrials.gov record
Testing the Addition of the AKT Inhibitor, Ipatasertib, to Treatment With the Hormonal Agent Megestrol Acetate for Recurrent or Metastatic Endometrial Cancers
ClinicalTrials.gov ID: NCT05538897
Public ClinicalTrials.gov record NCT05538897. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase IB and Randomized Phase II Trial of Megestrol Acetate With or Without Ipatasertib in Recurrent or Metastatic Endometrioid Endometrial Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This phase Ib/II trial tests the safety, side effects, best dose, and effectiveness of the combination of ipatasertib with megestrol acetate to megestrol acetate alone in patients with endometrial cancer that has come back (recurrent) or has spread to other places in the body (metastatic). Ipatasertib may stop the growth of tumor cells and may kill them by blocking some of the enzymes needed for cell growth. Megestrol acetate lowers the amount of estrogen and also blocks the use of estrogen made by the body. This may help stop the growth of tumor cells that need estrogen to grow. The combination of ipatasertib and megestrol acetate may be more effective in treating endometrial cancer than megestrol acetate alone.
Study identification
- NCT ID
- NCT05538897
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 96 participants
Conditions and interventions
Conditions
Interventions
- Biospecimen Collection Procedure
- Computed Tomography Procedure
- Ipatasertib Drug
- Magnetic Resonance Imaging Procedure
- Megestrol Acetate Drug
Procedure · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 31, 2023 (Actual)
- Primary completion
- Jan 31, 2027 (Estimated)
- Completion
- Jan 31, 2027 (Estimated)
- Last update posted
- Oct 1, 2026
2023 – 2027
United States locations
- U.S. sites
- 152
- U.S. states
- 34
- U.S. cities
- 122
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner University Medical Center - Tucson | Tucson | Arizona | 85719 | — |
| University of Arizona Cancer Center-North Campus | Tucson | Arizona | 85719 | — |
| Highlands Oncology Group - Fayetteville | Fayetteville | Arkansas | 72703 | — |
| Highlands Oncology Group - Rogers | Rogers | Arkansas | 72758 | — |
| Highlands Oncology Group | Springdale | Arkansas | 72762 | — |
| University of California Davis Comprehensive Cancer Center | Sacramento | California | 95817 | — |
| UCHealth University of Colorado Hospital | Aurora | Colorado | 80045 | — |
| UF Health Cancer Institute - Gainesville | Gainesville | Florida | 32610 | — |
| Sarasota Memorial Hospital-Venice | N. Venice | Florida | 34275 | — |
| Florida Cancer Specialists - Sarasota Downtown | Sarasota | Florida | 34239 | — |
| FPG - Surgical Oncology Clinics Gynecologic Oncology Surgery | Sarasota | Florida | 34239 | — |
| Sarasota Memorial Hospital | Sarasota | Florida | 34239 | — |
| Florida Cancer Specialists - Venice Pinebrook | Venice | Florida | 34275 | — |
| Augusta University Medical Center | Augusta | Georgia | 30912 | — |
| Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | 83706 | — |
| Saint Luke's Cancer Institute - Boise | Boise | Idaho | 83712 | — |
| Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho | 83605 | — |
| Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho | 83814 | — |
| Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho | 83619 | — |
| Saint Luke's Cancer Institute - Meridian | Meridian | Idaho | 83642 | — |
| Saint Alphonsus Cancer Care Center-Nampa | Nampa | Idaho | 83687 | — |
| Saint Luke's Cancer Institute - Nampa | Nampa | Idaho | 83687 | — |
| Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho | 83854 | — |
| Kootenai Clinic Cancer Services - Sandpoint | Sandpoint | Idaho | 83864 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| University of Illinois | Chicago | Illinois | 60612 | — |
| Carle at The Riverfront | Danville | Illinois | 61832 | — |
| Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | 62526 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Northwestern Medicine Cancer Center Kishwaukee | DeKalb | Illinois | 60115 | — |
| Carle Physician Group-Effingham | Effingham | Illinois | 62401 | — |
| Crossroads Cancer Center | Effingham | Illinois | 62401 | — |
| Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | 60134 | — |
| Northwestern Medicine Grayslake Outpatient Center | Grayslake | Illinois | 60030 | — |
| Northwestern Medicine Lake Forest Hospital | Lake Forest | Illinois | 60045 | — |
| Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | 61938 | — |
| Cancer Care Center of O'Fallon | O'Fallon | Illinois | 62269 | — |
| Northwestern Medicine Orland Park | Orland Park | Illinois | 60462 | — |
| Southern Illinois University School of Medicine | Springfield | Illinois | 62702 | — |
| Springfield Clinic | Springfield | Illinois | 62702 | — |
| Springfield Memorial Hospital | Springfield | Illinois | 62781 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | 60555 | — |
| IU Health North Hospital | Carmel | Indiana | 46032 | — |
| Parkview Regional Medical Center | Fort Wayne | Indiana | 46845 | — |
| Goshen Center for Cancer Care | Goshen | Indiana | 46526 | — |
| Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | 46202 | — |
| Memorial Hospital of South Bend | South Bend | Indiana | 46601 | — |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic | Ankeny | Iowa | 50023 | — |
| Iowa Methodist Medical Center | Des Moines | Iowa | 50309 | — |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic | Des Moines | Iowa | 50309 | — |
| University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Iowa | 52242 | — |
| University of Kansas Cancer Center | Kansas City | Kansas | 66160 | — |
| University of Kansas Hospital-Indian Creek Campus | Overland Park | Kansas | 66211 | — |
| University of Kansas Hospital-Westwood Cancer Center | Westwood | Kansas | 66205 | — |
| Harold Alfond Center for Cancer Care | Augusta | Maine | 04330 | — |
| MaineHealth Maine Medical Center- Scarborough | Scarborough | Maine | 04074 | — |
| Walter Reed National Military Medical Center | Bethesda | Maryland | 20889-5600 | — |
| University of Michigan Rogel Cancer Center | Ann Arbor | Michigan | 48109 | — |
| Bronson Battle Creek | Battle Creek | Michigan | 49017 | — |
| Corewell Health Grand Rapids Hospitals - Butterworth Hospital | Grand Rapids | Michigan | 49503 | — |
| Trinity Health Grand Rapids Hospital | Grand Rapids | Michigan | 49503 | — |
| Bronson Methodist Hospital | Kalamazoo | Michigan | 49007 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| Beacon Kalamazoo Cancer Center | Kalamazoo | Michigan | 49009 | — |
| Trinity Health Muskegon Hospital | Muskegon | Michigan | 49444 | — |
| Corewell Health Lakeland Hospitals - Niles Hospital | Niles | Michigan | 49120 | — |
| Cancer and Hematology Centers of Western Michigan - Norton Shores | Norton Shores | Michigan | 49444 | — |
| Corewell Health Reed City Hospital | Reed City | Michigan | 49677 | — |
| Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center | Saint Joseph | Michigan | 49085 | — |
| Corewell Health Lakeland Hospitals - Saint Joseph Hospital | Saint Joseph | Michigan | 49085 | — |
| Munson Medical Center | Traverse City | Michigan | 49684 | — |
| University of Michigan Health - West | Wyoming | Michigan | 49519 | — |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Fairview Southdale Hospital | Edina | Minnesota | 55435 | — |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| University of Minnesota/Masonic Cancer Center | Minneapolis | Minnesota | 55455 | — |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | 55416 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| United Hospital | Saint Paul | Minnesota | 55102 | — |
| Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota | 55125 | — |
| MU Health - University Hospital/Ellis Fischel Cancer Center | Columbia | Missouri | 65212 | — |
| MU Health Care Goldschmidt Cancer Center | Jefferson City | Missouri | 65109 | — |
| University of Kansas Cancer Center - North | Kansas City | Missouri | 64154 | — |
| Mercy Hospital Springfield | Springfield | Missouri | 65804 | — |
| Mercy Hospital South | St Louis | Missouri | 63128 | — |
| Mercy Hospital Saint Louis | St Louis | Missouri | 63141 | — |
| Community Hospital of Anaconda | Anaconda | Montana | 59711 | — |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | — |
| Bozeman Health Deaconess Hospital | Bozeman | Montana | 59715 | — |
| Benefis Sletten Cancer Institute | Great Falls | Montana | 59405 | — |
| Community Medical Center | Missoula | Montana | 59804 | — |
| Cooper Hospital University Medical Center | Camden | New Jersey | 08103 | — |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | 87106 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| State University of New York Upstate Medical University | Syracuse | New York | 13210 | — |
| Montefiore Medical Center-Einstein Campus | The Bronx | New York | 10461 | — |
| Montefiore Medical Center-Weiler Hospital | The Bronx | New York | 10461 | — |
| Montefiore Medical Center - Moses Campus | The Bronx | New York | 10467 | — |
| UNC Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina | 27599 | — |
| Carolinas Medical Center/Levine Cancer Institute | Charlotte | North Carolina | 28203 | — |
| Atrium Health Cabarrus/LCI-Concord | Concord | North Carolina | 28025 | — |
| Summa Health System - Akron Campus | Akron | Ohio | 44304 | — |
| UHHS-Chagrin Highlands Medical Center | Beachwood | Ohio | 44122 | — |
| Miami Valley Hospital South | Centerville | Ohio | 45459 | — |
| Geauga Hospital | Chardon | Ohio | 44024 | — |
| Good Samaritan Hospital - Cincinnati | Cincinnati | Ohio | 45220 | — |
| Case Western Reserve University | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | — |
| Riverside Methodist Hospital | Columbus | Ohio | 43214 | — |
| Miami Valley Hospital | Dayton | Ohio | 45409 | — |
| Miami Valley Hospital North | Dayton | Ohio | 45415 | — |
| Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | 45005-1066 | — |
| Miami Valley Cancer Care and Infusion | Greenville | Ohio | 45331 | — |
| UH Seidman Cancer Center at Lake Health Mentor Campus | Mentor | Ohio | 44060 | — |
| Upper Valley Medical Center | Troy | Ohio | 45373 | — |
| UH Seidman Cancer Center at Saint John Medical Center | Westlake | Ohio | 44145 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Oklahoma Cancer Specialists and Research Institute-Tulsa | Tulsa | Oklahoma | 74146 | — |
| Saint Alphonsus Cancer Care Center-Ontario | Ontario | Oregon | 97914 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Providence Saint Vincent Medical Center | Portland | Oregon | 97225 | — |
| Jefferson Hospital | Jefferson Hills | Pennsylvania | 15025 | — |
| Forbes Hospital | Monroeville | Pennsylvania | 15146 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| West Penn Hospital | Pittsburgh | Pennsylvania | 15224 | — |
| Wexford Health and Wellness Pavilion | Wexford | Pennsylvania | 15090 | — |
| Asplundh Cancer Pavilion | Willow Grove | Pennsylvania | 19090 | — |
| Women and Infants Hospital | Providence | Rhode Island | 02905 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | 37232 | — |
| Parkland Memorial Hospital | Dallas | Texas | 75235 | — |
| UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | 75390 | — |
| UT Southwestern/Simmons Cancer Center-Fort Worth | Fort Worth | Texas | 76104 | — |
| Lyndon Baines Johnson General Hospital | Houston | Texas | 77026-1967 | — |
| Memorial Hermann Texas Medical Center | Houston | Texas | 77030 | — |
| UT MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| UT Southwestern Clinical Center at Richardson/Plano | Richardson | Texas | 75080 | — |
| Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | 84112 | — |
| University of Virginia Cancer Center | Charlottesville | Virginia | 22908 | — |
| VCU Massey Cancer Center at Stony Point | Richmond | Virginia | 23235 | — |
| VCU Massey Comprehensive Cancer Center | Richmond | Virginia | 23298 | — |
| Carilion Roanoke Memorial Hospital | Roanoke | Virginia | 24033 | — |
| Swedish Cancer Institute-Edmonds | Edmonds | Washington | 98026 | — |
| Swedish Cancer Institute-Issaquah | Issaquah | Washington | 98029 | — |
| Swedish Medical Center-First Hill | Seattle | Washington | 98122 | — |
| Vandalia Health/CAMC Institute for Academic Medicine | Charleston | West Virginia | 25304 | — |
| University of Wisconsin Carbone Cancer Center - Eastpark Medical Center | Madison | Wisconsin | 53718 | — |
| University of Wisconsin Carbone Cancer Center - University Hospital | Madison | Wisconsin | 53792 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05538897, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 1, 2026 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05538897 live on ClinicalTrials.gov.