PBI-0451 (Pomotrelvir) Phase 2 Study in Nonhospitalized Symptomatic Adults With COVID-19
Public ClinicalTrials.gov record NCT05543707. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Double-blind, Randomized Study to Evaluate the Antiviral Activity, Safety, and Efficacy of Orally Administered PBI-0451(Pomotrelvir) Compared With Placebo in Nonhospitalized Symptomatic Adults With COVID-19
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a phase 2 double-blind, randomized study of PBI-0451(Pomotrelvir) in nonhospitalized symptomatic adults with COVID-19. PBI-0451(Pomotrelvir) is a new chemical entity and inhibitor of the main protease of coronaviruses, including the SARS-CoV-2 that causes COVID-19 disease. This study is designed to evaluate the antiviral activity, safety, and efficacy of orally administered PBI-0451(Pomotrelvir) compared with placebo.
Study identification
- NCT ID
- NCT05543707
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 242 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 64 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 21, 2022 (Actual)
- Primary completion
- Jan 27, 2023 (Actual)
- Completion
- Apr 14, 2023 (Actual)
- Last update posted
- Dec 11, 2024
2022 – 2023
United States locations
- U.S. sites
- 54
- U.S. states
- 15
- U.S. cities
- 44
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Voyage Medical | Mesa | Arizona | 85210 | — |
| Franco A Felizarta MD | Bakersfield | California | 93301-1692 | — |
| Hope Clinical Research, LLC | Canoga Park | California | 91303 | — |
| Biopharma Informatic, LLC | Encino | California | 91436 | — |
| Ascada Research LLC | Fullerton | California | 92835-3424 | — |
| Ark Clinical Research - Long Beach - Clinedge - PPDS | Long Beach | California | 92868 | — |
| Valiance Clinical Research | Tarzana | California | 91356-6695 | — |
| Allianz Research Institute - Colorado | Westminster | California | 92683-4454 | — |
| TrueBlue Clinical Research- Brandon - HyperCore - PPDS | Brandon | Florida | 33511-4850 | — |
| Beautiful Minds Clinical Research Center | Cutler Bay | Florida | 33157 | — |
| Indago Research and Health Center | Hialeah | Florida | 33012-4174 | — |
| Quality Research of South Florida | Hialeah | Florida | 33016-1811 | — |
| Gonzalez M.D. & Aswad M.D. Health Care Services | Miami | Florida | 33125 | — |
| Universal Medical and Research Center, LLC | Miami | Florida | 33126 | — |
| CCM Clinical Research Group | Miami | Florida | 33133-4231 | — |
| D&H National Research Centers | Miami | Florida | 33155-3262 | — |
| Allied Biomedical Research Institute | Miami | Florida | 33155-4630 | — |
| Florida International Medical Research | Miami | Florida | 33155 | — |
| P&S Research, LLC | Miami | Florida | 33175 | — |
| The Angel Medical Research Corporation | Miami Lakes | Florida | 33016-1641 | — |
| South Florida Research | Miami Springs | Florida | 33166 | — |
| EMINAT Research | Miramar | Florida | 33027 | — |
| Combined Research Orlando Phase I-IV LLC | Orlando | Florida | 32803 | — |
| Ormond Beach Clinical Research | Ormond Beach | Florida | 32174 | — |
| CTMD Research, Inc. - Palm Springs - Hunt - PPDS | Palm Springs | Florida | 33406 | — |
| IMIC Inc. | Palmetto Bay | Florida | 33157-5503 | — |
| Infectious Disease Consultants of the Treasure Coast | Sebastian | Florida | 32958 | — |
| Westchester General Hospital | South Miami | Florida | 33143-5045 | — |
| DBC Research | Tamarac | Florida | 33321 | — |
| Alliance Clinical Research-(Tampa) | Tampa | Florida | 33615-3816 | — |
| Palm Beach Research - ClinEdge - PPDS | West Palm Beach | Florida | 33409 | — |
| Agile Clinical Research Trials, LLC | Atlanta | Georgia | 30328 | — |
| Centricity Research - Roswell - HyperCore - PPDS | Columbus | Georgia | 31904 | — |
| Eagle Clinical Research | Chicago | Illinois | 60621-3116 | — |
| Revival Research Corporation - Clinedge - PPDS | Sterling Heights | Michigan | 48312 | — |
| Safe Haven Clinical Research | Clinton | Mississippi | 39056-5606 | — |
| Mercury Street Medical Group | Butte | Montana | 59701-1652 | — |
| Las Vegas Medical Research | Las Vegas | Nevada | 89128-0373 | — |
| Research Carolina Elite | Denver | North Carolina | 28037-7929 | — |
| WellNow Urgent Care Troy Urgent Care | Dayton | Ohio | 45424 | — |
| STAT Research | Vandalia | Ohio | 45377 | — |
| Clinovacare Medical Clinical Research Center | West Columbia | South Carolina | 29169 | — |
| Veritas Health Care Group | West Columbia | South Carolina | 29169 | — |
| Clinical Trials Center of Middle Tennessee | Franklin | Tennessee | 37067-5663 | — |
| Central Texas Clinical Research | Austin | Texas | 78705 | — |
| Zenos Clinical Research | Dallas | Texas | 75230-6895 | — |
| Proactive Clinical Research, LLC Edinburg | Edinburg | Texas | 78539-4660 | — |
| Care United Research, LLC | Forney | Texas | 75126-4174 | — |
| Mercy Family Clinic | Houston | Texas | 75211 | — |
| Xpress Trials | Houston | Texas | 77036-8280 | — |
| Diversified Medical Practices, P.A. | Houston | Texas | 77084 | — |
| Epic Clinical Research | Lewisville | Texas | 75057 | — |
| VIP Trials | San Antonio | Texas | 78230 | — |
| Suffolk Multispecialty Research | Suffolk | Virginia | 23435-3762 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05543707, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 11, 2024 · Synced Oct 31, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05543707 live on ClinicalTrials.gov.