Study of the Efficacy and Safety of Ponsegromab in Patients With Cancer, Cachexia and Elevated GDF-15
Public ClinicalTrials.gov record NCT05546476. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO INVESTIGATE THE EFFICACY, SAFETY AND TOLERABILITY OF PONSEGROMAB IN PATIENTS WITH CANCER, CACHEXIA, AND ELEVATED CONCENTRATIONS OF GDF-15, FOLLOWED BY AN OPTIONAL OPEN-LABEL TREATMENT PERIOD (PROACC -1)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Study to evaluate the efficacy, safety and tolerability of ponsegromab compared to placebo in patients with cancer, cachexia, and elevated GDF 15.
Study identification
- NCT ID
- NCT05546476
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 187 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 20, 2022
- Primary completion
- Mar 12, 2024
- Completion
- Apr 22, 2025
- Last update posted
- Jun 2, 2026
2022 – 2025
United States locations
- U.S. sites
- 19
- U.S. states
- 8
- U.S. cities
- 17
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| CARTI Conway | Conway | Arkansas | 72034 | — |
| CARTI Cancer Center | Little Rock | Arkansas | 72205 | — |
| CARTI North Little Rock | North Little Rock | Arkansas | 72117 | — |
| CARTI Stuttgart | Stuttgart | Arkansas | 72160 | — |
| Pacific Cancer Medical Center INC | Anaheim | California | 92801 | — |
| Beverly Hills Cancer Center | Beverly Hills | California | 90211 | — |
| Emad Ibrahim,MD,INC. | Redlands | California | 92373 | — |
| Providence Medical Foundation | Santa Rosa | California | 95403 | — |
| IU Health Arnett Cancer Center | Lafayette | Indiana | 47904 | — |
| Pennington Biomedical Research Center | Baton Rouge | Louisiana | 70808 | — |
| Tandem Clinical Research | Marrero | Louisiana | 70072 | — |
| Bozeman Health Deaconess Hospital | Bozeman | Montana | 59715 | — |
| Oregon Health and Science University: Center for Health and Healing 1 | Portland | Oregon | 97239 | — |
| Oregon Health and Science University: Center for Health and Healing 2 | Portland | Oregon | 97239 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Carta - Clinical Associates in Research Therapeutics of America, LLC | San Antonio | Texas | 78212 | — |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | — |
| Wenatchee Valley Hospital | Wenatchee | Washington | 98801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 59 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05546476, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 2, 2026 · Synced Sep 3, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05546476 live on ClinicalTrials.gov.