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Recruiting Phase 4 Interventional

Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study

ClinicalTrials.gov ID: NCT05548283

Public ClinicalTrials.gov record NCT05548283. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 1, 2026, 5:33 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Standardizing Treatments for Pulmonary Exacerbations: A Platform for Evaluating Treatment Decisions to Improve Outcomes (STOP360) Aminoglycoside Study (AG Study)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this study is to look at pulmonary exacerbations in people with cystic fibrosis (CF) that need to be treated with antibiotics given through a tube inserted into a vein (intravenous or IV). A pulmonary exacerbation is a worsening of respiratory symptoms in people with CF that needs medical intervention. Both doctors and CF patients are trying to understand the best way to treat pulmonary exacerbations. This study is trying to answer the following questions about treating a pulmonary exacerbation: * Do participants have the same improvement in lung function and symptoms if they are treated with one type of antibiotic (called beta-lactams or β-lactams) versus taking two different types of antibiotics (tobramycin and β-lactams)? * Is taking one type of antibiotic just as good as taking two types?

Study identification

NCT ID
NCT05548283
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 4
Lead sponsor
Chris Goss
Other
Enrollment
730 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
6 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Apr 22, 2023
Primary completion
May 30, 2027
Completion
May 30, 2027
Last update posted
Jul 7, 2026

2023 – 2027

United States locations

U.S. sites
59
U.S. states
32
U.S. cities
52
Facility City State ZIP Site status
The Children's Hospital Alabama, University of Alabama at Birmingham Birmingham Alabama 35233 Recruiting
Tucson Cystic Fibrosis Center Tucson Arizona 85724 Recruiting
University of California San Diego La Jolla California 92093 Recruiting
Long Beach Memorial Medical Center Long Beach California 90806 Recruiting
CHOC Children's Hospital Orange California 92868 Recruiting
University of California at Davis Medical Center Sacramento California 95817 Recruiting
Children's National Medical Center Washington D.C. District of Columbia 20010 Not yet recruiting
University of Florida Gainesville Florida 32610 Recruiting
Joe DiMaggio Children's Hospital Hollywood Florida 33021 Recruiting
Nemours Children's Clinic Jacksonville Florida 32207 Recruiting
University of Miami Miami Florida 33136 Recruiting
All Children's Hospital St. Petersburg Florida 33701 Recruiting
Emory University Atlanta Georgia 30327 Recruiting
Saint Luke's Cystic Fibrosis Center of Idaho Boise Idaho 83702 Recruiting
Ann & Robert H. Lurie Children's Hospital of Chicago Chicago Illinois 60611 Recruiting
Northwestern University Chicago Illinois 60611 Recruiting
OSF Saint Francis Medical Center Peoria Illinois 61637 Recruiting
Indiana University Medical Center Indianapolis Indiana 46202 Recruiting
Riley Hospital for Children Indianapolis Indiana 46202 Recruiting
University of Iowa Iowa City Iowa 52242 Recruiting
University of Kansas Medical Center Kansas City Kansas 66160 Recruiting
University of Louisville Louisville Kentucky 40202 Recruiting
Maine Medical Center Portland Maine 04102 Recruiting
John Hopkins Hospital Baltimore Maryland 21205 Recruiting
Boston Children's Hospital, Brigham & Women's Hospital Boston Massachusetts 02115 Recruiting
University of Massachusetts Memorial Health Care Worcester Massachusetts 01655 Recruiting
University of Michigan, Michigan Medicine Ann Arbor Michigan 48109 Recruiting
Helen DeVos Children's Hospital Grand Rapids Michigan 49546 Recruiting
SSM Health Cardinal Glennon Children's Hospital St Louis Missouri 63104 Recruiting
Washington University School of Medicine St Louis Missouri 63110 Recruiting
Billings Clinic Billings Montana 59101 Recruiting
Dartmouth Hitchcock Medical Center Lebanon New Hampshire 03756 Recruiting
Morristown Medical Center Morristown New Jersey 07960 Recruiting
Rutgers - Robert Wood Johnson Medical School New Brunswick New Jersey 08903 Recruiting
Lenox Hill Hospital Cystic Fibrosis Center New York New York 10003 Recruiting
Children's Hospital of New York New York New York 10032 Recruiting
New York Medical College at Westchester Medical Center Valhalla New York 10595 Recruiting
Children's Hospital Medical Center of Akron Akron Ohio 44308 Recruiting
Cincinnati Children's Hospital Medical Center Cincinnati Ohio 45229 Recruiting
University of Cincinnati Medical Center Cincinnati Ohio 45267 Recruiting
Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center Cleveland Ohio 44146 Recruiting
Nationwide Children's Hospital Columbus Ohio 43205 Recruiting
Dayton Children's Hospital Dayton Ohio 45404 Recruiting
Toledo Children's Hospital Toledo Ohio 43606 Recruiting
Oklahoma Cystic Fibrosis Center Oklahoma City Oklahoma 73104 Recruiting
Oregon Health Sciences University Portland Oregon 97239 Recruiting
University of Pennsylvania Philadelphia Pennsylvania 19104 Recruiting
Children's Hospital of Pittsburgh of UPMC Pittsburgh Pennsylvania 15224 Recruiting
Medical University of South Carolina Charleston South Carolina 29425 Recruiting
Vanderbilt Children's Hospital Nashville Tennessee 37232 Recruiting
University of Texas Southwestern / Children's Health Dallas Texas 75207 Recruiting
University of Texas Southwestern Dallas Texas 75390 Recruiting
Cook Children's Medical Center Fort Worth Texas 76104 Recruiting
Virginia Commonwealth University Richmond Virginia 23219 Recruiting
Seattle Children's Hospital Seattle Washington 98105 Recruiting
University of Washington Medical Center Seattle Washington 98195 Recruiting
Providence Medical Group, Cystic Fibrosis Clinic Spokane Washington 99204 Recruiting
West Virginia University - Morgantown Morgantown West Virginia 26507 Recruiting
University of Wisconsin Madison Wisconsin 53792 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05548283, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jul 7, 2026 · Synced Sep 1, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05548283 live on ClinicalTrials.gov.

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