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Recruiting Phase 3 Interventional

A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma

ClinicalTrials.gov ID: NCT05552222

Public ClinicalTrials.gov record NCT05552222. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 10, 2026, 8:52 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3 Randomized Study Comparing Teclistamab in Combination With Daratumumab SC and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab SC and Lenalidomide (Tal-DR) Versus Daratumumab SC, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma Who Are Either Ineligible or Not Intended for Autologous Stem Cell Transplant as Initial Therapy

Study identification

NCT ID
NCT05552222
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Janssen Research & Development, LLC
Industry
Enrollment
1,590 participants

Conditions and interventions

Interventions

  • Daratumumab Drug
  • Dexamethasone Drug
  • Lenalidomide Drug
  • Talquetamab Drug
  • Teclistamab Drug

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Oct 24, 2022
Primary completion
Apr 29, 2031
Completion
Oct 27, 2033
Last update posted
May 7, 2026

2022 – 2033

United States locations

U.S. sites
63
U.S. states
25
U.S. cities
52
Facility City State ZIP Site status
Banner MD Anderson Cancer Center Gilbert Arizona 85234 Recruiting
University of Arizona Cancer Center Tucson Arizona 85719 Recruiting
UCSF Fresno Clovis California 93611 Recruiting
City of Hope Duarte Duarte California 91010 Recruiting
City of Hope Orange County Lennar Foundation Cancer Center Irvine California 92618 Recruiting
Cancer and Blood Specialty Clinic Los Alamitos California 90720 Recruiting
Valkyrie Clinical Trials Los Angeles California 90067 Recruiting
University of Connecticut Farmington Connecticut 06030 Recruiting
Yale New Haven Hospital New Haven Connecticut 06510 Recruiting
ChristianaCare Helen F Graham Cancer Center and Research Institute Newark Delaware 19713 Recruiting
AdventHealth Medical Group Blood & Marrow Transplant at Orlando Orlando Florida 32804 Recruiting
Cleveland Clinic Florida Weston Florida 33331 Recruiting
City of Hope Cancer Center Newnan Georgia 30265 Recruiting
University Of Illinois Medical Center Chicago Illinois 60612 Recruiting
Loyola University Medical Center Maywood Illinois 60153 Recruiting
University of Iowa Health Care Waukee Iowa 50263 Recruiting
Norton Cancer Institute Louisville Kentucky 40207 Recruiting
LSUHSC Shreveport Feist-Weiller Cancer Center Shreveport Louisiana 71103 Recruiting
Johns Hopkins University School of Medicine JHUSOM Baltimore Maryland 21231 Recruiting
Center for Cancer and Blood Disorders Bethesda Maryland 20817 Recruiting
University of Michigan Ann Arbor Michigan 48109 Recruiting
Henry Ford Cancer - Detroit Brigitte Harris Cancer Pavilion Detroit Michigan 48202 Recruiting
Cancer And Hematology Centers of Western Michigan PC Grand Rapids Michigan 49503 Recruiting
Henry Ford Providence Novi Hospital Novi Michigan 48374 Recruiting
Henry Ford Providence Southfield CK Potluri Cancer Center Southfield Michigan 48075 Recruiting
Nebraska Cancer Specialists Omaha Nebraska 68130 Recruiting
University of Nebraska Medical Center Omaha Nebraska 68198 Recruiting
Dartmouth Hitchcock Medical Center Lebanon New Hampshire 03756 Recruiting
Astera Cancer Care East Brunswick New Jersey 08816 Recruiting
Christus St. Vincent Regional Cancer Center Santa Fe New Mexico 87505 Recruiting
Hematology-Oncology Associates of CNY East Syracuse New York 13057 Recruiting
Northwell Health Cancer Institute Lake Success New York 11042 Recruiting
NYU Langone Hospital Long Island Mineola New York 11500 Recruiting
Perlmutter Cancer Center at NYU Langone Health New York New York 10016 Recruiting
Memorial Sloan Kettering Cancer Center New York New York 10065 Recruiting
Weill Cornell Medical College New York New York 10065 Recruiting
Levine Cancer Institute Charlotte North Carolina 28204 Recruiting
Novant Health Charlotte North Carolina 28204 Recruiting
Durham VAMC Durham North Carolina 27705 Recruiting
Novant Health Zimmer Cancer Institute Wilmington North Carolina 28401 Recruiting
Novant Health Forsyth Medical Center Winston-Salem North Carolina 27103 Recruiting
Atrium Health Wake Forest Baptist Comprehensive Cancer Center Winston-Salem North Carolina 27157 Recruiting
The Christ Hospital Cancer Center Cincinnati Ohio 45219 Recruiting
Oncology Hematology Care Cincinnati Ohio 45236 Recruiting
University of Cincinnati Cincinnati Ohio 45267 Recruiting
University Hospitals Cleveland Medical Center Cleveland Ohio 44106 Recruiting
Cleveland Clinic Main Campus Cleveland Ohio 44195 Recruiting
The Ohio State University- James Cancer Hospital Columbus Ohio 43210 Recruiting
OhioHealth Columbus Ohio 43214 Recruiting
Penn State Milton S Hershey Medical Ctr Hershey Pennsylvania 17033 Recruiting
Allegheny Health Network Pittsburgh Pennsylvania 15224 Recruiting
Henry-Joyce Cancer Clinic Nashville Tennessee 37232 Recruiting
University of Texas Southwestern Medical Center Dallas Texas 75235 Recruiting
Houston Methodist Hospital Houston Texas 77030 Recruiting
Joe Arrington Cancer Research Treatment Center Lubbock Texas 79410 Recruiting
Utah Cancer Specialists Salt Lake City Utah 84106 Recruiting
Huntsman Cancer Institute Salt Lake City Utah 84112 Recruiting
University of Virginia Charlottesville Virginia 22903 Completed
Alexander T. Augusta Military Medical Center Fort Belvoir Virginia 22060 Recruiting
Virginia Oncology Associates Brock Cancer Center Norfolk Virginia 23502 Recruiting
Richmond VA Medical Center Richmond Virginia 23249 Recruiting
Virginia Commonwealth University Medical Center Richmond Virginia 23298 Recruiting
NorthWest Medical Specialties, PLLC Tacoma Washington 98405 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 202 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05552222, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted May 7, 2026 · Synced May 10, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05552222 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →