A Study of Olezarsen Administered Subcutaneously to Participants With Severe Hypertriglyceridemia
Public ClinicalTrials.gov record NCT05552326. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Patients With Severe Hypertriglyceridemia
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the efficacy of olezarsen as compared to placebo on the percent change in fasting triglycerides (TG) from baseline.
Study identification
- NCT ID
- NCT05552326
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 446 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 31, 2022 (Actual)
- Primary completion
- Dec 17, 2024 (Actual)
- Completion
- Sep 12, 2025 (Actual)
- Last update posted
- Oct 22, 2025
2022 – 2025
United States locations
- U.S. sites
- 63
- U.S. states
- 24
- U.S. cities
- 54
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Central Research Associates, Inc. | Birmingham | Alabama | 35205 | — |
| Alabama Clinical Therapeutics, LLC Alabaster | Birmingham | Alabama | 35235 | — |
| Onyx Clinical Research | Peoria | Arizona | 85381 | — |
| NRC Research Institute | Los Angeles | California | 90015 | — |
| Accel Research Sites | DeLand | Florida | 32720 | — |
| Finlay Medical Research | Greenacres City | Florida | 33467 | — |
| University of Florida Jacksonville | Jacksonville | Florida | 32209 | — |
| Meridien Research | Maitland | Florida | 32751 | — |
| Columbus Clinical Services | Miami | Florida | 33125 | — |
| Harmony Clinical Research, Inc | North Miami Beach | Florida | 33162 | — |
| Combined Research Orlando Phase I-IV | Orlando | Florida | 32807 | — |
| 3Sync Research | Sunrise | Florida | 33325 | — |
| R & B Medical Center LLC | Tampa | Florida | 33614 | — |
| JSV Clinical Research Study, Inc. | Tampa | Florida | 33634 | — |
| Metabolic Research Institute | West Palm Beach | Florida | 33401 | — |
| Emory University | Atlanta | Georgia | 30322 | — |
| Accel Clinical Research | Eatonton | Georgia | 31024 | — |
| Northeast Georgia Medical Center | Gainesville | Georgia | 30501 | — |
| Randomize Now | Newnan | Georgia | 30265 | — |
| St. Vincent Medical Group | Carmel | Indiana | 46290 | — |
| University of Kansas Medical Center (KUMC) | Kansas City | Kansas | 66160 | — |
| The Research Group of Lexington, LLC | Lexington | Kentucky | 40503 | — |
| University of Louisville | Louisville | Kentucky | 40202 | — |
| Louisville Metabolic and Atherosclerosis Research Center (L-MARC) | Louisville | Kentucky | 40213 | — |
| Grace Research, LLC | Bossier City | Louisiana | 71111 | — |
| Clinical Trials of America LA, LLC | Monroe | Louisiana | 71201 | — |
| University of Maryland School of Medicine | Baltimore | Maryland | 21201 | — |
| Maryland Cardiovascular Specialists | Baltimore | Maryland | 21229 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Onyx Clinical Research | Flint | Michigan | 48532 | — |
| Onyx Clinical Research | Rochester Hills | Michigan | 48307 | — |
| Stern Cardiovascular | Southaven | Mississippi | 38671 | — |
| NYU Langone Hospital - Long Island | Mineola | New York | 11501 | — |
| Orchard Park Family Practice | Orchard Park | New York | 14127 | — |
| Clinical Trials of America, LLC | Lenoir | North Carolina | 28645 | — |
| Diabetes and Endocrinology Consultants, P.C. | Morehead City | North Carolina | 28557 | — |
| OnSite Clinical Solutions, LLC | Salisbury | North Carolina | 28144 | — |
| The Ohio State University (OSU) | Columbus | Ohio | 43203 | — |
| SV Research LLC | Marion | Ohio | 43302 | — |
| Oklahoma Heart Institute | Tulsa | Oklahoma | 74133 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Medical University of South Carolina (MUSC) | Charleston | South Carolina | 29425 | — |
| Main Street Physicians Care Waterway | Little River | South Carolina | 29566 | — |
| Monument Health Clinical Research | Rapid City | South Dakota | 57701 | — |
| The Jackson Clinic | Jackson | Tennessee | 38305 | — |
| Texas Health Family Care | Fort Worth | Texas | 76107 | — |
| Vilo Research Group | Houston | Texas | 77017 | — |
| Juno Research | Houston | Texas | 77040 | — |
| Juno Research | Houston | Texas | 77054 | — |
| Clinical Trial Network | Houston | Texas | 77074 | — |
| Pioneer Research Solutions, Inc | Houston | Texas | 77099 | — |
| Sante Clinical Research, LLC | Kerrville | Texas | 78028 | — |
| FMC Science | Lampasas | Texas | 76550 | — |
| DCT - McAllen Primary Care, LLC | McAllen | Texas | 78503 | — |
| Texas Institute of Cardiology | McKinney | Texas | 75071 | — |
| SMS Clinical Research, LLC | Mesquite | Texas | 75149 | — |
| Southern Endocrinology Associates | Mesquite | Texas | 75149 | — |
| Permian Research Foundation | Odessa | Texas | 79761 | — |
| Diabetes & Glandular Disease Clinic, P.A. | San Antonio | Texas | 78229 | — |
| Tranquil Research | Webster | Texas | 77598 | — |
| Aspen Clinical Research | Orem | Utah | 84058 | — |
| Ogden Clinic Grandview | Roy | Utah | 84401 | — |
| Clinical Investigation Specialists Inc. | Kenosha | Wisconsin | 53144 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 142 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05552326, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 22, 2025 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05552326 live on ClinicalTrials.gov.