Safety and Immunogenicity of Quadrivalent Influenza mRNA Vaccine MRT5407 in Adult Participants18 Years of Age and Older
Public ClinicalTrials.gov record NCT05553301. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Safety and Immunogenicity of Quadrivalent Influenza mRNA Vaccine MRT5407 in Adults Aged 18 Years and Older
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the safety and immunogenicity of a single intramuscular (IM) injection of up to 2 dose levels of Quadrivalent Influenza messenger ribonucleic acid (mRNA) Vaccine MRT5407 compared to an active control (QIV standard-dose (SD), QIV high-dose (HD) \[adults ≥ 65 years of age only\], or quadrivalent recombinant influenza vaccine (RIV4)) in adults 18 years of age and older.
Study identification
- NCT ID
- NCT05553301
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 560 participants
Conditions and interventions
Conditions
Interventions
- Quadrivalent Influenza mRNA Vaccine MRT5407 Biological
- Quadrivalent Recombinant Influenza Vaccine Biological
- Quadrivalent Influenza Standard Dose Vaccine Biological
- Quadrivalent Influenza High-Dose Vaccine Biological
Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 3, 2022 (Actual)
- Primary completion
- Jan 19, 2024 (Actual)
- Completion
- Jan 19, 2024 (Actual)
- Last update posted
- Jan 24, 2025
2022 – 2024
United States locations
- U.S. sites
- 23
- U.S. states
- 10
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Peninsula Research Associates Site Number : 8400025 | Rolling Hills Estates | California | 90274 | — |
| Optimal Research Site Number : 8400059 | San Diego | California | 92108 | — |
| California Research Foundation Site Number : 8400008 | San Diego | California | 92123-1881 | — |
| Accel Clinical Research-Deland Clinical Research Unit Site Number : 8400052 | DeLand | Florida | 32720-0834 | — |
| SIMEDHealth, LLC Site Number : 8400024 | Gainesville | Florida | 32607 | — |
| Indago Research and Health Center Site Number : 8400014 | Hialeah | Florida | 33012 | — |
| Cenexel Research Centers of America Site Number : 8400048 | Hollywood | Florida | 33024 | — |
| Dade Research Center Site Number : 8400011 | Miami | Florida | 33135 | — |
| Suncoast Research Group, LLC Site Number : 8400038 | Miami | Florida | 33135 | — |
| Florida International Research Center Site Number : 8400051 | Miami | Florida | 33173 | — |
| Palm Beach Research Center Site Number : 8400020 | West Palm Beach | Florida | 33409 | — |
| DM Clinical Research Site Number : 8400032 | Melrose Park | Illinois | 60160 | — |
| DM Clinical Research - Chicago Site Number : 8400028 | River Forest | Illinois | 60305 | — |
| Brengle Family Medicine Site Number : 8400005 | Indianapolis | Indiana | 46260 | — |
| AMR Lexington Site Number : 8400054 | Lexington | Kentucky | 40509 | — |
| AMR Kansas City Site Number : 8400006 | Kansas City | Missouri | 64114 | — |
| Velocity Clinical Research Site Number : 8400003 | Omaha | Nebraska | 68134 | — |
| Coastal Carolina Research Center - N Charleston Site Number : 8400010 | North Charleston | South Carolina | 29405 | — |
| AMR Knoxville Site Number : 8400046 | Knoxville | Tennessee | 37920 | — |
| Elligo Health Research Site Number : 8400056 | Austin | Texas | 78704 | — |
| Sun Research Institute Site Number : 8400030 | San Antonio | Texas | 78215 | — |
| Clinical Trials of Texas, Inc. Site Number : 8400026 | San Antonio | Texas | 78229 | — |
| DM Clinical Research - Sugar Land Site Number : 8400031 | Sugar Land | Texas | 77478 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05553301, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 24, 2025 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05553301 live on ClinicalTrials.gov.