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ClinicalTrials.gov record
Active, not recruiting Phase 2 Interventional

Testing the Use of the Combination of Selumetinib and Olaparib or Selumetinib Alone Targeted Treatment for RAS Pathway Mutant Recurrent or Persistent Ovarian and Endometrial Cancers, A ComboMATCH Treatment Trial

ClinicalTrials.gov ID: NCT05554328

Public ClinicalTrials.gov record NCT05554328. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Sep 7, 2026, 4:47 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized Trial of Selumetinib and Olaparib or Selumetinib Alone in Patients With Recurrent or Persistent RAS Pathway Mutant Ovarian and Endometrial Cancers: A ComboMATCH Treatment Trial

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This phase II ComboMATCH treatment trial compares selumetinib plus olaparib to selumetinib alone in women with endometrial or ovarian (fallopian tube and primary peritoneal) cancer that has come back (recurrent) or that remains despite treatment (persistent) and harbors a mutation in the RAS pathway. Selumetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Olaparib is an inhibitor of PARP, an enzyme that helps repair deoxyribonucleic acid (DNA) when it becomes damaged. Blocking PARP may help keep tumor cells from repairing their damaged DNA, causing them to die. PARP inhibitors are a type of targeted therapy. The addition of olaparib to selumetinib could increase the percentage of tumors that shrink as well as lengthen the time that the tumors remain stable (without progression) as compared to selumetinib alone.

Study identification

NCT ID
NCT05554328
Recruitment status
Active, not recruiting
Study type
Interventional
Phase
Phase 2
Enrollment
165 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
Female
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Apr 24, 2023
Primary completion
Sep 30, 2028
Completion
Sep 30, 2028
Last update posted
Aug 3, 2026

2023 – 2028

United States locations

U.S. sites
292
U.S. states
36
U.S. cities
232
Facility City State ZIP Site status
University of Alabama at Birmingham Cancer Center Birmingham Alabama 35233
University of South Alabama Mitchell Cancer Institute Mobile Alabama 36688
Alaska Women's Cancer Care Anchorage Alaska 99508
CTCA at Western Regional Medical Center Goodyear Arizona 85338
Kingman Regional Medical Center Kingman Arizona 86401
PCR Oncology Arroyo Grande California 93420
Cedars-Sinai Medical Center Los Angeles California 90048
Saint Joseph Hospital - Orange Orange California 92868
Stanford Cancer Institute Palo Alto Palo Alto California 94304
Presbyterian Intercommunity Hospital Whittier California 90602
UM Sylvester Comprehensive Cancer Center at Aventura Aventura Florida 33180
UM Sylvester Comprehensive Cancer Center at Coral Gables Coral Gables Florida 33146
UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach Florida 33442
Mayo Clinic in Florida Jacksonville Florida 32224-9980
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami Florida 33136
UM Sylvester Comprehensive Cancer Center at Kendall Miami Florida 33176
University of Miami Sylvester Comprehensive Cancer Center at Sole Mia North Miami Florida 33181
UM Sylvester Comprehensive Cancer Center at Plantation Plantation Florida 33324
Queen's Cancer Cenrer - POB I Honolulu Hawaii 96813
Queen's Medical Center Honolulu Hawaii 96813
University of Hawaii Cancer Center Honolulu Hawaii 96813
Queen's Cancer Center - Kuakini Honolulu Hawaii 96817
Kapiolani Medical Center for Women and Children Honolulu Hawaii 96826
The Queen's Medical Center - West Oahu ‘Ewa Beach Hawaii 96706
Saint Alphonsus Cancer Care Center-Boise Boise Idaho 83706
Saint Luke's Cancer Institute - Boise Boise Idaho 83712
Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho 83605
Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho 83814
Saint Luke's Cancer Institute - Fruitland Fruitland Idaho 83619
Saint Luke's Cancer Institute - Meridian Meridian Idaho 83642
Saint Alphonsus Cancer Care Center-Nampa Nampa Idaho 83687
Saint Luke's Cancer Institute - Nampa Nampa Idaho 83687
Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho 83854
Kootenai Clinic Cancer Services - Sandpoint Sandpoint Idaho 83864
Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho 83301
Advocate Good Shepherd Hospital Barrington Illinois 60010
Illinois CancerCare-Bloomington Bloomington Illinois 61704
Illinois CancerCare-Canton Canton Illinois 61520
Illinois CancerCare-Carthage Carthage Illinois 62321
Centralia Oncology Clinic Centralia Illinois 62801
John H Stroger Jr Hospital of Cook County Chicago Illinois 60612
University of Illinois Chicago Illinois 60612
University of Chicago Comprehensive Cancer Center Chicago Illinois 60637
Advocate Illinois Masonic Medical Center Chicago Illinois 60657
AMG Crystal Lake - Oncology Crystal Lake Illinois 60014
Carle at The Riverfront Danville Illinois 61832
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526
Decatur Memorial Hospital Decatur Illinois 62526
Illinois CancerCare-Dixon Dixon Illinois 61021
Advocate Good Samaritan Hospital Downers Grove Illinois 60515
Carle Physician Group-Effingham Effingham Illinois 62401
Crossroads Cancer Center Effingham Illinois 62401
Advocate Sherman Hospital Elgin Illinois 60123
Illinois CancerCare-Eureka Eureka Illinois 61530
NorthShore University HealthSystem-Evanston Hospital Evanston Illinois 60201
Illinois CancerCare-Galesburg Galesburg Illinois 61401
NorthShore University HealthSystem-Glenbrook Hospital Glenview Illinois 60026
Advocate South Suburban Hospital Hazel Crest Illinois 60429
NorthShore University HealthSystem-Highland Park Hospital Highland Park Illinois 60035
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443
AMG Libertyville - Oncology Libertyville Illinois 60048
Condell Memorial Hospital Libertyville Illinois 60048
Illinois CancerCare-Macomb Macomb Illinois 61455
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938
UC Comprehensive Cancer Center at Silver Cross New Lenox Illinois 60451
Carle BroMenn Medical Center Normal Illinois 61761
Carle Cancer Institute Normal Normal Illinois 61761
Cancer Care Center of O'Fallon O'Fallon Illinois 62269
Advocate Christ Medical Center Oak Lawn Illinois 60453-2699
University of Chicago Medicine-Orland Park Orland Park Illinois 60462
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350
Advocate Lutheran General Hospital Park Ridge Illinois 60068
Illinois CancerCare-Pekin Pekin Illinois 61554
Illinois CancerCare-Peoria Peoria Illinois 61615
Illinois CancerCare-Peru Peru Illinois 61354
Illinois CancerCare-Princeton Princeton Illinois 61356
Southern Illinois University School of Medicine Springfield Illinois 62702
Springfield Clinic Springfield Illinois 62702
Springfield Memorial Hospital Springfield Illinois 62781
Carle Cancer Center Urbana Illinois 61801
Illinois CancerCare - Washington Washington Illinois 61571
UChicago Medicine Northwest Indiana Crown Point Indiana 46307
UI Health Care Mission Cancer and Blood - Ankeny Clinic Ankeny Iowa 50023
UI Health Care Mission Cancer and Blood - West Des Moines Clinic Clive Iowa 50325
UI Health Care Mission Cancer and Blood - Des Moines Clinic Des Moines Iowa 50309
Mercy Medical Center - Des Moines Des Moines Iowa 50314
UI Health Care Mission Cancer and Blood - Laurel Clinic Des Moines Iowa 50314
UI Health Care Mission Cancer and Blood - Waukee Clinic Waukee Iowa 50263
University of Kentucky/Markey Cancer Center Lexington Kentucky 40536
Ochsner Baptist Medical Center New Orleans Louisiana 70115
Ochsner Medical Center Jefferson New Orleans Louisiana 70121
Harold Alfond Center for Cancer Care Augusta Maine 04330
Lafayette Family Cancer Center-EMMC Brewer Maine 04412
MaineHealth Maine Medical Center- Scarborough Scarborough Maine 04074
University of Maryland/Greenebaum Cancer Center Baltimore Maryland 21201
Walter Reed National Military Medical Center Bethesda Maryland 20889-5600
National Institutes of Health Clinical Center Bethesda Maryland 20892
UPMC Western Maryland Cumberland Maryland 21502
Tufts Medical Center Boston Massachusetts 02111
Baystate Medical Center Springfield Massachusetts 01199
Tufts Medical Center Cancer Center Stoneham Stoneham Massachusetts 02180
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor Michigan 48106
University of Michigan Rogel Cancer Center Ann Arbor Michigan 48109
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan 48114
Trinity Health Medical Center - Brighton Brighton Michigan 48114
University of Michigan - Brighton Center for Specialty Care Brighton Michigan 48116
Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan 48188
Trinity Health Medical Center - Canton Canton Michigan 48188
Chelsea Hospital Chelsea Michigan 48118
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan 48118
Corewell Health Dearborn Hospital Dearborn Michigan 48124
Corewell Health Farmington Hills Hospital Farmington Hills Michigan 48336
Cancer Hematology Centers - Flint Flint Michigan 48503
Genesee Hematology Oncology PC Flint Michigan 48503
Genesys Hurley Cancer Institute Flint Michigan 48503
Hurley Medical Center Flint Michigan 48503
University of Michigan Health - Sparrow Lansing Lansing Michigan 48912
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154
Henry Ford Saint John Hospital - Macomb Medical Macomb Michigan 48044
Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac Michigan 48341
Corewell Health William Beaumont University Hospital Royal Oak Michigan 48073
Corewell Health Beaumont Troy Hospital Troy Michigan 48085
Huron Gastroenterology PC Ypsilanti Michigan 48106
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan 48197
Mercy Hospital Coon Rapids Minnesota 55433
Essentia Health - Deer River Clinic Deer River Minnesota 56636
Essentia Health Cancer Center Duluth Minnesota 55805
Fairview Southdale Hospital Edina Minnesota 55435
Essentia Health Hibbing Clinic Hibbing Minnesota 55746
Fairview Clinics and Surgery Center Maple Grove Maple Grove Minnesota 55369
Abbott-Northwestern Hospital Minneapolis Minnesota 55407
Mayo Clinic in Rochester Rochester Minnesota 55905
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416
Regions Hospital Saint Paul Minnesota 55101
United Hospital Saint Paul Minnesota 55102
Essentia Health Sandstone Sandstone Minnesota 55072
Essentia Health Virginia Clinic Virginia Minnesota 55792
Saint Francis Medical Center Cape Girardeau Missouri 63703
Parkland Health Center - Farmington Farmington Missouri 63640
Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri 63670
Washington University School of Medicine St Louis Missouri 63110
Missouri Baptist Medical Center St Louis Missouri 63131
Missouri Baptist Sullivan Hospital Sullivan Missouri 63080
Community Hospital of Anaconda Anaconda Montana 59711
Billings Clinic Cancer Center Billings Montana 59101
Bozeman Health Deaconess Hospital Bozeman Montana 59715
Benefis Sletten Cancer Institute Great Falls Montana 59405
Logan Health Medical Center Kalispell Montana 59901
Community Medical Center Missoula Montana 59804
OptumCare Cancer Care at Charleston Las Vegas Nevada 89102
OptumCare Cancer Care at Fort Apache Las Vegas Nevada 89183
Jersey City Medical Center Jersey City New Jersey 07302
Monmouth Medical Center Southern Campus Lakewood New Jersey 08701
Monmouth Medical Center Long Branch New Jersey 07740
Memorial Sloan Kettering Monmouth Middletown New Jersey 07748
Rutgers Cancer Institute of New Jersey New Brunswick New Jersey 08903
Sidney Kimmel Cancer Center Washington Township Sewell New Jersey 08080
University of New Mexico Cancer Center Albuquerque New Mexico 87106
Roswell Park Cancer Institute Buffalo New York 14263
Memorial Sloan Kettering Commack Commack New York 11725
Memorial Sloan Kettering Westchester Harrison New York 10604
Memorial Sloan Kettering Cancer Center New York New York 10065
State University of New York Upstate Medical University Syracuse New York 13210
Cone Health MedCenter Asheboro Asheboro North Carolina 27205
Mission Hospital Asheville North Carolina 28801
Hope Women's Cancer Centers-Asheville Asheville North Carolina 28816
Cone Health Cancer Center at Alamance Regional Burlington North Carolina 27215
Duke University Medical Center Durham North Carolina 27710
Cone Health Cancer Center Greensboro North Carolina 27403
Cone Health Cancer Center at Drawbridge Parkway Greensboro North Carolina 27410
Duke Women's Cancer Care Raleigh Raleigh North Carolina 27607
Annie Penn Memorial Hospital Reidsville North Carolina 27320
Sanford Bismarck Medical Center Bismarck North Dakota 58501
Sanford Broadway Medical Center Fargo North Dakota 58122
Sanford Roger Maris Cancer Center Fargo North Dakota 58122
UH Seidman Cancer Center at UH Avon Health Center Avon Ohio 44011
UHHS-Chagrin Highlands Medical Center Beachwood Ohio 44122
Strecker Cancer Center-Belpre Belpre Ohio 45714
Aultman Health Foundation Canton Ohio 44710
Miami Valley Hospital South Centerville Ohio 45459
Adena Regional Medical Center Chillicothe Ohio 45601
Good Samaritan Hospital - Cincinnati Cincinnati Ohio 45220
Case Western Reserve University Cleveland Ohio 44106
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210
Mount Carmel East Hospital Columbus Ohio 43213
Riverside Methodist Hospital Columbus Ohio 43214
The Mark H Zangmeister Center Columbus Ohio 43219
Miami Valley Hospital Dayton Ohio 45409
Dayton Physician LLC - Englewood Dayton Ohio 45415
Miami Valley Hospital North Dayton Ohio 45415
Dublin Methodist Hospital Dublin Ohio 43016
Atrium Medical Center-Middletown Regional Hospital Franklin Ohio 45005-1066
Miami Valley Cancer Care and Infusion Greenville Ohio 45331
Kettering Medical Center Kettering Ohio 45429
Fairfield Medical Center Lancaster Ohio 43130
OhioHealth Mansfield Hospital Mansfield Ohio 44903
Marietta Memorial Hospital Marietta Ohio 45750
Memorial Hospital Marysville Ohio 43040
UH Seidman Cancer Center at Lake Health Mentor Campus Mentor Ohio 44060
Knox Community Hospital Mount Vernon Ohio 43050
Licking Memorial Hospital Newark Ohio 43055
Mercy Health - Perrysburg Hospital Perrysburg Ohio 43551
OhioHealth Pickerington Methodist Hospital Pickerington Ohio 43147
Southern Ohio Medical Center Portsmouth Ohio 45662
Springfield Regional Cancer Center Springfield Ohio 45504
Springfield Regional Medical Center Springfield Ohio 45504
Mercy Health - Saint Anne Hospital Toledo Ohio 43623
Upper Valley Medical Center Troy Ohio 45373
Saint Ann's Hospital Westerville Ohio 43081
OhioHealth Westerville Medical Campus/Westerville Cancer Center Westerville Ohio 43082
UH Seidman Cancer Center at Saint John Medical Center Westlake Ohio 44145
Genesis Healthcare System Cancer Care Center Zanesville Ohio 43701
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104
Providence Newberg Medical Center Newberg Oregon 97132
Saint Alphonsus Cancer Care Center-Ontario Ontario Oregon 97914
Providence Willamette Falls Medical Center Oregon City Oregon 97045
Providence Portland Medical Center Portland Oregon 97213
Providence Saint Vincent Medical Center Portland Oregon 97225
Oregon Health and Science University Portland Oregon 97239
Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania 18103
UPMC Altoona Altoona Pennsylvania 16601
Lehigh Valley Hospital - Muhlenberg Bethlehem Pennsylvania 18017
Bryn Mawr Hospital Bryn Mawr Pennsylvania 19010
Pocono Medical Center East Stroudsburg Pennsylvania 18301
UPMC Hillman Cancer Center Erie Erie Pennsylvania 16505
UPMC Cancer Centers - Arnold Palmer Pavilion Greensburg Pennsylvania 15601
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion Mechanicsburg Pennsylvania 17050
Riddle Memorial Hospital Media Pennsylvania 19063
UPMC Hillman Cancer Center - Monroeville Monroeville Pennsylvania 15146
Paoli Memorial Hospital Paoli Pennsylvania 19301
Pennsylvania Hospital Philadelphia Pennsylvania 19107
Thomas Jefferson University Hospital Philadelphia Pennsylvania 19107
Fox Chase Cancer Center Philadelphia Pennsylvania 19111
UPMC-Magee Womens Hospital Pittsburgh Pennsylvania 15213
UPMC Hillman Cancer Center Pittsburgh Pennsylvania 15232
UPMC-Passavant Hospital Pittsburgh Pennsylvania 15237
Asplundh Cancer Pavilion Willow Grove Pennsylvania 19090
Lankenau Medical Center Wynnewood Pennsylvania 19096
Women and Infants Hospital Providence Rhode Island 02905
Rapid City Regional Hospital Rapid City South Dakota 57701
Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota 57104
Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota 57117-5134
UT MD Anderson - The Woodlands Conroe Texas 77384
UT Southwestern/Simmons Cancer Center-Dallas Dallas Texas 75390
Lyndon Baines Johnson General Hospital Houston Texas 77026-1967
UT MD Anderson Cancer Center Houston Texas 77030
UT MD Anderson - West Houston Houston Texas 77079
UT MD Anderson - League City League City Texas 77573
UT MD Anderson - Sugar Land Sugar Land Texas 77478
University of Virginia Cancer Center Charlottesville Virginia 22908
Henrico Doctor's Hospital Richmond Virginia 23229
Virginia Cancer Institute Richmond Virginia 23229
VCU Massey Cancer Center at Stony Point Richmond Virginia 23235
VCU Massey Comprehensive Cancer Center Richmond Virginia 23298
Carilion Roanoke Memorial Hospital Roanoke Virginia 24033
VCU Community Memorial Health Center South Hill Virginia 23970
Swedish Cancer Institute-Edmonds Edmonds Washington 98026
Swedish Cancer Institute-Issaquah Issaquah Washington 98029
Providence Regional Cancer System-Lacey Lacey Washington 98503
Valley Medical Center Renton Washington 98055
Swedish Medical Center-First Hill Seattle Washington 98122
Providence Saint Mary Regional Cancer Center Walla Walla Washington 99362
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima Washington 98902
Edwards Comprehensive Cancer Center Huntington West Virginia 25701
West Virginia University Healthcare Morgantown West Virginia 26506
Duluth Clinic Ashland Ashland Wisconsin 54806
Aurora Cancer Care-Southern Lakes VLCC Burlington Wisconsin 53105
Aurora Saint Luke's South Shore Cudahy Wisconsin 53110
Aurora Health Care Germantown Health Center Germantown Wisconsin 53022
Aurora Cancer Care-Grafton Grafton Wisconsin 53024
Saint Vincent Hospital Cancer Center Green Bay Green Bay Wisconsin 54301
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay Wisconsin 54303
Aurora BayCare Medical Center Green Bay Wisconsin 54311
Aurora Cancer Care-Kenosha South Kenosha Wisconsin 53142
Gundersen Lutheran Medical Center La Crosse Wisconsin 54601
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center Madison Wisconsin 53718
University of Wisconsin Carbone Cancer Center - University Hospital Madison Wisconsin 53792
Aurora Bay Area Medical Group-Marinette Marinette Wisconsin 54143
Aurora Cancer Care-Milwaukee Milwaukee Wisconsin 53209
Aurora Saint Luke's Medical Center Milwaukee Wisconsin 53215
Aurora Sinai Medical Center Milwaukee Wisconsin 53233
Cancer Center of Western Wisconsin New Richmond Wisconsin 54017
Saint Vincent Hospital Cancer Center at Oconto Falls Oconto Falls Wisconsin 54154
Vince Lombardi Cancer Clinic - Oshkosh Oshkosh Wisconsin 54904
Aurora Cancer Care-Racine Racine Wisconsin 53406
Saint Vincent Hospital Cancer Center at Sheboygan Sheboygan Wisconsin 53081
Vince Lombardi Cancer Clinic-Sheboygan Sheboygan Wisconsin 53081
Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay Wisconsin 54235-1495
Aurora Medical Center in Summit Summit Wisconsin 53066
Vince Lombardi Cancer Clinic-Two Rivers Two Rivers Wisconsin 54241
Aurora Cancer Care-Milwaukee West Wauwatosa Wisconsin 53226
Aurora West Allis Medical Center West Allis Wisconsin 53227

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05554328, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 3, 2026 · Synced Sep 7, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05554328 live on ClinicalTrials.gov.

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