ClinicalTrials.gov record
Testing the Use of Fulvestrant and Binimetinib Targeted Treatment for NF1 Mutation in Hormone Receptor-Positive Metastatic Breast Cancer (A ComboMATCH Treatment Trial)
ClinicalTrials.gov ID: NCT05554354
Public ClinicalTrials.gov record NCT05554354. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase 2 Trial of Fulvestrant and Binimetinib in Patients With Hormone Receptor-Positive Metastatic Breast Cancer With Inactivating or Inferred Inactivating NF1 Alterations: A ComboMATCH Treatment Trial
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This phase II ComboMATCH treatment trial compares the usual treatment alone (fulvestrant) to using binimetinib plus the usual treatment in patients with hormone receptor positive breast cancer that has spread from where it first started to other places in the body (metastatic) and has an NF1 genetic change. Fulvestrant is a hormonal therapy that binds to estrogen receptors in tumor cells, resulting in estrogen receptor destruction and decreased estrogen binding, which may inhibit the growth of estrogen-sensitive tumor cells. Binimetinib is a targeted therapy that may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. The addition of binimetinib to fulvestrant in breast cancers with an NF1 genetic change could increase the percentage of tumors that shrink as well as lengthen the time that the tumors remain stable (without progression) as compared to fulvestrant alone.
Study identification
- NCT ID
- NCT05554354
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 1 participant
Conditions and interventions
Conditions
Interventions
- Binimetinib Drug
- Biopsy Procedure Procedure
- Biospecimen Collection Procedure
- Bone Scan Procedure
- Computed Tomography Procedure
- Echocardiography Test Procedure
- Fulvestrant Drug
- Magnetic Resonance Imaging Procedure
- Multigated Acquisition Scan Procedure
Drug · Procedure
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 13, 2024 (Actual)
- Primary completion
- Apr 4, 2025 (Actual)
- Completion
- Apr 4, 2025 (Actual)
- Last update posted
- Mar 3, 2026
2024 – 2025
United States locations
- U.S. sites
- 192
- U.S. states
- 28
- U.S. cities
- 158
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | 35233 | — |
| Kingman Regional Medical Center | Kingman | Arizona | 86401 | — |
| PCR Oncology | Arroyo Grande | California | 93420 | — |
| Epic Care-Dublin | Dublin | California | 94568 | — |
| Epic Care Partners in Cancer Care | Emeryville | California | 94608 | — |
| Contra Costa Regional Medical Center | Martinez | California | 94553-3156 | — |
| Saint Joseph Hospital - Orange | Orange | California | 92868 | — |
| Saint John's Cancer Institute | Santa Monica | California | 90404 | — |
| Epic Care Cyberknife Center | Walnut Creek | California | 94597 | — |
| UM Sylvester Comprehensive Cancer Center at Aventura | Aventura | Florida | 33180 | — |
| UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables | Florida | 33146 | — |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida | 33442 | — |
| Mayo Clinic in Florida | Jacksonville | Florida | 32224-9980 | — |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | 33136 | — |
| UM Sylvester Comprehensive Cancer Center at Kendall | Miami | Florida | 33176 | — |
| UM Sylvester Comprehensive Cancer Center at Plantation | Plantation | Florida | 33324 | — |
| Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | 83706 | — |
| Saint Luke's Cancer Institute - Boise | Boise | Idaho | 83712 | — |
| Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho | 83605 | — |
| Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho | 83814 | — |
| Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho | 83619 | — |
| Saint Luke's Cancer Institute - Meridian | Meridian | Idaho | 83642 | — |
| Saint Alphonsus Cancer Care Center-Nampa | Nampa | Idaho | 83687 | — |
| Saint Luke's Cancer Institute - Nampa | Nampa | Idaho | 83687 | — |
| Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho | 83854 | — |
| Kootenai Clinic Cancer Services - Sandpoint | Sandpoint | Idaho | 83864 | — |
| Saint Luke's Cancer Institute - Twin Falls | Twin Falls | Idaho | 83301 | — |
| Advocate Good Shepherd Hospital | Barrington | Illinois | 60010 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| John H Stroger Jr Hospital of Cook County | Chicago | Illinois | 60612 | — |
| Advocate Illinois Masonic Medical Center | Chicago | Illinois | 60657 | — |
| AMG Crystal Lake - Oncology | Crystal Lake | Illinois | 60014 | — |
| Carle at The Riverfront | Danville | Illinois | 61832 | — |
| Northwestern Medicine Cancer Center Kishwaukee | DeKalb | Illinois | 60115 | — |
| Carle Physician Group-Effingham | Effingham | Illinois | 62401 | — |
| Advocate Sherman Hospital | Elgin | Illinois | 60123 | — |
| Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | 60134 | — |
| Advocate South Suburban Hospital | Hazel Crest | Illinois | 60429 | — |
| Northwestern Medicine Lake Forest Hospital | Lake Forest | Illinois | 60045 | — |
| AMG Libertyville - Oncology | Libertyville | Illinois | 60048 | — |
| Condell Memorial Hospital | Libertyville | Illinois | 60048 | — |
| Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | 61938 | — |
| Advocate Christ Medical Center | Oak Lawn | Illinois | 60453-2699 | — |
| Northwestern Medicine Orland Park | Orland Park | Illinois | 60462 | — |
| Advocate Lutheran General Hospital | Park Ridge | Illinois | 60068 | — |
| Memorial Hospital East | Shiloh | Illinois | 62269 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | 60555 | — |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic | Ankeny | Iowa | 50023 | — |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic | Des Moines | Iowa | 50309 | — |
| Mercy Medical Center - Des Moines | Des Moines | Iowa | 50314 | — |
| University of Kentucky/Markey Cancer Center | Lexington | Kentucky | 40536 | — |
| Lafayette Family Cancer Center-EMMC | Brewer | Maine | 04412 | — |
| University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | 21201 | — |
| National Institutes of Health Clinical Center | Bethesda | Maryland | 20892 | — |
| UPMC Western Maryland | Cumberland | Maryland | 21502 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor | Ann Arbor | Michigan | 48106 | — |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton | Brighton | Michigan | 48114 | — |
| Trinity Health Medical Center - Brighton | Brighton | Michigan | 48114 | — |
| Trinity Health IHA Medical Group Hematology Oncology - Canton | Canton | Michigan | 48188 | — |
| Trinity Health Medical Center - Canton | Canton | Michigan | 48188 | — |
| Chelsea Hospital | Chelsea | Michigan | 48118 | — |
| Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital | Chelsea | Michigan | 48118 | — |
| Corewell Health Dearborn Hospital | Dearborn | Michigan | 48124 | — |
| Corewell Health Farmington Hills Hospital | Farmington Hills | Michigan | 48336 | — |
| Cancer Hematology Centers - Flint | Flint | Michigan | 48503 | — |
| Genesee Hematology Oncology PC | Flint | Michigan | 48503 | — |
| Genesys Hurley Cancer Institute | Flint | Michigan | 48503 | — |
| Hurley Medical Center | Flint | Michigan | 48503 | — |
| University of Michigan Health - Sparrow Lansing | Lansing | Michigan | 48912 | — |
| Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | 48154 | — |
| Henry Ford Saint John Hospital - Macomb Medical | Macomb | Michigan | 48044 | — |
| Corewell Health William Beaumont University Hospital | Royal Oak | Michigan | 48073 | — |
| MyMichigan Medical Center Saginaw | Saginaw | Michigan | 48601 | — |
| Oncology Hematology Associates of Saginaw Valley PC | Saginaw | Michigan | 48604 | — |
| MyMichigan Medical Center Tawas | Tawas City | Michigan | 48764 | — |
| Corewell Health Beaumont Troy Hospital | Troy | Michigan | 48085 | — |
| Saint Mary's Oncology/Hematology Associates of West Branch | West Branch | Michigan | 48661 | — |
| Huron Gastroenterology PC | Ypsilanti | Michigan | 48106 | — |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus | Ypsilanti | Michigan | 48197 | — |
| Sanford Joe Lueken Cancer Center | Bemidji | Minnesota | 56601 | — |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Essentia Health - Deer River Clinic | Deer River | Minnesota | 56636 | — |
| Essentia Health Cancer Center | Duluth | Minnesota | 55805 | — |
| Fairview Southdale Hospital | Edina | Minnesota | 55435 | — |
| Essentia Health Hibbing Clinic | Hibbing | Minnesota | 55746 | — |
| Saint John's Hospital - Healtheast | Maplewood | Minnesota | 55109 | — |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Mayo Clinic in Rochester | Rochester | Minnesota | 55905 | — |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | 55416 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| United Hospital | Saint Paul | Minnesota | 55102 | — |
| Essentia Health Sandstone | Sandstone | Minnesota | 55072 | — |
| Essentia Health Virginia Clinic | Virginia | Minnesota | 55792 | — |
| Gulfport Memorial Hospital | Gulfport | Mississippi | 39502 | — |
| Siteman Cancer Center at Saint Peters Hospital | City of Saint Peters | Missouri | 63376 | — |
| Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri | 63141 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Siteman Cancer Center-South County | St Louis | Missouri | 63129 | — |
| Siteman Cancer Center at Christian Hospital | St Louis | Missouri | 63136 | — |
| Community Hospital of Anaconda | Anaconda | Montana | 59711 | — |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | — |
| Bozeman Health Deaconess Hospital | Bozeman | Montana | 59715 | — |
| Benefis Sletten Cancer Institute | Great Falls | Montana | 59405 | — |
| Logan Health Medical Center | Kalispell | Montana | 59901 | — |
| Community Medical Center | Missoula | Montana | 59804 | — |
| OptumCare Cancer Care at Seven Hills | Henderson | Nevada | 89052 | — |
| OptumCare Cancer Care at Charleston | Las Vegas | Nevada | 89102 | — |
| OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada | 89148 | — |
| Montefiore Medical Center-Einstein Campus | The Bronx | New York | 10461 | — |
| Sanford Bismarck Medical Center | Bismarck | North Dakota | 58501 | — |
| Sanford Broadway Medical Center | Fargo | North Dakota | 58122 | — |
| Sanford Roger Maris Cancer Center | Fargo | North Dakota | 58122 | — |
| Strecker Cancer Center-Belpre | Belpre | Ohio | 45714 | — |
| Aultman Health Foundation | Canton | Ohio | 44710 | — |
| Miami Valley Hospital South | Centerville | Ohio | 45459 | — |
| Adena Regional Medical Center | Chillicothe | Ohio | 45601 | — |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | — |
| Mount Carmel East Hospital | Columbus | Ohio | 43213 | — |
| The Mark H Zangmeister Center | Columbus | Ohio | 43219 | — |
| Miami Valley Hospital | Dayton | Ohio | 45409 | — |
| Premier Blood and Cancer Center | Dayton | Ohio | 45409 | — |
| Dayton Physician LLC - Englewood | Dayton | Ohio | 45415 | — |
| Miami Valley Hospital North | Dayton | Ohio | 45415 | — |
| Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | 45005-1066 | — |
| Miami Valley Cancer Care and Infusion | Greenville | Ohio | 45331 | — |
| Kettering Medical Center | Kettering | Ohio | 45429 | — |
| Fairfield Medical Center | Lancaster | Ohio | 43130 | — |
| Marietta Memorial Hospital | Marietta | Ohio | 45750 | — |
| Memorial Hospital | Marysville | Ohio | 43040 | — |
| Knox Community Hospital | Mount Vernon | Ohio | 43050 | — |
| Licking Memorial Hospital | Newark | Ohio | 43055 | — |
| Mercy Health - Perrysburg Hospital | Perrysburg | Ohio | 43551 | — |
| Southern Ohio Medical Center | Portsmouth | Ohio | 45662 | — |
| Springfield Regional Cancer Center | Springfield | Ohio | 45504 | — |
| Springfield Regional Medical Center | Springfield | Ohio | 45504 | — |
| Mercy Health - Saint Anne Hospital | Toledo | Ohio | 43623 | — |
| Upper Valley Medical Center | Troy | Ohio | 45373 | — |
| Saint Ann's Hospital | Westerville | Ohio | 43081 | — |
| Genesis Healthcare System Cancer Care Center | Zanesville | Ohio | 43701 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Providence Newberg Medical Center | Newberg | Oregon | 97132 | — |
| Saint Alphonsus Cancer Care Center-Ontario | Ontario | Oregon | 97914 | — |
| Providence Willamette Falls Medical Center | Oregon City | Oregon | 97045 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Providence Saint Vincent Medical Center | Portland | Oregon | 97225 | — |
| UPMC Altoona | Altoona | Pennsylvania | 16601 | — |
| Bryn Mawr Hospital | Bryn Mawr | Pennsylvania | 19010 | — |
| UPMC Hillman Cancer Center Erie | Erie | Pennsylvania | 16505 | — |
| UPMC Cancer Centers - Arnold Palmer Pavilion | Greensburg | Pennsylvania | 15601 | — |
| UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion | Mechanicsburg | Pennsylvania | 17050 | — |
| Riddle Memorial Hospital | Media | Pennsylvania | 19063 | — |
| UPMC Hillman Cancer Center - Monroeville | Monroeville | Pennsylvania | 15146 | — |
| Paoli Memorial Hospital | Paoli | Pennsylvania | 19301 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania | 15232 | — |
| UPMC-Passavant Hospital | Pittsburgh | Pennsylvania | 15237 | — |
| Asplundh Cancer Pavilion | Willow Grove | Pennsylvania | 19090 | — |
| Lankenau Medical Center | Wynnewood | Pennsylvania | 19096 | — |
| Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | 57104 | — |
| Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | 57117-5134 | — |
| M D Anderson Cancer Center | Houston | Texas | 77030 | — |
| Virginia Cancer Institute | Richmond | Virginia | 23229 | — |
| VCU Massey Cancer Center at Stony Point | Richmond | Virginia | 23235 | — |
| Virginia Commonwealth University/Massey Cancer Center | Richmond | Virginia | 23298 | — |
| VCU Community Memorial Health Center | South Hill | Virginia | 23970 | — |
| Swedish Cancer Institute-Edmonds | Edmonds | Washington | 98026 | — |
| Swedish Cancer Institute-Issaquah | Issaquah | Washington | 98029 | — |
| Valley Medical Center | Renton | Washington | 98055 | — |
| North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | Yakima | Washington | 98902 | — |
| Duluth Clinic Ashland | Ashland | Wisconsin | 54806 | — |
| Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin | 53105 | — |
| Aurora Saint Luke's South Shore | Cudahy | Wisconsin | 53110 | — |
| Aurora Health Care Germantown Health Center | Germantown | Wisconsin | 53022 | — |
| Aurora Cancer Care-Grafton | Grafton | Wisconsin | 53024 | — |
| Aurora BayCare Medical Center | Green Bay | Wisconsin | 54311 | — |
| Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin | 53142 | — |
| Gundersen Lutheran Medical Center | La Crosse | Wisconsin | 54601 | — |
| University of Wisconsin Carbone Cancer Center - Eastpark Medical Center | Madison | Wisconsin | 53718 | — |
| University of Wisconsin Carbone Cancer Center - University Hospital | Madison | Wisconsin | 53792 | — |
| Aurora Bay Area Medical Group-Marinette | Marinette | Wisconsin | 54143 | — |
| Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin | 53209 | — |
| Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | 53215 | — |
| Aurora Sinai Medical Center | Milwaukee | Wisconsin | 53233 | — |
| Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin | 54904 | — |
| Aurora Cancer Care-Racine | Racine | Wisconsin | 53406 | — |
| Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin | 53081 | — |
| Aurora Medical Center in Summit | Summit | Wisconsin | 53066 | — |
| Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin | 54241 | — |
| Aurora Cancer Care-Milwaukee West | Wauwatosa | Wisconsin | 53226 | — |
| Aurora West Allis Medical Center | West Allis | Wisconsin | 53227 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05554354, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 3, 2026 · Synced Oct 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05554354 live on ClinicalTrials.gov.