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Active, not recruiting Phase 2 Interventional

Palbociclib and Binimetinib in RAS-Mutant Cancers, A ComboMATCH Treatment Trial

ClinicalTrials.gov ID: NCT05554367

Public ClinicalTrials.gov record NCT05554367. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 23, 2026, 2:11 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Palbociclib and Binimetinib in RAS-Mutant Cancers: A ComboMATCH Treatment Trial

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This phase II ComboMATCH treatment trial evaluates the effectiveness of palbociclib and binimetinib in treating patients with RAS-mutated cancers. Palbociclib and binimetinib are both in a class of medications called kinase inhibitors. They work by blocking the action of abnormal proteins that signals cancer cells to multiply. This trial may help researchers understand if giving the combination of palbociclib and binimetinib can help improve the amount of time before the cancer grows in patients with patients with low grade serous ovarian cancer who have certain changes in the tumor DNA. This trial may also help researchers understand if giving the combination of palbociclib and binimetinib can help improve outcomes among patients with low grade serous ovarian cancer who have previously received a MEK inhibitor. For patients with other tumors, with the exception of lung cancer, colon cancer, melanoma and low grade serous ovarian cancers, this trial may help researchers understand if giving the combination of palbociclib and binimetinib can improve the clinical outcome of survival without progression in patients who have certain changes in their tumor's DNA.

Study identification

NCT ID
NCT05554367
Recruitment status
Active, not recruiting
Study type
Interventional
Phase
Phase 2
Enrollment
199 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 13, 2023 (Actual)
Primary completion
Aug 26, 2028 (Estimated)
Completion
Aug 26, 2028 (Estimated)
Last update posted
Aug 21, 2026

2023 – 2028

United States locations

U.S. sites
264
U.S. states
35
U.S. cities
209
Facility City State ZIP Site status
University of Alabama at Birmingham Cancer Center Birmingham Alabama 35233 —
University of South Alabama Mitchell Cancer Institute Mobile Alabama 36688 —
Providence Alaska Medical Center Anchorage Alaska 99508 —
UC San Diego Health System - Encinitas Encinitas California 92024 —
UC San Diego Moores Cancer Center La Jolla California 92093 —
VA Palo Alto Health Care System Palo Alto California 94304 —
UC San Diego Medical Center - Hillcrest San Diego California 92103 —
UCHealth University of Colorado Hospital Aurora Colorado 80045 —
Poudre Valley Hospital Fort Collins Colorado 80524 —
Cancer Care and Hematology-Fort Collins Fort Collins Colorado 80528 —
UCHealth Greeley Hospital Greeley Colorado 80631 —
Medical Center of the Rockies Loveland Colorado 80538 —
UM Sylvester Comprehensive Cancer Center at Aventura Aventura Florida 33180 —
UM Sylvester Comprehensive Cancer Center at Coral Gables Coral Gables Florida 33146 —
UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach Florida 33442 —
UF Health Cancer Institute - Gainesville Gainesville Florida 32610 —
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami Florida 33136 —
UM Sylvester Comprehensive Cancer Center at Kendall Miami Florida 33176 —
UM Sylvester Comprehensive Cancer Center at Plantation Plantation Florida 33324 —
Saint Alphonsus Cancer Care Center-Boise Boise Idaho 83706 —
Saint Luke's Cancer Institute - Boise Boise Idaho 83712 —
Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho 83605 —
Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho 83814 —
Saint Luke's Cancer Institute - Fruitland Fruitland Idaho 83619 —
Saint Luke's Cancer Institute - Meridian Meridian Idaho 83642 —
Saint Alphonsus Cancer Care Center-Nampa Nampa Idaho 83687 —
Saint Luke's Cancer Institute - Nampa Nampa Idaho 83687 —
Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho 83854 —
Kootenai Clinic Cancer Services - Sandpoint Sandpoint Idaho 83864 —
Advocate Good Shepherd Hospital Barrington Illinois 60010 —
Illinois CancerCare-Bloomington Bloomington Illinois 61704 —
Illinois CancerCare-Canton Canton Illinois 61520 —
Illinois CancerCare-Carthage Carthage Illinois 62321 —
Northwestern University Chicago Illinois 60611 —
John H Stroger Jr Hospital of Cook County Chicago Illinois 60612 —
University of Chicago Comprehensive Cancer Center Chicago Illinois 60637 —
Advocate Illinois Masonic Medical Center Chicago Illinois 60657 —
AMG Crystal Lake - Oncology Crystal Lake Illinois 60014 —
Carle at The Riverfront Danville Illinois 61832 —
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526 —
Decatur Memorial Hospital Decatur Illinois 62526 —
Northwestern Medicine Cancer Center Kishwaukee DeKalb Illinois 60115 —
Illinois CancerCare-Dixon Dixon Illinois 61021 —
Advocate Good Samaritan Hospital Downers Grove Illinois 60515 —
Carle Physician Group-Effingham Effingham Illinois 62401 —
Crossroads Cancer Center Effingham Illinois 62401 —
Advocate Sherman Hospital Elgin Illinois 60123 —
Illinois CancerCare-Eureka Eureka Illinois 61530 —
Illinois CancerCare-Galesburg Galesburg Illinois 61401 —
Northwestern Medicine Cancer Center Delnor Geneva Illinois 60134 —
Northwestern Medicine Glenview Outpatient Center Glenview Illinois 60026 —
Northwestern Medicine Grayslake Outpatient Center Grayslake Illinois 60030 —
Advocate South Suburban Hospital Hazel Crest Illinois 60429 —
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443 —
Northwestern Medicine Lake Forest Hospital Lake Forest Illinois 60045 —
AMG Libertyville - Oncology Libertyville Illinois 60048 —
Condell Memorial Hospital Libertyville Illinois 60048 —
Illinois CancerCare-Macomb Macomb Illinois 61455 —
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938 —
UC Comprehensive Cancer Center at Silver Cross New Lenox Illinois 60451 —
Cancer Care Center of O'Fallon O'Fallon Illinois 62269 —
Advocate Christ Medical Center Oak Lawn Illinois 60453-2699 —
Advocate Outpatient Center - Oak Lawn Oak Lawn Illinois 60453 —
Northwestern Medicine Orland Park Orland Park Illinois 60462 —
University of Chicago Medicine-Orland Park Orland Park Illinois 60462 —
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350 —
Advocate High Tech Medical Park Palos Heights Illinois 60463 —
Advocate Lutheran General Hospital Park Ridge Illinois 60068 —
Illinois CancerCare-Pekin Pekin Illinois 61554 —
Illinois CancerCare-Peoria Peoria Illinois 61615 —
Illinois CancerCare-Peru Peru Illinois 61354 —
Illinois CancerCare-Princeton Princeton Illinois 61356 —
Mercyhealth Cancer Institute - Rockford Rockford Illinois 61114 —
Southern Illinois University School of Medicine Springfield Illinois 62702 —
Springfield Clinic Springfield Illinois 62702 —
Springfield Memorial Hospital Springfield Illinois 62781 —
Carle Cancer Center Urbana Illinois 61801 —
Northwestern Medicine Cancer Center Warrenville Warrenville Illinois 60555 —
Illinois CancerCare - Washington Washington Illinois 61571 —
UI Health Care Mission Cancer and Blood - Ankeny Clinic Ankeny Iowa 50023 —
Mercy Hospital Cedar Rapids Iowa 52403 —
Oncology Associates at Mercy Medical Center Cedar Rapids Iowa 52403 —
UI Health Care Mission Cancer and Blood - Des Moines Clinic Des Moines Iowa 50309 —
UI Health Care Mission Cancer and Blood - Waukee Clinic Waukee Iowa 50263 —
University of Kentucky/Markey Cancer Center Lexington Kentucky 40536 —
Harold Alfond Center for Cancer Care Augusta Maine 04330 —
Lafayette Family Cancer Center-EMMC Brewer Maine 04412 —
MaineHealth Maine Medical Center- Scarborough Scarborough Maine 04074 —
MaineHealth Cancer Care and IV Therapy - South Portland South Portland Maine 04106 —
University of Maryland/Greenebaum Cancer Center Baltimore Maryland 21201 —
Walter Reed National Military Medical Center Bethesda Maryland 20889-5600 —
National Institutes of Health Clinical Center Bethesda Maryland 20892 —
UPMC Western Maryland Cumberland Maryland 21502 —
Dana-Farber Cancer Institute Boston Massachusetts 02215 —
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor Michigan 48106 —
Bronson Battle Creek Battle Creek Michigan 49017 —
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan 48114 —
Trinity Health Medical Center - Brighton Brighton Michigan 48114 —
Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan 48188 —
Trinity Health Medical Center - Canton Canton Michigan 48188 —
Chelsea Hospital Chelsea Michigan 48118 —
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan 48118 —
Corewell Health Dearborn Hospital Dearborn Michigan 48124 —
OSF Saint Francis Hospital and Medical Group Escanaba Michigan 49829 —
Corewell Health Farmington Hills Hospital Farmington Hills Michigan 48336 —
Cancer Hematology Centers - Flint Flint Michigan 48503 —
Genesee Hematology Oncology PC Flint Michigan 48503 —
Genesys Hurley Cancer Institute Flint Michigan 48503 —
Hurley Medical Center Flint Michigan 48503 —
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids Michigan 49503 —
Trinity Health Grand Rapids Hospital Grand Rapids Michigan 49503 —
Bronson Methodist Hospital Kalamazoo Michigan 49007 —
West Michigan Cancer Center Kalamazoo Michigan 49007 —
Beacon Kalamazoo Cancer Center Kalamazoo Michigan 49009 —
University of Michigan Health - Sparrow Lansing Lansing Michigan 48912 —
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154 —
Trinity Health Muskegon Hospital Muskegon Michigan 49444 —
Corewell Health Lakeland Hospitals - Niles Hospital Niles Michigan 49120 —
Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores Michigan 49444 —
Michigan Healthcare Professionals Pontiac Pontiac Michigan 48341 —
Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac Michigan 48341 —
Corewell Health Reed City Hospital Reed City Michigan 49677 —
Corewell Health William Beaumont University Hospital Royal Oak Michigan 48073 —
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Saint Joseph Michigan 49085 —
Corewell Health Lakeland Hospitals - Saint Joseph Hospital Saint Joseph Michigan 49085 —
Munson Medical Center Traverse City Michigan 49684 —
Corewell Health Beaumont Troy Hospital Troy Michigan 48085 —
University of Michigan Health - West Wyoming Michigan 49519 —
Huron Gastroenterology PC Ypsilanti Michigan 48106 —
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan 48197 —
Sanford Joe Lueken Cancer Center Bemidji Minnesota 56601 —
Essentia Health - Deer River Clinic Deer River Minnesota 56636 —
Essentia Health Cancer Center Duluth Minnesota 55805 —
Essentia Health Hibbing Clinic Hibbing Minnesota 55746 —
Hennepin County Medical Center Minneapolis Minnesota 55415 —
Essentia Health Sandstone Sandstone Minnesota 55072 —
Essentia Health Virginia Clinic Virginia Minnesota 55792 —
Saint Francis Medical Center Cape Girardeau Missouri 63703 —
Siteman Cancer Center at Saint Peters Hospital City of Saint Peters Missouri 63376 —
Siteman Cancer Center at West County Hospital Creve Coeur Missouri 63141 —
Parkland Health Center - Farmington Farmington Missouri 63640 —
Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri 63670 —
Washington University School of Medicine St Louis Missouri 63110 —
Siteman Cancer Center-South County St Louis Missouri 63129 —
Missouri Baptist Medical Center St Louis Missouri 63131 —
Siteman Cancer Center at Christian Hospital St Louis Missouri 63136 —
Missouri Baptist Sullivan Hospital Sullivan Missouri 63080 —
Community Hospital of Anaconda Anaconda Montana 59711 —
Billings Clinic Cancer Center Billings Montana 59101 —
Bozeman Health Deaconess Hospital Bozeman Montana 59715 —
Benefis Sletten Cancer Institute Great Falls Montana 59405 —
Logan Health Medical Center Kalispell Montana 59901 —
Community Medical Center Missoula Montana 59804 —
OptumCare Cancer Care at Charleston Las Vegas Nevada 89102 —
OptumCare Cancer Care at Fort Apache Las Vegas Nevada 89183 —
Rutgers Cancer Institute of New Jersey New Brunswick New Jersey 08903 —
University of New Mexico Cancer Center Albuquerque New Mexico 87106 —
Roswell Park Cancer Institute Buffalo New York 14263 —
Mount Sinai Hospital New York New York 10029 —
Upstate Cancer Center at Oswego Oswego New York 13126 —
State University of New York Upstate Medical University Syracuse New York 13210 —
Upstate Cancer Center at Verona Verona New York 13478 —
Duke University Medical Center Durham North Carolina 27710 —
Sanford Bismarck Medical Center Bismarck North Dakota 58501 —
Sanford Broadway Medical Center Fargo North Dakota 58122 —
Sanford Roger Maris Cancer Center Fargo North Dakota 58122 —
Miami Valley Hospital South Centerville Ohio 45459 —
Good Samaritan Hospital - Cincinnati Cincinnati Ohio 45220 —
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210 —
Columbus Oncology and Hematology Associates Inc Columbus Ohio 43214 —
Riverside Methodist Hospital Columbus Ohio 43214 —
Grant Medical Center Columbus Ohio 43215 —
Doctors Hospital Columbus Ohio 43228 —
Miami Valley Hospital Dayton Ohio 45409 —
Premier Blood and Cancer Center Dayton Ohio 45409 —
Dayton Physician LLC - Englewood Dayton Ohio 45415 —
Miami Valley Hospital North Dayton Ohio 45415 —
Delaware Health Center-Grady Cancer Center Delaware Ohio 43015 —
Grady Memorial Hospital Delaware Ohio 43015 —
Columbus Oncology and Hematology Associates Dublin Ohio 43016 —
Dublin Methodist Hospital Dublin Ohio 43016 —
Atrium Medical Center-Middletown Regional Hospital Franklin Ohio 45005-1066 —
Miami Valley Cancer Care and Infusion Greenville Ohio 45331 —
Kettering Medical Center Kettering Ohio 45429 —
OhioHealth Mansfield Hospital Mansfield Ohio 44903 —
OhioHealth Marion General Hospital Marion Ohio 43302 —
Upper Valley Medical Center Troy Ohio 45373 —
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 —
Providence Newberg Medical Center Newberg Oregon 97132 —
Saint Alphonsus Cancer Care Center-Ontario Ontario Oregon 97914 —
Providence Willamette Falls Medical Center Oregon City Oregon 97045 —
Providence Portland Medical Center Portland Oregon 97213 —
Providence Saint Vincent Medical Center Portland Oregon 97225 —
UPMC Altoona Altoona Pennsylvania 16601 —
Bryn Mawr Hospital Bryn Mawr Pennsylvania 19010 —
UPMC Hillman Cancer Center Erie Erie Pennsylvania 16505 —
UPMC Cancer Centers - Arnold Palmer Pavilion Greensburg Pennsylvania 15601 —
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion Mechanicsburg Pennsylvania 17050 —
Riddle Memorial Hospital Media Pennsylvania 19063 —
UPMC Hillman Cancer Center - Monroeville Monroeville Pennsylvania 15146 —
Paoli Memorial Hospital Paoli Pennsylvania 19301 —
UPMC Hillman Cancer Center Pittsburgh Pennsylvania 15232 —
UPMC-Passavant Hospital Pittsburgh Pennsylvania 15237 —
Lankenau Medical Center Wynnewood Pennsylvania 19096 —
Women and Infants Hospital Providence Rhode Island 02905 —
Prisma Health Cancer Institute - Spartanburg Boiling Springs South Carolina 29316 —
Prisma Health Cancer Institute - Easley Easley South Carolina 29640 —
Prisma Health Cancer Institute - Butternut Greenville South Carolina 29605 —
Prisma Health Cancer Institute - Faris Greenville South Carolina 29605 —
Prisma Health Cancer Institute - Eastside Greenville South Carolina 29615 —
Prisma Health Cancer Institute - Greer Greer South Carolina 29650 —
Prisma Health Cancer Institute - Seneca Seneca South Carolina 29672 —
Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota 57104 —
Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota 57117-5134 —
Vanderbilt University/Ingram Cancer Center Nashville Tennessee 37232 —
Hendrick Medical Center Abilene Texas 79601 —
Houston Methodist Hospital Houston Texas 77030 —
UT MD Anderson Cancer Center Houston Texas 77030 —
Methodist Willowbrook Hospital Houston Texas 77070 —
Houston Methodist West Hospital Houston Texas 77094 —
Houston Methodist Saint John Hospital Nassau Bay Texas 77058 —
Houston Methodist Sugar Land Hospital Sugar Land Texas 77479 —
Houston Methodist The Woodlands Hospital The Woodlands Texas 77385 —
University of Virginia Cancer Center Charlottesville Virginia 22908 —
Inova Schar Cancer Institute Fairfax Virginia 22031 —
Inova Fairfax Hospital Falls Church Virginia 22042 —
VCU Massey Comprehensive Cancer Center Richmond Virginia 23298 —
Swedish Cancer Institute-Edmonds Edmonds Washington 98026 —
Swedish Cancer Institute-Issaquah Issaquah Washington 98029 —
Swedish Medical Center-First Hill Seattle Washington 98122 —
West Virginia University Healthcare Morgantown West Virginia 26506 —
ThedaCare Regional Cancer Center Appleton Wisconsin 54911 —
Duluth Clinic Ashland Ashland Wisconsin 54806 —
Aurora Cancer Care-Southern Lakes VLCC Burlington Wisconsin 53105 —
Aurora Saint Luke's South Shore Cudahy Wisconsin 53110 —
Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin 54701 —
Aurora Health Care Germantown Health Center Germantown Wisconsin 53022 —
Aurora Cancer Care-Grafton Grafton Wisconsin 53024 —
Saint Vincent Hospital Cancer Center Green Bay Green Bay Wisconsin 54301 —
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay Wisconsin 54303 —
Aurora BayCare Medical Center Green Bay Wisconsin 54311 —
Mercyhealth Hospital and Cancer Center - Janesville Janesville Wisconsin 53548 —
Aurora Cancer Care-Kenosha South Kenosha Wisconsin 53142 —
Gundersen Lutheran Medical Center La Crosse Wisconsin 54601 —
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center Madison Wisconsin 53718 —
University of Wisconsin Carbone Cancer Center - University Hospital Madison Wisconsin 53792 —
Aurora Bay Area Medical Group-Marinette Marinette Wisconsin 54143 —
Marshfield Medical Center-Marshfield Marshfield Wisconsin 54449 —
Aurora Cancer Care-Milwaukee Milwaukee Wisconsin 53209 —
Aurora Saint Luke's Medical Center Milwaukee Wisconsin 53215 —
Aurora Sinai Medical Center Milwaukee Wisconsin 53233 —
Marshfield Medical Center - Minocqua Minocqua Wisconsin 54548 —
Saint Vincent Hospital Cancer Center at Oconto Falls Oconto Falls Wisconsin 54154 —
Vince Lombardi Cancer Clinic - Oshkosh Oshkosh Wisconsin 54904 —
Aurora Cancer Care-Racine Racine Wisconsin 53406 —
Marshfield Medical Center-Rice Lake Rice Lake Wisconsin 54868 —
Vince Lombardi Cancer Clinic-Sheboygan Sheboygan Wisconsin 53081 —
Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin 54482 —
Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay Wisconsin 54235-1495 —
Aurora Medical Center in Summit Summit Wisconsin 53066 —
Vince Lombardi Cancer Clinic-Two Rivers Two Rivers Wisconsin 54241 —
Aurora Cancer Care-Milwaukee West Wauwatosa Wisconsin 53226 —
Aurora West Allis Medical Center West Allis Wisconsin 53227 —
Marshfield Medical Center - Weston Weston Wisconsin 54476 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05554367, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 21, 2026 · Synced Oct 23, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT05554367 live on ClinicalTrials.gov.

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