ClinicalTrials.gov record
Active, not recruiting Phase 2 Interventional

Palbociclib and Binimetinib in RAS-Mutant Cancers, A ComboMATCH Treatment Trial

ClinicalTrials.gov ID: NCT05554367

Public ClinicalTrials.gov record NCT05554367. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced May 6, 2026, 8:32 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Palbociclib and Binimetinib in RAS-Mutant Cancers: A ComboMATCH Treatment Trial

Study identification

NCT ID
NCT05554367
Recruitment status
Active, not recruiting
Study type
Interventional
Phase
Phase 2
Lead sponsor
National Cancer Institute (NCI)
NIH
Enrollment
199 participants

Conditions and interventions

Interventions

  • Binimetinib Drug
  • Biopsy Procedure Procedure
  • Biospecimen Collection Procedure
  • Bone Scan Procedure
  • Computed Tomography Procedure
  • Magnetic Resonance Imaging Procedure
  • Palbociclib Drug

Drug · Procedure

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 12, 2023
Primary completion
Aug 25, 2026
Completion
Aug 25, 2026
Last update posted
Apr 30, 2026

2023 – 2026

United States locations

U.S. sites
265
U.S. states
35
U.S. cities
210
Facility City State ZIP Site status
University of Alabama at Birmingham Cancer Center Birmingham Alabama 35233
University of South Alabama Mitchell Cancer Institute Mobile Alabama 36688
Providence Alaska Medical Center Anchorage Alaska 99508
UC San Diego Health System - Encinitas Encinitas California 92024
UC San Diego Moores Cancer Center La Jolla California 92093
VA Palo Alto Health Care System Palo Alto California 94304
UC San Diego Medical Center - Hillcrest San Diego California 92103
UCHealth University of Colorado Hospital Aurora Colorado 80045
Poudre Valley Hospital Fort Collins Colorado 80524
Cancer Care and Hematology-Fort Collins Fort Collins Colorado 80528
UCHealth Greeley Hospital Greeley Colorado 80631
Medical Center of the Rockies Loveland Colorado 80538
UM Sylvester Comprehensive Cancer Center at Aventura Aventura Florida 33180
UM Sylvester Comprehensive Cancer Center at Coral Gables Coral Gables Florida 33146
UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach Florida 33442
UF Health Cancer Institute - Gainesville Gainesville Florida 32610
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami Florida 33136
UM Sylvester Comprehensive Cancer Center at Kendall Miami Florida 33176
UM Sylvester Comprehensive Cancer Center at Plantation Plantation Florida 33324
Saint Alphonsus Cancer Care Center-Boise Boise Idaho 83706
Saint Luke's Cancer Institute - Boise Boise Idaho 83712
Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho 83605
Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho 83814
Saint Luke's Cancer Institute - Fruitland Fruitland Idaho 83619
Saint Luke's Cancer Institute - Meridian Meridian Idaho 83642
Saint Alphonsus Cancer Care Center-Nampa Nampa Idaho 83687
Saint Luke's Cancer Institute - Nampa Nampa Idaho 83687
Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho 83854
Kootenai Clinic Cancer Services - Sandpoint Sandpoint Idaho 83864
Advocate Good Shepherd Hospital Barrington Illinois 60010
Illinois CancerCare-Bloomington Bloomington Illinois 61704
Illinois CancerCare-Canton Canton Illinois 61520
Illinois CancerCare-Carthage Carthage Illinois 62321
Northwestern University Chicago Illinois 60611
John H Stroger Jr Hospital of Cook County Chicago Illinois 60612
University of Chicago Comprehensive Cancer Center Chicago Illinois 60637
Advocate Illinois Masonic Medical Center Chicago Illinois 60657
AMG Crystal Lake - Oncology Crystal Lake Illinois 60014
Carle at The Riverfront Danville Illinois 61832
Northwestern Medicine Cancer Center Kishwaukee DeKalb Illinois 60115
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526
Decatur Memorial Hospital Decatur Illinois 62526
Illinois CancerCare-Dixon Dixon Illinois 61021
Advocate Good Samaritan Hospital Downers Grove Illinois 60515
Carle Physician Group-Effingham Effingham Illinois 62401
Crossroads Cancer Center Effingham Illinois 62401
Advocate Sherman Hospital Elgin Illinois 60123
Illinois CancerCare-Eureka Eureka Illinois 61530
Illinois CancerCare-Galesburg Galesburg Illinois 61401
Northwestern Medicine Cancer Center Delnor Geneva Illinois 60134
Northwestern Medicine Glenview Outpatient Center Glenview Illinois 60026
Northwestern Medicine Grayslake Outpatient Center Grayslake Illinois 60030
Advocate South Suburban Hospital Hazel Crest Illinois 60429
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443
Northwestern Medicine Lake Forest Hospital Lake Forest Illinois 60045
AMG Libertyville - Oncology Libertyville Illinois 60048
Condell Memorial Hospital Libertyville Illinois 60048
Illinois CancerCare-Macomb Macomb Illinois 61455
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938
UC Comprehensive Cancer Center at Silver Cross New Lenox Illinois 60451
Cancer Care Center of O'Fallon O'Fallon Illinois 62269
Advocate Christ Medical Center Oak Lawn Illinois 60453-2699
Advocate Outpatient Center - Oak Lawn Oak Lawn Illinois 60453
Northwestern Medicine Orland Park Orland Park Illinois 60462
University of Chicago Medicine-Orland Park Orland Park Illinois 60462
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350
Advocate High Tech Medical Park Palos Heights Illinois 60463
Advocate Lutheran General Hospital Park Ridge Illinois 60068
Illinois CancerCare-Pekin Pekin Illinois 61554
Illinois CancerCare-Peoria Peoria Illinois 61615
Illinois CancerCare-Peru Peru Illinois 61354
Illinois CancerCare-Princeton Princeton Illinois 61356
Mercyhealth Cancer Institute - Rockford Rockford Illinois 61114
Southern Illinois University School of Medicine Springfield Illinois 62702
Springfield Clinic Springfield Illinois 62702
Springfield Memorial Hospital Springfield Illinois 62781
Carle Cancer Center Urbana Illinois 61801
Northwestern Medicine Cancer Center Warrenville Warrenville Illinois 60555
Illinois CancerCare - Washington Washington Illinois 61571
UI Health Care Mission Cancer and Blood - Ankeny Clinic Ankeny Iowa 50023
Mercy Hospital Cedar Rapids Iowa 52403
Oncology Associates at Mercy Medical Center Cedar Rapids Iowa 52403
UI Health Care Mission Cancer and Blood - Des Moines Clinic Des Moines Iowa 50309
UI Health Care Mission Cancer and Blood - Waukee Clinic Waukee Iowa 50263
University of Kentucky/Markey Cancer Center Lexington Kentucky 40536
Harold Alfond Center for Cancer Care Augusta Maine 04330
Lafayette Family Cancer Center-EMMC Brewer Maine 04412
MaineHealth Maine Medical Center- Scarborough Scarborough Maine 04074
MaineHealth Cancer Care and IV Therapy - South Portland South Portland Maine 04106
University of Maryland/Greenebaum Cancer Center Baltimore Maryland 21201
Walter Reed National Military Medical Center Bethesda Maryland 20889-5600
National Institutes of Health Clinical Center Bethesda Maryland 20892
UPMC Western Maryland Cumberland Maryland 21502
Dana-Farber Cancer Institute Boston Massachusetts 02215
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor Michigan 48106
Bronson Battle Creek Battle Creek Michigan 49017
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan 48114
Trinity Health Medical Center - Brighton Brighton Michigan 48114
Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan 48188
Trinity Health Medical Center - Canton Canton Michigan 48188
Chelsea Hospital Chelsea Michigan 48118
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan 48118
Corewell Health Dearborn Hospital Dearborn Michigan 48124
OSF Saint Francis Hospital and Medical Group Escanaba Michigan 49829
Corewell Health Farmington Hills Hospital Farmington Hills Michigan 48336
Cancer Hematology Centers - Flint Flint Michigan 48503
Genesee Hematology Oncology PC Flint Michigan 48503
Genesys Hurley Cancer Institute Flint Michigan 48503
Hurley Medical Center Flint Michigan 48503
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids Michigan 49503
Trinity Health Grand Rapids Hospital Grand Rapids Michigan 49503
Bronson Methodist Hospital Kalamazoo Michigan 49007
West Michigan Cancer Center Kalamazoo Michigan 49007
Beacon Kalamazoo Cancer Center Kalamazoo Michigan 49009
University of Michigan Health - Sparrow Lansing Lansing Michigan 48912
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154
Trinity Health Muskegon Hospital Muskegon Michigan 49444
Corewell Health Lakeland Hospitals - Niles Hospital Niles Michigan 49120
Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores Michigan 49444
Michigan Healthcare Professionals Pontiac Pontiac Michigan 48341
Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac Michigan 48341
Corewell Health Reed City Hospital Reed City Michigan 49677
Corewell Health William Beaumont University Hospital Royal Oak Michigan 48073
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Saint Joseph Michigan 49085
Corewell Health Lakeland Hospitals - Saint Joseph Hospital Saint Joseph Michigan 49085
Munson Medical Center Traverse City Michigan 49684
Corewell Health Beaumont Troy Hospital Troy Michigan 48085
University of Michigan Health - West Wyoming Michigan 49519
Huron Gastroenterology PC Ypsilanti Michigan 48106
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan 48197
Sanford Joe Lueken Cancer Center Bemidji Minnesota 56601
Essentia Health - Deer River Clinic Deer River Minnesota 56636
Essentia Health Cancer Center Duluth Minnesota 55805
Essentia Health Hibbing Clinic Hibbing Minnesota 55746
Hennepin County Medical Center Minneapolis Minnesota 55415
Essentia Health Sandstone Sandstone Minnesota 55072
Essentia Health Virginia Clinic Virginia Minnesota 55792
Saint Francis Medical Center Cape Girardeau Missouri 63703
Siteman Cancer Center at Saint Peters Hospital City of Saint Peters Missouri 63376
Siteman Cancer Center at West County Hospital Creve Coeur Missouri 63141
Parkland Health Center - Farmington Farmington Missouri 63640
Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri 63670
Washington University School of Medicine St Louis Missouri 63110
Siteman Cancer Center-South County St Louis Missouri 63129
Missouri Baptist Medical Center St Louis Missouri 63131
Siteman Cancer Center at Christian Hospital St Louis Missouri 63136
Missouri Baptist Sullivan Hospital Sullivan Missouri 63080
BJC Outpatient Center at Sunset Hills Sunset Hills Missouri 63127
Community Hospital of Anaconda Anaconda Montana 59711
Billings Clinic Cancer Center Billings Montana 59101
Bozeman Health Deaconess Hospital Bozeman Montana 59715
Benefis Sletten Cancer Institute Great Falls Montana 59405
Logan Health Medical Center Kalispell Montana 59901
Community Medical Center Missoula Montana 59804
OptumCare Cancer Care at Charleston Las Vegas Nevada 89102
OptumCare Cancer Care at Fort Apache Las Vegas Nevada 89183
Rutgers Cancer Institute of New Jersey New Brunswick New Jersey 08903
University of New Mexico Cancer Center Albuquerque New Mexico 87106
Roswell Park Cancer Institute Buffalo New York 14263
Mount Sinai Hospital New York New York 10029
Upstate Cancer Center at Oswego Oswego New York 13126
State University of New York Upstate Medical University Syracuse New York 13210
Upstate Cancer Center at Verona Verona New York 13478
Duke University Medical Center Durham North Carolina 27710
Sanford Bismarck Medical Center Bismarck North Dakota 58501
Sanford Broadway Medical Center Fargo North Dakota 58122
Sanford Roger Maris Cancer Center Fargo North Dakota 58122
Miami Valley Hospital South Centerville Ohio 45459
Good Samaritan Hospital - Cincinnati Cincinnati Ohio 45220
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210
Columbus Oncology and Hematology Associates Inc Columbus Ohio 43214
Riverside Methodist Hospital Columbus Ohio 43214
Grant Medical Center Columbus Ohio 43215
Doctors Hospital Columbus Ohio 43228
Miami Valley Hospital Dayton Ohio 45409
Premier Blood and Cancer Center Dayton Ohio 45409
Dayton Physician LLC - Englewood Dayton Ohio 45415
Miami Valley Hospital North Dayton Ohio 45415
Delaware Health Center-Grady Cancer Center Delaware Ohio 43015
Grady Memorial Hospital Delaware Ohio 43015
Columbus Oncology and Hematology Associates Dublin Ohio 43016
Dublin Methodist Hospital Dublin Ohio 43016
Atrium Medical Center-Middletown Regional Hospital Franklin Ohio 45005-1066
Miami Valley Cancer Care and Infusion Greenville Ohio 45331
Kettering Medical Center Kettering Ohio 45429
OhioHealth Mansfield Hospital Mansfield Ohio 44903
OhioHealth Marion General Hospital Marion Ohio 43302
Upper Valley Medical Center Troy Ohio 45373
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104
Providence Newberg Medical Center Newberg Oregon 97132
Saint Alphonsus Cancer Care Center-Ontario Ontario Oregon 97914
Providence Willamette Falls Medical Center Oregon City Oregon 97045
Providence Portland Medical Center Portland Oregon 97213
Providence Saint Vincent Medical Center Portland Oregon 97225
UPMC Altoona Altoona Pennsylvania 16601
Bryn Mawr Hospital Bryn Mawr Pennsylvania 19010
UPMC Hillman Cancer Center Erie Erie Pennsylvania 16505
UPMC Cancer Centers - Arnold Palmer Pavilion Greensburg Pennsylvania 15601
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion Mechanicsburg Pennsylvania 17050
Riddle Memorial Hospital Media Pennsylvania 19063
UPMC Hillman Cancer Center - Monroeville Monroeville Pennsylvania 15146
Paoli Memorial Hospital Paoli Pennsylvania 19301
University of Pittsburgh Cancer Institute (UPCI) Pittsburgh Pennsylvania 15232
UPMC-Passavant Hospital Pittsburgh Pennsylvania 15237
Lankenau Medical Center Wynnewood Pennsylvania 19096
Women and Infants Hospital Providence Rhode Island 02905
Prisma Health Cancer Institute - Spartanburg Boiling Springs South Carolina 29316
Prisma Health Cancer Institute - Easley Easley South Carolina 29640
Prisma Health Cancer Institute - Butternut Greenville South Carolina 29605
Prisma Health Cancer Institute - Faris Greenville South Carolina 29605
Prisma Health Cancer Institute - Eastside Greenville South Carolina 29615
Prisma Health Cancer Institute - Greer Greer South Carolina 29650
Prisma Health Cancer Institute - Seneca Seneca South Carolina 29672
Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota 57104
Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota 57117-5134
Vanderbilt University/Ingram Cancer Center Nashville Tennessee 37232
Hendrick Medical Center Abilene Texas 79601
Houston Methodist Hospital Houston Texas 77030
M D Anderson Cancer Center Houston Texas 77030
Methodist Willowbrook Hospital Houston Texas 77070
Houston Methodist West Hospital Houston Texas 77094
Houston Methodist Saint John Hospital Nassau Bay Texas 77058
Houston Methodist Sugar Land Hospital Sugar Land Texas 77479
Houston Methodist The Woodlands Hospital The Woodlands Texas 77385
University of Virginia Cancer Center Charlottesville Virginia 22908
Inova Schar Cancer Institute Fairfax Virginia 22031
Inova Fairfax Hospital Falls Church Virginia 22042
VCU Massey Comprehensive Cancer Center Richmond Virginia 23298
Swedish Cancer Institute-Edmonds Edmonds Washington 98026
Swedish Cancer Institute-Issaquah Issaquah Washington 98029
Swedish Medical Center-First Hill Seattle Washington 98122
West Virginia University Healthcare Morgantown West Virginia 26506
ThedaCare Regional Cancer Center Appleton Wisconsin 54911
Duluth Clinic Ashland Ashland Wisconsin 54806
Aurora Cancer Care-Southern Lakes VLCC Burlington Wisconsin 53105
Aurora Saint Luke's South Shore Cudahy Wisconsin 53110
Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin 54701
Aurora Health Care Germantown Health Center Germantown Wisconsin 53022
Aurora Cancer Care-Grafton Grafton Wisconsin 53024
Saint Vincent Hospital Cancer Center Green Bay Green Bay Wisconsin 54301
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay Wisconsin 54303
Aurora BayCare Medical Center Green Bay Wisconsin 54311
Mercyhealth Hospital and Cancer Center - Janesville Janesville Wisconsin 53548
Aurora Cancer Care-Kenosha South Kenosha Wisconsin 53142
Gundersen Lutheran Medical Center La Crosse Wisconsin 54601
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center Madison Wisconsin 53718
University of Wisconsin Carbone Cancer Center - University Hospital Madison Wisconsin 53792
Aurora Bay Area Medical Group-Marinette Marinette Wisconsin 54143
Marshfield Medical Center-Marshfield Marshfield Wisconsin 54449
Aurora Cancer Care-Milwaukee Milwaukee Wisconsin 53209
Aurora Saint Luke's Medical Center Milwaukee Wisconsin 53215
Aurora Sinai Medical Center Milwaukee Wisconsin 53233
Marshfield Medical Center - Minocqua Minocqua Wisconsin 54548
Saint Vincent Hospital Cancer Center at Oconto Falls Oconto Falls Wisconsin 54154
Vince Lombardi Cancer Clinic - Oshkosh Oshkosh Wisconsin 54904
Aurora Cancer Care-Racine Racine Wisconsin 53406
Marshfield Medical Center-Rice Lake Rice Lake Wisconsin 54868
Vince Lombardi Cancer Clinic-Sheboygan Sheboygan Wisconsin 53081
Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin 54482
Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay Wisconsin 54235-1495
Aurora Medical Center in Summit Summit Wisconsin 53066
Vince Lombardi Cancer Clinic-Two Rivers Two Rivers Wisconsin 54241
Aurora Cancer Care-Milwaukee West Wauwatosa Wisconsin 53226
Aurora West Allis Medical Center West Allis Wisconsin 53227
Marshfield Medical Center - Weston Weston Wisconsin 54476

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05554367, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Apr 30, 2026 · Synced May 6, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05554367 live on ClinicalTrials.gov.

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