ClinicalTrials.gov record
Study of Chemotherapy Plus Ipatasertib for People With Solid Tumors With PTEN/AKT Mutations, A ComboMATCH Treatment Trial
ClinicalTrials.gov ID: NCT05554380
Public ClinicalTrials.gov record NCT05554380. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase 2 Study of Paclitaxel (NSC #673089) + Ipatasertib (NSC #781451) in Taxane-Refractory Participants With PTEN/AKT-Altered Advanced Non-Breast Solid Tumors: A ComboMATCH Treatment Trial
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This phase II ComboMATCH treatment trial tests the usual treatment of chemotherapy (paclitaxel) plus ipatasertib in patients with solid tumor cancers that that cannot be removed by surgery (unresectable), has spread to nearby tissue or lymph nodes (locally advanced) or from where it first started (primary site) to other places in the body (metastatic), and has PTEN and AKT genetic changes. Chemotherapy drugs, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Targeted therapy, such as Ipatasertib, may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. The addition of ipatasertib to paclitaxel in solid tumors with PTEN and AKT genetic changes could increase the percentage of tumors that shrink as well as lengthen the time that the tumors remain stable (without progression). Researchers hope to learn if paclitaxel plus ipatasertib will shrink this type of cancer or stop its growth.
Study identification
- NCT ID
- NCT05554380
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 33 participants
Conditions and interventions
Conditions
Interventions
- Biopsy Procedure Procedure
- Biospecimen Collection Procedure
- Computed Tomography Procedure
- Ipatasertib Drug
- Magnetic Resonance Imaging Procedure
- Paclitaxel Drug
Procedure · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 22, 2023 (Actual)
- Primary completion
- Feb 1, 2027 (Estimated)
- Completion
- Feb 1, 2027 (Estimated)
- Last update posted
- Aug 24, 2026
2023 – 2027
United States locations
- U.S. sites
- 207
- U.S. states
- 30
- U.S. cities
- 170
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | 35233 | — |
| University of South Alabama Mitchell Cancer Institute | Mobile | Alabama | 36688 | — |
| Alaska Women's Cancer Care | Anchorage | Alaska | 99508 | — |
| Kingman Regional Medical Center | Kingman | Arizona | 86401 | — |
| PCR Oncology | Arroyo Grande | California | 93420 | — |
| UC San Diego Moores Cancer Center | La Jolla | California | 92093 | — |
| The Angeles Clinic and Research Institute - West Los Angeles Office | Los Angeles | California | 90025 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| Saint Joseph Hospital - Orange | Orange | California | 92868 | — |
| Stanford Cancer Institute Palo Alto | Palo Alto | California | 94304 | — |
| Saint John's Cancer Institute | Santa Monica | California | 90404 | — |
| UM Sylvester Comprehensive Cancer Center at Aventura | Aventura | Florida | 33180 | — |
| UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables | Florida | 33146 | — |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida | 33442 | — |
| Mayo Clinic in Florida | Jacksonville | Florida | 32224-9980 | — |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | 33136 | — |
| UM Sylvester Comprehensive Cancer Center at Kendall | Miami | Florida | 33176 | — |
| UM Sylvester Comprehensive Cancer Center at Plantation | Plantation | Florida | 33324 | — |
| Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | 83706 | — |
| Saint Luke's Cancer Institute - Boise | Boise | Idaho | 83712 | — |
| Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho | 83605 | — |
| Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho | 83814 | — |
| Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho | 83619 | — |
| Saint Luke's Cancer Institute - Meridian | Meridian | Idaho | 83642 | — |
| Saint Alphonsus Cancer Care Center-Nampa | Nampa | Idaho | 83687 | — |
| Saint Luke's Cancer Institute - Nampa | Nampa | Idaho | 83687 | — |
| Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho | 83854 | — |
| Kootenai Clinic Cancer Services - Sandpoint | Sandpoint | Idaho | 83864 | — |
| Saint Luke's Cancer Institute - Twin Falls | Twin Falls | Idaho | 83301 | — |
| Advocate Good Shepherd Hospital | Barrington | Illinois | 60010 | — |
| John H Stroger Jr Hospital of Cook County | Chicago | Illinois | 60612 | — |
| University of Chicago Comprehensive Cancer Center | Chicago | Illinois | 60637 | — |
| Advocate Illinois Masonic Medical Center | Chicago | Illinois | 60657 | — |
| AMG Crystal Lake - Oncology | Crystal Lake | Illinois | 60014 | — |
| Carle at The Riverfront | Danville | Illinois | 61832 | — |
| Advocate Good Samaritan Hospital | Downers Grove | Illinois | 60515 | — |
| Carle Physician Group-Effingham | Effingham | Illinois | 62401 | — |
| Advocate Sherman Hospital | Elgin | Illinois | 60123 | — |
| Advocate South Suburban Hospital | Hazel Crest | Illinois | 60429 | — |
| AMG Libertyville - Oncology | Libertyville | Illinois | 60048 | — |
| Condell Memorial Hospital | Libertyville | Illinois | 60048 | — |
| Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | 61938 | — |
| UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois | 60451 | — |
| Advocate Christ Medical Center | Oak Lawn | Illinois | 60453-2699 | — |
| University of Chicago Medicine-Orland Park | Orland Park | Illinois | 60462 | — |
| Advocate Lutheran General Hospital | Park Ridge | Illinois | 60068 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic | Ankeny | Iowa | 50023 | — |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic | Des Moines | Iowa | 50309 | — |
| Mercy Medical Center - Des Moines | Des Moines | Iowa | 50314 | — |
| UI Health Care Mission Cancer and Blood - Waukee Clinic | Waukee | Iowa | 50263 | — |
| University of Kentucky/Markey Cancer Center | Lexington | Kentucky | 40536 | — |
| Harold Alfond Center for Cancer Care | Augusta | Maine | 04330 | — |
| Lafayette Family Cancer Center-EMMC | Brewer | Maine | 04412 | — |
| MaineHealth Maine Medical Center- Scarborough | Scarborough | Maine | 04074 | — |
| University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | 21201 | — |
| National Institutes of Health Clinical Center | Bethesda | Maryland | 20892 | — |
| UPMC Western Maryland | Cumberland | Maryland | 21502 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor | Ann Arbor | Michigan | 48106 | — |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton | Brighton | Michigan | 48114 | — |
| Trinity Health Medical Center - Brighton | Brighton | Michigan | 48114 | — |
| Trinity Health IHA Medical Group Hematology Oncology - Canton | Canton | Michigan | 48188 | — |
| Trinity Health Medical Center - Canton | Canton | Michigan | 48188 | — |
| Chelsea Hospital | Chelsea | Michigan | 48118 | — |
| Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital | Chelsea | Michigan | 48118 | — |
| Corewell Health Dearborn Hospital | Dearborn | Michigan | 48124 | — |
| Corewell Health Farmington Hills Hospital | Farmington Hills | Michigan | 48336 | — |
| Cancer Hematology Centers - Flint | Flint | Michigan | 48503 | — |
| Genesee Hematology Oncology PC | Flint | Michigan | 48503 | — |
| Genesys Hurley Cancer Institute | Flint | Michigan | 48503 | — |
| Hurley Medical Center | Flint | Michigan | 48503 | — |
| University of Michigan Health - Sparrow Lansing | Lansing | Michigan | 48912 | — |
| Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | 48154 | — |
| Henry Ford Saint John Hospital - Macomb Medical | Macomb | Michigan | 48044 | — |
| Trinity Health Saint Joseph Mercy Oakland Hospital | Pontiac | Michigan | 48341 | — |
| Corewell Health William Beaumont University Hospital | Royal Oak | Michigan | 48073 | — |
| MyMichigan Medical Center Saginaw | Saginaw | Michigan | 48601 | — |
| Oncology Hematology Associates of Saginaw Valley PC | Saginaw | Michigan | 48604 | — |
| MyMichigan Medical Center Tawas | Tawas City | Michigan | 48764 | — |
| Corewell Health Beaumont Troy Hospital | Troy | Michigan | 48085 | — |
| Saint Mary's Oncology/Hematology Associates of West Branch | West Branch | Michigan | 48661 | — |
| Huron Gastroenterology PC | Ypsilanti | Michigan | 48106 | — |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus | Ypsilanti | Michigan | 48197 | — |
| Sanford Joe Lueken Cancer Center | Bemidji | Minnesota | 56601 | — |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Essentia Health - Deer River Clinic | Deer River | Minnesota | 56636 | — |
| Essentia Health Cancer Center | Duluth | Minnesota | 55805 | — |
| Fairview Southdale Hospital | Edina | Minnesota | 55435 | — |
| Essentia Health Hibbing Clinic | Hibbing | Minnesota | 55746 | — |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Mayo Clinic in Rochester | Rochester | Minnesota | 55905 | — |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | 55416 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| United Hospital | Saint Paul | Minnesota | 55102 | — |
| Essentia Health Sandstone | Sandstone | Minnesota | 55072 | — |
| Essentia Health Virginia Clinic | Virginia | Minnesota | 55792 | — |
| Community Hospital of Anaconda | Anaconda | Montana | 59711 | — |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | — |
| Bozeman Health Deaconess Hospital | Bozeman | Montana | 59715 | — |
| Benefis Sletten Cancer Institute | Great Falls | Montana | 59405 | — |
| Logan Health Medical Center | Kalispell | Montana | 59901 | — |
| Community Medical Center | Missoula | Montana | 59804 | — |
| OptumCare Cancer Care at Charleston | Las Vegas | Nevada | 89102 | — |
| OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada | 89183 | — |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08903 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| Mount Sinai Hospital | New York | New York | 10029 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Sanford Bismarck Medical Center | Bismarck | North Dakota | 58501 | — |
| Sanford Broadway Medical Center | Fargo | North Dakota | 58122 | — |
| Sanford Roger Maris Cancer Center | Fargo | North Dakota | 58122 | — |
| UH Seidman Cancer Center at UH Avon Health Center | Avon | Ohio | 44011 | — |
| UHHS-Chagrin Highlands Medical Center | Beachwood | Ohio | 44122 | — |
| Strecker Cancer Center-Belpre | Belpre | Ohio | 45714 | — |
| Aultman Health Foundation | Canton | Ohio | 44710 | — |
| Adena Regional Medical Center | Chillicothe | Ohio | 45601 | — |
| Case Western Reserve University | Cleveland | Ohio | 44106 | — |
| Mount Carmel East Hospital | Columbus | Ohio | 43213 | — |
| Columbus Oncology and Hematology Associates Inc | Columbus | Ohio | 43214 | — |
| Riverside Methodist Hospital | Columbus | Ohio | 43214 | — |
| Grant Medical Center | Columbus | Ohio | 43215 | — |
| The Mark H Zangmeister Center | Columbus | Ohio | 43219 | — |
| Doctors Hospital | Columbus | Ohio | 43228 | — |
| Dayton Physician LLC - Englewood | Dayton | Ohio | 45415 | — |
| Delaware Health Center-Grady Cancer Center | Delaware | Ohio | 43015 | — |
| Grady Memorial Hospital | Delaware | Ohio | 43015 | — |
| Columbus Oncology and Hematology Associates | Dublin | Ohio | 43016 | — |
| Dublin Methodist Hospital | Dublin | Ohio | 43016 | — |
| Kettering Medical Center | Kettering | Ohio | 45429 | — |
| Fairfield Medical Center | Lancaster | Ohio | 43130 | — |
| OhioHealth Mansfield Hospital | Mansfield | Ohio | 44903 | — |
| OhioHealth Marion General Hospital | Marion | Ohio | 43302 | — |
| Memorial Hospital | Marysville | Ohio | 43040 | — |
| UH Seidman Cancer Center at Lake Health Mentor Campus | Mentor | Ohio | 44060 | — |
| Knox Community Hospital | Mount Vernon | Ohio | 43050 | — |
| Licking Memorial Hospital | Newark | Ohio | 43055 | — |
| Mercy Health - Perrysburg Hospital | Perrysburg | Ohio | 43551 | — |
| Southern Ohio Medical Center | Portsmouth | Ohio | 45662 | — |
| Springfield Regional Cancer Center | Springfield | Ohio | 45504 | — |
| Springfield Regional Medical Center | Springfield | Ohio | 45504 | — |
| Mercy Health - Saint Anne Hospital | Toledo | Ohio | 43623 | — |
| Saint Ann's Hospital | Westerville | Ohio | 43081 | — |
| OhioHealth Westerville Medical Campus/Westerville Cancer Center | Westerville | Ohio | 43082 | — |
| Genesis Healthcare System Cancer Care Center | Zanesville | Ohio | 43701 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Providence Newberg Medical Center | Newberg | Oregon | 97132 | — |
| Saint Alphonsus Cancer Care Center-Ontario | Ontario | Oregon | 97914 | — |
| Providence Willamette Falls Medical Center | Oregon City | Oregon | 97045 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Providence Saint Vincent Medical Center | Portland | Oregon | 97225 | — |
| Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania | 18103 | — |
| UPMC Altoona | Altoona | Pennsylvania | 16601 | — |
| Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania | 18017 | — |
| Bryn Mawr Hospital | Bryn Mawr | Pennsylvania | 19010 | — |
| Pocono Medical Center | East Stroudsburg | Pennsylvania | 18301 | — |
| UPMC Hillman Cancer Center Erie | Erie | Pennsylvania | 16505 | — |
| UPMC Cancer Centers - Arnold Palmer Pavilion | Greensburg | Pennsylvania | 15601 | — |
| Lehigh Valley Hospital-Hazleton | Hazleton | Pennsylvania | 18201 | — |
| UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion | Mechanicsburg | Pennsylvania | 17050 | — |
| Riddle Memorial Hospital | Media | Pennsylvania | 19063 | — |
| UPMC Hillman Cancer Center - Monroeville | Monroeville | Pennsylvania | 15146 | — |
| Paoli Memorial Hospital | Paoli | Pennsylvania | 19301 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| UPMC-Magee Womens Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| UPMC-Passavant Hospital | Pittsburgh | Pennsylvania | 15237 | — |
| Lankenau Medical Center | Wynnewood | Pennsylvania | 19096 | — |
| Women and Infants Hospital | Providence | Rhode Island | 02905 | — |
| Rapid City Regional Hospital | Rapid City | South Dakota | 57701 | — |
| Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | 57104 | — |
| Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | 57117-5134 | — |
| UT MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| University of Virginia Cancer Center | Charlottesville | Virginia | 22908 | — |
| Inova Schar Cancer Institute | Fairfax | Virginia | 22031 | — |
| Inova Fairfax Hospital | Falls Church | Virginia | 22042 | — |
| Virginia Cancer Institute | Richmond | Virginia | 23229 | — |
| VCU Massey Cancer Center at Stony Point | Richmond | Virginia | 23235 | — |
| VCU Massey Comprehensive Cancer Center | Richmond | Virginia | 23298 | — |
| Carilion Roanoke Memorial Hospital | Roanoke | Virginia | 24033 | — |
| VCU Community Memorial Health Center | South Hill | Virginia | 23970 | — |
| Swedish Cancer Institute-Edmonds | Edmonds | Washington | 98026 | — |
| Swedish Cancer Institute-Issaquah | Issaquah | Washington | 98029 | — |
| Valley Medical Center | Renton | Washington | 98055 | — |
| Swedish Medical Center-First Hill | Seattle | Washington | 98122 | — |
| North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | Yakima | Washington | 98902 | — |
| Duluth Clinic Ashland | Ashland | Wisconsin | 54806 | — |
| Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin | 53105 | — |
| Aurora Saint Luke's South Shore | Cudahy | Wisconsin | 53110 | — |
| Aurora Health Care Germantown Health Center | Germantown | Wisconsin | 53022 | — |
| Aurora Cancer Care-Grafton | Grafton | Wisconsin | 53024 | — |
| Aurora BayCare Medical Center | Green Bay | Wisconsin | 54311 | — |
| Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin | 53142 | — |
| Gundersen Lutheran Medical Center | La Crosse | Wisconsin | 54601 | — |
| University of Wisconsin Carbone Cancer Center - Eastpark Medical Center | Madison | Wisconsin | 53718 | — |
| University of Wisconsin Carbone Cancer Center - University Hospital | Madison | Wisconsin | 53792 | — |
| Aurora Bay Area Medical Group-Marinette | Marinette | Wisconsin | 54143 | — |
| Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin | 53209 | — |
| Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | 53215 | — |
| Aurora Sinai Medical Center | Milwaukee | Wisconsin | 53233 | — |
| Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin | 54904 | — |
| Aurora Cancer Care-Racine | Racine | Wisconsin | 53406 | — |
| Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin | 53081 | — |
| Aurora Medical Center in Summit | Summit | Wisconsin | 53066 | — |
| Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin | 54241 | — |
| Aurora Cancer Care-Milwaukee West | Wauwatosa | Wisconsin | 53226 | — |
| Aurora West Allis Medical Center | West Allis | Wisconsin | 53227 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05554380, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 24, 2026 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05554380 live on ClinicalTrials.gov.