Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)

ClinicalTrials.gov ID: NCT05554393

Public ClinicalTrials.gov record NCT05554393. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 3:55 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Measurable Residual Disease (MRD) Focused, Phase II Study of Venetoclax Plus Chemotherapy for Newly Diagnosed Younger Patients With Intermediate Risk Acute Myeloid Leukemia: A Tier 1 MYELOMATCH SubStudy

Study identification

NCT ID: NCT05554393
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: National Cancer Institute (NCI); NIH
Enrollment: 153 participants

Conditions and interventions

Conditions

Acute Myeloid Leukemia

Interventions

Azacitidine Drug
Biospecimen Collection Procedure
Bone Marrow Aspiration Procedure
Cytarabine Drug
Daunorubicin Hydrochloride Drug
Venetoclax Drug

Drug · Procedure

Eligibility (public fields only)

Age range: 18 Years to 59 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Sep 12, 2024
Primary completion: Dec 30, 2027
Completion: Dec 30, 2027
Last update posted: May 3, 2026

2024 – 2027

United States locations

U.S. sites: 167
U.S. states: 40
U.S. cities: 139

Facility	City	State	ZIP	Site status
University of Alabama at Birmingham Cancer Center	Birmingham	Alabama	35233	Recruiting
Banner University Medical Center - Tucson	Tucson	Arizona	85719	Recruiting
University of Arizona Cancer Center-North Campus	Tucson	Arizona	85719	Recruiting
University of Arkansas for Medical Sciences	Little Rock	Arkansas	72205	Recruiting
Alta Bates Summit Medical Center-Herrick Campus	Berkeley	California	94704	Suspended
Cedars-Sinai Medical Center	Los Angeles	California	90048	Recruiting
UCSF Medical Center-Parnassus	San Francisco	California	94143	Recruiting
Miami Cancer Institute	Miami	Florida	33176	Recruiting
Memorial Hospital West	Pembroke Pines	Florida	33028	Recruiting
Phoebe Putney Memorial Hospital	Albany	Georgia	31701	Recruiting
Saint Alphonsus Cancer Care Center-Boise	Boise	Idaho	83706	Recruiting
Saint Luke's Cancer Institute - Boise	Boise	Idaho	83712	Recruiting
Saint Alphonsus Cancer Care Center-Caldwell	Caldwell	Idaho	83605	Recruiting
Kootenai Health - Coeur d'Alene	Coeur d'Alene	Idaho	83814	Recruiting
Saint Luke's Cancer Institute - Fruitland	Fruitland	Idaho	83619	Recruiting
Saint Luke's Cancer Institute - Meridian	Meridian	Idaho	83642	Recruiting
Saint Alphonsus Cancer Care Center-Nampa	Nampa	Idaho	83687	Recruiting
Saint Luke's Cancer Institute - Nampa	Nampa	Idaho	83687	Recruiting
Kootenai Clinic Cancer Services - Post Falls	Post Falls	Idaho	83854	Recruiting
Kootenai Clinic Cancer Services - Sandpoint	Sandpoint	Idaho	83864	Recruiting
Centralia Oncology Clinic	Centralia	Illinois	62801	Recruiting
Northwestern University	Chicago	Illinois	60611	Recruiting
University of Chicago Comprehensive Cancer Center	Chicago	Illinois	60637	Recruiting
Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	62526	Recruiting
Decatur Memorial Hospital	Decatur	Illinois	62526	Recruiting
Crossroads Cancer Center	Effingham	Illinois	62401	Recruiting
NorthShore University HealthSystem-Evanston Hospital	Evanston	Illinois	60201	Recruiting
NorthShore University HealthSystem-Glenbrook Hospital	Glenview	Illinois	60026	Recruiting
NorthShore University HealthSystem-Highland Park Hospital	Highland Park	Illinois	60035	Recruiting
Loyola University Medical Center	Maywood	Illinois	60153	Recruiting
UC Comprehensive Cancer Center at Silver Cross	New Lenox	Illinois	60451	Recruiting
Cancer Care Center of O'Fallon	O'Fallon	Illinois	62269	Recruiting
University of Chicago Medicine-Orland Park	Orland Park	Illinois	60462	Recruiting
Southern Illinois University School of Medicine	Springfield	Illinois	62702	Recruiting
Springfield Clinic	Springfield	Illinois	62702	Recruiting
Springfield Memorial Hospital	Springfield	Illinois	62781	Recruiting
UChicago Medicine Northwest Indiana	Crown Point	Indiana	46307	Recruiting
University of Iowa/Holden Comprehensive Cancer Center	Iowa City	Iowa	52242	Recruiting
University of Kansas Clinical Research Center	Fairway	Kansas	66205	Recruiting
University of Kansas Cancer Center	Kansas City	Kansas	66160	Recruiting
University of Kansas Hospital-Indian Creek Campus	Overland Park	Kansas	66211	Recruiting
University of Kansas Hospital-Westwood Cancer Center	Westwood	Kansas	66205	Recruiting
University of Kentucky/Markey Cancer Center	Lexington	Kentucky	40536	Recruiting
The James Graham Brown Cancer Center at University of Louisville	Louisville	Kentucky	40202	Recruiting
UofL Health Medical Center Northeast	Louisville	Kentucky	40245	Recruiting
LSU Health Baton Rouge-North Clinic	Baton Rouge	Louisiana	70805	Recruiting
Our Lady of the Lake Physician Group	Baton Rouge	Louisiana	70808	Recruiting
Our Lady of The Lake	Baton Rouge	Louisiana	70808	Recruiting
MaineHealth Maine Medical Center - Portland	Portland	Maine	04102	Recruiting
MaineHealth Maine Medical Center- Scarborough	Scarborough	Maine	04074	Recruiting
MaineHealth Cancer Care and IV Therapy - South Portland	South Portland	Maine	04106	Recruiting
Walter Reed National Military Medical Center	Bethesda	Maryland	20889-5600	Recruiting
Tufts Medical Center	Boston	Massachusetts	02111	Recruiting
Dana-Farber Cancer Institute	Boston	Massachusetts	02215	Recruiting
Lahey Hospital and Medical Center	Burlington	Massachusetts	01805	Recruiting
Lahey Medical Center-Peabody	Peabody	Massachusetts	01960	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Brighton	Brighton	Michigan	48114	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Canton	Canton	Michigan	48188	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital	Chelsea	Michigan	48118	Recruiting
Henry Ford Macomb Hospital-Clinton Township	Clinton Township	Michigan	48038	Recruiting
Henry Ford Hospital	Detroit	Michigan	48202	Recruiting
Cancer Hematology Centers - Flint	Flint	Michigan	48503	Recruiting
Genesee Hematology Oncology PC	Flint	Michigan	48503	Suspended
Genesys Hurley Cancer Institute	Flint	Michigan	48503	Recruiting
Hurley Medical Center	Flint	Michigan	48503	Recruiting
Allegiance Health	Jackson	Michigan	49201	Recruiting
Trinity Health Saint Mary Mercy Livonia Hospital	Livonia	Michigan	48154	Recruiting
Henry Ford Medical Center-Columbus	Novi	Michigan	48377	Recruiting
Trinity Health Saint Joseph Mercy Oakland Hospital	Pontiac	Michigan	48341	Recruiting
Henry Ford West Bloomfield Hospital	West Bloomfield	Michigan	48322	Recruiting
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus	Ypsilanti	Michigan	48197	Recruiting
Mercy Hospital	Coon Rapids	Minnesota	55433	Recruiting
Essentia Health - Deer River Clinic	Deer River	Minnesota	56636	Recruiting
Essentia Health Cancer Center	Duluth	Minnesota	55805	Recruiting
Fairview Southdale Hospital	Edina	Minnesota	55435	Recruiting
Essentia Health Hibbing Clinic	Hibbing	Minnesota	55746	Recruiting
Abbott-Northwestern Hospital	Minneapolis	Minnesota	55407	Recruiting
Park Nicollet Clinic - Saint Louis Park	Saint Louis Park	Minnesota	55416	Recruiting
Regions Hospital	Saint Paul	Minnesota	55101	Recruiting
United Hospital	Saint Paul	Minnesota	55102	Recruiting
Essentia Health Sandstone	Sandstone	Minnesota	55072	Recruiting
Essentia Health Virginia Clinic	Virginia	Minnesota	55792	Recruiting
Baptist Memorial Hospital and Cancer Center-Golden Triangle	Columbus	Mississippi	39705	Recruiting
Baptist Cancer Center-Grenada	Grenada	Mississippi	38901	Recruiting
Baptist Memorial Hospital and Cancer Center-Union County	New Albany	Mississippi	38652	Recruiting
Baptist Memorial Hospital and Cancer Center-Oxford	Oxford	Mississippi	38655	Recruiting
Baptist Memorial Hospital and Cancer Center-Desoto	Southhaven	Mississippi	38671	Recruiting
Siteman Cancer Center at Saint Peters Hospital	City of Saint Peters	Missouri	63376	Recruiting
Siteman Cancer Center at West County Hospital	Creve Coeur	Missouri	63141	Recruiting
Washington University School of Medicine	St Louis	Missouri	63110	Recruiting
Siteman Cancer Center-South County	St Louis	Missouri	63129	Recruiting
Siteman Cancer Center at Christian Hospital	St Louis	Missouri	63136	Recruiting
Community Hospital of Anaconda	Anaconda	Montana	59711	Recruiting
Billings Clinic Cancer Center	Billings	Montana	59101	Recruiting
Bozeman Health Deaconess Hospital	Bozeman	Montana	59715	Recruiting
Benefis Sletten Cancer Institute	Great Falls	Montana	59405	Recruiting
Logan Health Medical Center	Kalispell	Montana	59901	Recruiting
Community Medical Center	Missoula	Montana	59804	Recruiting
Nebraska Medicine-Bellevue	Bellevue	Nebraska	68123	Recruiting
Nebraska Medicine-Village Pointe	Omaha	Nebraska	68118	Recruiting
University of Nebraska Medical Center	Omaha	Nebraska	68198	Recruiting
OptumCare Cancer Care at Charleston	Las Vegas	Nevada	89102	Recruiting
OptumCare Cancer Care at Fort Apache	Las Vegas	Nevada	89183	Recruiting
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center	Lebanon	New Hampshire	03756	Recruiting
Memorial Sloan Kettering Basking Ridge	Basking Ridge	New Jersey	07920	Recruiting
Saint Barnabas Medical Center	Livingston	New Jersey	07039	Recruiting
Monmouth Medical Center	Long Branch	New Jersey	07740	Recruiting
Memorial Sloan Kettering Monmouth	Middletown	New Jersey	07748	Recruiting
Memorial Sloan Kettering Bergen	Montvale	New Jersey	07645	Recruiting
Rutgers Cancer Institute of New Jersey	New Brunswick	New Jersey	08903	Recruiting
The Valley Hospital - Luckow Pavilion	Paramus	New Jersey	07652	Recruiting
Valley Health System Ridgewood Campus	Ridgewood	New Jersey	07450	Recruiting
Community Medical Center	Toms River	New Jersey	08755	Recruiting
University of New Mexico Cancer Center	Albuquerque	New Mexico	87106	Recruiting
Roswell Park Cancer Institute	Buffalo	New York	14263	Recruiting
Memorial Sloan Kettering Commack	Commack	New York	11725	Recruiting
Mount Sinai Hospital	New York	New York	10029	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
University of Rochester	Rochester	New York	14642	Recruiting
Stony Brook University Medical Center	Stony Brook	New York	11794	Recruiting
Montefiore Medical Center - Moses Campus	The Bronx	New York	10467	Recruiting
Memorial Sloan Kettering Nassau	Uniondale	New York	11553	Recruiting
Carolinas Medical Center/Levine Cancer Institute	Charlotte	North Carolina	28203	Recruiting
Novant Health Presbyterian Medical Center	Charlotte	North Carolina	28204	Recruiting
Duke University Medical Center	Durham	North Carolina	27710	Recruiting
East Carolina University	Greenville	North Carolina	27834	Recruiting
Novant Health Forsyth Medical Center	Winston-Salem	North Carolina	27103	Recruiting
Wake Forest University Health Sciences	Winston-Salem	North Carolina	27157	Recruiting
Case Western Reserve University	Cleveland	Ohio	44106	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
Saint Alphonsus Cancer Care Center-Ontario	Ontario	Oregon	97914	Recruiting
Providence Portland Medical Center	Portland	Oregon	97213	Recruiting
Providence Saint Vincent Medical Center	Portland	Oregon	97225	Recruiting
Lehigh Valley Hospital-Cedar Crest	Allentown	Pennsylvania	18103	Recruiting
Geisinger Medical Center	Danville	Pennsylvania	17822	Recruiting
Penn State Milton S Hershey Medical Center	Hershey	Pennsylvania	17033-0850	Recruiting
Lewistown Hospital	Lewistown	Pennsylvania	17044	Recruiting
University of Pittsburgh Cancer Institute (UPCI)	Pittsburgh	Pennsylvania	15232	Recruiting
Reading Hospital	West Reading	Pennsylvania	19611	Recruiting
Geisinger Wyoming Valley/Henry Cancer Center	Wilkes-Barre	Pennsylvania	18711	Recruiting
Prisma Health Cancer Institute - Spartanburg	Boiling Springs	South Carolina	29316	Recruiting
Prisma Health Cancer Institute - Easley	Easley	South Carolina	29640	Recruiting
Prisma Health Cancer Institute - Butternut	Greenville	South Carolina	29605	Recruiting
Prisma Health Cancer Institute - Faris	Greenville	South Carolina	29605	Recruiting
Prisma Health Cancer Institute - Eastside	Greenville	South Carolina	29615	Recruiting
Prisma Health Cancer Institute - Greer	Greer	South Carolina	29650	Recruiting
Prisma Health Cancer Institute - Seneca	Seneca	South Carolina	29672	Recruiting
Baptist Memorial Hospital and Cancer Center-Collierville	Collierville	Tennessee	38017	Recruiting
Baptist Memorial Hospital and Cancer Center-Memphis	Memphis	Tennessee	38120	Recruiting
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center	Houston	Texas	77030	Recruiting
Ben Taub General Hospital	Houston	Texas	77030	Recruiting
Huntsman Cancer Institute/University of Utah	Salt Lake City	Utah	84112	Recruiting
University of Vermont Medical Center	Burlington	Vermont	05401	Recruiting
University of Vermont and State Agricultural College	Burlington	Vermont	05405	Recruiting
University of Virginia Cancer Center	Charlottesville	Virginia	22908	Recruiting
Inova Schar Cancer Institute	Fairfax	Virginia	22031	Recruiting
Inova Fairfax Hospital	Falls Church	Virginia	22042	Recruiting
Swedish Cancer Institute-Edmonds	Edmonds	Washington	98026	Recruiting
Swedish Cancer Institute-Issaquah	Issaquah	Washington	98029	Recruiting
Swedish Medical Center-First Hill	Seattle	Washington	98122	Recruiting
Duluth Clinic Ashland	Ashland	Wisconsin	54806	Recruiting
Saint Vincent Hospital Cancer Center Green Bay	Green Bay	Wisconsin	54301	Recruiting
Saint Vincent Hospital Cancer Center at Saint Mary's	Green Bay	Wisconsin	54303	Recruiting
Gundersen Lutheran Medical Center	La Crosse	Wisconsin	54601	Recruiting
Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting
Marshfield Medical Center-River Region at Stevens Point	Stevens Point	Wisconsin	54482	Recruiting
Marshfield Medical Center - Weston	Weston	Wisconsin	54476	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 10 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05554393, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 3, 2026 · Synced May 8, 2026

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The complete protocol, eligibility criteria, and contact information for NCT05554393 live on ClinicalTrials.gov.

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