ClinicalTrials.gov record
Testing the Effects of Novel Therapeutics for Newly Diagnosed, Untreated Patients With High-Risk Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial)
ClinicalTrials.gov ID: NCT05554406
Public ClinicalTrials.gov record NCT05554406. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 9, 2026, 11:50 PM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Phase II Study Comparing Cytarabine + Daunorubicin (7+3) vs (Daunorubicin and Cytarabine) Liposome, Cytarabine + Daunorubicin + Venetoclax, Azacitidine + Venetoclax, and (Daunorubicin and Cytarabine) Liposome + Venetoclax in Patients Aged 59 or Younger Who Are Considered High-Risk (Adverse) Acute Myeloid Leukemia As Determined by MYELOMATCH; A MYELOMATCH Clinical Trial
Study identification
- NCT ID
- NCT05554406
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- National Cancer Institute (NCI)
- NIH
- Enrollment
- 335 participants
Conditions and interventions
Conditions
Interventions
- Azacitidine Drug
- Biospecimen Collection Procedure
- Bone Marrow Aspiration Procedure
- Cytarabine Drug
- Daunorubicin Hydrochloride Drug
- Echocardiography Test Procedure
- Liposome-encapsulated Daunorubicin-Cytarabine Drug
- Multigated Acquisition Scan Procedure
- Venetoclax Drug
Drug · Procedure
Eligibility (public fields only)
- Age range
- 18 Years to 59 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 24, 2024
- Primary completion
- Mar 30, 2027
- Completion
- Mar 30, 2027
- Last update posted
- May 4, 2026
2024 – 2027
United States locations
- U.S. sites
- 211
- U.S. states
- 41
- U.S. cities
- 174
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | 35233 | Recruiting |
| Mayo Clinic Hospital in Arizona | Phoenix | Arizona | 85054 | Recruiting |
| Banner University Medical Center - Tucson | Tucson | Arizona | 85719 | Recruiting |
| University of Arizona Cancer Center-North Campus | Tucson | Arizona | 85719 | Recruiting |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | Recruiting |
| Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California | 94704 | Recruiting |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | Recruiting |
| University of California Davis Comprehensive Cancer Center | Sacramento | California | 95817 | Recruiting |
| UCSF Medical Center-Parnassus | San Francisco | California | 94143 | Recruiting |
| Mills Health Center | San Mateo | California | 94401 | Recruiting |
| Yale University | New Haven | Connecticut | 06520 | Recruiting |
| Mayo Clinic in Florida | Jacksonville | Florida | 32224-9980 | Recruiting |
| Miami Cancer Institute | Miami | Florida | 33176 | Recruiting |
| Memorial Hospital West | Pembroke Pines | Florida | 33028 | Recruiting |
| Phoebe Putney Memorial Hospital | Albany | Georgia | 31701 | Recruiting |
| Augusta University Medical Center | Augusta | Georgia | 30912 | Recruiting |
| Hawaii Cancer Care Inc - Waterfront Plaza | Honolulu | Hawaii | 96813 | Recruiting |
| Straub Clinic and Hospital | Honolulu | Hawaii | 96813 | Recruiting |
| Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | 96826 | Recruiting |
| Hawaii Cancer Care - Westridge | ‘Aiea | Hawaii | 96701 | Recruiting |
| Pali Momi Medical Center | ‘Aiea | Hawaii | 96701 | Recruiting |
| Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | 83706 | Recruiting |
| Saint Luke's Cancer Institute - Boise | Boise | Idaho | 83712 | Recruiting |
| Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho | 83605 | Recruiting |
| Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho | 83814 | Recruiting |
| Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho | 83619 | Recruiting |
| Saint Luke's Cancer Institute - Meridian | Meridian | Idaho | 83642 | Recruiting |
| Saint Alphonsus Cancer Care Center-Nampa | Nampa | Idaho | 83687 | Recruiting |
| Saint Luke's Cancer Institute - Nampa | Nampa | Idaho | 83687 | Recruiting |
| Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho | 83854 | Recruiting |
| Kootenai Clinic Cancer Services - Sandpoint | Sandpoint | Idaho | 83864 | Recruiting |
| OSF Saint Joseph Medical Center | Bloomington | Illinois | 61701 | Recruiting |
| Illinois CancerCare-Bloomington | Bloomington | Illinois | 61704 | Recruiting |
| Illinois CancerCare-Canton | Canton | Illinois | 61520 | Recruiting |
| Illinois CancerCare-Carthage | Carthage | Illinois | 62321 | Recruiting |
| Northwestern University | Chicago | Illinois | 60611 | Recruiting |
| University of Chicago Comprehensive Cancer Center | Chicago | Illinois | 60637 | Recruiting |
| Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | 62526 | Recruiting |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | Recruiting |
| Illinois CancerCare-Dixon | Dixon | Illinois | 61021 | Recruiting |
| Crossroads Cancer Center | Effingham | Illinois | 62401 | Recruiting |
| Illinois CancerCare-Eureka | Eureka | Illinois | 61530 | Recruiting |
| NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois | 60201 | Recruiting |
| Illinois CancerCare-Galesburg | Galesburg | Illinois | 61401 | Recruiting |
| NorthShore University HealthSystem-Glenbrook Hospital | Glenview | Illinois | 60026 | Recruiting |
| NorthShore University HealthSystem-Highland Park Hospital | Highland Park | Illinois | 60035 | Recruiting |
| Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois | 61443 | Recruiting |
| Illinois CancerCare-Macomb | Macomb | Illinois | 61455 | Recruiting |
| Loyola University Medical Center | Maywood | Illinois | 60153 | Recruiting |
| UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois | 60451 | Recruiting |
| Cancer Care Center of O'Fallon | O'Fallon | Illinois | 62269 | Recruiting |
| University of Chicago Medicine-Orland Park | Orland Park | Illinois | 60462 | Recruiting |
| Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | 61350 | Recruiting |
| Illinois CancerCare-Pekin | Pekin | Illinois | 61554 | Recruiting |
| Illinois CancerCare-Peoria | Peoria | Illinois | 61615 | Recruiting |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61636 | Recruiting |
| OSF Saint Francis Medical Center | Peoria | Illinois | 61637 | Recruiting |
| Illinois CancerCare-Peru | Peru | Illinois | 61354 | Recruiting |
| Illinois CancerCare-Princeton | Princeton | Illinois | 61356 | Recruiting |
| Southern Illinois University School of Medicine | Springfield | Illinois | 62702 | Recruiting |
| Springfield Clinic | Springfield | Illinois | 62702 | Recruiting |
| Springfield Memorial Hospital | Springfield | Illinois | 62781 | Recruiting |
| Illinois CancerCare - Washington | Washington | Illinois | 61571 | Recruiting |
| UChicago Medicine Northwest Indiana | Crown Point | Indiana | 46307 | Recruiting |
| Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | 46202 | Recruiting |
| University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Iowa | 52242 | Recruiting |
| University of Kansas Clinical Research Center | Fairway | Kansas | 66205 | Recruiting |
| University of Kansas Cancer Center | Kansas City | Kansas | 66160 | Recruiting |
| University of Kansas Hospital-Indian Creek Campus | Overland Park | Kansas | 66211 | Recruiting |
| University of Kansas Hospital-Westwood Cancer Center | Westwood | Kansas | 66205 | Recruiting |
| University of Kentucky/Markey Cancer Center | Lexington | Kentucky | 40536 | Recruiting |
| The James Graham Brown Cancer Center at University of Louisville | Louisville | Kentucky | 40202 | Recruiting |
| UofL Health Medical Center Northeast | Louisville | Kentucky | 40245 | Recruiting |
| LSU Health Baton Rouge-North Clinic | Baton Rouge | Louisiana | 70805 | Recruiting |
| Our Lady of the Lake Physician Group | Baton Rouge | Louisiana | 70808 | Recruiting |
| Our Lady of The Lake | Baton Rouge | Louisiana | 70808 | Recruiting |
| MaineHealth Maine Medical Center - Portland | Portland | Maine | 04102 | Recruiting |
| MaineHealth Maine Medical Center- Scarborough | Scarborough | Maine | 04074 | Recruiting |
| MaineHealth Cancer Care and IV Therapy - South Portland | South Portland | Maine | 04106 | Recruiting |
| Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Maryland | 21287 | Recruiting |
| Walter Reed National Military Medical Center | Bethesda | Maryland | 20889-5600 | Recruiting |
| Tufts Medical Center | Boston | Massachusetts | 02111 | Recruiting |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | Recruiting |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | Recruiting |
| Lahey Hospital and Medical Center | Burlington | Massachusetts | 01805 | Recruiting |
| Lahey Medical Center-Peabody | Peabody | Massachusetts | 01960 | Recruiting |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor | Ann Arbor | Michigan | 48106 | Recruiting |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton | Brighton | Michigan | 48114 | Recruiting |
| Trinity Health IHA Medical Group Hematology Oncology - Canton | Canton | Michigan | 48188 | Recruiting |
| Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital | Chelsea | Michigan | 48118 | Recruiting |
| Henry Ford Macomb Hospital-Clinton Township | Clinton Township | Michigan | 48038 | Recruiting |
| Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | 48201 | Recruiting |
| Henry Ford Hospital | Detroit | Michigan | 48202 | Recruiting |
| Weisberg Cancer Treatment Center | Farmington Hills | Michigan | 48334 | Recruiting |
| Cancer Hematology Centers - Flint | Flint | Michigan | 48503 | Recruiting |
| Genesee Hematology Oncology PC | Flint | Michigan | 48503 | Suspended |
| Genesys Hurley Cancer Institute | Flint | Michigan | 48503 | Recruiting |
| Hurley Medical Center | Flint | Michigan | 48503 | Recruiting |
| Allegiance Health | Jackson | Michigan | 49201 | Recruiting |
| Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | 48154 | Recruiting |
| Henry Ford Medical Center-Columbus | Novi | Michigan | 48377 | Recruiting |
| Trinity Health Saint Joseph Mercy Oakland Hospital | Pontiac | Michigan | 48341 | Recruiting |
| Henry Ford West Bloomfield Hospital | West Bloomfield | Michigan | 48322 | Recruiting |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus | Ypsilanti | Michigan | 48197 | Recruiting |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | Recruiting |
| Essentia Health - Deer River Clinic | Deer River | Minnesota | 56636 | Recruiting |
| Essentia Health Cancer Center | Duluth | Minnesota | 55805 | Recruiting |
| Fairview Southdale Hospital | Edina | Minnesota | 55435 | Recruiting |
| Essentia Health Hibbing Clinic | Hibbing | Minnesota | 55746 | Recruiting |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | Recruiting |
| Mayo Clinic in Rochester | Rochester | Minnesota | 55905 | Recruiting |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | 55416 | Recruiting |
| Regions Hospital | Saint Paul | Minnesota | 55101 | Recruiting |
| United Hospital | Saint Paul | Minnesota | 55102 | Recruiting |
| Essentia Health Sandstone | Sandstone | Minnesota | 55072 | Recruiting |
| Essentia Health Virginia Clinic | Virginia | Minnesota | 55792 | Recruiting |
| Baptist Memorial Hospital and Cancer Center-Golden Triangle | Columbus | Mississippi | 39705 | Recruiting |
| Baptist Cancer Center-Grenada | Grenada | Mississippi | 38901 | Recruiting |
| Baptist Memorial Hospital and Cancer Center-Union County | New Albany | Mississippi | 38652 | Recruiting |
| Baptist Memorial Hospital and Cancer Center-Oxford | Oxford | Mississippi | 38655 | Recruiting |
| Baptist Memorial Hospital and Cancer Center-Desoto | Southhaven | Mississippi | 38671 | Recruiting |
| Siteman Cancer Center at Saint Peters Hospital | City of Saint Peters | Missouri | 63376 | Recruiting |
| Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri | 63141 | Recruiting |
| Washington University School of Medicine | St Louis | Missouri | 63110 | Recruiting |
| Siteman Cancer Center-South County | St Louis | Missouri | 63129 | Recruiting |
| Siteman Cancer Center at Christian Hospital | St Louis | Missouri | 63136 | Recruiting |
| Community Hospital of Anaconda | Anaconda | Montana | 59711 | Recruiting |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | Recruiting |
| Bozeman Health Deaconess Hospital | Bozeman | Montana | 59715 | Recruiting |
| Benefis Sletten Cancer Institute | Great Falls | Montana | 59405 | Recruiting |
| Logan Health Medical Center | Kalispell | Montana | 59901 | Recruiting |
| Community Medical Center | Missoula | Montana | 59804 | Recruiting |
| Nebraska Medicine-Bellevue | Bellevue | Nebraska | 68123 | Recruiting |
| Nebraska Medicine-Village Pointe | Omaha | Nebraska | 68118 | Recruiting |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | Recruiting |
| OptumCare Cancer Care at Charleston | Las Vegas | Nevada | 89102 | Recruiting |
| OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada | 89183 | Recruiting |
| Memorial Sloan Kettering Basking Ridge | Basking Ridge | New Jersey | 07920 | Recruiting |
| Cooper Hospital University Medical Center | Camden | New Jersey | 08103 | Recruiting |
| Saint Barnabas Medical Center | Livingston | New Jersey | 07039 | Recruiting |
| Monmouth Medical Center | Long Branch | New Jersey | 07740 | Recruiting |
| Memorial Sloan Kettering Monmouth | Middletown | New Jersey | 07748 | Recruiting |
| Memorial Sloan Kettering Bergen | Montvale | New Jersey | 07645 | Recruiting |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08903 | Recruiting |
| The Valley Hospital - Luckow Pavilion | Paramus | New Jersey | 07652 | Recruiting |
| Valley Health System Ridgewood Campus | Ridgewood | New Jersey | 07450 | Recruiting |
| Community Medical Center | Toms River | New Jersey | 08755 | Recruiting |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | 87106 | Recruiting |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | Recruiting |
| Memorial Sloan Kettering Commack | Commack | New York | 11725 | Recruiting |
| Memorial Sloan Kettering Westchester | Harrison | New York | 10604 | Recruiting |
| Northwell Health/Center for Advanced Medicine | Lake Success | New York | 11042 | Recruiting |
| North Shore University Hospital | Manhasset | New York | 11030 | Recruiting |
| Mount Sinai Hospital | New York | New York | 10029 | Recruiting |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | Recruiting |
| University of Rochester | Rochester | New York | 14642 | Recruiting |
| Stony Brook University Medical Center | Stony Brook | New York | 11794 | Recruiting |
| State University of New York Upstate Medical University | Syracuse | New York | 13210 | Recruiting |
| Montefiore Medical Center - Moses Campus | The Bronx | New York | 10467 | Recruiting |
| Memorial Sloan Kettering Nassau | Uniondale | New York | 11553 | Recruiting |
| Carolinas Medical Center/Levine Cancer Institute | Charlotte | North Carolina | 28203 | Recruiting |
| Duke University Medical Center | Durham | North Carolina | 27710 | Recruiting |
| East Carolina University | Greenville | North Carolina | 27834 | Recruiting |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | Recruiting |
| Case Western Reserve University | Cleveland | Ohio | 44106 | Recruiting |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | Recruiting |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | Recruiting |
| Saint Alphonsus Cancer Care Center-Ontario | Ontario | Oregon | 97914 | Recruiting |
| Providence Portland Medical Center | Portland | Oregon | 97213 | Recruiting |
| Providence Saint Vincent Medical Center | Portland | Oregon | 97225 | Recruiting |
| Oregon Health and Science University | Portland | Oregon | 97239 | Recruiting |
| Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania | 18103 | Recruiting |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | Recruiting |
| Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania | 17033-0850 | Recruiting |
| Lewistown Hospital | Lewistown | Pennsylvania | 17044 | Recruiting |
| University of Pennsylvania/Abramson Cancer Center | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | Recruiting |
| University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania | 15232 | Recruiting |
| Reading Hospital | West Reading | Pennsylvania | 19611 | Recruiting |
| Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | 18711 | Recruiting |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | Recruiting |
| Prisma Health Cancer Institute - Spartanburg | Boiling Springs | South Carolina | 29316 | Recruiting |
| Prisma Health Cancer Institute - Easley | Easley | South Carolina | 29640 | Recruiting |
| Prisma Health Cancer Institute - Butternut | Greenville | South Carolina | 29605 | Recruiting |
| Prisma Health Cancer Institute - Faris | Greenville | South Carolina | 29605 | Recruiting |
| Prisma Health Cancer Institute - Eastside | Greenville | South Carolina | 29615 | Recruiting |
| Prisma Health Cancer Institute - Greer | Greer | South Carolina | 29650 | Recruiting |
| Prisma Health Cancer Institute - Seneca | Seneca | South Carolina | 29672 | Recruiting |
| Baptist Memorial Hospital and Cancer Center-Collierville | Collierville | Tennessee | 38017 | Recruiting |
| University of Tennessee - Knoxville | Knoxville | Tennessee | 37920 | Recruiting |
| Baptist Memorial Hospital and Cancer Center-Memphis | Memphis | Tennessee | 38120 | Recruiting |
| Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | 84112 | Recruiting |
| University of Vermont Medical Center | Burlington | Vermont | 05401 | Recruiting |
| University of Vermont and State Agricultural College | Burlington | Vermont | 05405 | Recruiting |
| University of Virginia Cancer Center | Charlottesville | Virginia | 22908 | Recruiting |
| Inova Schar Cancer Institute | Fairfax | Virginia | 22031 | Recruiting |
| Inova Fairfax Hospital | Falls Church | Virginia | 22042 | Recruiting |
| Swedish Cancer Institute-Edmonds | Edmonds | Washington | 98026 | Recruiting |
| Swedish Cancer Institute-Issaquah | Issaquah | Washington | 98029 | Recruiting |
| Swedish Medical Center-First Hill | Seattle | Washington | 98122 | Recruiting |
| ThedaCare Regional Cancer Center | Appleton | Wisconsin | 54911 | Recruiting |
| ThedaCare Regional Medical Center - Appleton | Appleton | Wisconsin | 54911 | Recruiting |
| Duluth Clinic Ashland | Ashland | Wisconsin | 54806 | Recruiting |
| Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin | 54301 | Recruiting |
| Saint Vincent Hospital Cancer Center at Saint Mary's | Green Bay | Wisconsin | 54303 | Recruiting |
| Gundersen Lutheran Medical Center | La Crosse | Wisconsin | 54601 | Recruiting |
| University of Wisconsin Carbone Cancer Center - Eastpark Medical Center | Madison | Wisconsin | 53718 | Recruiting |
| University of Wisconsin Carbone Cancer Center - University Hospital | Madison | Wisconsin | 53792 | Recruiting |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | Recruiting |
| Marshfield Medical Center-River Region at Stevens Point | Stevens Point | Wisconsin | 54482 | Recruiting |
| Marshfield Medical Center - Weston | Weston | Wisconsin | 54476 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 10 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05554406, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 4, 2026 · Synced May 9, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05554406 live on ClinicalTrials.gov.