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ClinicalTrials.gov record
Recruiting Phase 2 Interventional

Testing New Therapies for Patients With Acute Myeloid Leukemia Who Are Newly Diagnosed and Have Not Yet Started Treatment (A MyeloMATCH Treatment Trial)

ClinicalTrials.gov ID: NCT05554406

Public ClinicalTrials.gov record NCT05554406. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 16, 2026, 6:55 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized Phase II Study Comparing Cytarabine + Daunorubicin (7 + 3) vs (Daunorubicin and Cytarabine) Liposome, Cytarabine + Daunorubicin + Venetoclax, Azacitidine + Venetoclax, and (Daunorubicin and Cytarabine) Liposome + Venetoclax in Patients Aged 59 or Younger Who Are Considered High-Risk (Adverse) Acute Myeloid Leukemia As Determined by MYELOMATCH; A MYELOMATCH SubStudy

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This phase II MyeloMATCH treatment trial tests whether the standard approach of cytarabine and daunorubicin in comparison to the following experimental regimens works to shrink cancer in patients with high risk acute myeloid leukemia (AML): 1) daunorubicin and cytarabine liposome alone; 2) cytarabine and daunorubicin with venetoclax; 3) azacitidine and venetoclax; 4) daunorubicin and cytarabine liposome and venetoclax. "High-risk" refers to traits that have been known to make the AML harder to treat. Cytarabine is in a class of medications called antimetabolites. It works by slowing or stopping the growth of cancer cells in the body. Daunorubicin is in a class of medications called anthracyclines. It also works by slowing or stopping the growth of cancer cells in the body. Azacitidine is in a class of medications called demethylation agents. It works by helping the bone marrow to produce normal blood cells and by killing abnormal cells. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. There is evidence that these newer experimental treatment regimens may work better in getting rid of more AML compared to the standard approach of cytarabine and daunorubicin.

Study identification

NCT ID
NCT05554406
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 2
Enrollment
335 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years to 59 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Sep 25, 2024 (Actual)
Primary completion
Mar 31, 2027 (Estimated)
Completion
Mar 31, 2027 (Estimated)
Last update posted
Oct 14, 2026

2024 – 2027

United States locations

U.S. sites
215
U.S. states
41
U.S. cities
178
Facility City State ZIP Site status
University of Alabama at Birmingham Cancer Center Birmingham Alabama 35233 Recruiting
Mayo Clinic Hospital in Arizona Phoenix Arizona 85054 Recruiting
Banner University Medical Center - Tucson Tucson Arizona 85719 Recruiting
University of Arizona Cancer Center-North Campus Tucson Arizona 85719 Recruiting
University of Arkansas for Medical Sciences Little Rock Arkansas 72205 Recruiting
Alta Bates Summit Medical Center-Herrick Campus Berkeley California 94704 Active, not recruiting
Cedars-Sinai Medical Center Los Angeles California 90048 Recruiting
Kaiser Permanente-Oakland Oakland California 94611 Recruiting
Kaiser Permanente-Roseville Roseville California 95661 Recruiting
University of California Davis Comprehensive Cancer Center Sacramento California 95817 Recruiting
UCSF Medical Center-Parnassus San Francisco California 94143 Recruiting
Mills Health Center San Mateo California 94401 Active, not recruiting
Kaiser Permanente Medical Center - Santa Clara Santa Clara California 95051 Recruiting
Yale University New Haven Connecticut 06520 Recruiting
Mayo Clinic in Florida Jacksonville Florida 32224-9980 Recruiting
Miami Cancer Institute Miami Florida 33176 Recruiting
Memorial Hospital West Pembroke Pines Florida 33028 Recruiting
Phoebe Putney Memorial Hospital Albany Georgia 31701 Recruiting
Augusta University Medical Center Augusta Georgia 30912 Recruiting
Hawaii Cancer Care Inc - Waterfront Plaza Honolulu Hawaii 96813 Recruiting
Straub Clinic and Hospital Honolulu Hawaii 96813 Recruiting
Kapiolani Medical Center for Women and Children Honolulu Hawaii 96826 Recruiting
Hawaii Cancer Care - Westridge ‘Aiea Hawaii 96701 Recruiting
Pali Momi Medical Center ‘Aiea Hawaii 96701 Recruiting
Saint Alphonsus Cancer Care Center-Boise Boise Idaho 83706 Recruiting
Saint Luke's Cancer Institute - Boise Boise Idaho 83712 Recruiting
Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho 83605 Recruiting
Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho 83814 Recruiting
Saint Luke's Cancer Institute - Fruitland Fruitland Idaho 83619 Recruiting
Saint Luke's Cancer Institute - Meridian Meridian Idaho 83642 Recruiting
Saint Alphonsus Cancer Care Center-Nampa Nampa Idaho 83687 Recruiting
Saint Luke's Cancer Institute - Nampa Nampa Idaho 83687 Recruiting
Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho 83854 Recruiting
Kootenai Clinic Cancer Services - Sandpoint Sandpoint Idaho 83864 Recruiting
OSF Saint Joseph Medical Center Bloomington Illinois 61701 Recruiting
Illinois CancerCare-Bloomington Bloomington Illinois 61704 Recruiting
Illinois CancerCare-Canton Canton Illinois 61520 Recruiting
Illinois CancerCare-Carthage Carthage Illinois 62321 Recruiting
Northwestern University Chicago Illinois 60611 Recruiting
University of Chicago Comprehensive Cancer Center Chicago Illinois 60637 Recruiting
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526 Recruiting
Decatur Memorial Hospital Decatur Illinois 62526 Recruiting
Illinois CancerCare-Dixon Dixon Illinois 61021 Recruiting
Crossroads Cancer Center Effingham Illinois 62401 Recruiting
Illinois CancerCare-Eureka Eureka Illinois 61530 Recruiting
NorthShore University HealthSystem-Evanston Hospital Evanston Illinois 60201 Recruiting
Illinois CancerCare-Galesburg Galesburg Illinois 61401 Recruiting
NorthShore University HealthSystem-Glenbrook Hospital Glenview Illinois 60026 Recruiting
NorthShore University HealthSystem-Highland Park Hospital Highland Park Illinois 60035 Recruiting
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443 Recruiting
Illinois CancerCare-Macomb Macomb Illinois 61455 Recruiting
Loyola University Medical Center Maywood Illinois 60153 Recruiting
UC Comprehensive Cancer Center at Silver Cross New Lenox Illinois 60451 Recruiting
Cancer Care Center of O'Fallon O'Fallon Illinois 62269 Recruiting
University of Chicago Medicine-Orland Park Orland Park Illinois 60462 Recruiting
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350 Recruiting
Illinois CancerCare-Pekin Pekin Illinois 61554 Recruiting
Illinois CancerCare-Peoria Peoria Illinois 61615 Recruiting
Methodist Medical Center of Illinois Peoria Illinois 61636 Recruiting
OSF Saint Francis Medical Center Peoria Illinois 61637 Recruiting
Illinois CancerCare-Peru Peru Illinois 61354 Recruiting
Illinois CancerCare-Princeton Princeton Illinois 61356 Recruiting
Southern Illinois University School of Medicine Springfield Illinois 62702 Recruiting
Springfield Clinic Springfield Illinois 62702 Recruiting
Springfield Memorial Hospital Springfield Illinois 62781 Recruiting
Illinois CancerCare - Washington Washington Illinois 61571 Recruiting
UChicago Medicine Northwest Indiana Crown Point Indiana 46307 Recruiting
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis Indiana 46202 Recruiting
University of Iowa/Holden Comprehensive Cancer Center Iowa City Iowa 52242 Recruiting
University of Kansas Clinical Research Center Fairway Kansas 66205 Recruiting
University of Kansas Cancer Center Kansas City Kansas 66160 Recruiting
University of Kansas Hospital-Indian Creek Campus Overland Park Kansas 66211 Recruiting
University of Kansas Hospital-Westwood Cancer Center Westwood Kansas 66205 Recruiting
University of Kentucky/Markey Cancer Center Lexington Kentucky 40536 Recruiting
The James Graham Brown Cancer Center at University of Louisville Louisville Kentucky 40202 Recruiting
UofL Health Medical Center Northeast Louisville Kentucky 40245 Recruiting
LSU Health Baton Rouge-North Clinic Baton Rouge Louisiana 70805 Recruiting
Our Lady of the Lake Physician Group Baton Rouge Louisiana 70808 Recruiting
Our Lady of The Lake Baton Rouge Louisiana 70808 Recruiting
MaineHealth Maine Medical Center - Portland Portland Maine 04102 Recruiting
MaineHealth Maine Medical Center- Scarborough Scarborough Maine 04074 Recruiting
MaineHealth Cancer Care and IV Therapy - South Portland South Portland Maine 04106 Recruiting
Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore Maryland 21287 Recruiting
Walter Reed National Military Medical Center Bethesda Maryland 20889-5600 Recruiting
Tufts Medical Center Boston Massachusetts 02111 Recruiting
Beth Israel Deaconess Medical Center Boston Massachusetts 02215 Recruiting
Dana-Farber Cancer Institute Boston Massachusetts 02215 Recruiting
Lahey Clinic Burlington Massachusetts 01805 Recruiting
Lahey Clinic Peabody Peabody Massachusetts 01960 Recruiting
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor Michigan 48106 Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan 48114 Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan 48188 Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan 48118 Recruiting
Henry Ford Macomb Hospital-Clinton Township Clinton Township Michigan 48038 Active, not recruiting
Wayne State University/Karmanos Cancer Institute Detroit Michigan 48201 Recruiting
Henry Ford Hospital Detroit Michigan 48202 Active, not recruiting
Weisberg Cancer Treatment Center Farmington Hills Michigan 48334 Recruiting
Cancer Hematology Centers - Flint Flint Michigan 48503 Recruiting
Genesee Hematology Oncology PC Flint Michigan 48503 Suspended
Genesys Hurley Cancer Institute Flint Michigan 48503 Recruiting
Hurley Medical Center Flint Michigan 48503 Recruiting
Allegiance Health Jackson Michigan 49201 Active, not recruiting
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154 Recruiting
Henry Ford Medical Center-Columbus Novi Michigan 48377 Active, not recruiting
Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac Michigan 48341 Recruiting
Henry Ford West Bloomfield Hospital West Bloomfield Michigan 48322 Active, not recruiting
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan 48197 Recruiting
Mercy Hospital Coon Rapids Minnesota 55433 Recruiting
Essentia Health - Deer River Clinic Deer River Minnesota 56636 Recruiting
Essentia Health Cancer Center Duluth Minnesota 55805 Recruiting
Fairview Southdale Hospital Edina Minnesota 55435 Recruiting
Essentia Health Hibbing Clinic Hibbing Minnesota 55746 Recruiting
Abbott-Northwestern Hospital Minneapolis Minnesota 55407 Recruiting
Mayo Clinic in Rochester Rochester Minnesota 55905 Recruiting
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416 Recruiting
Regions Hospital Saint Paul Minnesota 55101 Recruiting
United Hospital Saint Paul Minnesota 55102 Recruiting
Essentia Health Sandstone Sandstone Minnesota 55072 Recruiting
Essentia Health Virginia Clinic Virginia Minnesota 55792 Recruiting
Baptist Memorial Hospital and Cancer Center-Golden Triangle Columbus Mississippi 39705 Recruiting
Baptist Cancer Center-Grenada Grenada Mississippi 38901 Recruiting
Baptist Memorial Hospital and Cancer Center-Union County New Albany Mississippi 38652 Recruiting
Baptist Memorial Hospital and Cancer Center-Oxford Oxford Mississippi 38655 Recruiting
Baptist Memorial Hospital and Cancer Center-Desoto Southhaven Mississippi 38671 Recruiting
Siteman Cancer Center at Saint Peters Hospital City of Saint Peters Missouri 63376 Recruiting
Siteman Cancer Center at West County Hospital Creve Coeur Missouri 63141 Recruiting
Washington University School of Medicine St Louis Missouri 63110 Recruiting
Siteman Cancer Center-South County St Louis Missouri 63129 Recruiting
Siteman Cancer Center at Christian Hospital St Louis Missouri 63136 Recruiting
Community Hospital of Anaconda Anaconda Montana 59711 Recruiting
Billings Clinic Cancer Center Billings Montana 59101 Recruiting
Bozeman Health Deaconess Hospital Bozeman Montana 59715 Recruiting
Benefis Sletten Cancer Institute Great Falls Montana 59405 Recruiting
Logan Health Medical Center Kalispell Montana 59901 Recruiting
Community Medical Center Missoula Montana 59804 Recruiting
Nebraska Medicine-Bellevue Bellevue Nebraska 68123 Recruiting
Nebraska Medicine-Village Pointe Omaha Nebraska 68118 Recruiting
University of Nebraska Medical Center Omaha Nebraska 68198 Recruiting
OptumCare Cancer Care at Charleston Las Vegas Nevada 89102 Suspended
OptumCare Cancer Care at Fort Apache Las Vegas Nevada 89183 Suspended
Memorial Sloan Kettering Basking Ridge Basking Ridge New Jersey 07920 Recruiting
Cooper Hospital University Medical Center Camden New Jersey 08103 Recruiting
Cooperman Barnabas Medical Center Livingston New Jersey 07039 Recruiting
Monmouth Medical Center Long Branch New Jersey 07740 Recruiting
Memorial Sloan Kettering Monmouth Middletown New Jersey 07748 Recruiting
Memorial Sloan Kettering Bergen Montvale New Jersey 07645 Recruiting
Rutgers Cancer Institute of New Jersey New Brunswick New Jersey 08903 Recruiting
The Valley Hospital - Luckow Pavilion Paramus New Jersey 07652 Recruiting
Valley Health System Ridgewood Campus Ridgewood New Jersey 07450 Recruiting
Community Medical Center Toms River New Jersey 08755 Recruiting
University of New Mexico Cancer Center Albuquerque New Mexico 87106 Recruiting
Roswell Park Cancer Institute Buffalo New York 14263 Recruiting
Memorial Sloan Kettering Commack Commack New York 11725 Recruiting
Memorial Sloan Kettering Westchester Harrison New York 10604 Recruiting
Northwell Health/Center for Advanced Medicine Lake Success New York 11042 Recruiting
North Shore University Hospital Manhasset New York 11030 Recruiting
Mount Sinai Hospital New York New York 10029 Recruiting
Memorial Sloan Kettering Cancer Center New York New York 10065 Recruiting
University of Rochester Rochester New York 14642 Recruiting
Stony Brook University Medical Center Stony Brook New York 11794 Recruiting
State University of New York Upstate Medical University Syracuse New York 13210 Recruiting
Montefiore Medical Center - Moses Campus The Bronx New York 10467 Recruiting
Memorial Sloan Kettering Nassau Uniondale New York 11553 Recruiting
Carolinas Medical Center/Levine Cancer Institute Charlotte North Carolina 28203 Recruiting
Duke University Medical Center Durham North Carolina 27710 Recruiting
East Carolina University Greenville North Carolina 27834 Recruiting
Wake Forest University Health Sciences Winston-Salem North Carolina 27157 Recruiting
Case Western Reserve University Cleveland Ohio 44106 Recruiting
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210 Recruiting
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 Recruiting
Saint Alphonsus Cancer Care Center-Ontario Ontario Oregon 97914 Recruiting
Providence Portland Medical Center Portland Oregon 97213 Recruiting
Providence Saint Vincent Medical Center Portland Oregon 97225 Recruiting
Oregon Health and Science University Portland Oregon 97239 Active, not recruiting
Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania 18103 Recruiting
Geisinger Medical Center Danville Pennsylvania 17822 Recruiting
Penn State Milton S Hershey Medical Center Hershey Pennsylvania 17033-0850 Recruiting
Lewistown Hospital Lewistown Pennsylvania 17044 Recruiting
University of Pennsylvania/Abramson Cancer Center Philadelphia Pennsylvania 19104 Recruiting
Thomas Jefferson University Hospital Philadelphia Pennsylvania 19107 Recruiting
UPMC Hillman Cancer Center Pittsburgh Pennsylvania 15232 Recruiting
Reading Hospital West Reading Pennsylvania 19611 Recruiting
Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania 18711 Recruiting
Rhode Island Hospital Providence Rhode Island 02903 Recruiting
Prisma Health Cancer Institute - Spartanburg Boiling Springs South Carolina 29316 Recruiting
Medical University of South Carolina Charleston South Carolina 29425 Recruiting
Prisma Health Cancer Institute - Easley Easley South Carolina 29640 Recruiting
Prisma Health Cancer Institute - Butternut Greenville South Carolina 29605 Recruiting
Prisma Health Cancer Institute - Faris Greenville South Carolina 29605 Recruiting
Prisma Health Cancer Institute - Eastside Greenville South Carolina 29615 Recruiting
Prisma Health Cancer Institute - Greer Greer South Carolina 29650 Recruiting
Prisma Health Cancer Institute - Seneca Seneca South Carolina 29672 Recruiting
Baptist Memorial Hospital and Cancer Center-Collierville Collierville Tennessee 38017 Recruiting
University of Tennessee - Knoxville Knoxville Tennessee 37920 Suspended
Baptist Memorial Hospital and Cancer Center-Memphis Memphis Tennessee 38120 Recruiting
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112 Recruiting
University of Vermont Medical Center Burlington Vermont 05401 Recruiting
University of Vermont and State Agricultural College Burlington Vermont 05405 Recruiting
University of Virginia Cancer Center Charlottesville Virginia 22908 Recruiting
Inova Schar Cancer Institute Fairfax Virginia 22031 Recruiting
Inova Fairfax Hospital Falls Church Virginia 22042 Recruiting
Swedish Cancer Institute-Edmonds Edmonds Washington 98026 Recruiting
Swedish Cancer Institute-Issaquah Issaquah Washington 98029 Recruiting
Swedish Medical Center-First Hill Seattle Washington 98122 Recruiting
ThedaCare Regional Cancer Center Appleton Wisconsin 54911 Recruiting
ThedaCare Regional Medical Center - Appleton Appleton Wisconsin 54911 Recruiting
Duluth Clinic Ashland Ashland Wisconsin 54806 Recruiting
Saint Vincent Hospital Cancer Center Green Bay Green Bay Wisconsin 54301 Recruiting
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay Wisconsin 54303 Recruiting
Gundersen Lutheran Medical Center La Crosse Wisconsin 54601 Recruiting
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center Madison Wisconsin 53718 Recruiting
University of Wisconsin Carbone Cancer Center - University Hospital Madison Wisconsin 53792 Recruiting
Medical College of Wisconsin Milwaukee Wisconsin 53226 Recruiting
Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin 54482 Recruiting
Marshfield Medical Center - Weston Weston Wisconsin 54476 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 11 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05554406, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Oct 14, 2026 · Synced Oct 16, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT05554406 live on ClinicalTrials.gov.

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