Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2

ClinicalTrials.gov ID: NCT05555589

Public ClinicalTrials.gov record NCT05555589. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 22, 2026, 4:35 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Multi-Center, Randomized, Parallel, Double Masked, Placebo-Controlled Clinical Study to Assess the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of Neurotrophic Keratopathy (SEER-2)

Study identification

NCT ID: NCT05555589
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: ReGenTree, LLC; Industry
Enrollment: 70 participants

Conditions and interventions

Conditions

Neurotrophic Keratopathy

Interventions

RGN-259 Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Apr 10, 2023
Primary completion: Apr 29, 2026
Completion: May 29, 2026
Last update posted: Dec 22, 2025

2023 – 2026

United States locations

U.S. sites: 29
U.S. states: 18
U.S. cities: 28

Facility	City	State	ZIP	Site status
Harvard Eye Associates	Laguna Hills	California	92653	Recruiting
Loma Linda University Eye Institute	Loma Linda	California	92354	Recruiting
Retina Consultants of Southern Colorado	Colorado Springs	Colorado	80909	Active, not recruiting
Advance Vision Research Institute	Longmont	Colorado	80503	Recruiting
Connecticut Eye Consultants, P.C. Danbury Eye Physicians & Surgeons	Danbury	Connecticut	06810	Recruiting
Nature Coast Clinical Research	Crystal River	Florida	34429	Recruiting
University of Miami - Bascom Palmer Eye Institute, Miami	Miami	Florida	33136	Recruiting
University of South Florida, Ophthalmolgoy	Tampa	Florida	33612	Recruiting
Thomas Eye Group, P.C.	Sandy Springs	Georgia	30328	Recruiting
Northwestern	Chicago	Illinois	60611	Recruiting
Midwest Cornea Associates, LLC.	Carmel	Indiana	46290	Recruiting
Huffman & Huffman, PSC	Lexington	Kentucky	40509	Active, not recruiting
Midwest Vision Research Foundation	Chesterfield	Missouri	63017	Recruiting
Washington University Eye Center	St Louis	Missouri	63108	Recruiting
Metropolitan Eye Research and Surgery Institute	Palisades Park	New Jersey	07650	Recruiting
Montefiore Medical Center	The Bronx	New York	10467	Recruiting
Duke Eye Center	Durham	North Carolina	27710	Recruiting
Oculus Research	Raleigh	North Carolina	27617	Active, not recruiting
CORE, Inc. / Vita Eye Clinic	Shelby	North Carolina	28150	Active, not recruiting
University Hospitals Cleveland Medical Center	Cleveland	Ohio	44106	Recruiting
Cleveland Clinic, Cole Eye Institute	Cleveland	Ohio	44195	Recruiting
Pacific ClearVision Institute	Eugene	Oregon	97401	Active, not recruiting
Cataract & Laser Institute of Southern Oregon	Medford	Oregon	97504	Recruiting
OHSU Casey Eye Institute	Portland	Oregon	97239	Recruiting
UPMC Eye Center	Pittsburgh	Pennsylvania	15213	Recruiting
MCOA Eye Care	San Antonio	Texas	78240	Recruiting
Berkeley Eye Center	Sugar Land	Texas	77478	Recruiting
Virginia Eye Consultants	Norfolk	Virginia	23502	Recruiting
University of Washington, Department of Ophthalmology	Seatle	Washington	98104	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05555589, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Dec 22, 2025 · Synced Jul 22, 2026

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The complete protocol, eligibility criteria, and contact information for NCT05555589 live on ClinicalTrials.gov.

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